Title

Emergence of diversity in homogeneous coupled Boolean networks.

Document Type

Article

Publication Date

5-1-2018

Abstract

The origin of multicellularity in metazoa is one of the fundamental questions of evolutionary biology. We have modeled the generic behaviors of gene regulatory networks in isogenic cells as stochastic nonlinear dynamical systems-coupled Boolean networks with perturbation. Model simulations under a variety of dynamical regimes suggest that the central characteristic of multicellularity, permanent spatial differentiation (diversification), indeed can arise. Additionally, we observe that diversification is more likely to occur near the critical regime of Lyapunov stability.

Department

Institute for Systems Biology

Volume

97

Issue

5-1

First Page

052415

Last Page

052415

PubMed ID

29906914

Journal Title

Phys Rev E

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