Title

Diminished Susceptibility of African-Americans to Non-tuberculous Mycobacterial Disease.

Document Type

Article

Publication Date

2-1-2018

Publication Title

Lung

Keywords

African Americans; Bronchiectasis; Humans; Incidence; Mycobacterium Infections, Nontuberculous; Risk Factors; United States

Abstract

The incidence of three granulomatous response diseases-sarcoidosis, tuberculosis, and non-tuberculous mycobacterial pulmonary disease-differ markedly in African-Americans versus Caucasians. In reviewing a large compendium of non-cystic-fibrosis bronchiectasis, we noted that complicating infection with non-tuberculous mycobacteria was relatively infrequent among individuals of African-American descent, confirming previous observations of their inherent resistance. Disease-specific variance among African-Americans in the efficacy of their granulomatous response suggests a nexus, a mediating, immunological mechanism. Environmentally conditioned selection of SLC11A1 (Nramp1) alleles may account for this ethnic variance.

Department

Pulmonary Medicine

Department

Earle A. Chiles Research Institute

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