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Submissions from 2018

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Erratum to inequivalence of non-aggressiveness in clinically diagnosed lung cancers and overdiagnosis in lung cancer screening trials., Jerome M Reich and Jong S Kim

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NKTR-214 (CD122-biased agonist) and NKTR-262 (TLR7/8 agonist) combination treatment pairs local innate immune activation with systemic CD8+ T cell expansion to enhance anti-tumor immunity, Annah S. Rolig, Daniel Rose, Saul Kivimäe, Deborah Charych, Werner Rubas, Jonathan Zalevsky, and William L. Redmond

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MHC class I loaded ligands from breast cancer cell lines: A potential HLA-I-typed antigen collection., Dmitri V Rozanov, Nikita D Rozanov, Kami E Chiotti, Ashok Reddy, Phillip A Wilmarth, Larry L David, Seung W Cha, Sunghee Woo, Pavel Pevzner, Vineet Bafna, Gregory G Burrows, Juha K Rantala, Trevor Levin, Pavana Anur, Katie Johnson-Camacho, Shaadi Tabatabaei, Daniel J Munson, Tullia C Bruno, Jill E Slansky, John W Kappler, Naoto Hirano, Sebastian Boegel, Bernard A Fox, Colt Egelston, Diana L Simons, Grecia Jimenez, Peter P Lee, Joe W Gray, and Paul T Spellman

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The Epigenomic Landscape of Pituitary Adenomas Reveals Specific Alterations and Differentiates Among Acromegaly, Cushing's Disease and Endocrine-Inactive Subtypes., Matthew P Salomon, Xiaowen Wang, Diego M Marzese, Sandy C Hsu, Nellie Nelson, Xin Zhang, Chikako Matsuba, Yuki Takasumi, Carmen Ballesteros-Merino, Bernard A Fox, Garni Barkhoudarian, Daniel F Kelly, and Dave S B Hoon

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Preliminary results from a first-in-human phase 1 study of the CD40 agonist monoclonal antibody (mAb) CDX-1140, Rachel Sanborn, Michael S. Gordon, Mark O'Hara, Nina Bhardwaj, Yi He, Tracey Rawls, Tibor Keler, and Michael Yellin

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Immunotherapy in metastatic urothelial carcinoma: focus on immune checkpoint inhibition., Arlene Siefker-Radtke and Brendan Curti

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Combined anti-PD-1 and anti-LAG-3 checkpoint blockade enhances CD8+ TIL effector function while reducing Tregs leading to reduced immune suppression and improved overall survival, Elizabeth Sturgill, Courtney Mick, David Jenkins, Johanna Kaufmann, and William L. Redmond

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An update on the Society for Immunotherapy of Cancer consensus statement on tumor immunotherapy for the treatment of cutaneous melanoma: version 2.0., Ryan J Sullivan, Michael B Atkins, John M Kirkwood, Sanjiv S Agarwala, Joseph I Clark, Marc S Ernstoff, Leslie Fecher, Thomas F Gajewski, Brian Gastman, David H Lawson, Jose Lutzky, David F McDermott, Kim A Margolin, Janice M Mehnert, Anna C Pavlick, Jon M Richards, Krista M Rubin, William Sharfman, Steven Silverstein, Craig L Slingluff, Vernon K Sondak, Ahmad A Tarhini, John A Thompson, Walter J Urba, Richard L White, Eric D Whitman, F Stephen Hodi, and Howard L Kaufman

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Association of Immunologic Markers With Survival in Upfront Resectable Pancreatic Cancer., Ephraim S Tang, Philippa H Newell, Ronald F Wolf, Paul Daniel Hansen, Benjamin Cottam, Carmen Ballesteros-Merino, and Michael J Gough

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Tumor mutational burden is a determinant of immune-mediated survival in breast cancer., Alexandra Thomas, Eric D Routh, Ashok Pullikuth, Guangxu Jin, Jing Su, Jeff W Chou, Katherine A Hoadley, Cristin Print, Nick Knowlton, Michael A Black, Sandra Demaria, Ena Wang, Davide Bedognetti, Wendell D Jones, Gaurav A Mehta, Michael L Gatza, Charles M Perou, David B Page, Pierre Triozzi, and Lance D Miller

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Mertk is a therapeutic target in combination with radiation to promote adaptive immune tumor responses, Garth Tormoen, Jason R Baird, Gwen Kramer, Shelly Bambina, Marka R Crittenden, and Michael J. Gough

Role of the immunosuppressive microenvironment in immunotherapy., Garth W Tormoen, Marka R Crittenden, and Michael J. Gough

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Glatiramer Acetate Enhances Myeloid-Derived Suppressor Cell Function via Recognition of Paired Ig-like Receptor B., William van der Touw, Kyeongah Kang, Yi Luan, Ge Ma, Sunny Mai, Lihui Qin, Guanglin Bian, Ruihua Zhang, Sathish Kumar Mungamuri, Hong-Ming Hu, Cheng Cheng Zhang, Stuart A Aaronson, Marc Feldmann, Wen-Chin Yang, Shu-Hsia Chen, and Ping-Ying Pan

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Autophagosome-based strategy to monitor apparent tumor-specific CD8 T cells in patients with prostate cancer., Rieneke van de Ven, Traci L Hilton, Hong-Ming Hu, Christopher J Dubay, Daniel Haley, Christopher Paustian, Sachin Puri, Walter Urba, Brendan Curti, Sandra Aung, and Bernard A Fox

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Autophagosome-based strategy to monitor apparent tumor-specific CD8 T cells in patients with prostate cancer, Rieneke van de Ven, Traci L. Hilton, Hong-Ming Hu, Christopher J. Dubay, Daniel Haley, Christopher Paustian, Sachin Puri, Walter J. Urba, Brendan D. Curti, Sandra Aung, and Bernard A. Fox

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Tumor cell-released autophagosomes (TRAPs) promote immunosuppression through induction of M2-like macrophages with increased expression of PD-L1., Zhi-Fa Wen, Hongxiang Liu, Rong Gao, Meng Zhou, Jie Ma, Yue Zhang, Jinjin Zhao, Yongqiang Chen, Tianyu Zhang, Fang Huang, Ning Pan, Jinping Zhang, Bernard A Fox, Hong-Ming Hu, and Li-Xin Wang

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ALT-803, an IL-15 superagonist, in combination with nivolumab in patients with metastatic non-small cell lung cancer: a non-randomised, open-label, phase 1b trial., John M Wrangle, Vamsidhar Velcheti, Manish R Patel, Elizabeth Garrett-Mayer, Elizabeth G Hill, James G Ravenel, Jeffrey S Miller, Mohammad Farhad, Kate Anderton, Kathryn Lindsey, Michele Taffaro-Neskey, Carol Sherman, Samantha Suriano, Marzena Swiderska-Syn, Amy Sion, Joni Harris, Andie R Edwards, Julie A Rytlewski, Catherine M Sanders, Erik C Yusko, Mark D Robinson, Carsten Krieg, William L Redmond, Jack O Egan, Peter R Rhode, Emily K Jeng, Amy D Rock, Hing C Wong, and Mark P Rubinstein

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Whole-mount Confocal Microscopy for Adult Ear Skin: A Model System to Study Neuro-vascular Branching Morphogenesis and Immune Cell Distribution., Tomoko Yamazaki, Wenling Li, and Yoh-Suke Mukouyama

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Whole-Mount Adult Ear Skin Imaging Reveals Defective Neuro-Vascular Branching Morphogenesis in Obese and Type 2 Diabetic Mouse Models., Tomoko Yamazaki, Wenling Li, Ling Yang, Ping Li, Haiming Cao, Sei-Ichiro Motegi, Mark C Udey, Elise Bernhard, Takahisa Nakamura, and Yoh-Suke Mukouyama

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Tissue Specific Origin, Development, and Pathological Perspectives of Pericytes., Tomoko Yamazaki and Yoh-Suke Mukouyama

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Enhanced detection of neoantigen-reactive T cells targeting unique and shared oncogenes for personalized cancer immunotherapy., Rami Yossef, Eric Tran, Drew C Deniger, Alena Gros, Anna Pasetto, Maria R Parkhurst, Jared J Gartner, Todd D Prickett, Gal Cafri, Paul F Robbins, and Steven A Rosenberg

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Vx3-Functionalized Alumina Nanoparticles Assisted Enrichment of Ubiquitinated Proteins from Cancer Cells for Enhanced Cancer Immunotherapy., Jinjin Zhao, Ning Pan, Fang Huang, Mohanad Aldarouish, Zhifa Wen, Rong Gao, Yuye Zhang, Hong-Ming Hu, Yanfei Shen, and Li-Xin Wang

Submissions from 2017

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Phase 1b trial of proteasome inhibitor carfilzomib with irinotecan in lung cancer and other irinotecan-sensitive malignancies that have progressed on prior therapy (Onyx IST reference number: CAR-IST-553)., Susanne M Arnold, Kari Chansky, Markos Leggas, Michael A Thompson, John L Villano, John Hamm, Rachel E Sanborn, Glen J Weiss, Gurkamal Chatta, and Maria Q Baggstrom

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Surgical Navigation: A Systematic Review of Indications, Treatments, and Outcomes in Oral and Maxillofacial Surgery., Iman Azarmehr, Kasper Stokbro, R Bryan Bell, and Torben Thygesen

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STING expression and response to treatment with STING ligands in premalignant and malignant disease., Jason R Baird, Zipei Feng, Hong D Xiao, David Friedman, Ben Cottam, Bernard A Fox, Gwen Kramer, Rom S Leidner, Richard Bryan Bell, Kristina H Young, Marka R Crittenden, and Michael J Gough

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Immunotherapy of head and neck cancer: Emerging clinical trials from a National Cancer Institute Head and Neck Cancer Steering Committee Planning Meeting., Julie E Bauman, Ezra Cohen, Robert L Ferris, David J Adelstein, David M Brizel, John A Ridge, Brian O'Sullivan, Barbara A Burtness, Lisa H Butterfield, William E Carson, Mary L Disis, Bernard A Fox, Thomas F Gajewski, Maura L Gillison, James W Hodge, Quynh-Thu Le, David Raben, Scott E Strome, Jean Lynn, and Shakun Malik

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Relationships matter in oral cancer: will single-stain immunohistochemistry become irrelevant in the age of multispectral imaging?, R Bryan Bell and Bernard A Fox

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Erratum to 'Cytoreductive surgery for head and neck squamous cell carcinoma in the new age of immunotherapy' [Oral Oncol. 61 (2016) 166-176]., R Bryan Bell, Michael J Gough, Steven K Seung, Zeljka Jutric, Andrew D Weinberg, Bernard A Fox, Marka R Crittenden, Rom S Leidner, and Brendan Curti

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Head and neck surgeons at the vanguard of immunotherapy., Richard Bryan Bell

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Immunoprofiling as a predictor of patient's response to cancer therapy-promises and challenges., Daniel Bethmann, Zipei Feng, and Bernard A Fox

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Multiparametric immune profiling in HPV- oral squamous cell cancer., Zipei Feng, Daniel Bethmann, Matthias Kappler, Carmen Ballesteros-Merino, Alexander Eckert, R Bryan Bell, Allen Cheng, Tuan Bui, Rom Leidner, Walter Urba, Kent Johnson, Clifford Hoyt, Carlo Bifulco, Juergen Bukur, Claudia Wickenhauser, Barbara Seliger, and Bernard A Fox

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Immunotherapy biomarkers 2016: overcoming the barriers., James L Gulley, Jay A Berzofsky, Marcus O Butler, Alessandra Cesano, Bernard A Fox, Sacha Gnjatic, Sylvia Janetzki, Shyam Kalavar, Vaios Karanikas, Samir N Khleif, Ilan Kirsch, Peter P Lee, Cristina Maccalli, Holden Maecker, Jeffrey Schlom, Barbara Seliger, Janet Siebert, David F Stroncek, Magdalena Thurin, Jianda Yuan, and Lisa H Butterfield

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Predictors of responses to immune checkpoint blockade in advanced melanoma., N Jacquelot, M P Roberti, D P Enot, S Rusakiewicz, N Ternès, S Jegou, D M Woods, A L Sodré, M Hansen, Y Meirow, M Sade-Feldman, A Burra, S S Kwek, C Flament, M Messaoudene, C P M Duong, L Chen, B S Kwon, A C Anderson, V K Kuchroo, B Weide, F Aubin, C Borg, S Dalle, O Beatrix, M Ayyoub, B Balme, G Tomasic, A M Di Giacomo, M Maio, D Schadendorf, I Melero, B Dréno, A Khammari, R Dummer, M Levesque, Yoshinobu Koguchi, L Fong, M Lotem, M Baniyash, H Schmidt, I M Svane, G Kroemer, A Marabelle, S Michiels, A Cavalcanti, M J Smyth, J S Weber, A M Eggermont, and L Zitvogel

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Neuroinflammatory and cognitive consequences of combined radiation and immunotherapy in a novel preclinical model., Gwendolyn J McGinnis, David Friedman, Kristina H Young, Eileen Ruth S Torres, Charles R Thomas, Michael J Gough, and Jacob Raber

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Timing of PD-1 Blockade Is Critical to Effective Combination Immunotherapy with Anti-OX40., David J Messenheimer, Shawn M. Jensen, Michael E Afentoulis, Keith W Wegman, Zipei Feng, David J Friedman, Michael J. Gough, Walter Urba, and Bernard A Fox

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The Effect of Superparamagnetic Iron Oxide Nanoparticle Surface Charge on Antigen Cross-Presentation., Yongbin Mou, Yun Xing, Hongyan Ren, Zhihua Cui, Yu Zhang, Guangjie Yu, Walter J Urba, Qingang Hu, and Hongming Hu

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Differentiated State of Initiating Tumor Cells Is Key to Distinctive Immune Responses Seen in H-Ras, Michael A Podolsky, Jacob T Bailey, Andrew J Gunderson, Carrie J Oakes, Kyle Breech, and Adam B Glick

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A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses., Kara M Pryke, Jinu Abraham, Tina M Sali, Bryan J Gall, Iris Archer, Andrew Liu, Shelly Bambina, Jason R Baird, Michael J. Gough, Marita Chakhtoura, Elias K Haddad, Ilsa T Kirby, Aaron Nilsen, Daniel N Streblow, Alec J Hirsch, Jessica L Smith, and Victor R DeFilippis

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Anomalies in the dominant sarcoidosis paradigm justify its displacement., Jerome M Reich

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Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab., Nadeem Riaz, Jonathan J Havel, Vladimir Makarov, Alexis Desrichard, Walter Urba, Jennifer S Sims, F Stephen Hodi, Salvador Martín-Algarra, Rajarsi Mandal, William H Sharfman, Shailender Bhatia, Wen-Jen Hwu, Thomas F Gajewski, Craig L Slingluff, Diego Chowell, Sviatoslav M Kendall, Han Chang, Rachna Shah, Fengshen Kuo, Luc G T Morris, John-William Sidhom, Jonathan P Schneck, Christine E Horak, Nils Weinhold, and Timothy A Chan

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Differential phenotypes of memory CD4 and CD8 T cells in the spleen and peripheral tissues following immunostimulatory therapy., Gail D Sckisel, Annie Mirsoian, Christine M Minnar, Marka R Crittenden, Brendan Curti, Jane Q Chen, Bruce R Blazar, Alexander D Borowsky, Arta M Monjazeb, and William J Murphy

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A Milestone for CAR T Cells., Eric Tran, Dan L Longo, and Walter Urba

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Proceedings of the first international state-of-the-art conference on minimally-invasive pancreatic resection (MIPR)., Charles M Vollmer, Horacio J Asbun, Jeffrey Barkun, Marc G Besselink, Ugo Boggi, Kevin C P Conlon, Ho-Seong Han, Paul D Hansen, Michael L Kendrick, Andre L Montagnini, C Palanivelu, Bård I Røsok, Shailesh V Shrikhande, Go Wakabayashi, Herbert J Zeh, and David A Kooby

Submissions from 2016

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Earle A. Chiles Research Institute 2015 Year In Review, Earle A. Chiles Research Institute