Authors

Rebecca Sims
Sven J van der Lee
Adam C Naj
Céline Bellenguez
Nandini Badarinarayan
Johanna Jakobsdottir
Brian W Kunkle
Anne Boland
Rachel Raybould
Joshua C Bis
Eden R Martin
Benjamin Grenier-Boley
Stefanie Heilmann-Heimbach
Vincent Chouraki
Amanda B Kuzma
Kristel Sleegers
Maria Vronskaya
Agustin Ruiz
Robert R Graham
Robert Olaso
Per Hoffmann
Megan L Grove
Badri N Vardarajan
Mikko Hiltunen
Markus M Nöthen
Charles C White
Kara L Hamilton-Nelson
Jacques Epelbaum
Wolfgang Maier
Seung-Hoan Choi
Gary W Beecham
Cécile Dulary
Stefan Herms
Albert V Smith
Cory C Funk, Institute for Systems Biology, Seattle, WA, 98109-5263, USA.Follow
Céline Derbois
Andreas J Forstner
Shahzad Ahmad
Hongdong Li, Institute for Systems Biology, Seattle, Washington, USA
Delphine Bacq
Denise Harold
Claudia L Satizabal
Otto Valladares
Alessio Squassina
Rhodri Thomas
Jennifer A Brody
Liming Qu
Pascual Sánchez-Juan
Taniesha Morgan
Frank J Wolters
Yi Zhao
Florentino Sanchez Garcia
Nicola Denning
Myriam Fornage
John Malamon
Maria Candida Deniz Naranjo
Elisa Majounie
Thomas H Mosley
Beth Dombroski
David Wallon
Michelle K Lupton
Josée Dupuis
Patrice Whitehead
Laura Fratiglioni
Christopher Medway
Xueqiu Jian
Shubhabrata Mukherjee
Lina Keller
Kristelle Brown
Honghuang Lin
Laura B Cantwell
Francesco Panza
Bernadette McGuinness
Sonia Moreno-Grau
Jeremy D Burgess
Vincenzo Solfrizzi
Petra Proitsi
Hieab H Adams
Mariet Allen
Davide Seripa
Pau Pastor
L Adrienne Cupples
Nathan D Price, Institute for Systems Biology, 401 Terry Avenue N, Seattle, WA, 98109, USA.Follow
Didier Hannequin
Ana Frank-García
Daniel Levy
Paramita Chakrabarty
Paolo Caffarra
Ina Giegling
Alexa S Beiser
Vilmantas Giedraitis
Harald Hampel
Melissa E Garcia
Xue Wang
Lars Lannfelt
Patrizia Mecocci
Gudny Eiriksdottir
Paul K Crane
Florence Pasquier
Virginia Boccardi
Isabel Henández
Robert C Barber
Martin Scherer
Lluis Tarraga
Perrie M Adams
Markus Leber
Yuning Chen
Marilyn S Albert
Steffi Riedel-Heller
Valur Emilsson
Duane Beekly
Anne Braae
Reinhold Schmidt
Deborah Blacker
Carlo Masullo
Helena Schmidt
Rachelle S Doody
Gianfranco Spalletta
W T Longstreth
Thomas J Fairchild
Paola Bossù
Oscar L Lopez
Matthew P Frosch
Eleonora Sacchinelli
Bernardino Ghetti
Qiong Yang
Ryan M Huebinger
Frank Jessen
Shuo Li
M Ilyas Kamboh
John Morris
Oscar Sotolongo-Grau
Mindy J Katz
Chris Corcoran
Melanie Dunstan
Amy Braddel
Charlene Thomas
Alun Meggy
Rachel Marshall
Amy Gerrish
Jade Chapman
Miquel Aguilar
Sarah Taylor
Matt Hill
Mònica Díez Fairén
Angela Hodges
Bruno Vellas
Hilkka Soininen
Iwona Kloszewska
Makrina Daniilidou
James Uphill
Yogen Patel
Joseph T Hughes
Jenny Lord
James Turton
Annette M Hartmann
Roberta Cecchetti
Chiara Fenoglio
Maria Serpente
Marina Arcaro
Carlo Caltagirone
Maria Donata Orfei
Antonio Ciaramella
Sabrina Pichler
Manuel Mayhaus
Wei Gu
Alberto Lleó
Juan Fortea
Rafael Blesa
Imelda S Barber
Keeley Brookes
Chiara Cupidi
Raffaele Giovanni Maletta
David Carrell
Sandro Sorbi
Susanne Moebus
Maria Urbano
Alberto Pilotto
Johannes Kornhuber
Paolo Bosco
Stephen Todd
David Craig
Janet Johnston
Michael Gill
Brian Lawlor
Aoibhinn Lynch
Nick C Fox
John Hardy
Roger L Albin
Liana G Apostolova
Steven E Arnold
Sanjay Asthana
Craig S Atwood
Clinton T Baldwin
Lisa L Barnes
Sandra Barral
Thomas G Beach
James T Becker
Eileen H Bigio
Thomas D Bird
Bradley F Boeve
James D Bowen
Adam Boxer
James R Burke
Jeffrey M Burns
Joseph D Buxbaum
Nigel J Cairns
Chuanhai Cao
Chris S Carlson
Cynthia M Carlsson
Regina M Carney
Minerva M Carrasquillo
Steven L Carroll
Carolina Ceballos Diaz
Helena C Chui
David G Clark
David H Cribbs
Elizabeth A Crocco
Charles DeCarli
Malcolm Dick
Ranjan Duara
Denis A Evans
Kelley M Faber
Kenneth B Fallon
David W Fardo
Martin R Farlow
Steven Ferris
Tatiana M Foroud
Douglas R Galasko
Marla Gearing
Daniel H Geschwind
John R Gilbert
Neill R Graff-Radford
Robert C Green
John H Growdon
Ronald L Hamilton
Lindy E Harrell
Lawrence S Honig
Matthew J Huentelman
Christine M Hulette
Bradley T Hyman
Gail P Jarvik
Erin Abner
Lee-Way Jin
Gyungah Jun
Anna Karydas
Jeffrey A Kaye
Ronald Kim
Neil W Kowall
Joel H Kramer
Frank M LaFerla
James J Lah
James B Leverenz
Allan I Levey
Ge Li
Andrew P Lieberman
Kathryn L Lunetta
Constantine G Lyketsos
Daniel C Marson
Frank Martiniuk
Deborah C Mash
Eliezer Masliah
Wayne C McCormick
Susan M McCurry
Andrew N McDavid
Ann C McKee
Marsel Mesulam
Bruce L Miller
Carol A Miller
Joshua W Miller
John C Morris
Jill R Murrell
Amanda J Myers
Sid O'Bryant
John M Olichney
Vernon S Pankratz
Joseph E Parisi
Henry L Paulson
William Perry
Elaine Peskind
Aimee Pierce
Wayne W Poon
Huntington Potter
Joseph F Quinn
Ashok Raj
Murray Raskind
Barry Reisberg
Christiane Reitz
John M Ringman
Erik D Roberson
Ekaterina Rogaeva
Howard J Rosen
Roger N Rosenberg
Mark A Sager
Andrew J Saykin
Julie A Schneider
Lon S Schneider
William W Seeley
Amanda G Smith
Joshua A Sonnen
Salvatore Spina
Robert A Stern
Russell H Swerdlow
Rudolph E Tanzi
Tricia A Thornton-Wells
John Q Trojanowski
Juan C Troncoso
Vivianna M Van Deerlin
Linda J Van Eldik
Harry V Vinters
Jean Paul Vonsattel
Sandra Weintraub
Kathleen A Welsh-Bohmer
Kirk C Wilhelmsen
Jennifer Williamson
Thomas S Wingo
Randall L Woltjer
Clinton B Wright
Chang-En Yu
Lei Yu
Fabienne Garzia
Feroze Golamaully
Gislain Septier
Sebastien Engelborghs
Rik Vandenberghe
Peter P De Deyn
Carmen Muñoz Fernadez
Yoland Aladro Benito
Hakan Thonberg
Charlotte Forsell
Lena Lilius
Anne Kinhult-Stählbom
Lena Kilander
RoseMarie Brundin
Letizia Concari
Seppo Helisalmi
Anne Maria Koivisto
Annakaisa Haapasalo
Vincent Dermecourt
Nathalie Fievet
Olivier Hanon
Carole Dufouil
Alexis Brice
Karen Ritchie
Bruno Dubois
Jayanadra J Himali
C Dirk Keene
JoAnn Tschanz
Annette L Fitzpatrick
Walter A Kukull
Maria Norton
Thor Aspelund
Eric B Larson
Ron Munger
Jerome I Rotter
Richard B Lipton
María J Bullido
Albert Hofman
Thomas J Montine
Eliecer Coto
Eric Boerwinkle
Ronald C Petersen
Victoria Alvarez
Fernando Rivadeneira
Eric M Reiman
Maura Gallo
Christopher J O'Donnell
Joan S Reisch
Amalia Cecilia Bruni
Donald R Royall
Martin Dichgans
Mary Sano
Daniela Galimberti
Peter St George-Hyslop
Elio Scarpini
Debby W Tsuang
Michelangelo Mancuso
Ubaldo Bonuccelli
Ashley R Winslow
Antonio Daniele
Chuang-Kuo Wu
Oliver Peters
Benedetta Nacmias
Matthias Riemenschneider
Reinhard Heun
Carol Brayne
David C Rubinsztein
Jose Bras
Rita Guerreiro
Ammar Al-Chalabi
Christopher E Shaw
John Collinge
David Mann
Magda Tsolaki
Jordi Clarimón
Rebecca Sussams
Simon Lovestone
Michael C O'Donovan
Michael J Owen
Timothy W Behrens
Simon Mead
Alison M Goate
Andre G Uitterlinden
Clive Holmes
Carlos Cruchaga
Martin Ingelsson
David A Bennett
John Powell
Todd E Golde
Caroline Graff
Philip L De Jager
Kevin Morgan
Nilufer Ertekin-Taner
Onofre Combarros
Bruce M Psaty
Peter Passmore
Steven G Younkin
Claudine Berr
Vilmundur Gudnason
Dan Rujescu
Dennis W Dickson
Jean-François Dartigues
Anita L DeStefano
Sara Ortega-Cubero
Hakon Hakonarson
Dominique Campion
Merce Boada
John Keoni Kauwe
Lindsay A Farrer
Christine Van Broeckhoven
M Arfan Ikram
Lesley Jones
Jonathan L Haines
Christophe Tzourio
Lenore J Launer
Valentina Escott-Price
Richard Mayeux
Jean-François Deleuze
Najaf Amin
Peter A Holmans
Margaret A Pericak-Vance
Philippe Amouyel
Cornelia M van Duijn
Alfredo Ramirez
Li-San Wang
Jean-Charles Lambert
Sudha Seshadri
Julie Williams
Gerard D Schellenberg

Document Type

Article

Publication Date

9-1-2017

Publication Title

Nature genetics

Keywords

Adaptor Proteins, Signal Transducing; Alzheimer Disease; Amino Acid Sequence; Case-Control Studies; Exome; Gene Expression Profiling; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Immunity, Innate; Linkage Disequilibrium; Membrane Glycoproteins; Microglia; Odds Ratio; Phospholipase C gamma; Polymorphism, Single Nucleotide; Protein Interaction Maps; Receptors, Immunologic; Sequence Homology, Amino Acid

Abstract

We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (P < 1 × 10

Department

Institute for Systems Biology

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