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Submissions from 2022

Increased Drug Intoxications Seen in Heart Transplant Donors During COVID-19 Pandemic, V Nguyen, Jacob Abraham, J Gelow, K Koomalsingh, and D Oseran

Cardiogenic Shock by SCAI Classification in Patients Awaiting Heart Transplantation, V Nguyen, J Gelow, and Jacob Abraham

The Effect of Center Transplant Rate and the Use of Temporary Mechanical Circulatory Support on Heart Transplant Outcomes, Vidang P. Nguyen, Jacob Abraham, Sophia Airhart, Jill M Gelow, J Kay, and Kevin Koomalsingh

Increased Drug Intoxications Seen in Heart Transplant Donors During COVID-19 Pandemic, Vidang P. Nguyen, Jacob Abraham, Jill M Gelow, Kevin Koomalsingh, and Daniel S. Oseran

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Addition of Allograft and Acromioclavicular Cerclage Improves Outcomes of Arthroscopic-Assisted Reconstruction of Acromioclavicular Separation With a Single Coracoclavicular Tunnel., Matthew P Noyes, Pablo Narbona, Paul C Brady, David P Huberty, Christopher R Adams, Javier Ardebol, and Patrick J Denard

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Advancing Care and Outcomes for African American Patients With Multiple Sclerosis., Annette F Okai, Annette M Howard, Mitzi J Williams, Justine Brink, Chiayi Chen, tamela stuchiner, Elizabeth Baraban, Grace Jeong, and Stanley Cohan

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ASO Visual Abstract: Impact of Locoregional Treatment on Survival in Young Patients with Early-Stage Breast Cancer Undergoing Upfront Surgery., Javier I Orozco, Jennifer Keller, Shu-Ching Chang, Crystal E Fancher, and Janie Grumley

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Impact of Locoregional Treatment on Survival in Young Patients with Early-Stage Breast Cancer undergoing Upfront Surgery., Javier I Orozco, Jennifer Keller, Shu-Ching Chang, Crystal E Fancher, and Janie Grumley

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Safety and efficiency of percutaneous coronary intervention using a standardised optical coherence tomography workflow., Eric A Osborn, Michael Johnson, Aziz Maksoud, Daniel Spoon, Frank J Zidar, Ethan C Korngold, Jana Buccola, Hector Garcia Cabrera, Richard J Rapoza, Nick E J West, and Judah Rauch

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The Human Tumor Atlas Network's beginning steps toward the future of collaborative multi-omic discovery., David B Page

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Brain radiotherapy, tremelimumab-mediated CTLA-4-directed blockade +/- trastuzumab in patients with breast cancer brain metastases., David B Page, Kathryn Beal, Stefanie N Linch, Kateri Spinelli, Micaela Rodine, Darragh Halpenny, Shanu Modi, Sujata Patil, Robert J Young, Thomas Kaley, Taha Merghoub, David Redmond, Phillip Wong, Christopher A Barker, Adi Diab, Larry Norton, and Heather L McArthur

Applications of statistical regression to improve the TIL score and other immune-based biomarkers in breast cancer, DB Page

172P Phase I study of JTX-8064, a LILRB2 (ILT4) inhibitor, as monotherapy and combination with pimivalimab (pimi), a PD-1 inhibitor (PD-1i), in patients (pts) with advanced solid tumors, K Papadopoulos, Rachel Sanborn, and See all authors in comments

1296 ­Radiomics-based multi-modal prediction of treatment response to PD-1/PD-L1 immune checkpoint inhibitor (ICI) therapy in stage IV non-small cell lung carcinoma (mNSCLC), Ravi Parikh, Brendan Curti, Roshanthi Weerasinghe, and See all authors in comments

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Chemoradiation therapy alters the PD-L1 score in locoregional recurrent squamous cell carcinomas of the head and neck., Brian J Park, Austin K Mattox, Daniel Clayburgh, Mihir Patel, R Bryan Bell, Bevan Yueh, Rom Leidner, Hong Xiao, Marcus Couey, Shiting Li, Tingting Qin, Maureen A Sartor, Belinda Cairns, Tracy MacDonough, Kyle Halliwill, Daniel Deschler, Derrick T Lin, William C Faquin, Peter M Sadow, and Sara I Pai

Case Studies: Digital Ischemia, Alejandro Perez

Disorders that mimic PAD, Alejandro Perez

Finger Ischemia Attributed to Oxymetazoline Nasal Spray, Alejandro Perez

Medical Management of PAD, Alejandro Perez

Medical Management of PAD, Alejandro Perez

Medical Management of Venous disease, Alejandro Perez

Monoplace Chamber Operations Walkthrough, Alejandro Perez

Monoplace Chamber Operations Walkthrough, Alejandro Perez

Peripheral Artery Disease, Alejandro Perez

Screening and Physical Evaluation of CLTI/PAD Patients, Alejandro Perez

Screening and Physical Evaluation of CLTI/PAD Patients, Alejandro Perez

Venous Disease Management, Alejandro Perez

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The effect of maternal SARS-CoV-2 infection timing on birth outcomes: a retrospective multicentre cohort study., Samantha N Piekos, Ryan Roper, Yeon Mi Hwang, Tanya K Sorensen, Nathan D Price, Leroy Hood, and Jennifer J Hadlock

Real-World Evidence Insights in Cancer Research and Care, Brian D. Piening

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Pathogenic fusion detection in solid malignancies utilizing RNA-DNA based comprehensive genomic profiling (CGP) testing., Brian D. Piening, Alexa K Dowdell, Ryan Meng, Ann Vita, Roshanthi Weerasinghe, Alisha Stein, Bela Bapat, Brock Shroeder, Shu-Ching Chang, Lauren Harold, Mark Schmidt, Thomas R. Ward, Josiah T Wagner, Stanley Piotrowski, Phillip G. Febbo, and Carlo Bifulco

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Elucidating Diversity in Obesity-Related Phenotypes Using Longitudinal and Multi-omic Approaches, Brian D. Piening, Alexa K Dowdell, and Michael P. Snyder

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Whole transcriptome profiling of prospective endomyocardial biopsies reveals prognostic and diagnostic signatures of cardiac allograft rejection., Brian D. Piening, Alexa K Dowdell, Mengqi Zhang, Bao-Li Loza, David Walls, Hui Gao, Maede Mohebnasab, Yun Rose Li, Eric Elftmann, Eric Wei, Divya Gandla, Hetal Lad, Hassan Chaib, Nancy K Sweitzer, Mario Deng, Alexandre C Pereira, Martin Cadeiras, Abraham Shaked, Michael P Snyder, and Brendan J Keating

Design and Implementation of a Decentralized Virtual Molecular Tumor Board across a Large, Diverse Community Health System, Brian Piening, Patrick Foley, K Matlock, H Wright, Lauren Harold, Roshanthi Weerasinghe, A Viita, C Moung-Wen, Jacob Abel, Vassil Kaimaktchiev, A Dowdell, Ryan Meng, Walter Urba, G Srinivasa, Philip Gold, Gina Vaccaro, and Carlo Bifulco

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Adjuvant and Neoadjuvant Therapies in Cutaneous Melanoma., Jay Ponto and Richard Bryan Bell

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The Care Ecosystem: The Effectiveness and Implementation of Telephone-Based Collaborative Dementia Care., Katherine L Possin, Alissa Bernstein Sideman, Sarah Dulaney, Kirby Lee, Jennifer Merrilees, Steve Bonasera, Winston Chiong, Sarah M Hooper, Rachel Kiekhofer, Joanne Robinson-Teran, Isabel Elaine Allen, Tamara Braley, Elan Guterman, Talita D Rosa, Krista L Harrison, Lauren Hunt, James G Kahn, Serggio Lanata, Bruce L Miller, Ashley LaRoche, Robert John Sawyer, Adreanne Brungardt, Hillary Lum, Mailee Hess, Katie Ward, Mary E. Kuebrich, Marian O. Hodges, Nicholas T Olney, Michelle Barclay, and Michael H Rosenbloom

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Epacadostat Plus Pembrolizumab and Chemotherapy for Advanced Solid Tumors: Results from the Phase I/II ECHO-207/KEYNOTE-723 Study., John D Powderly, Samuel J Klempner, Aung Naing, Johanna Bendell, Ignacio Garrido-Laguna, Daniel V T Catenacci, Matthew H Taylor, James J Lee, Fred Zheng, Feng Zhou, Xiaohua Gong, Hema Gowda, and Gregory L Beatty

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CT209 / 9 - A first-in-human phase 1 trial of IO-108, an antagonist antibody targeting LILRB2 (ILT4), as monotherapy and in combination with pembrolizumab in adult patients with advanced relapsed or refractory solid tumors (NCT05054348), John Powderly, Matthew H Taylor, and See full list of authors in comments

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AACR Project GENIE: 100,000 cases and beyond., Trevor J Pugh, Jonathan L Bell, Jeff P Bruce, Gary J Doherty, Matthew Galvin, Michelle F Green, Haley Hunter-Zinck, Priti Kumari, Michele L LeNoue-Newton, Marilyn M Li, James Lindsay, Tali Mazor, Andrea Ovalle, Stephen-John Sammut, Nikolaus Schultz, Thomas V Yu, Shawn M Sweeney, Brady Bernard, and Aacr Project Genie Consortium

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The Elusive "Switch Process" in Bipolar Disorder and Photoperiodism: A Hypothesis Centering on NADPH Oxidase-Generated Reactive Oxygen Species Within the Bed Nucleus of the Stria Terminalis., Martin N Raitiere

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Fulminant Myocarditis Following SARS-CoV-2 Infection:, Saurabh Rajpal, Rami Kahwash, Matthew S Tong, Kelly Paschke, Anjali A Satoskar, Beth Foreman, Larry A Allen, Nicole M Bhave, Tyler J Gluckman, and Valentin Fuster

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Fulminant Myocarditis Following SARS-CoV-2 Infection: JACC Patient Care Pathways., Saurabh Rajpal, Rami Kahwash, Matthew S Tong, Kelly Paschke, Anjali A Satoskar, Beth Foreman, Larry A Allen, Nicole M Bhave, Tyler J Gluckman, and Valentin Fuster

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Efficacy of oral and topical antioxidants in the prevention and management of oral mucositis in head and neck cancer patients: a systematic review and meta-analyses., Afsheen Raza, Nelli Karimyan, Amber L Watters, Chitra P Emperumal, Kamal Al-Eryani, and Reyes Enciso

Response to aPD-1 + aLAG-3 checkpoint blockade is associated with Treg functional reprogramming and instability, William Redmond

Multimodal single-cell analysis of human TILs across multiple tumor types reveals heterogeneity and potential opportunities for personalized immunotherapy, William L. Redmond

Novel mechanisms to augment the efficacy of cancer immunotherapy, William L. Redmond

Multimodal single-cell analysis of human tumor infiltrating immune cells across multiple tumor types reveals heterogeneity and potential opportunities for personalized immunotherapeutic strategies., William L. Redmond and See full list of authors in comments

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Modified dose of guselkumab for treatment of pyoderma gangrenosum., Ashley M Reese, Katherine Erickson, Katherine B Reed, and Alex G Ortega-Loayza

Icons and Plain Language in Written Home Care Instructions, Jennifer Reynolds

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Combining bempegaldesleukin (CD122-preferential IL-2 pathway agonist) and NKTR-262 (TLR7/8 agonist) improves systemic antitumor CD8, Annah S Rolig, Daniel Rose, Grace Helen McGee, Werner Rubas, Saul Kivimäe, and William L. Redmond

Response to anti-PD-1 and anti-LAG-3 immune checkpoint blockade is associated with induction of pro-inflammatory Tregs., AS Rolig, William L. Redmond, and See full list of authors in comments

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AHPBA graduated fellows' assessments of strengths, weaknesses, opportunities and threats facing fellowship training in HPB surgery: "HPB training excellence means volume, knowledge, and mentorship"., Fernanda Romero-Hernandez, Phoebe Miller, Rosa V Mora, Dorothy Hughes, Susanne Warner, Adnan Alseidi, Brendan Visser, Michele Babicky, and AHPBA SWOT Taskforce

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Discordance Between Standard Equations for Determination of LDL Cholesterol in Patients With Atherosclerosis., Aparna Sajja, Hsin-Fang Li, Kateri Spinelli, Roger S Blumenthal, Salim S Virani, Seth S Martin, and Tyler J Gluckman

Novel Combinatorial Approaches with LAG-3, Rachel Sanborn

Targeting OX-40 and LAG-3 to Overcome T-cell Exhaustion, Rachel Sanborn

Vaccines and emerging immunotherapy approaches for NSCLC, Rachel Sanborn

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Safety, tolerability and efficacy of agonist anti-CD27 antibody (varlilumab) administered in combination with anti-PD-1 (nivolumab) in advanced solid tumors., Rachel E Sanborn, Michael J Pishvaian, Margaret K Callahan, Amy Weise, Branimir I Sikic, Osama Rahma, Daniel C Cho, Naiyer A Rizvi, Mario Sznol, Jose Lutzky, Julie E Bauman, Rhonda L Bitting, Alexander Starodub, Antonio Jimeno, David A Reardon, Thomas Kaley, Fabio Iwamoto, Joachim M Baehring, Deepa S Subramaniam, Jeanny B Aragon-Ching, Thomas R Hawthorne, Tracey Rawls, Michael Yellin, and Tibor Keler

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Beyond Checkpoint Inhibitors: Enhancing Antitumor Immune Response in Lung Cancer., Rachel E Sanborn, Famke L Schneiders, Suresh Senan, and Shirish M Gadgeel

Results from a phase 1 study of CDX-1140, a fully human anti-CD40 agonist monoclonal antibody (mAb), in combination with pembrolizumab, Rachel E. Sanborn and See all authors in comments

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Beyond Checkpoint Inhibitors: Enhancing Antitumor Immune Response in Lung Cancer, Rachel E Sanborn and See full list of authors in comments

Candidate antigens for a ductal carcinoma in situ vaccine, essential for breast cancer cell survival across multiple subtypes, are immunogenic in DCIS and IBC, SE Sanborn

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Disparities in the impact of the AJCC 8th edition staging system on differentiated thyroid cancer outcomes., Juan A Santamaria-Barria, Amanda N Graff-Baker, Shu-Ching Chang, Adam Khader, Anthony J Scholer, Mary Garland-Kledzik, and Melanie Goldfarb

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Evidence of neuroinflammation and immunotherapy responsiveness in individuals with down syndrome regression disorder., Jonathan D Santoro, Rebecca Partridge, Runi Tanna, Dania Pagarkar, Mellad Khoshnood, Mustafa Rehmani, Ryan M Kammeyer, Grace Y Gombolay, Kristen Fisher, Allison Conravey, Jane El-Dahr, Alison Christy, Lina Patel, Melanie A Manning, Heather Van Mater, Michael S Rafii, and Eileen A Quinn

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Assessment and Diagnosis of Down Syndrome Regression Disorder: International Expert Consensus., Jonathan D Santoro, Lina Patel, Ryan Kammeyer, Robyn A Filipink, Grace Y Gombolay, Kathleen M Cardinale, Diego Real de Asua, Shahid Zaman, Stephanie L Santoro, Sammer M Marzouk, Mellad Khoshnood, Benjamin N Vogel, Runi Tanna, Dania Pagarkar, Sofia Dhanani, Maria Del Carmen Ortega, Rebecca Partridge, Maria A Stanley, Jessica S Sanders, Alison Christy, Elise M Sannar, Ruth Brown, Andrew A McCormick, Heather Van Mater, Cathy Franklin, Gordon Worley, Eileen A Quinn, George T Capone, Brian Chicoine, Brian G Skotko, and Michael S Rafii

Population Health: Turning In-Basket Into ROI, J Sauer, X Huang, and LJ Larson

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2021 Digital Commons Annual Report, Amanda Schwartz

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2021 System Library Services Visual Annual Report, Amanda Schwartz

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The diverse landscape of dermatologic toxicities of non-immune checkpoint inhibitor monoclonal antibody-based cancer therapy., Riyad N H Seervai, Sarah K Friske, Emily Y Chu, Rhea Phillips, Kelly C Nelson, Auris Huen, Woo Cheal Cho, Phyu P Aung, Carlos A Torres-Cabala, Victor G Prieto, and Jonathan L Curry

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Mechanisms of dermatologic toxicities to immune checkpoint inhibitor cancer therapies., Riyad N H Seervai, Avilasha Sinha, and Rajan P Kulkarni

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Lisocabtagene maraleucel as second-line therapy in adults with relapsed or refractory large B-cell lymphoma who were not intended for haematopoietic stem cell transplantation (PILOT): an open-label, phase 2 study., Alison Sehgal, Daanish Hoda, Peter A Riedell, Nilanjan Ghosh, Mehdi Hamadani, Gerhard C Hildebrandt, John E Godwin, Patrick M Reagan, Nina Wagner-Johnston, James Essell, Rajneesh Nath, Scott R Solomon, Rebecca Champion, Edward Licitra, Suzanne Fanning, Neel Gupta, Ronald Dubowy, Aleco D'Andrea, Lei Wang, Ken Ogasawara, Jerill Thorpe, and Leo I Gordon

Emergency Severity Index Comparisons Among Race. Podium talk presented at Providence Management Report, 2022, Portland, OR., D Selander and ST Chin

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Clinical Trial Participation and COVID-19: a Descriptive Analysis from the American Heart Association's Get With The Guidelines Registry., Kevin S Shah, Adriana E Reyes-Miranda, Steven M Bradley, Khadijah Breathett, Sandeep R Das, Tyler J Gluckman, Divya Gupta, Daniel T Leung, R Kannan Mutharasan, Pamela N Peterson, Emily S Spivak, and Rashmee U Shah

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Clinical Trial Participation and COVID-19: a Descriptive Analysis from the American Heart Association's Get With The Guidelines Registry., Kevin S Shah, Adriana E Reyes-Miranda, Steven M Bradley, Khadijah Breathett, Sandeep R Das, Tyler J Gluckman, Divya Gupta, Daniel T Leung, R Kannan Mutharasan, Pamela N Peterson, Emily S Spivak, and Rashmee U Shah

772 A phase 1/2 dose escalation/expansion study evaluating the safety, pharmacokinetics, pharmacodynamics, and antitumor activity of E-602, a bi-sialidase fusion protein, in advanced cancer (GLIMMER-01), Manish Sharma, Brendan Curti, and See all authors in comments

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Immunotherapy in head and neck squamous cell carcinoma: a narrative review., Shay Sharon and R Bryan Bell

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Inhaled anaesthesia and analgesia contribute to climate change., Jodi D Sherman and Brian B. Chesebro

Comparison of Exparel with Other Analgesic Medication for the Traumatic Rib Fracture: A Retrospective Study, K Shrestha, HF Li, and See all authors in comments

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Amivantamab and lazertinib in patients with EGFR-mutant non–small cell lung (NSCLC) after progression on osimertinib and platinum-based chemotherapy: Updated results from CHRYSALIS-2., Catherine A. Shu, Rachel E Sanborn, and See full list of authors in comments

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Contemporary, national patterns of surgery after preoperative therapy for stage II/III rectal adenocarcinoma., Celine Soriano, Henry T Bahnson, Jennifer A Kaplan, Bruce Lin, Ravi Moonka, Huong T Pham, Hagen F Kennecke, and Vlad Simianu

Registry Data Show Complication Rates and Cost in Revision Hip Arthroplasty, R Southgate, HF Li, Genevieve Rollier, and See all authors in comments

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Use of Novel Strategies to Develop Guidelines for Management of Pyogenic Osteomyelitis in Adults: A WikiGuidelines Group Consensus Statement., Brad Spellberg, Gloria Aggrey, Meghan B Brennan, Brent Footer, Graeme Forrest, Fergus Hamilton, Emi Minejima, Jessica Moore, Jaimo Ahn, Michael Angarone, Robert M Centor, Kartikeya Cherabuddi, Jennifer Curran, Kusha Davar, Joshua Davis, Mei Qin Dong, Bassam Ghanem, Doug Hutcheon, Philipp Jent, Minji Kang, Rachael Lee, Emily G McDonald, Andrew M Morris, Rebecca Reece, Ilan S Schwartz, Miranda So, Steven Tong, Christopher Tucker, Noah Wald-Dickler, Erica J Weinstein, Riley Williams, Christina Yen, Shiwei Zhou, Todd C Lee, and WikiGuidelines Group

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Preoperative Risk Prediction for Pancreatectomy: A Comparative Analysis of Three Scoring Systems., Holly Spitzer, Ryan Yang, Phillip Kemp Bohan, Shu-Ching Chang, Gary Grunkemeier, Timothy Vreeland, and Daniel W Nelson

A phase I dose escalation study of STEMVAC, a multi-antigen, multi-epitope Th1 selective plasmid-based vaccine, targeting stem cell associated proteins in patients with advanced breast cancer, S Stanton

Systemic therapy strategies in triple negative breast cancer, S Stanton

Neoadjuvant survivin-targeted immunotherapy maveropepimut-S (MVP-S) to increase Th1 immune response in Ki67-high hormone receptor-positive (HR+) early-stage breast cancer (ESBC)., Sasha Stanton

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549 Booster vaccination of a HER2 helper T-cell vaccine increased HER2 immunity in metastatic HER2 positive breast cancer., Sasha Stanton, Jennifer Childs, Doreen Higgins, Angela Kask, Yi Yang, and Mary Disis

Phase I trial of the safety and immunogenicity of a tri-antigen vaccine targeting HER2, IGFBP-2, and IGF-IR in patients with non-metastatic breast cancer, Sasha E. Stanton and See all authors in comments

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Neoadjuvant survivin-targeted immunotherapy maveropepimut-S (MVP-S) to increase Th1 immune response in Ki67-high hormone receptor-positive (HR+) early-stage breast cancer (ESBC)., Sasha Stanton, Lisa Diana MacDonald, Staci Mellinger, Nikki Moxon, Tracy L. Kelly, Heather Ann Hirsch, Stephan Fiset, Kristina H Young, and David B Page

646 Neoadjuvant immunotherapy combining maveropepimut-S (MVP-S) with letrozole decreases Ki67 and increases Th1 immune response in hormone receptor positive (HR+) early-stage breast cancer (ESBC), Sasha Stanton, David Page, Kristina Young, and See all authors in comments

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Abstract PR007: Candidate antigens for a ductal carcinoma in situ vaccine, essential for breast cancer cell survival across multiple subtypes, are immunogenic in DCIS and IBC, Sasha Stanton, Jason Schlumbohm, and Mary L. Disis

Neoadjuvant survivin-targeted immunotherapy maveropepimut-S (MVP-S) to increase Th1 immune response in Ki67-high hormone receptor-positive (HR+) early-stage breast cancer (ESBC), Sasha Stanton and See all authors in comments

Phase I trial of the safety and immunogenicity of a tri-antigen vaccine targeting HER2, IGFBP-2, and IGF-IR in patients with non-metastatic breast cancer, Sasha Stanton and See all authors in comments

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3380 / 8 - Seven autoantibody panel, validated in two independent patient serum collections, can detect women with DCIS and invasive breast cancer, Sasha Stanton and See full list of authors in comments

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Neoadjuvant survivin-targeted immunotherapy maveropepimut-S (MVP-S) to increase Th1 immune response in Ki67-high hormone receptor-positive (HR+) early-stage breast cancer (ESBC)., Sasha Stanton, Kristina H Young, David B Page, and See all authors in comments

Immunology 101, SE Stanton

647 Phase I studies of AgenT-797, a novel allogeneic invariant natural killer T (iNKT) cell therapy, for the treatment of patients with solid tumors or multiple myeloma, Don Stevens, Rachel Sanborn, and See all authors in comments

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Characterizing 30-Day Postoperative Acute Care Visits: A National Surgical Quality Improvement Program Collaborative Analysis., Ashley L Sweet, Thomas L Sutton, Krista A Curtis, Nathan Knapp, Brett C Sheppard, and Karen A Zink

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Grace Under Pressure., Nancy K Sweitzer, Daniel Burkhoff, Sophia Airhart, and James C Fang

Cabozantinib in combination with atezolizumab as a first-line therapy in patients with radioiodinerefractory differentiated thyroid cancer: Results from cohort 18 of the phase 1b COSMIC-21 study., M Taylor

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Health-related quality-of-life analyses from a multicenter, randomized, double-blind phase 2 study of patients with differentiated thyroid cancer treated with lenvatinib 18 or 24 mg/day., Matthew H. Taylor, Sophie Leboulleux, Yury Panaseykin, Bhavana Konda, Christelle de La Fouchardiere, Brett G M Hughes, Andrew G Gianoukakis, Young Joo Park, Ilia Romanov, Monika K Krzyzanowska, Diana Garbinsky, Bintu Sherif, Jie Janice Pan, Terri A Binder, Nicholas Sauter, Ran Xie, and Marcia S Brose

IO in Thyroid Cancer, Michael Taylor