Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer.
Document Type
Article
Publication Date
4-1-2019
Publication Title
Cancer Immunol Res
Abstract
Adoptive cell therapy (ACT) with T cells targeting neoantigens can mediate durable responses in patients with metastatic cancer. Cell therapies targeting common shared antigens for epithelial cancers are not yet broadly available. Here, we report the identification and characterization in one patient of T-cell receptors (TCRs) recognizing mutated p53 p.R175H, which is shared among a subset of patients with cancer. Tumor-infiltrating lymphocytes were screened for recognition of mutated neoantigens in a patient with metastatic colorectal cancer. HLA-A*0201-restricted recognition of mutated p53 p.R175H was identified, and the minimal peptide epitope was HMTEVVR
Clinical Institute
Cancer
Clinical Institute
Digestive Health
Department
Earle A. Chiles Research Institute
Department
Oncology
Department
Gastroenterology
Recommended Citation
Lo, Winifred; Parkhurst, Maria; Robbins, Paul F; Tran, Eric; Lu, Yong-Chen; Jia, Li; Gartner, Jared J; Pasetto, Anna; Deniger, Drew; Malekzadeh, Parisa; Shelton, Thomas E; Prickett, Todd; Ray, Satyajit; Kivitz, Scott; Paria, Biman C; Kriley, Isaac; Schrump, David S; and Rosenberg, Steven A, "Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer." (2019). Articles, Abstracts, and Reports. 1181.
https://digitalcommons.providence.org/publications/1181
