Role of the immunosuppressive microenvironment in immunotherapy.
Adv Radiat Oncol
Immunotherapy is reshaping cancer treatment paradigms; however, response rates to immune therapies are low and depend on the host's pre-existing antitumor immunity. The tumor microenvironment is comprised of malignant cells, stroma, and extracellular molecules and can hinder immune control of tumors. Herein, we review how anti-tumor immune responses are formed and how tumors avoid immune destruction. We also outline potential therapeutic targets in the immunosuppressive tumor microenvironment to promote immune control of tumors.
Earle A. Chiles Research Institute
Tormoen, Garth W; Crittenden, Marka R; and Gough, Michael J., "Role of the immunosuppressive microenvironment in immunotherapy." (2018). Articles, Abstracts, and Reports. 1014.