Testicular tumors in prepubescent patients.

Document Type

Article

Publication Date

9-1-2018

Publication Title

Journal of pediatric surgery

Keywords

Child; Child, Preschool; Databases, Factual; Follow-Up Studies; Humans; Infant; Infant, Newborn; Male; Prognosis; Retrospective Studies; Testicular Neoplasms; United States

Abstract

BACKGROUND/PURPOSE: Pediatric testicular tumors are rare, constituting only 1% of all pediatric solid tumors. Single-institution studies addressing pediatric testicular tumors published to date have been limited in the number of patients.

METHODS: We utilized the National Cancer Data Base (1998-2012) to review all prepubescent patients (≤12 years old) with testicular neoplasms. Demographics, tumor characteristics, treatment modalities, and outcomes were abstracted.

RESULTS: A total of 479 patients were identified, with a median age of 3 years (IQR 0-4) at diagnosis. 67% of cases were diagnosed by 3 years of age. Yolk sac tumors were the most common histology (202 patients, 42.2%). Most tumors were diagnosed at a low stage. Resection was performed in 465 boys, with 75% having undergone radical orchiectomies. Chemotherapy was utilized in 28% of cases and radiotherapy in 7%. With mean follow-up of 5.6 years, mortality rate was 3%. No difference in mortality was noted based on histology or extent of surgical resection.

CONCLUSIONS: This series of prepubertal testicular tumors is the largest yet reported and highlights the patient demographics, tumor characteristics, treatment modalities and outcomes for these tumors.

TYPE OF STUDY: Prognosis study LEVEL OF EVIDENCE: II.

Clinical Institute

Cancer

Clinical Institute

Women & Children

Department

Oncology

Department

Pediatrics

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