Adult; Chromosome Mapping; Chromosomes, Human, X; Computational Biology; Computer Simulation; Family Health; Genetic Markers; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Haplotypes; Humans; Male; Neoplasms, Germ Cell and Embryonal; Polymorphism, Single Nucleotide; Risk; Testicular Neoplasms; Young Adult
The international Testicular Cancer Consortium (TECAC) combined five published genome-wide association studies of testicular germ cell tumor (TGCT; 3,558 cases and 13,970 controls) to identify new susceptibility loci. We conducted a fixed-effects meta-analysis, including, to our knowledge, the first analysis of the X chromosome. Eight new loci mapping to 2q14.2, 3q26.2, 4q35.2, 7q36.3, 10q26.13, 15q21.3, 15q22.31, and Xq28 achieved genome-wide significance (P < 5 × 10
Institute for Systems Biology
Wang, Zhaoming; McGlynn, Katherine A; Rajpert-De Meyts, Ewa; Bishop, D Timothy; Chung, Charles C; Dalgaard, Marlene D; Greene, Mark H; Gupta, Ramneek; Grotmol, Tom; Haugen, Trine B; Karlsson, Robert; Litchfield, Kevin; Mitra, Nandita; Nielsen, Kasper; Pyle, Louise C; Schwartz, Stephen M; Thorsson, Vésteinn; Vardhanabhuti, Saran; Wiklund, Fredrik; Turnbull, Clare; Chanock, Stephen J; Kanetsky, Peter A; and Nathanson, Katherine L, "Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor." (2017). Articles, Abstracts, and Reports. 1350.