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Submissions from 2021

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Utilizing an interim futility analysis of the OVAL study (VB-111-701/GOG 3018) for potential reduction of risk: A phase III, double blind, randomized controlled trial of ofranergene obadenovec (VB-111) and weekly paclitaxel in patients with platinum resistant ovarian cancer., Rebecca C Arend, Bradley J Monk, Thomas J Herzog, Kathleen N Moore, Ronnie Shapira-Frommer, Jonathan A Ledermann, Krishnansu S Tewari, Angeles Alvarez Secord, Tamar Rachmilewitz Minei, Laurence S Freedman, Austin Miller, Shifra Fain Shmueli, Michal Lavi, and Richard T Penson

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iNetModels 2.0: an interactive visualization and database of multi-omics data., Muhammad Arif, Cheng Zhang, Xiangyu Li, Cem Güngör, Buğra Çakmak, Metin Arslantürk, Abdellah Tebani, Berkay Özcan, Oğuzhan Subaş, Wenyu Zhou, Brian Piening, Hasan Turkez, Linn Fagerberg, Nathan Price, Leroy Hood, Michael Snyder, Jens Nielsen, Mathias Uhlen, and Adil Mardinoglu

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The State of Melanoma: Emergent Challenges and Opportunities., Michael B Atkins, Clara Curiel-Lewandrowski, David E Fisher, Susan M Swetter, Hensin Tsao, Julio A Aguirre-Ghiso, Maria S Soengas, Ashani T Weeraratna, Keith T Flaherty, Meenhard Herlyn, Jeffrey A Sosman, Hussein A Tawbi, Anna C Pavlick, Pamela B Cassidy, Sunandana Chandra, Paul B Chapman, Adil Daud, Zeynep Eroglu, Laura K Ferris, Bernard A Fox, Jeffrey E Gerhsenwald, Geoffrey T Gibney, Douglas Grossman, Brent A Hanks, Douglas Hanniford, Eva Hernando, Joanne M Jeter, Douglas B Johnson, Samir N Khleif, John M Kirkwood, Sancy A Leachman, Darren Mays, Kelly C Nelson, Vernon K Sondak, Ryan J Sullivan, and Glenn Merlino

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Arginase therapy combines effectively with checkpoint blockade or agonist anti-OX40 immunotherapy to control tumor growth., Mark D Badeaux, Annah S Rolig, Giulia Agnello, Danlee Enzler, Melissa Kasiewicz, Leslie Priddy, Jason F Wiggins, Alexander Muir, Mark R Sullivan, Jessica Van Cleef, Christopher Daige, Matthew G Vander Heiden, Venkatesh Rajamanickam, James Wooldridge, William L. Redmond, and Scott W Rowlinson

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Immune-based mutation classification enables neoantigen prioritization and immune feature discovery in cancer immunotherapy., Peng Bai, Yongzheng Li, Qiuping Zhou, Jiaqi Xia, Peng-Cheng Wei, Hexiang Deng, Min Wu, Sanny K Chan, John W Kappler, Yu Zhou, Eric Tran, Philippa Marrack, and Lei Yin

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Prevalence and Correlates of Successful Smoking Cessation in Bladder Cancer Survivors., Jeffrey C Bassett, Richard S Matulewicz, Lorna Kwan, William J McCarthy, John L Gore, and Christopher S Saigal

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A national database propensity score-matched comparison of minimally invasive and open colectomy for long-term opioid use., Amir L Bastawrous, Kara K Brockhaus, Melissa I Chang, Gediwon Milky, I-Fan Shih, Yanli Li, and Robert K Cleary

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Identifying breast cancer recurrence histories via patient-reported outcomes., J David Beatty, Qin Sun, Daniel Markowitz, Jessica Chubak, Bin Huang, and Ruth Etzioni

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The miR-181a-SFRP4 axis regulates Wnt activation to drive stemness and platinum resistance in ovarian cancer., Anil Belur Nagaraj, Matthew Knarr, Sreeja Sekhar, R Shae Connor, Peronne Joseph, Olga Kovalenko, Alexis Fleming, Arshia Surti, Elmar Nurmemmedov, Luca Beltrame, Sergio Marchini, Michael Kahn, and Analisa DiFeo

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Salvage Pulmonary Resections After Definitive Chemoradiotherapy., Adam J Bograd and Eric Vallieres

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Acalabrutinib in Treatment-Naïve Chronic Lymphocytic Leukemia., John C Byrd, Jennifer A Woyach, Richard R Furman, Peter Martin, Susan O'Brien, Jennifer R Brown, Deborah M Stephens, Jacqueline Barrientos, Stephen Devereux, Peter Hillmen, John M Pagel, Ahmed Hamdy, Raquel Izumi, Priti Patel, Min Hui Wang, Nitin Jain, and William George Wierda

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Subgroup analysis of nelipepimut-S plus GM-CSF combined with trastuzumab versus trastuzumab alone to prevent recurrences in patients with high-risk, HER2 low-expressing breast cancer., R Connor Chick, G Travis Clifton, Diane F Hale, Timothy J Vreeland, Annelies T Hickerson, Phillip M Kemp Bohan, Patrick M McCarthy, Jennifer K Litton, Gheath Alatrash, Rashmi K Murthy, Na Qiao, Anne Philips, Jason Lukas, Jarrod P Holmes, Elizabeth A Mittendorf, and George E Peoples

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Long-term progression-free survival of patients with metastatic melanoma or renal cell carcinoma following high-dose interleukin-2., Joseph I Clark, Brendan Curti, Elizabeth J Davis, Howard Kaufman, Asim Amin, Ajjai Alva, Theodore F Logan, Ralph Hauke, Gerald P Miletello, Ulka Vaishampayan, Douglas B Johnson, Richard L White, Peter H Wiernik, and Janice P Dutcher

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Implementation of human papillomavirus video education for women participating in mass cervical cancer screening in Tanzania., Emma C Cooper, Justine A Maher, Ariana Naaseh, Elizabeth W Crawford, Justine O Chinn, Ava S Runge, Alexa N Lucas, Danielle C Zezoff, Kevin R Bera, Andreea I Dinicu, Kayla M White, Sujata E Tewari, Anjali Hari, Megan Bernstein, Jenny Chang, Argyrios Ziogas, Diana C Pearre, and Krishnansu S Tewari

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Laboratory and Clinical Implications of Incidental and Secondary Germline Findings During Tumor Testing., Allison Cushman-Vokoun, Josh Lauring, John Pfeifer, Damon R Olson, Anna Berry, John Thorson, Karl Voelkerding, Jonathan Myles, James Barbeau, Pranil Chandra, Marilyn Li, Gail H Vance, Brad W Jensen, Molly Y Hansen, and Sophia Yohe

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Double-blind, randomized placebo-controlled trial of 8-week self-administered at-home behavioral skills-based virtual reality (VR) for chronic low back pain (during COVID-19)., Beth Darnall, Laura Garcia, Brandon Birckhead, Parthasarathy Krishnamurthy, Ian Mackey, Josh Sackman, Robert Louis, and Todd Maddox

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Disparities in Amputation Rates for Non-metastatic Extremity Soft Tissue Sarcomas and the Impact on Survival., Joshua C Dilday, Daniel W Nelson, Trevan D Fischer, and Melanie Goldfarb

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Neoadjuvant anti-OX40 (MEDI6469) therapy in patients with head and neck squamous cell carcinoma activates and expands antigen-specific tumor-infiltrating T cells., Rebekka Duhen, Carmen Ballesteros-Merino, Alexandra K Frye, Eric Tran, Venkatesh Rajamanickam, Shu-Ching Chang, Yoshinobu Koguchi, Carlo Bifulco, Brady Bernard, Rom Leidner, Brendan Curti, Bernard A Fox, Walter Urba, Richard Bryan Bell, and Andrew D Weinberg

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Cryopreserved placental tissue allograft accelerates time to continence following robot-assisted radical prostatectomy., Peter A Elliott, Stephanie Hsiang, Ramkishen Narayanan, James Bierylo, Shu-Ching Chang, Przemyslaw Twardowski, and Timothy G Wilson

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Enhancing the generation of Eomeshi CD8+ T cells augment the efficacy of OX40- and CTLA-4-targeted immunotherapy., Dana A Emerson, Annah S Rolig, and William L. Redmond

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Associations of practical, emotional, and physical problems with psychosocial distress among cancer patients., Mark William Flanagan, Heather H Goltz, John W Henson, and Matthew Lee Smith

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Umbralisib, a Dual PI3Kδ/CK1ε Inhibitor in Patients With Relapsed or Refractory Indolent Lymphoma., Nathan H Fowler, Felipe Samaniego, Wojciech Jurczak, Nilanjan Ghosh, Enrico Derenzini, James A Reeves, Wanda Knopińska-Posłuszny, Chan Y Cheah, Tycel Phillips, Ewa Lech-Maranda, Bruce D Cheson, Paolo F Caimi, Sebastian Grosicki, Lori A Leslie, Julio C Chavez, Gustavo Fonseca, Sunil Babu, Daniel J Hodson, Spencer H Shao, John M Burke, Jeff P Sharman, Jennie Y Law, John M Pagel, Hari P Miskin, Peter Sportelli, Owen A O'Connor, Michael S Weiss, and Pier Luigi Zinzani

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Pleural Drainage Strategy After IPC Placement: A Focused Clinical Review., Christopher R Gilbert and Russell J Miller

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The longitudinal relationship between immune cell profiles and frailty in patients with breast cancer receiving chemotherapy., Nikesha Gilmore, Supriya Mohile, Lianlian Lei, Eva Culakova, Mostafa Mohamed, Allison Magnuson, Kah Poh Loh, Ronald Maggiore, Elizabeth Belcher, Alison Conlin, Lora Weiselberg, Mary Ontko, and Michelle Janelsins

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Identifying the miRNA Signature Association with Aging-Related Senescence in Glioblastoma., Mutharasu Gnanavel, Akshaya Murugesan, Saravanan Konda Mani, Olli Yli-Harja, and Meenakshisundaram Kandhavelu

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Perspectives on COVID-19 and cancer immunotherapy: a review series., Jason D Goldman and Paolo Antonio Ascierto

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Adult pilocytic astrocytoma in the molecular era: a comprehensive review., Timothy A Gregory, Lyndon B Chumbley, John W Henson, and Brett J Theeler

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Germinal center reactions in tertiary lymphoid structures associate with neoantigen burden, humoral immunity and long-term survivorship in pancreatic cancer., Andrew J Gunderson, Venkatesh Rajamanickam, Cynthia Bui, Brady Bernard, Joanna Pucilowska, Carmen Ballesteros-Merino, Mark Schmidt, Kayla McCarty, Michaela Philips, Brian D. Piening, Christopher Dubay, Terry R Medler, Phillipa Newell, Paul D Hansen, Eric Tran, Ephraim Tang, Carlo Bifulco, Marka R Crittenden, Michael J. Gough, and Kristina H Young

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Reconciling Non-Genetic Plasticity with Somatic Evolution in Cancer., Sui Huang

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Integrated genetic and metabolic landscapes predict vulnerabilities of temozolomide resistant glioblastoma cells., Selva Rupa Christinal Immanuel, Avinash D Ghanate, Dharmeshkumar S Parmar, Ritu Yadav, Riya Uthup, Venkateswarlu Panchagnula, and Anu Raghunathan

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Response to: Is there any association between a delay in surgery and nodal positivity in the ER-negative Her2 negative breast cancer subgroups?, Adam Khader and Trevan Fischer

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Improved image reconstruction of, Julian Kirchner, Joseph A O'Donoghue, Anton S Becker, and Gary A Ulaner

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An empirical antigen selection method identifies neoantigens that either elicit broad anti-tumor T cell responses or drive tumor growth., Hubert Lam, Lisa K McNeil, Hanna Starobinets, Victoria L DeVault, Roger B Cohen, Przemyslaw Twardowski, Melissa L Johnson, Maura L Gillison, Mark N Stein, Ulka N Vaishampayan, Arthur P DeCillis, James J Foti, Vijetha Vemulapalli, Emily Tjon, Kyle Ferber, Daniel B DeOliveira, Wendy Broom, Parul Agnihotri, Elizabeth M Jaffee, Kwok-Kin Wong, Charles G Drake, Pamela M Carroll, Thomas A Davis, and Jessica Baker Flechtner

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Pregnancy outcomes in women with epilepsy and MTHFR mutations supplemented with methylated folate and methylcobalamin (methylated B12)., Emma M Lascar, Nicole M Warner, and Michael J Doherty

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Improved Survival Outcomes in Medically Fit Patients With Early-Stage Non-Small-Cell Lung Cancer Undergoing Stereotactic Body Radiotherapy., Jason Liu, Caressa Hui, Colton Ladbury, Thomas Waddington, Loretta Erhunmwunsee, Dan Raz, Jae Kim, Ravi Salgia, Stafford Chenery, Daryl Pearlstein, Amanda Schwer, and Arya Amini

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Niraparib in the maintenance treatment of advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer: safety and efficacy., Marisa C Liu, Joyce Sutedja, and Krishnansu S Tewari

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Caregiver-Oncologist Prognostic Concordance, Caregiver Mastery, and Caregiver Psychological Health and Quality of Life., Kah Poh Loh, Mostafa R Mohamed, Sindhuja Kadambi, Eva Culakova, Huiwen Xu, Allison Magnuson, Marie Flannery, Paul R Duberstein, Ronald M Epstein, Colin McHugh, Ryan D Nipp, Kelly M Trevino, Chandrika Sanapala, Bianca A Hall, Beverly Canin, Arlene A Gayle, Alison Conlin, James Bearden, and Supriya G Mohile

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A CRISPR/Cas9-engineered ARID1A-deficient human gastric cancer organoid model reveals essential and non-essential modes of oncogenic transformation., Yuan-Hung Lo, Kevin S Kolahi, Yuhong Du, Chiung-Ying Chang, Andrey Krokhotin, Ajay Nair, Walter D Sobba, Kasper Karlsson, Sunny J Jones, Teri A Longacre, Amanda T Mah, Bahar Tercan, Alexandra Sockell, Hang Xu, Jose A Seoane, Jin Chen, Ilya Shmulevich, Jonathan S Weissman, Christina Curtis, Andrea Califano, Haian Fu, Gerald R Crabtree, and Calvin J Kuo

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Prognostic gene expression signatures of breast cancer are lacking a sensible biological meaning., Kalifa Manjang, Shailesh Tripathi, Olli Yli-Harja, Matthias Dehmer, Galina Glazko, and Frank Emmert-Streib

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Trifluridine/tipiracil in patients with metastatic gastroesophageal junction cancer: a subgroup analysis from the phase 3 TAGS study., Wasat Mansoor, Hendrik-Tobias Arkenau, Maria Alsina, Kohei Shitara, Peter Thuss-Patience, Sinead Cuffe, Mikhail Dvorkin, David Park, Takayuki Ando, Marc Van Den Eynde, Giordano D Beretta, Alberto Zaniboni, Toshihiko Doi, Josep Tabernero, David H Ilson, Lukas Makris, Karim A Benhadji, and Eric Van Cutsem

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Phosphorylation of SMAD3 in immune cells predicts survival of patients with early stage non-small cell lung cancer., Sebastian Marwitz, Carmen Ballesteros-Merino, Shawn M. Jensen, Martin Reck, Christian Kugler, Sven Perner, Daniel Drömann, Torsten Goldmann, and Bernard A Fox

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Pirtobrutinib in relapsed or refractory B-cell malignancies (BRUIN): a phase 1/2 study., Anthony R Mato, Nirav N Shah, Wojciech Jurczak, Chan Y Cheah, John M Pagel, Jennifer A Woyach, Bita Fakhri, Toby A Eyre, Nicole Lamanna, Manish R Patel, Alvaro Alencar, Ewa Lech-Maranda, William G Wierda, Catherine C Coombs, James N Gerson, Paolo Ghia, Steven Le Gouill, David John Lewis, Suchitra Sundaram, Jonathon B Cohen, Ian W Flinn, Constantine S Tam, Minal A Barve, Bryone Kuss, Justin Taylor, Omar Abdel-Wahab, Stephen J Schuster, M Lia Palomba, Katharine L Lewis, Lindsey E Roeker, Matthew S Davids, Xuan Ni Tan, Timothy S Fenske, Johan Wallin, Donald E Tsai, Nora C Ku, Edward Zhu, Jessica Chen, Ming Yin, Binoj Nair, Kevin Ebata, Narasimha Marella, Jennifer R Brown, and Michael Wang

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A Microcosm of Disparities in Breast Cancer: Comparison Between a Private Hospital and a Safety-Net County Hospital Within Los Angeles County., Natalie C McClintock, Reed I Ayabe, Ruben D Salas Parra, Amy H Kaji, Javier I Orozco, Diego M Marzese, Estela Samuels, Stacey L Stern, Christine Dauphine, and Junko J Ozao-Choy

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HDAC inhibition prevents transgene expression downregulation and loss-of-function in T-cell-receptor-transduced T cells., Tamson V Moore, Gina M Scurti, Matthew DeJong, Siao-Yi Wang, Annika V Dalheim, Courtney R Wagner, Kelli A Hutchens, Jodi J Speiser, Constantine V Godellas, Chris Fountain, Jessica Fleser, Tarsem Moudgil, Mallory Thomas, David Murray, Brendan D Curti, Joseph I Clark, Bernard A Fox, and Michael I Nishimura

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Induction of ADAM10 by RT drives fibrosis, resistance, and EMT in pancreatic cancer., Adam C Mueller, Miles Piper, Andrew Goodspeed, Shiv Bhuvane, Jason S Williams, Shilpa Bhatia, Andy V Phan, Benjamin Van Court, Kathryn L Zolman, Brisa Peña, Ayman J Oweida, Sara Zakem, Cheryl Meguid, Michael W Knitz, Laurel Darragh, Thomas E Bickett, Jacob Gadwa, Luisa Mestroni, Matthew R G Taylor, Kimberly R Jordan, Peter Dempsey, M Scott Lucia, Martin D McCarter, Marco Del Chiaro, Wells A Messersmith, Richard D Schulick, Karyn A Goodman, Michael J. Gough, Casey S Greene, James C Costello, Antonio Galvao Neto, David Lagares, Kirk C Hansen, Adrie Van Bokhoven, and Sana D Karam

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Regulation of MRE11A by UBQLN4 leads to cisplatin resistance in patients with esophageal squamous cell carcinoma., Tomohiro Murakami, Yoshiaki Shoji, Tomohiko Nishi, Shu-Ching Chang, Ron D Jachimowicz, Sojun Hoshimoto, Shigeshi Ono, Yosef Shiloh, Hiroya Takeuchi, Yuko Kitagawa, Dave Hoon, and Matias Bustos

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Molecular interaction study of novel indoline derivatives with EGFR-kinase domain using multiple computational analysis., Suresh Palanivel, Olli Yli-Harja, and Meenakshisundaram Kandhavelu

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A Randomized Phase II Study of Androgen Deprivation Therapy with or without Palbociclib in RB-positive Metastatic Hormone Sensitive Prostate Cancer (mHSPC)., Phillip L Palmbos, Stephanie Daignault-Newton, Scott A Tomlins, Neeraj Agarwal, Przemyslaw Twardowski, Alicia K Morgans, William K Kelly, Vivek K Arora, Emmanuel S Antonarakis, Javed Siddiqui, Jon Jacobson, Mathew S Davenport, Dan R Robinson, Arul M Chinnaiyan, Karen E Knudsen, and Maha Hussain

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Immune checkpoint inhibitor therapy in HIV-associated Merkel cell carcinoma: A case series of 3 patients., Song Y Park, Candice Church, Nora A Alexander, Michi M Shinohara, Kelly G Paulson, Karl D Lewis, Nancy S Lee, and Paul Nghiem

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Mobile Smartphone Thermal Imaging Characterization and Identification of Microvascular Flow Insufficiencies in Deep Inferior Epigastric Artery Perforator Free Flaps., Cody J Phillips, Morgan R Barron, John Kuckelman, Michael Derickson, Vance Y Sohn, Keith T Paige, and Kevin Beshlian

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Phase II study of the histone deacetylase inhibitor vorinostat (Suberoylanilide Hydroxamic Acid; SAHA) in recurrent or metastatic transitional cell carcinoma of the urothelium - an NCI-CTEP sponsored: California Cancer Consortium trial, NCI 6879., David I Quinn, Denice D Tsao-Wei, Przemyslaw Twardowski, Ana M Aparicio, Paul Frankel, Gurkamal Chatta, John J Wright, Susan G Groshen, Stella Khoo, Heinz-Josef Lenz, Primo N Lara, David R Gandara, and Edward Newman

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Predictive biomarkers with isatuximab plus pomalidomide and dexamethasone in relapsed/refractory multiple myeloma., Paul G Richardson, Thierry Facon, William I Bensinger, Xavier Leleu, Frank Campana, Sandrine Macé, Marielle Chiron, Helgi van de Velde, and Joseph Mikhael

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Optimal oncologic and perioperative outcomes of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy are attainable at a community center., Colin J Rog, Gary Lucas, Shelby Reiter, Susan Vetto, Mohamed Alassas, and Evan Ong

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Sanborn and Gaffar Share Clinical and Economic Treatment Insights in NSCLC, Rachel E Sanborn and Yousuf A. Gaffar

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Multiplex immunofluorescence to measure dynamic changes in tumor-infiltrating lymphocytes and PD-L1 in early-stage breast cancer., Katherine Sanchez, Isaac Kim, Brie Chun, Joanna Pucilowska, William L. Redmond, Walter Urba, Maritza Martel, Yaping Wu, Mary Campbell, Zhaoyu Sun, Gary Grunkemeier, Shu-Ching Chang, Brady Bernard, and David B Page

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Increased Intracranial Pressure: The Use of an Individualized Ladder Approach., Marlon G Saria and Santosh Kesari

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SmartPhrase: Development of an Electronic Health Record System to Promote Chemotherapy and Immunotherapy Safety., Mary Jo Sarver, Monica McManus, Amy Allen, Bethany Johnson, and Dennielle Padgett

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Germline genetic contribution to the immune landscape of cancer., Rosalyn W Sayaman, Mohamad Saad, Vésteinn Thorsson, Donglei Hu, Wouter Hendrickx, Jessica Roelands, Eduard Porta-Pardo, Younes Mokrab, Farshad Farshidfar, Tomas Kirchhoff, Randy F Sweis, Oliver F Bathe, Carolina Heimann, Michael J Campbell, Cynthia Stretch, Scott Huntsman, Rebecca E Graff, Najeeb Syed, Laszlo Radvanyi, Simon Shelley, Denise Wolf, Francesco M Marincola, Michele Ceccarelli, Jérôme Galon, Elad Ziv, and Davide Bedognetti

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Testing the acceptability and feasibility of a tablet-based supportive cancer platform for patients with metastatic breast cancer., Kathryn H Schmitz, Erica Schleicher, Shawna Doerksen, Christina Truica, Leah Cream, Rena Kass, Michelle Farnan, Robin Suess, Brett Gordon, David S Zucker, and Michael Hayes

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Phase I trial of intranasal NEO100, highly purified perillyl alcohol, in adult patients with recurrent glioblastoma., Axel H Schönthal, David M Peereboom, Naveed Wagle, Rose Lai, Anna J Mathew, Kyle M Hurth, Vincent F Simmon, Steven P Howard, Lynne P Taylor, Frances Chow, Clovis O da Fonseca, and Thomas C Chen

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Influence of Socioeconomic Status on Incident Medical Conditions in Two-Year Survivors of Adolescent or Young Adult Differentiated Thyroid Cancer., Thomas J Semrad, Qian Li, Melanie Goldfarb, Alison Semrad, Michael Campbell, D Gregory Farwell, and Theresa H M Keegan

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Open-label, phase II study of ladiratuzumab vedotin (LV) for castration-resistant prostate cancer (SGNLVA-005, trial-in-progress)., Amna Falak Sher, Justine Yang Bruce, Nashat Y. Gabrail, Ian Churchill Anderson, Anna Patrikidou, Rachel E Sanborn, Jae Yong Cho, Arielle Shebay Lee, Jong-Seok Lee, Louise M. Nott, Do-Youn Oh, Sang Cheul Oh, Sung Yong Oh, Yinghui Wang, Zejing Wang, and Troy H. Guthrie

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Psychometric Characteristics and Validity of the PROMIS Cancer Function Brief 3D Profile., Sean R Smith, Mary Vargo, David Zucker, Samman Shahpar, Lynn Gerber, Maryanne Henderson, Gina Jay, Minji Lee, and Andrea Cheville

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Small molecules inhibitors of the heterogeneous ribonuclear protein A18 (hnRNP A18): a regulator of protein translation and an immune checkpoint., Eduardo Solano-Gonzalez, Katherine M Coburn, Wenbo Yu, Gerald M Wilson, Elmar Nurmemmedov, Santosh Kesari, Elizabeth T Chang, Alexander D MacKerell, David J Weber, and France Carrier

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Small molecules inhibitors of the heterogeneous ribonuclear protein A18 (hnRNP A18): a regulator of protein translation and an immune checkpoint., Eduardo Solano-Gonzalez, Katherine M Coburn, Wenbo Yu, Gerald M Wilson, Elmar Nurmemmedov, Santosh Kesari, Elizabeth T Chang, Alexander D MacKerell, David J Weber, and France Carrier

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The importance of low-dose CT screening to identify emphysema in asymptomatic participants with and without a prior diagnosis of COPD., David Steiger, M Faisal Siddiqi, Rowena Yip, David F Yankelevitz, Claudia I Henschke, I-ELCAP investigators, Ralph W Aye (I-ELCAP investigator), and Kristin Manning (I-ELCAP investigator)

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Galectin-3 inhibition with belapectin combined with anti-OX40 therapy reprograms the tumor microenvironment to favor anti-tumor immunity., Elizabeth Sturgill, Annah S Rolig, Stefanie N Linch, Courtney Mick, Melissa Kasiewicz, Zhaoyu Sun, Peter G Traber, Harold Shlevin, and William L. Redmond

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Developing an enhanced 7-color multiplex IHC protocol to dissect immune infiltration in human cancers., Zhaoyu Sun, Richard Nyberg, Yaping Wu, Brady Bernard, and William L. Redmond

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The LEAP program: lenvatinib plus pembrolizumab for the treatment of advanced solid tumors., Matthew H Taylor, Emmett V Schmidt, Corina Dutcus, Elaine M Pinheiro, Yasuhiro Funahashi, Gregory Lubiniecki, and Drew Rasco

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Correlation of Performance Status and Neutrophil-Lymphocyte Ratio With Efficacy in Radioiodine-Refractory Differentiated Thyroid Cancer Treated With Lenvatinib., Matthew H Taylor, Shunji Takahashi, Jaume Capdevila, Makoto Tahara, Sophie Leboulleux, Naomi Kiyota, Corina E Dutcus, Ran Xie, Bruce Robinson, Steven I Sherman, Mouhammed Amir Habra, Rossella Elisei, and Lori J Wirth

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Intratumoral Plasmid IL12 Expands CD8, Melinda L Telli, Hiroshi Nagata, Irene Wapnir, Chaitanya R Acharya, Kaitlin Zablotsky, Bernard A Fox, Carlo Bifulco, Shawn M. Jensen, Carmen Ballesteros-Merino, Mai Hope Le, Robert H Pierce, Erica Browning, Reneta Hermiz, Lauren Svenson, Donna Bannavong, Kim Jaffe, Jendy Sell, Kellie Malloy Foerter, David A Canton, Christopher G Twitty, Takuya Osada, H Kim Lyerly, and Erika J Crosby

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A Caenorhabditis elegans behavioral assay distinguishes early stage prostate cancer patient urine from controls, Morgan Thompson, Noemi Sarabia Feria, Ally Yoshioka, Eugene Tu, Fehmi Civitci, Suzanne Estes, and Josiah T Wagner

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A Histopathologic Scoring System for Perineural Invasion Correlates With Adverse Outcomes in Patients With Cutaneous Squamous Cell Carcinoma., Mariam B Totonchy, Jennifer M McNiff, Kathleen C Suozzi, David J Leffell, and Sean R Christensen

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Assessment of Cell-Free microRNA by NGS Whole-Transcriptome Analysis in Cutaneous Melanoma Patients' Blood., Kevin Tran, Rebecca Gross, Negin Rahimzadeh, Shanthy Chenathukattil, Dave Hoon, and Matias A Bustos

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18F-FDG-Avid Lymph Nodes After COVID-19 Vaccination on 18F-FDG PET/CT., Gary A Ulaner and Peter Giuliano

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Long-Term Outcomes of Intra-Arterial Chemotherapy for Progressive or Unresectable Pilocytic Astrocytomas: Case Studies., Kutluay Uluc, Dominic A Siler, Ricardo Lopez, Csanad Varallyay, Joao Prola Netto, Jenny Firkins, Cindy Lacy, Amy Huddleston, Prakash Ambady, and Edward A Neuwelt

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The impact of obesity on minimally invasive colorectal surgery: A report from the Surgical Care Outcomes Assessment Program collaborative., Kenley R Unruh, Amir Bastawrous, Jennifer A Kaplan, Ravi Moonka, Laila Rashidi, and Vlad V Simianu

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TARGIT-IORT during lumpectomy for breast cancer - better for patients than other PBI approaches., Jayant S Vaidya, Max Bulsara, Elena Sperk, Samuele Massarut, Michael Douek, Michael Alvarado, Steffi Pigorsch, Dennis R Holmes, Marcelle Bernstein, Christobel Saunders, Henrik Flyger, David Joseph, Frederik Wenz, and Jeffrey S Tobias

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Associations of Uncertainty With Psychological Health and Quality of Life in Older Adults With Advanced Cancer., Haydee C Verduzco-Aguirre, Dilip Babu, Supriya G Mohile, Javier Bautista, Huiwen Xu, Eva Culakova, Beverly Canin, Yingzi Zhang, Megan Wells, Ronald M Epstein, Paul Duberstein, Colin McHugh, William Dale, Alison Conlin, James Bearden, Jeffrey Berenberg, Mohamedtaki Tejani, and Kah Poh Loh

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Tumor Microenvironment, HLA Class I and APM Expression in HPV-Negative Oral Squamous Cell Carcinoma., Claudia Wickenhauser, Daniel Bethmann, Matthias Kappler, Alexander Walter Eckert, André Steven, Jürgen Bukur, Bernard Aloysius Fox, Jana Beer, and Barbara Seliger

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Successful and durable response of primary CNS T-cell lymphoma to upfront temozolomide monotherapy., Meghna Yalamanchi, Akanksha Sharma, Minh Nguyen, Judy Truong, Jose A Carrillo, Naveed Wagle, Jaya M Gill, and Santosh Kesari

Submissions from 2020

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Pemigatinib for previously treated, locally advanced or metastatic cholangiocarcinoma: a multicentre, open-label, phase 2 study., Ghassan K Abou-Alfa, Vaibhav Sahai, Antoine Hollebecque, Gina Vaccaro, Davide Melisi, Raed Al-Rajabi, Andrew S Paulson, Mitesh J Borad, David Gallinson, Adrian G Murphy, Do-Youn Oh, Efrat Dotan, Daniel V Catenacci, Eric Van Cutsem, Tao Ji, Christine F Lihou, Huiling Zhen, Luis Féliz, and Arndt Vogel

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Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer., Joanna Achinger-Kawecka, Fatima Valdes-Mora, Phuc-Loi Luu, Katherine A Giles, C Elizabeth Caldon, Wenjia Qu, Shalima Nair, Sebastian Soto, Warwick J Locke, Nicole S Yeo-Teh, Cathryn M Gould, Qian Du, Grady C Smith, Irene R Ramos, Kristine F Fernandez, Dave S B Hoon, Julia M W Gee, Clare Stirzaker, and Susan J Clark

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Cytotoxic T cell depletion with increasing epithelial abnormality in women with benign breast disease., Sabina Adhikary, Tanya L Hoskin, Melody L Stallings-Mann, Muhammad Arshad, Marlene H Frost, Stacey J Winham, Alvaro Peña, Delphine J Lee, Linda M Murphy, Michele Rakoff, Lori A Denison, Keith L Knutson, Derek C Radisky, Daniel W Visscher, and Amy C Degnim

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A generalizable data-driven multicellular model of pancreatic ductal adenocarcinoma., Boris Aguilar, David L Gibbs, David J Reiss, Mark McConnell, Samuel A Danziger, Andrew Dervan, Matthew Trotter, Douglas Bassett, Robert Hershberg, Alexander V Ratushny, and Ilya Shmulevich

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Preoperative imaging characteristics predict poor survival and inadequate resection for left-sided pancreatic adenocarcinoma: a multi-institutional analysis., Farzad Alemi, Zeljka Jutric, George R Marshall, Elliot J Scott, Jan Grendar, Alexandra M Roch, Lucio L Pereira, An-Lin Cheng, Paul D Hansen, Eugene P Ceppa, Horacio J Asbun, Susanne Warner, and Adnan A Alseidi

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Intratumoral delivery of tavokinogene telseplasmid yields systemic immune responses in metastatic melanoma patients., A Algazi, S Bhatia, S Agarwala, M Molina, K Lewis, M Faries, L Fong, L P Levine, M Franco, A Oglesby, C Ballesteros-Merino, C B Bifulco, B A Fox, D Bannavong, R Talia, E Browning, M H Le, R H Pierce, S Gargosky, K K Tsai, C Twitty, and A I Daud

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Phase II Trial of IL-12 Plasmid Transfection and PD-1 Blockade in Immunologically Quiescent Melanoma., Alain P Algazi, Christopher G Twitty, Katy K Tsai, Mai Le, Robert Pierce, Erica Browning, Reneta Hermiz, David A Canton, Donna Bannavong, Arielle Oglesby, Murray Francisco, Lawrence Fong, Mikael J Pittet, Sean P Arlauckas, Christopher Garris, Lauren P Levine, Carlo Bifulco, Carmen Ballesteros-Merino, Shailender Bhatia, Sharron Gargosky, Robert H I Andtbacka, Bernard A Fox, Michael D Rosenblum, and Adil I Daud

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Estrogen and Progesterone Receptor Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Guideline Update., Kimberly H Allison, M Elizabeth H Hammond, Mitchell Dowsett, Shannon E McKernin, Lisa A Carey, Patrick L Fitzgibbons, Daniel F Hayes, Sunil R Lakhani, Mariana Chavez-MacGregor, Jane Perlmutter, Charles M Perou, Meredith M Regan, David L Rimm, W Fraser Symmans, Emina E Torlakovic, Leticia Varella, Giuseppe Viale, Tracey F Weisberg, Lisa M McShane, and Antonio C Wolff

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Estrogen and Progesterone Receptor Testing in Breast Cancer: ASCO/CAP Guideline Update., Kimberly H Allison, M Elizabeth H Hammond, Mitchell Dowsett, Shannon E McKernin, Lisa A Carey, Patrick L Fitzgibbons, Daniel F Hayes, Sunil R Lakhani, Mariana Chavez-MacGregor, Jane Perlmutter, Charles M Perou, Meredith M Regan, David L Rimm, W Fraser Symmans, Emina E Torlakovic, Leticia Varella, Giuseppe Viale, Tracey F Weisberg, Lisa M McShane, and Antonio C Wolff

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Physiological and Pathological Roles of Cdk5: Potential Directions for Therapeutic Targeting in Neurodegenerative Disease., Annamarie B Allnutt, Ariana K Waters, Santosh Kesari, and Venkata Mahidhar Yenugonda

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A phase 1b study of once-weekly carfilzomib combined with lenalidomide and dexamethasone in patients with newly diagnosed multiple myeloma., Melissa Alsina, Ola Landgren, Noopur Raje, Ruben Niesvizky, William Bensinger, Jesus G Berdeja, Tibor Kovacsovics, David H Vesole, Belle Fang, Amy S Kimball, and David S Siegel

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Intracellular Galectin-3 Is Essential for OX40-Mediated Memory CD8, Mohammad Farhad Amani, Annah S Rolig, and William L. Redmond

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Correction: Incorporating Breast Cancer Recurrence Events Into Population-Based Cancer Registries Using Medical Claims: Cohort Study., Teresa A'mar, J David Beatty, Catherine Fedorenko, Daniel Markowitz, Thomas Corey, Jane Lange, Stephen M Schwartz, Bin Huang, Jessica Chubak, and Ruth Etzioni

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Incorporating Breast Cancer Recurrence Events Into Population-Based Cancer Registries Using Medical Claims: Cohort Study., Teresa A'mar, J David Beatty, Catherine Fedorenko, Daniel Markowitz, Thomas Corey, Jane Lange, Stephen M Schwartz, Bin Huang, Jessica Chubak, and Ruth Etzioni

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Sgnlva-005: Open-label, phase II study of ladiratuzumab vedotin (LV) for advanced aerodigestive tract malignancies, Ian Churchill Anderson, Yinghui Wang, Zejing Wang, and Rachel E Sanborn

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Sgnlva-005: Open-label, phase II study of ladiratuzumab vedotin (LV) for advanced aerodigestive tract malignancies., Ian Churchill Anderson, Yinghui Wang, Zejing Wang, and Rachel E Sanborn

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The Supraorbital Eyebrow Craniotomy for Intra- and Extra-Axial Brain Tumors: A Single-Center Series and Technique Modification., Shaheryar F Ansari, Amy Eisenberg, Amanda Rodriguez, Garni Barkhoudarian, and Daniel F Kelly

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Safety and activity of varlilumab, a novel and first-in-class agonist anti-CD27 antibody, for hematologic malignancies., Stephen M Ansell, Ian Flinn, Matthew H Taylor, Branimir I Sikic, Joshua Brody, John Nemunaitis, Andrew Feldman, Thomas R Hawthorne, Tracey Rawls, Tibor Keler, and Michael J Yellin

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Updates on the Management of Thyroid Cancer., Katherine A Araque, Sriram Gubbi, and Joanna Klubo-Gwiezdzinska