Emergence of diversity in homogeneous coupled Boolean networks.
Document Type
Article
Publication Date
5-1-2018
Publication Title
Phys Rev E
Keywords
Evolution, Molecular; Gene Regulatory Networks; Models, Genetic
Abstract
The origin of multicellularity in metazoa is one of the fundamental questions of evolutionary biology. We have modeled the generic behaviors of gene regulatory networks in isogenic cells as stochastic nonlinear dynamical systems-coupled Boolean networks with perturbation. Model simulations under a variety of dynamical regimes suggest that the central characteristic of multicellularity, permanent spatial differentiation (diversification), indeed can arise. Additionally, we observe that diversification is more likely to occur near the critical regime of Lyapunov stability.
Department
Institute for Systems Biology
Recommended Citation
Kang, Chris; Aguilar, Boris; and Shmulevich, Ilya, "Emergence of diversity in homogeneous coupled Boolean networks." (2018). Articles, Abstracts, and Reports. 189.
https://digitalcommons.providence.org/publications/189
