Ki-67 index as a predictor of vestibular schwannoma regrowth or recurrence.
The Journal of laryngology and otology
Female; Humans; Ki-67 Antigen; Male; Middle Aged; Neoplasm Recurrence, Local; Neuroma, Acoustic; Predictive Value of Tests; Retrospective Studies; Acoustic; Vestibular; Neuroma; Recurrence; Schwannoma
BACKGROUND: Ki-67 is a monoclonal antibody that provides a means of evaluating the growth fraction of normal and neoplastic human cell populations. A Ki-67 index of less than 3 per cent is expected for a typical schwannoma. Vestibular schwannomas with an index of greater than 3 per cent are presumed to be actively proliferating and pose a theoretically higher risk for regrowth or recurrence.
METHODS: A retrospective chart review was conducted. Ki-67 staining was performed and specimens were divided into two groups according to Ki-67 activity: less than 3 per cent (low index), and 3 per cent or greater (elevated index).
RESULTS: Eight patients (53.3 per cent) with elevated Ki-67 had recurrence or regrowth, versus five (8.5 per cent) in the low Ki-67 group. Among the 13 patients with recurrence or regrowth, the average Ki-67 value was 4.3 per cent. Among the 61 patients without recurrence or regrowth, the average Ki-67 value was 1.0 per cent.
CONCLUSION: The Ki-67 labelling index reliably identifies vestibular schwannomas with an elevated potential for recurrence or regrowth in subtotal or total resection cases. In patients with a Ki-67 index greater than 3 per cent, more frequent clinical examination and radiological follow up are recommended.
Prueter, J; Norvell, D; and Backous, D, "Ki-67 index as a predictor of vestibular schwannoma regrowth or recurrence." (2019). Articles, Abstracts, and Reports. 1468.