Histochemistry in the diagnosis of non-neoplastic gastrointestinal disorders.

Document Type

Article

Publication Date

11-1-2018

Publication Title

Seminars in diagnostic pathology

Keywords

Alimentary tract infections; Amyloidosis; Collagenous colitis; Gastrointestinal disorders; Histochemistry; Intestinal metaplasia; Neuroendocrine cell hyperplasia

Abstract

The alimentary tract serves as host to a large number of diseases. In the non-neoplastic group of disorders, conventional histochemistry continues to play an important diagnostic role. It is particularly important in recognizing specific infectious diseases, such as Helicobacter gastritis, Whipple disease, intestinal tuberculosis and other forms of mycobacteriosis, malakoplakia, intestinal spirochetosis, fungal enteritides, amebiasis, cryptosporidiosis, isosporiasis, and microsporidiosis. Those conditions and their histochemical properties are discussed in this review, along with the use of histochemistry in the characterization of structural gastrointestinal disorders. The latter include mucosal metaplasias, amyloidosis, glycogenic acanthosis of the esophagus, lymphocytic-collagenous colitis, gastric neuroendocrine hyperplasia, and pill gastritis.

Clinical Institute

Digestive Health

Department

Pathology & Laboratory Medicine

Department

Gastroenterology

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