Effects of Age and Sex of on Response to Ursodeoxycholic Acid and Transplant-free Survival in Patients With Primary Biliary Cholangitis.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Cholestatic Liver Disease; Mortality; Risk stratification; Stratified Medicine
BACKGROUND & AIMS: Primary biliary cholangitis (PBC) predominantly affects middle-aged women; there are few data on disease phenotypes and outcomes of PBC in men and younger patients. We investigated whether differences in sex and/or age at the start of ursodeoxycholic acid (UDCA) treatment are associated with response to therapy, based on biochemical markers, or differences in transplant-free survival.
METHODS: We performed a longitudinal retrospective study of 4355 adults in the Global PBC Study cohort, collected from 17 centers across Europe and North America. Patients received a diagnosis of PBC from 1961 through 2014. We evaluated the effects of sex and age on response to UDCA treatment (based on GLOBE score) and transplant-free survival using logistic regression and Cox regression analyses, respectively.
RESULTS: Male patients were older at the start of treatment (58.3±12.1 years vs 54.3±11.6 years for women; P
CONCLUSION: In longitudinal analysis of 4355 adults in the Global PBC Study, we associated patient age, but not sex, with response to UDCA treatment and transplant-free survival. Younger age at time of PBC diagnosis is associated with increased risk of treatment failure, liver transplant, and death.
Cheung, Angela C; Lammers, Willem J; Murillo Perez, Carla F; van Buuren, Henk R; Gulamhusein, Aliya; Trivedi, Palak J; Lazaridis, Konstantinos N; Ponsioen, Cyriel Y; Floreani, Annarosa; Hirschfield, Gideon M; Corpechot, Christophe; Mayo, Marlyn J; Invernizzi, Pietro; Battezzati, Pier Maria; Parés, Albert; Nevens, Frederik; Thorburn, Douglas; Mason, Andrew L; Carbone, Marco; Kowdley, Kris V; Bruns, Tony; Dalekos, George N; Gatselis, Nikolaos K; Verhelst, Xavier; Lindor, Keith D; Lleo, Ana; Poupon, Raoul; Janssen, Harry L; and Hansen, Bettina E, "Effects of Age and Sex of on Response to Ursodeoxycholic Acid and Transplant-free Survival in Patients With Primary Biliary Cholangitis." (2019). Articles, Abstracts, and Reports. 1105.