Cancer Genomics Proteomics
Early stage lung cancer; biomarkers; detection; diagnosis; immunoassay; non-small cell lung cancer; proteomics
BACKGROUND/AIM: In 2016 in the United States, 7 of 10 patients were estimated to die following lung cancer diagnosis. This is due to a lack of a reliable screening method that detects early-stage lung cancer. Our aim is to accurately detect early stage lung cancer using algorithms and protein biomarkers.
PATIENTS AND METHODS: A total of 1,479 human plasma samples were processed using a multiplex immunoassay platform. 82 biomarkers and 6 algorithms were explored. There were 351 NSCLC samples (90.3% Stage I, 2.3% Stage II, and 7.4% Stage III/IV).
RESULTS: We identified 33 protein biomarkers and developed a classifier using Random Forest. Our test detected early-stage Non-Small Cell Lung Cancer (NSCLC) with a 90% accuracy, 80% sensitivity, and 95% specificity in the validation set using the 33 markers.
CONCLUSION: A specific, non-invasive, early-detection test, in combination with low-dose computed tomography, could increase survival rates and reduce false positives from screenings.
Goebel, Cherylle; Louden, Christopher L; McKenna, Robert; Onugha, Osita; Wachtel, Andrew; and Long, Thomas, "Diagnosis of Non-small Cell Lung Cancer for Early Stage Asymptomatic Patients." (2019). Articles, Abstracts, and Reports. 1703.