Document Type
Article
Publication Date
10-1-2017
Publication Title
CNS Oncol
Keywords
Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; ErbB Receptors; Humans; Injections, Spinal; Male; Meningeal Carcinomatosis; Peripheral Nerves; Skin Neoplasms
Abstract
Squamous cell carcinoma (SCC) is a common cancer of the skin. Risk factors include fair skin, excessive sun and ultraviolet light exposure, and history of xeroderma pigmentosa. Perineural invasion (PNI), an uncommon manifestation of SCC, involves microscopic tumor cells invading various layers of the nerve sheath. It is associated with a poorer prognosis. Standard treatment for PNI includes radiation therapy. Here, we describe a case an older gentleman with a history of SCC with PNI successfully treated with erlotinib and intrathecal chemotherapy.
Clinical Institute
Neurosciences (Brain & Spine)
Clinical Institute
Cancer
Department
Neurosciences
Department
Oncology
Recommended Citation
van Vugt, Vincent Alexander; Saria, Marlon Garzo; Javier, Andres; Kesari, Navin; Turpin, Tiffany; and Kesari, Santosh, "Neurological improvement of perineural and leptomeningeal spread of squamous cell carcinoma treated with intrathecal chemotherapy and systemic EGFR inhibition." (2017). Articles, Abstracts, and Reports. 1722.
https://digitalcommons.providence.org/publications/1722