Triple-negative breast cancer in the elderly: Prognosis and treatment.

Document Type

Article

Publication Date

11-1-2017

Publication Title

The breast journal

Keywords

Adult; Age Factors; Aged; Aged, 80 and over; Cohort Studies; Disease-Free Survival; Female; Humans; Middle Aged; Neoplasm Staging; Prognosis; Proportional Hazards Models; Registries; Retrospective Studies; Triple Negative Breast Neoplasms; Washington

Abstract

Our objective is to characterize treatment of triple-negative breast cancer (TNBC) in older patients and measure mortality risk relative to younger women. We conducted a retrospective cohort study analysis of patients presenting with primary TNBC, age 25-93, stage I-III from 1990 to 2014, identified and tracked by our registry (n=771). Clinical characteristics were chart abstracted at diagnosis and follow-up. The Kaplan-Meier method was used to measure disease-specific survival (DSS) by age with Cox regression modeling for relative contribution of patient and clinical characteristics. Of patients, 80% were(n=612), 13% were 65-74 years (n=100), and 7% were 75 and older (n=59). Older women presented more often with lower stage BC (stage I: 31% age

Clinical Institute

Cancer

Clinical Institute

Women & Children

Department

Oncology

Department

Geriatrics

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