Document Type
Article
Publication Date
6-4-2019
Publication Title
J Am Heart Assoc
Abstract
Background Early rapid declines of kidney function may occur in patients with atherosclerotic renal artery stenosis with institution of medical therapy. The causes and consequences are not well understood. Methods and Results Patients enrolled in the medical therapy-only arm of the CORAL (Cardiovascular Outcomes With Renal Artery Lesions) study were assessed for a rapid decline (RD) in estimated glomerular filtration rate (eGFR), defined as a ≥30% decrease from baseline to either 3 months, 6 months, or both. In the medical therapy-only cohort, eGFR was available in 359 subjects at all time points, the subjects were followed for a median of 4.72 years, and 66 of 359 (18%) subjects experienced an early RD. Baseline log cystatin C (odds ratio, 1.78 [1.11-2.85]; P=0.02), age (odds ratio, 1.04 [1.00-1.07]; P
Clinical Institute
Kidney & Diabetes
Clinical Institute
Cardiovascular (Heart)
Department
Cardiology
Department
Nephrology
Recommended Citation
Cooper, Emily L; Xie, Yanmei; Nguyen, Hanh; Brewster, Pamela S; Sholl, Haden; Sharrett, Megan; Ren, Kaili; Chen, Tian; Tuttle, Katherine; Haller, Steven T; Jamerson, Kenneth; Murphy, Timothy P; D'Agostino, Ralph B; Massaro, Joseph M; Henrich, William; Cooper, Christopher J; Cutlip, Donald E; Dworkin, Lance D; and Shapiro, Joseph I, "Early Rapid Decline in Kidney Function in Medically Managed Patients With Atherosclerotic Renal Artery Stenosis." (2019). Articles, Abstracts, and Reports. 2021.
https://digitalcommons.providence.org/publications/2021
