angiogenesis; astrocytosis; gliosis; neuroblast; stroke
Neural repair after stroke involves initiation of a cellular proliferative program in the form of angiogenesis, neurogenesis, and molecular growth signals in the surrounding tissue elements. This cellular environment constitutes a niche in which regeneration of new blood vessels and new neurons leads to partial tissue repair after stroke. Cancer metastasis has similar proliferative cellular events in the brain and other organs. Do cancer and CNS tissue repair share similar cellular processes? In this study, we identify a novel role of the regenerative neurovascular niche induced by stroke in promoting brain melanoma metastasis through enhancing cellular interactions with surrounding niche components. Repair-mediated neurovascular signaling induces metastatic cells to express genes crucial to metastasis. Mimicking stroke-like conditions
Neurosciences (Brain & Spine)
Prakash, Roshini; Izraely, Sivan; Thareja, Nikita S; Lee, Rex H; Rappaport, Maya; Kawaguchi, Riki; Sagi-Assif, Orit; Ben-Menachem, Shlomit; Meshel, Tsipi; Machnicki, Michal; Ohe, Shuichi; Hoon, Dave S B; Coppola, Giovanni; Witz, Isaac P; and Carmichael, S Thomas, "Regeneration Enhances Metastasis: A Novel Role for Neurovascular Signaling in Promoting Melanoma Brain Metastasis." (2019). Articles, Abstracts, and Reports. 1421.