Journal of translational medicine [electronic resource]
BACKGROUND: The pleiotropic cytokine, transforming growth factor (TGF)-β, and CD4
METHODS: Using BALB/c, FoxP3eGFP and Rag
RESULTS: SM16 abrogates TGF-β-induced Treg generation in vitro but does not prevent global homeostatic expansion of CD4
CONCLUSIONS: These findings suggest that blockade of TGF-β signaling is a potentially useful strategy for blunting Treg function to enhance the anti-tumor response. Our data further suggest that the overall dampening of Treg function may involve the expansion of a quiescent Treg precursor population, which is CD4
Earle A. Chiles Research Institute
Polanczyk, Magdalena J; Walker, Edwin; Haley, Daniel; Guerrouahen, Bella S; and Akporiaye, Emmanuel T, "Blockade of TGF-β signaling to enhance the antitumor response is accompanied by dysregulation of the functional activity of CD4" (2019). Articles, Abstracts, and Reports. 1887.