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Submissions from 2020

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It's Time to Rethink Our Assumptions About Acute Wilson's Disease., Oren K Fix

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Clinical Best Practice Advice for Hepatology and Liver Transplant Providers During the COVID-19 Pandemic: AASLD Expert Panel Consensus Statement., Oren K Fix, Bilal Hameed, Robert J Fontana, Ryan M Kwok, Brendan M McGuire, David C Mulligan, Daniel S Pratt, Mark W Russo, Michael L Schilsky, Elizabeth C Verna, Rohit Loomba, David E Cohen, Jorge A Bezerra, K Rajender Reddy, and Raymond T Chung

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Telemedicine and Telehepatology During the COVID-19 Pandemic., Oren K Fix and Marina Serper

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Primary Sclerosing Cholangitis: Epidemiology, Genetics, Diagnosis, and Current Management., Eric Gochanour, Channa Jayasekera, and Kris V Kowdley

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Tumor slice culture as a biologic surrogate of human cancer., Heidi L Kenerson, Kevin M Sullivan, Yongwoo D Seo, Kathryn M Stadeli, Cigdem Ussakli, Xiaowei Yan, Christopher G Lausted, Venu G Pillarisetty, James O Park, Kimberly J Riehle, Matthew Yeh, Qiang Tian, and Raymond S Yeung

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Multicenter validation of association between decline in MRI-PDFF and histologic response in nonalcoholic steatohepatitis., Rohit Loomba, Brent A Neuschwander-Tetri, Arun Sanyal, Naga Chalasani, Anna Mae Diehl, Norah Terrault, Kris Kowdley, Srinivasan Dasarathy, David Kleiner, Cynthia Behling, Joel Lavine, Mark Van Natta, Michael Middleton, James Tonascia, and Claude Sirlin

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Alpha1-Antitrypsin Deficiency: A Cause of Chronic Liver Disease., Vignan Manne and Kris V Kowdley

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Primary Liver Cancers: Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma., Juan Mejia and Jennifer Pasko

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Goals of Treatment for Improved Survival in Primary Biliary Cholangitis: Treatment Target Should Be Bilirubin Within the Normal Range and Normalization of Alkaline Phosphatase., Carla F Murillo Perez, Maren H Harms, Keith D Lindor, Henk R van Buuren, Gideon M Hirschfield, Christophe Corpechot, Adriaan J van der Meer, Jordan J Feld, Aliya Gulamhusein, Willem J Lammers, Cyriel Y Ponsioen, Marco Carbone, Andrew L Mason, Marlyn J Mayo, Pietro Invernizzi, Pier Maria Battezzati, Annarosa Floreani, Ana Lleo, Frederik Nevens, Kris V Kowdley, Tony Bruns, George N Dalekos, Nikolaos K Gatselis, Douglas Thorburn, Palak J Trivedi, Xavier Verhelst, Albert Parés, Harry L A Janssen, and Bettina E Hansen

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Goals of Treatment for Improved Survival in Primary Biliary Cholangitis: Treatment Target Should Be Bilirubin Within the Normal Range and Normalization of Alkaline Phosphatase., Carla F Murillo Perez, Maren H Harms, Keith D Lindor, Henk R van Buuren, Gideon M Hirschfield, Christophe Corpechot, Adriaan J van der Meer, Jordan J Feld, Aliya Gulamhusein, Willem J Lammers, Cyriel Y Ponsioen, Marco Carbone, Andrew L Mason, Marlyn J Mayo, Pietro Invernizzi, Pier Maria Battezzati, Annarosa Floreani, Ana Lleo, Frederik Nevens, Kris V Kowdley, Tony Bruns, George N Dalekos, Nikolaos K Gatselis, Douglas Thorburn, Palak J Trivedi, Xavier Verhelst, Albert Parés, Harry L A Janssen, and Bettina E Hansen

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Cenicriviroc Treatment for Adults with Nonalcoholic Steatohepatitis and Fibrosis: Final Analysis of the Phase 2b CENTAUR Study., Vlad Ratziu, Arun Sanyal, Stephen A Harrison, Vincent Wai-Sun Wong, Sven Francque, Zachary Goodman, Guruprasad P Aithal, Kris V Kowdley, Star Seyedkazemi, Laurent Fischer, Rohit Loomba, Manal F Abdelmalek, and Frank Tacke

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Modeling the Hepatology Workforce in the United States: A Predicted Critical Shortage., Mark W Russo, Oren K Fix, Ayman A Koteish, Katie Duggan, Marcia Ditmyer, Michael Fuchs, Raymond T Chung, and Gautham Reddy

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Methylation signatures in peripheral blood are associated with marked age acceleration and disease progression in patients with primary sclerosing cholangitis., Michael Trauner, Yevgeniy Gindin, Zhaoshi Jiang, Chuhan Chung, G Mani Subramanian, Robert P Myers, Aliya Gulamhusein, Kris V Kowdley, Cynthia Levy, Zachary Goodman, Michael P Manns, Andrew J Muir, and Christopher L Bowlus

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Clinical Research in Hepatology in the COVID-19 Pandemic and Post-Pandemic Era: Challenges and the Need for Innovation., Elizabeth C Verna, Marina Serper, Jaime Chu, Kathleen Corey, Oren K Fix, Karen Hoyt, Kimberly A Page, Rohit Loomba, Ming Li, Gregory T Everson, Michael W Fried, Guadalupe Garcia-Tsao, Norah Terrault, Anna S Lok, Raymond T Chung, and K Rajender Reddy

Submissions from 2019

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Effects of Age and Sex of on Response to Ursodeoxycholic Acid and Transplant-free Survival in Patients With Primary Biliary Cholangitis., Angela C Cheung, Willem J Lammers, Carla F Murillo Perez, Henk R van Buuren, Aliya Gulamhusein, Palak J Trivedi, Konstantinos N Lazaridis, Cyriel Y Ponsioen, Annarosa Floreani, Gideon M Hirschfield, Christophe Corpechot, Marlyn J Mayo, Pietro Invernizzi, Pier Maria Battezzati, Albert Parés, Frederik Nevens, Douglas Thorburn, Andrew L Mason, Marco Carbone, Kris V Kowdley, Tony Bruns, George N Dalekos, Nikolaos K Gatselis, Xavier Verhelst, Keith D Lindor, Ana Lleo, Raoul Poupon, Harry L Janssen, and Bettina E Hansen

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Outcomes following early versus delayed cholecystectomy performed for acute cholangitis., Andrew Discolo, Shelby Reiter, Bryce French, Danielle Hayes, Gary Lucas, Lancy Tan, James M Scanlan, and Ryan Martinez

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Factors Associated With Progression and Outcomes of Early-stage Primary Biliary Cholangitis., Nikolaos K Gatselis, Jorn C Goet, Kalliopi Zachou, Willem J Lammers, Harry L A Janssen, Gideon Hirschfield, Christophe Corpechot, Keith D Lindor, Pietro Invernizzi, Marlyn J Mayo, Pier Maria Battezzati, Annarosa Floreani, Albert Pares, Vasiliki Lygoura, Frederik Nevens, Andrew L Mason, Kris V Kowdley, Cyriel Y Ponsioen, Tony Bruns, Douglas Thorburn, Xavier Verhelst, Maren H Harms, Henk R van Buuren, Bettina E Hansen, and George N Dalekos

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A Pilot Genome-Wide Analysis Study Identifies Loci Associated With Response to Obeticholic Acid in Patients With NASH., Samer Gawrieh, Xiuqing Guo, Jingyi Tan, Marie Lauzon, Kent D Taylor, Rohit Loomba, Oscar W Cummings, Sreekumar Pillai, Pallav Bhatnagar, Kris V Kowdley, Katherine Yates, Laura A Wilson, Yii-Der Ida Chen, Jerome I Rotter, and Naga Chalasani

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Histologic Findings of Advanced Fibrosis and Cirrhosis in Patients With Nonalcoholic Fatty Liver Disease Who Have Normal Aminotransferase Levels., Samer Gawrieh, Laura A Wilson, Oscar W Cummings, Jeanne M Clark, Rohit Loomba, Bilal Hameed, Manal F Abdelmalek, Srinivasan Dasarathy, Brent A Neuschwander-Tetri, Kris V Kowdley, David Kleiner, Edward Doo, James Tonascia, Arun Sanyal, and Naga Chalasani

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Number needed to treat with ursodeoxycholic acid therapy to prevent liver transplantation or death in primary biliary cholangitis., Maren H Harms, Rozanne C de Veer, Willem J Lammers, Christophe Corpechot, Douglas Thorburn, Harry L A Janssen, Keith D Lindor, Palak J Trivedi, Gideon M Hirschfield, Albert Pares, Annarosa Floreani, Marlyn J Mayo, Pietro Invernizzi, Pier Maria Battezzati, Frederik Nevens, Cyriel Y Ponsioen, Andrew L Mason, Kris V Kowdley, Bettina E Hansen, Henk R van Buuren, and Adriaan J van der Meer

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Ursodeoxycholic acid therapy and liver transplant-free survival in patients with primary biliary cholangitis., Maren H Harms, Henk R van Buuren, Christophe Corpechot, Douglas Thorburn, Harry L A Janssen, Keith D Lindor, Gideon M Hirschfield, Albert Parés, Annarosa Floreani, Marlyn J Mayo, Pietro Invernizzi, Pier Maria Battezzati, Frederik Nevens, Cyriel Y Ponsioen, Andrew L Mason, Kris V Kowdley, Willem J Lammers, Bettina E Hansen, and Adriaan J van der Meer

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Characterization of patients with both alcoholic and nonalcoholic fatty liver disease in a large United States cohort., George Khoudari, Amandeep Singh, Mazen Noureddin, Danielle Fritze, Rocio Lopez, Imad Asaad, Eric Lawitz, Fred Poordad, Kris V Kowdley, and Naim Alkhouri

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Association of Histologic Disease Activity With Progression of Nonalcoholic Fatty Liver Disease., David E Kleiner, Elizabeth M Brunt, Laura A Wilson, Cynthia Behling, Cynthia Guy, Melissa Contos, Oscar Cummings, Matthew Yeh, Ryan Gill, Naga Chalasani, Brent A Neuschwander-Tetri, Anna Mae Diehl, Srinivasan Dasarathy, Norah Terrault, Kris V Kowdley, Rohit Loomba, Patricia Belt, James Tonascia, Joel E Lavine, and Arun J Sanyal

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ACG Clinical Guideline: Hereditary Hemochromatosis., Kris V Kowdley, Kyle E Brown, Joseph Ahn, and Vinay Sundaram

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Efficacy and safety of ruzasvir 60 mg and uprifosbuvir 450 mg for 12 weeks in adults with chronic hepatitis C virus genotype 1, 2, 3, 4 or 6 infection., Eric Lawitz, Fred Poordad, Leah J Anderson, Michelle Vesay, Michelle M Kelly, Hong Liu, Wei Gao, Doreen Fernsler, Ernest Asante-Appiah, Michael N Robertson, George J Hanna, Eliav Barr, Joan Butterton, Kris V Kowdley, Tarek Hassanein, Amandeep Sahota, Stuart C Gordon, and Wendy W Yeh

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Underestimation of Liver Transplantation for Alcoholic Hepatitis in the National Transplant Database., Brian P Lee, Gene Y Im, John P Rice, Ethan Weinberg, Christine Hsu, Oren K Fix, George Therapondos, Hyosun Han, David W Victor, Sheila Eswaran, Haripriya Maddur, and Norah A Terrault

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Model to Calculate Harms and Benefits of Early vs Delayed Liver Transplantation for Patients with Alcohol-Associated Hepatitis., Brian P Lee, Sumeyye Samur, Ozden O Dalgic, Emily D Bethea, Michael R Lucey, Ethan Weinberg, Christine Hsu, Mary E Rinella, Gene Y Im, Oren K Fix, George Therapondos, Hyosun Han, David W Victor, Michael D Voigt, Sheila Eswaran, Norah A Terrault, and Jagpreet Chhatwal

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Surgical and anesthetic management for hepatectomy in two pediatric patients with trisomy 18, pulmonary hypertension, and hepatoblastoma., Donald J Lucas, Jeremy Rubinstein, Ankush Gosain, Greg Tiao, Tim Head, J Nick Pratap, Regan Williams, Sara Helmig, James Geller, Max Langham, and Angela Trobaugh-Lotrario

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Current perspectives into the evaluation and management of hepatitis B: a review., Vignan Manne, Eric Gochanour, and Kris V Kowdley

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Obeticholic acid in primary biliary cholangitis: where we stand., Vignan Manne and Kris V Kowdley

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Epidemiologic features of a large hepatitis C cohort evaluated in a major health system in the western United States., Nizar A Mukhtar, Erik M Ness, Manan Jhaveri, Oren K Fix, Marquis Hart, Christopher Dale, Cheryl Pratt, and Kris V Kowdley

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Provider Attitudes and Practice Patterns for Direct-Acting Antiviral Therapy for Patients with Hepatocellular Carcinoma., Nicole E Rich, Ju Dong Yang, Ponni V Perumalswami, Naim Alkhouri, Whitney Jackson, Neehar D Parikh, Neil Mehta, Reena Salgia, Andres Duarte-Rojo, Laura Kulik, Mina Rakoski, Adnan Said, Omobonike Oloruntoba, George N Ioannou, Maarouf A Hoteit, Andrew M Moon, Amol S Rangnekar, Sheila L Eswaran, Elizabeth Zheng, Janice H Jou, James Hanje, Anjana Pillai, Ruben Hernaez, Robert Wong, Steven Scaglione, Hrishikesh Samant, Devika Kapuria, Shaun Chandna, Russell Rosenblatt, Veeral Ajmera, Catherine Frenette, Sanjaya K Satapathy, Parvez Mantry, Prasun Jalal, Binu V John, Oren K Fix, Michael Leise, Christina C Lindenmeyer, Avegail Flores, Nayan Patel, Z Gordon Jiang, Nyan Latt, Renumathy Dhanasekaran, Mobolaji Odewole, Sofia Kagan, Jorge A Marrero, and Amit G Singal

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Treatment of patients with HIV or hepatitis C by pharmacist clinicians in a patient-centered medical home., Keenan L Ryan, Bernadette Jakeman, Jessica Conklin, Larry J Pineda, Paulina Deming, and Renee-Claude Mercier

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Treatment of patients with HIV or hepatitis C by pharmacist clinicians in a patient-centered medical home., Keenan L Ryan, Bernadette Jakeman, Jessica Conklin, Larry J Pineda, Paulina Deming, and Renee-Claude Mercier

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Pediatric cholestatic liver disease: Successful transition of care., Praveen Kc Selvakumar, Vera Hupertz, Naveen Mittal, Kris V Kowdley, and Naim Alkhouri

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Mechanisms and Treatments of Pruritus in Primary Biliary Cholangitis., Raj A Shah and Kris V Kowdley

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Serum ferritin as a biomarker for NAFLD: ready for prime time?, Raj A Shah and Kris V Kowdley

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The nonsteroidal FXR agonist cilofexor (GS-9674) improves markers of cholestasis and liver injury in patients with PSC., Michael Trauner, Aliya Gulamhusein, Bilal Hameed, Stephen Caldwell, Mitchell L Shiffman, Charles Landis, Bertus Eksteen, Kosh Agarwal, Andrew Muir, Simon Rushbrook, Xiaomin Lu, Jun Xu, Jen-Chieh Chuang, Andrew N Billin, Chuhan Chung, Georgia Li, G Mani Subramanian, Robert P Myers, Christopher L Bowlus, and Kris V Kowdley

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A Simple Measure of Hepatocellular Carcinoma Burden Predicts Tumor Recurrence after Liver Transplantation: The RH-IML Classification., Philip Vutien, Jennifer Dodge, Kiran M Bambha, Eric M Nordstrom, Jane Gralla, Kristen Campbell, Claire Levek, Trevor Nydam, Oren Fix, George Ioannou, and Scott W Biggins

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A Simple Measure of Hepatocellular Carcinoma Burden Predicts Tumor Recurrence After Liver Transplantation: The Recurrent Hepatocellular Carcinoma-Initial, Maximum, Last Classification., Philip Vutien, Jennifer Dodge, Kiran M Bambha, Eric M Nordstrom, Jane Gralla, Kristen Campbell, Claire Levek, Trevor Nydam, Oren K Fix, George Ioannou, and Scott W Biggins

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Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial., Zobair M Younossi, Vlad Ratziu, Rohit Loomba, Mary Rinella, Quentin M Anstee, Zachary Goodman, Pierre Bedossa, Andreas Geier, Susanne Beckebaum, Philip N Newsome, David Sheridan, Muhammad Y Sheikh, James Trotter, Whitfield Knapple, Eric Lawitz, Manal F Abdelmalek, Kris V Kowdley, Aldo J Montano-Loza, Jerome Boursier, Philippe Mathurin, Elisabetta Bugianesi, Giuseppe Mazzella, Antonio Olveira, Helena Cortez-Pinto, Isabel Graupera, David Orr, Lise Lotte Gluud, Jean-Francois Dufour, David Shapiro, Jason Campagna, Luna Zaru, Leigh MacConell, Reshma Shringarpure, Stephen Harrison, and Arun J Sanyal

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Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial., Zobair M Younossi, Vlad Ratziu, Rohit Loomba, Mary Rinella, Quentin M Anstee, Zachary Goodman, Pierre Bedossa, Andreas Geier, Susanne Beckebaum, Philip N Newsome, David Sheridan, Muhammad Y Sheikh, James Trotter, Whitfield Knapple, Eric Lawitz, Manal F Abdelmalek, Kris V Kowdley, Aldo J Montano-Loza, Jerome Boursier, Philippe Mathurin, Elisabetta Bugianesi, Giuseppe Mazzella, Antonio Olveira, Helena Cortez-Pinto, Isabel Graupera, David Orr, Lise Lotte Gluud, Jean-Francois Dufour, David Shapiro, Jason Campagna, Luna Zaru, Leigh MacConell, Reshma Shringarpure, Stephen Harrison, and Arun J Sanyal

Submissions from 2018

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Efficacy of Glecaprevir/Pibrentasvir for 8 or 12 Weeks in Patients With Hepatitis C Virus Genotype 2, 4, 5, or 6 Infection Without Cirrhosis., Tarik Asselah, Kris V Kowdley, Neddie Zadeikis, Stanley Wang, Tarek Hassanein, Yves Horsmans, Massimo Colombo, Filipe Calinas, Humberto Aguilar, Victor de Ledinghen, Parvez S Mantry, Christophe Hezode, Rui Tato Marinho, Kosh Agarwal, Frederik Nevens, Magdy Elkhashab, Jens Kort, Ran Liu, Teresa I Ng, Preethi Krishnan, Chih-Wei Lin, and Federico J Mensa

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Complement Factor D protects mice from ethanol-induced inflammation and liver injury., Rebecca L McCullough, Megan R McMullen, Megan M Sheehan, Kyle L Poulsen, Sanjoy Roychowdhury, Dian J Chiang, Michele T Pritchard, Juan Caballeria, and Laura E Nagy

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Development and validation of a primary sclerosing cholangitis-specific patient-reported outcomes instrument: The PSC PRO., Zobair M Younossi, Arian Afendy, Maria Stepanova, Andrei Racila, Fatema Nader, Rachel Gomel, Ricky Safer, William R Lenderking, Anne Skalicky, Leah Kleinman, Robert P Myers, G Mani Subramanian, John G McHutchison, Cynthia Levy, Christopher L Bowlus, Kris V Kowdley, and Andrew J Muir

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Diagnostic modalities for nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, and associated fibrosis., Zobair M Younossi, Rohit Loomba, Quentin M Anstee, Mary E Rinella, Elisabetta Bugianesi, Giulio Marchesini, Brent A Neuschwander-Tetri, Lawrence Serfaty, Francesco Negro, Stephen H Caldwell, Vlad Ratziu, Kathleen E Corey, Scott L Friedman, Manal F Abdelmalek, Stephen A Harrison, Arun J Sanyal, Joel E Lavine, Philippe Mathurin, Michael R Charlton, Zachary D Goodman, Naga P Chalasani, Kris V Kowdley, Jacob George, and Keith Lindor

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Current and future therapeutic regimens for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis., Zobair M Younossi, Rohit Loomba, Mary E Rinella, Elisabetta Bugianesi, Giulio Marchesini, Brent A Neuschwander-Tetri, Lawrence Serfaty, Francesco Negro, Stephen H Caldwell, Vlad Ratziu, Kathleen E Corey, Scott L Friedman, Manal F Abdelmalek, Stephen A Harrison, Arun J Sanyal, Joel E Lavine, Philippe Mathurin, Michael R Charlton, Naga P Chalasani, Quentin M Anstee, Kris V Kowdley, Jacob George, Zachary D Goodman, and Keith Lindor

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Patient-Reported Outcomes Following Treatment of Chronic Hepatitis C Virus Infection With Sofosbuvir and Velpatasvir, With or Without Voxilaprevir., Zobair M Younossi, Maria Stepanova, Stuart Gordon, Stefan Zeuzem, Michael P Mann, Ira Jacobson, Marc Bourliere, Curtis Cooper, Steven Flamm, K Rajender Reddy, Kris V Kowdley, Issah Younossi, and Sharon Hunt

Submissions from 2017

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Sofosbuvir, Velpatasvir, and Voxilaprevir for Previously Treated HCV Infection., Marc Bourlière, Stuart C Gordon, Steven L Flamm, Curtis L Cooper, Alnoor Ramji, Myron Tong, Natarajan Ravendhran, John M Vierling, Tram T Tran, Stephen Pianko, Meena B Bansal, Victor de Lédinghen, Robert H Hyland, Luisa M Stamm, Hadas Dvory-Sobol, Evguenia Svarovskaia, Jie Zhang, K C Huang, G Mani Subramanian, Diana M Brainard, John G McHutchison, Elizabeth C Verna, Peter Buggisch, Charles S Landis, Ziad H Younes, Michael P Curry, Simone I Strasser, Eugene R Schiff, K Rajender Reddy, Michael P Manns, Kris V Kowdley, and Stefan Zeuzem

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An Update on the Treatment and Follow-up of Patients with Primary Biliary Cholangitis., Blaire E Burman, Manan A Jhaveri, and Kris V Kowdley

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Effectiveness of 8- or 12-weeks of ledipasvir and sofosbuvir in real-world treatment-naïve, genotype 1 hepatitis C infected patients., M P Curry, E B Tapper, B Bacon, D Dieterich, S L Flamm, L Guest, K V Kowdley, Y Lee, S Milligan, N Tsai, Z Younossi, and N H Afdhal

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Differences in hepatic expression of iron, inflammation and stress-related genes in patients with nonalcoholic steatohepatitis., Priya Handa, Akhila L Vemulakonda, Bryan D Maliken, Vicki Morgan-Stevenson, James E Nelson, Barjinder K Dhillon, Kelly A Hennessey, Rohit Gupta, Matthew M Yeh, and Kris V Kowdley

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Nutritional Approaches to Achieve Weight Loss in Nonalcoholic Fatty Liver Disease., Christine C Hsu, Erik Ness, and Kris V Kowdley

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New developments in the treatment of primary biliary cholangitis - role of obeticholic acid., Manan A Jhaveri and Kris V Kowdley

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The Natural History of Severe Acute Liver Injury., David G Koch, J L Speiser, V Durkalski, R J Fontana, T Davern, B McGuire, R T Stravitz, A M Larson, I Liou, Oren K Fix, M L Schilsky, T McCashland, J E Hay, N Murray, O S Shaikh, D Ganger, A Zaman, S B Han, R T Chung, R S Brown, S Munoz, K R Reddy, L Rossaro, R Satyanarayana, A J Hanje, J Olson, R M Subramanian, C Karvellas, B Hameed, A H Sherker, W M Lee, and A Reuben

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Eight weeks of ledipasvir/sofosbuvir is effective for selected patients with genotype 1 hepatitis C virus infection., Kris V Kowdley, Vinay Sundaram, Christie Y Jeon, Kamran Qureshi, Nyan L Latt, Amandeep Sahota, Stephen Lott, Michael P Curry, Naoky Tsai, Nathorn Chaiyakunapruk, Yoori Lee, Jorg Petersen, and Peter Buggisch

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Post-treatment resistance analysis of hepatitis C virus from phase II and III clinical trials of ledipasvir/sofosbuvir., David Wyles, Hadas Dvory-Sobol, Evguenia S Svarovskaia, Brian P Doehle, Ross Martin, Nezam H Afdhal, Kris V Kowdley, Eric Lawitz, Diana M Brainard, Michael D Miller, Hongmei Mo, and Edward J Gane