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Submissions from 2020

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Phase II Trial of IL-12 Plasmid Transfection and PD-1 Blockade in Immunologically Quiescent Melanoma., Alain P Algazi, Christopher G Twitty, Katy K Tsai, Mai Le, Robert Pierce, Erica Browning, Reneta Hermiz, David A Canton, Donna Bannavong, Arielle Oglesby, Murray Francisco, Lawrence Fong, Mikael J Pittet, Sean P Arlauckas, Christopher Garris, Lauren P Levine, Carlo Bifulco, Carmen Ballesteros-Merino, Shailender Bhatia, Sharron Gargosky, Robert H I Andtbacka, Bernard A Fox, Michael D Rosenblum, and Adil I Daud

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Sgnlva-005: Open-label, phase II study of ladiratuzumab vedotin (LV) for advanced aerodigestive tract malignancies, Ian Churchill Anderson, Yinghui Wang, Zejing Wang, and Rachel E Sanborn

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Safety and activity of varlilumab, a novel and first-in-class agonist anti-CD27 antibody, for hematologic malignancies., Stephen M Ansell, Ian Flinn, Matthew H Taylor, Branimir I Sikic, Joshua Brody, John Nemunaitis, Andrew Feldman, Thomas R Hawthorne, Tracey Rawls, Tibor Keler, and Michael J Yellin

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Phase II Trial of Carfilzomib Plus Irinotecan in Patients with Small Cell Lung Cancer Who Have Progressed on Prior Platinum-Based Chemotherapy., Susanne M. Arnold, Kari Chansky, Maria Q. Baggstrom, Michael A. Thompson, Rachel E Sanborn, John L. Villano, Saiama N. Wagar, John Hamm, Markos Leggas, Maurice Willis, Joseph Rosales, and John J. Crowley

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Insights from immuno-oncology: The Society for Immunotherapy of Cancer statement on access to IL-6-targeting therapies for COVID-19, Paolo A. Ascierto; Bernard A Fox; Walter Urba; Ana Carrizosa Anderson; Michael Atkins; Ernest C. Borden; Julie R. Brahmer; Lisa H. Butterfield; Alessandra Cesano; Daniel S. Chen; Tanja D. De Gruijl; Robert O. Dillman; Charles G. Drake; Leisha A. Emens; Thomas F. Gajewski; James L. Gulley; F Stephen Hodi, Jr.; Patrick Hwu; David Kaufman; Howard L. Kaufman; Michael T. Lotze; Francesco M. Marincola; Kim A. Margolin; Michael J. Mastrangelo; Marcela V. Maus; Douglas G. McNeel; David R. Parkinson; Pedro J. Romero; Paul M. Sondel; Stefani Spranger; Mario Sznol; George J. Weiner; Jon M. Wigginton; and Jeffrey S. Weber

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Cohort Expansion Study of Neoadjvuant Immunoradiotherapy in Locoregionally Advanced HPV+ and HPV- Head and Neck Squamous Cell Carcinoma, Richard Bryan Bell, Rom Leidner, Kristina H Young, Brendan Curti, Marcus Couey, A Patel, Amber L Watters, Hong D Xiao, G Morris, L Rushforth, Michael J. Gough, and Marka R Crittenden

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Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-γ, CXCL9 and CXCL10., Cristina Bergamaschi, Hrishikesh Pandit, Bethany A Nagy, Dimitris Stellas, Shawn M. Jensen, Jenifer Bear, Maggie Cam, Antonio Valentin, Bernard A Fox, Barbara K Felber, and George N Pavlakis

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Dendritic Cell Maturation Defines Immunological Responsiveness of Tumors to Radiation Therapy., Tiffany C Blair, Shelly Bambina, Alejandro F Alice, Gwen Kramer, Terry R Medler, Jason R Baird, Miranda L Broz, Garth W Tormoen, Victoria Troesch, Marka R Crittenden, and Michael J. Gough

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Randomized phase II study of stereotactic body radiotherapy and interleukin-2 versus interleukin-2 in patients with metastatic melanoma., Brendan Curti, Marka R Crittenden, Steven K Seung, Christopher B Fountain, Roxanne Payne, ShuChing Chang, Jessica Fleser, Kimberly Phillips, Ian Malkasian, Lyn B Dobrunick, and Walter Urba

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Bempegaldesleukin (NKTR-214) plus Nivolumab in Patients with Advanced Solid Tumors: Phase I Dose-Escalation Study of Safety, Efficacy, and Immune Activation (PIVOT-02)., Adi Diab, Nizar M Tannir, Salah-Eddine Bentebibel, Patrick Hwu, Vassiliki Papadimitrakopoulou, Cara Haymaker, Harriet M Kluger, Scott N Gettinger, Mario Sznol, Scott S Tykodi, Brendan Curti, Mary A Tagliaferri, Jonathan Zalevsky, Alison L Hannah, Ute Hoch, Sandra Aung, Christie Fanton, Ahsan Rizwan, Ernesto Iacucci, Yijie Liao, Chantale Bernatchez, Michael E Hurwitz, and Daniel C Cho

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Genomic heterogeneity and clinical characterization of SARS-CoV-2 in Oregon, Alexa K Dowdell, Kevin Matlock, Fred L. Robinson, Roshanthi Weerasinghe, Rogan Rattray, Marina Pukay, Melvin Lathara, Anastacia Harlan, Thomas R. Ward, Mary Campbell, Walter Urba, Ganapati Srinivasa, Carlo Bifulco, and Brian D. Piening

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Safety and Clinical Activity of MEDI0562, a Humanized OX40 Agonist Monoclonal Antibody, in Adult Patients with Advanced Solid Tumors., Bonnie S Glisson, Rom Leidner, Robert L Ferris, John Powderly, Naiyer A Rizvi, Bhumsuk Keam, Reva Schneider, Sanjay Goel, James P Ohr, Jennifer Burton, Yanan Zheng, Steven Eck, Matthew Gribbin, Katie Streicher, Danielle M Townsley, and Sandip Pravin Patel

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A phase II single-arm study of pembrolizumab with enzalutamide in men with metastatic castration-resistant prostate cancer progressing on enzalutamide alone., Julie N Graff, Tomasz M Beer, Joshi J Alumkal, Rachel E Slottke, William L. Redmond, George V Thomas, Reid F Thompson, Mary A Wood, Yoshinobu Koguchi, Yiyi Chen, Emile Latour, Raymond C Bergan, Charles G Drake, and Amy E Moran

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TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking., Andrew J Gunderson, Tomoko Yamazaki, Kayla McCarty, Nathaniel E Fox, Michaela Phillips, Alejandro F Alice, Tiffany Blair, Mark Whiteford, David O'Brien, Rehan Ahmad, Maria X Kiely, Amanda Hayman, Todd Crocenzi, Michael J. Gough, Marka R. Crittenden, and Kristina H Young

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Results of Lung Cancer Screening in the Community., John R Handy, Michael Skokan, Erika Rauch, Steven Zinck, Rachel E Sanborn, Svetlana Kotova, and Mansen Wang

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Obesity Drives Delayed Infarct Expansion, Inflammation, and Distinct Gene Networks in a Mouse Stroke Model., Todd C Peterson, Kendra J Lechtenberg, Brian D. Piening, Tawaun A Lucas, Eric Wei, Hassan Chaib, Alexa K Dowdell, Michael Snyder, and Marion S Buckwalter

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Ageotypes: Distinct Biomolecular Trajectories in Human Aging., Brian D. Piening, Jennifer Lovejoy, and John C Earls

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AML risk stratification models utilizing ELN-2017 guidelines and additional prognostic factors: a SWOG report., Era L Pogosova-Agadjanyan, Anna Moseley, Megan Othus, Frederick R Appelbaum, Thomas R Chauncey, I-Ming L Chen, Harry P Erba, John E Godwin, Isaac C Jenkins, Min Fang, Mike Huynh, Kenneth J Kopecky, Alan F List, Jasmine Naru, Jerald P Radich, Emily Stevens, Brooke E Willborg, Cheryl L Willman, Brent L Wood, Qing Zhang, Soheil Meshinchi, and Derek L Stirewalt

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Comprehensive Immune Profiling of Medullary Thyroid Cancer., Nikita Pozdeyev, Timothy A Erickson, Lian Zhang, Kim Ellison, Christopher J Rivard, Sharon Sams, Fred R Hirsch, Bryan R Haugen, and Jena D French

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Confirmatory Tissue Sampling in Clinical Stage I Sarcoidosis., Jerome M Reich

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Response to Grannis FW. Current Controversies in Cardiothoracic Imaging: Overdiagnosis at Lung Cancer Screening-No So Bad After All-Counterpoint., Jerome M Reich and Jong S Kim

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Using nitrous acid-modified de Man, Rogosa, and Sharpe medium to selectively isolate and culture lactic acid bacteria from dairy foods., Matthew A Renschler, Asia Wyatt, Nnamdi Anene, Rona Robinson-Hill, Ethan S Pickerill, Nathaniel E Fox, Julie A Griffith, and John L McKillip

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Manual Scalp Cooling in Early Stage Breast Cancer: Value of Caretaker Training and Patient-Reported Experience to Optimize Efficacy and Patient Selection, Manaz Rezayee, Nikki Moxon, Staci Mellinger, Amanda Y Seino, Nicole E. Fredich, Tracy L. Kelly, Susan Mulligan, Patrick Rossi, Ijeoma Uche, Walter Urba, Alison Conlin, Janet Ruzich, and David B Page

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Effect of various decontamination procedures on disposable N95 mask integrity and SARS-CoV-2 infectivity, Jeffrey Smith, Haley Hanseler, John Welle, Rogan Rattray, Mary Campbell, Tacy Brotherton, Tarsem Moudgil, Thomas F. Pack, Keith W Wegman, Shawn M. Jensen, Justin Jin, Carlo Bifulco, Scott A. Prahl, Bernard A Fox, and Nicholas L Stucky

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The Society for Immunotherapy of Cancer statement on best practices for multiplex immunohistochemistry (IHC) and immunofluorescence (IF) staining and validation., Janis M Taube, Guray Akturk, Michael Angelo, Elizabeth L Engle, Sacha Gnjatic, Shirley Greenbaum, Noah F Greenwald, Cyrus V Hedvat, Travis J Hollmann, Jonathan Juco, Edwin R Parra, Marlon C Rebelatto, David L Rimm, Jaime Rodriguez-Canales, Kurt A Schalper, Edward C Stack, Cláudia S Ferreira, Konstanty Korski, Ana Lako, Scott J Rodig, Emanuel Schenck, Keith E Steele, Michael J Surace, Michael T Tetzlaff, Katharina von Loga, Ignacio I Wistuba, Carlo Bifulco, and Society for Immunotherapy of Cancer (SITC) Pathology Task Force.

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Urelumab alone or in combination with rituximab in patients with relapsed or refractory B-cell lymphoma., John Timmerman, Charles Herbaux, Vincent Ribrag, Andrew D Zelenetz, Roch Houot, Sattva S Neelapu, Theodore Logan, Izidore S Lossos, Walter Urba, Gilles Salles, Radhakrishnan Ramchandren, Caron Jacobson, John Godwin, Cecilia Carpio, Deanne Lathers, Yali Liu, Jaclyn Neely, Satyendra Suryawanshi, Yoshinobu Koguchi, and Ronald Levy

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PD-1 and PD-L1 Inhibitors: A Single Center Medication Assistance Program (MAP) Experience, Sarah Tu and Shuntao Cai

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Transoral robotic surgery and neck dissection for HPV-positive oropharyngeal carcinoma: Importance of nodal count in survival., Chi T Viet, Eric J Dierks, Allen C Cheng, Ashish Patel, Shu-Ching Chang, Marcus Couey, Amber L Watters, Thien Hoang, Hong D Xiao, Marka R Crittenden, Rom Leidner, Steven K Seung, Kristina H Young, and Richard Bryan Bell

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NKTR-214 immunotherapy synergizes with radiotherapy to stimulate systemic CD8, Joshua M Walker, Annah S Rolig, Deborah H Charych, Ute Hoch, Melissa Kasiewicz, Daniel Rose, Michael J McNamara, Ian F Hilgart-Martiszus, and William L. Redmond

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Agonist Abs to TNF Receptor Family Members, Andrew D Weinberg

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Transcriptional Upregulation of NLRC5 by Radiation Drives STING- and Interferon-Independent MHC-I Expression on Cancer Cells and T Cell Cytotoxicity., Lauren Zebertavage, Alejandro F Alice, Marka R Crittenden, and Michael J. Gough

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Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP., Yi Zhou, Mingjian Fei, Gu Zhang, Wei-Ching Liang, WeiYu Lin, Yan Wu, Robert Piskol, John Ridgway, Erin McNamara, Haochu Huang, Juan Zhang, Jaehak Oh, Jaina M Patel, Diana Jakubiak, Jeff Lau, Beth Blackwood, Daniel D Bravo, Yongchang Shi, Jianyong Wang, Hong-Ming Hu, Wyne P Lee, Rajiv Jesudason, Dewakar Sangaraju, Zora Modrusan, Keith R Anderson, Søren Warming, Merone Roose-Girma, and Minhong Yan

Submissions from 2019

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Current Landscape of Immunotherapy in Breast Cancer: A Review., Sylvia Adams, Margaret E Gatti-Mays, Kevin Kalinsky, Larissa A Korde, Elad Sharon, Laleh Amiri-Kordestani, Harry Bear, Heather L McArthur, Elizabeth Frank, Jane Perlmutter, David B Page, Benjamin Vincent, Jennifer F Hayes, James L Gulley, Jennifer K Litton, Gabriel N Hortobagyi, Stephen Chia, Ian Krop, Julia White, Joseph Sparano, Mary L Disis, and Elizabeth A Mittendorf

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Viral Targeting of Non-Muscle-Invasive Bladder Cancer and Priming of Antitumor Immunity Following Intravesical Coxsackievirus A21., Nicola E Annels, David Mansfield, Mehreen Arif, Carmen Ballesteros-Merino, Guy R Simpson, Mick Denyer, Sarbjinder S Sandhu, Alan A Melcher, Kevin J Harrington, Bronwyn Davies, Gough Au, Mark Grose, Izhar Bagwan, Bernard A Fox, Richard Vile, Hugh Mostafid, Darren Shafren, and Hardev S Pandha

Perspectives in immunotherapy: meeting report from the "Immunotherapy Bridge 2018" (28-29 November, 2018, Naples, Italy)., Paolo A Ascierto, Carlo Bifulco, Luigi Buonaguro, Leisha A Emens, Robert L Ferris, Bernard A Fox, Greg M Delgoffe, Jérôme Galon, Cesare Gridelli, Marco Merlano, Paul Nathan, Kunle Odunsi, Hideho Okada, Chrystal M Paulos, Sandro Pignata, Kurt A Schalper, Stefani Spranger, Giampaolo Tortora, Hassane Zarour, Lisa H Butterfield, and Igor Puzanov

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Pre-Analytic Variables and Tissue Stewardship for Reliable Next-Generation Sequencing (NGS) Clinical Analysis., Paolo A Ascierto, Carlo Bifulco, Giuseppe Palmieri, Solange Peters, and Nikoletta Sidiropoulos

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Contemporary Techniques in Orbital Reconstruction: A Review of the Literature and Report of a Case Combining Surgical Navigation, Computer-Aided Surgical Simulation, and a Patient-Specific Implant., Iman Azarmehr, Kasper Stokbro, Richard Bryan Bell, and Torben Thygesen

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Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop., Davide Bedognetti, Michele Ceccarelli, Lorenzo Galluzzi, Rongze Lu, Karolina Palucka, Josue Samayoa, Stefani Spranger, Sarah Warren, Kwok-Kin Wong, Elad Ziv, Diego Chowell, Lisa M Coussens, Daniel D De Carvalho, David G DeNardo, Jérôme Galon, Howard L Kaufman, Tomas Kirchhoff, Michael T Lotze, Jason J Luke, Andy J Minn, Katerina Politi, Leonard D Shultz, Richard Simon, Vésteinn Thórsson, Joanne B Weidhaas, Maria Libera Ascierto, Paolo Antonio Ascierto, James M Barnes, Valentin Barsan, Praveen K Bommareddy, Adrian Bot, Sarah E Church, Gennaro Ciliberto, Andrea De Maria, Dobrin Draganov, Winson S Ho, Heather M McGee, Anne Monette, Joseph F Murphy, Paola Nisticò, Wungki Park, Maulik Patel, Michael Quigley, Laszlo Radvanyi, Harry Raftopoulos, Nils-Petter Rudqvist, Alexandra Snyder, Randy F Sweis, Sara Valpione, Lisa H Butterfield, Mary L Disis, Bernard A Fox, Alessandra Cesano, and Francesco M Marincola

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Correction to: Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop., Davide Bedognetti, Michele Ceccarelli, Lorenzo Galluzzi, Rongze Lu, Karolina Palucka, Josue Samayoa, Stefani Spranger, Sarah Warren, Kwok-Kin Wong, Elad Ziv, Diego Chowell, Lisa M Coussens, Daniel D De Carvalho, David G DeNardo, Jérôme Galon, Howard L Kaufman, Tomas Kirchhoff, Michael T Lotze, Jason J Luke, Andy J Minn, Katerina Politi, Leonard D Shultz, Richard Simon, Vésteinn Thorsson, Joanne B Weidhaas, Maria Libera Ascierto, Paolo Antonio Ascierto, James M Barnes, Valentin Barsan, Praveen K Bommareddy, Adrian Bot, Sarah E Church, Gennaro Ciliberto, Andrea De Maria, Dobrin Draganov, Winson S Ho, Heather M McGee, Anne Monette, Joseph F Murphy, Paola Nisticò, Wungki Park, Maulik Patel, Michael Quigley, Laszlo Radvanyi, Harry Raftopoulos, Nils-Petter Rudqvist, Alexandra Snyder, Randy F Sweis, Sara Valpione, Roberta Zappasodi, Lisa H Butterfield, Mary L Disis, Bernard A Fox, Alessandra Cesano, and Francesco M Marincola

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Advances in drug delivery for post-surgical cancer treatment., Lin-Lin Bu, Junjie Yan, Zejun Wang, Huitong Ruan, Qian Chen, Vivienne Gunadhi, Richard Bryan Bell, and Zhen Gu

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Simultaneous T Cell Activation and Macrophage Polarization to Promote Potent Tumor Suppression by Iron Oxide-Embedded Large-Pore Mesoporous Organosilica Core-Shell Nanospheres., Lin Chen, Xiaobo Ma, Meng Dang, Heng Dong, Hong-Ming Hu, Xiaodan Su, Wenfei Liu, Qing Wang, Yongbin Mou, and Zhaogang Teng

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Tumor-released autophagosomes induces CD4, Yong-Qiang Chen, Peng-Cheng Li, Ning Pan, Rong Gao, Zhi-Fa Wen, Tian-Yu Zhang, Fang Huang, Fang-Yuan Wu, Xi-Long Ou, Jin-Ping Zhang, Xue-Jun Zhu, Hong-Ming Hu, Kang Chen, Yun-Lang Cai, and Li-Xin Wang

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The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC)., Ezra E W Cohen, Richard Bryan Bell, Carlo Bifulco, Barbara Burtness, Maura L Gillison, Kevin J Harrington, Quynh-Thu Le, Nancy Y Lee, Rom Leidner, Rebecca L Lewis, Lisa Licitra, Hisham Mehanna, Loren K Mell, Adam Raben, Andrew G Sikora, Ravindra Uppaluri, Fernanda Whitworth, Dan P Zandberg, and Robert L Ferris

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Overall survival by clinical risk category for high dose interleukin-2 (HD IL-2) treated patients with metastatic renal cell cancer (mRCC): data from the PROCLAIM, M Fishman, J P Dutcher, J I Clark, A Alva, G P Miletello, B Curti, Neeraj Agarwal, R Hauke, K M Mahoney, H Moon, J Treisman, S S Tykodi, G Daniels, M A Morse, M K K Wong, H Kaufman, N Gregory, and D F McDermott

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Significant differences in outcome between Immunoscore categories in stage I colon cancer patients., J Galon, F Hermitte, B Mlecnik, F Marliot, Carlo Bifulco, A Lugli, I Nagtegaal, A Hartmann, M Van den Eynde, M Roehrl, P Ohashi, E Zavadova, T Torigoe, P Patel, Y Wang, Y Kawakami, F Marincola, P Ascierto, Bernard A Fox, and F Pagès

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If we build it they will come: targeting the immune response to breast cancer., Margaret E Gatti-Mays, Justin M Balko, Sofia R Gameiro, Harry D Bear, Sangeetha Prabhakaran, Jami Fukui, Mary L Disis, Rita Nanda, James L Gulley, Kevin Kalinsky, Houssein Abdul Sater, Joseph A Sparano, David Cescon, David B Page, Heather McArthur, Sylvia Adams, and Elizabeth A Mittendorf

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Recognition of human gastrointestinal cancer neoantigens by circulating PD-1+ lymphocytes., Alena Gros, Eric Tran, Maria R Parkhurst, Sadia Ilyas, Anna Pasetto, Eric M Groh, Paul F Robbins, Rami Yossef, Andrea Garcia-Garijo, Carlos A Fajardo, Todd D Prickett, Li Jia, Jared J Gartner, Satyajit Ray, Lien Ngo, John R Wunderllich, James C Yang, and Steven A Rosenberg

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Blockade of fibroblast activation protein in combination with radiation treatment in murine models of pancreatic adenocarcinoma., Andrew J Gunderson, Tomoko Yamazaki, Kayla McCarty, Michaela Phillips, Alejandro F Alice, Shelly Bambina, Lauren Zebertavage, David Friedman, Benjamin Cottam, Pippa Newell, Michael J. Gough, Marka R Crittenden, Pieter Van der Veken, and Kristina H Young

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Multi-antigen Vaccination With Simultaneous Engagement of the OX40 Receptor Delays Malignant Mesothelioma Growth and Increases Survival in Animal Models., Peter R Hoffmann, Fukun W Hoffmann, Thomas A Premeaux, Tsuyoshi Fujita, Elisa Soprana, Maddalena Panigada, Glen M Chew, Guilhem Richard, Pooja Hindocha, Mark Menor, Vedbar S Khadka, Youping Deng, Lenny Moise, Lishomwa C Ndhlovu, Antonio Siccardi, Andrew D Weinberg, Anne S De Groot, and Pietro Bertino

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Monitoring therapeutic response and resistance: analysis of circulating tumor DNA in patients with ALK+ lung cancer., Leora Horn, Jennifer G Whisenant, Heather Wakelee, Karen L Reckamp, Huan Qiao, Ticiana A Leal, Liping Du, Jennifer Hernandez, Vincent Huang, George R Blumenschein, Saiama N Waqar, Sandip P Patel, Jorge Nieva, Geoffrey R Oxnard, Rachel E Sanborn, Tristan Shaffer, Kavita Garg, Allison Holzhausen, Kimberly Harrow, Chris Liang, Lee P Lim, Mark Li, and Christine M Lovly

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Circulating tumor (ct) DNA analysis to monitor response and resistance to ensartinib in patients (pts) with ALK+ non-small cell lung cancer (NSCLC)., L Horn, J G Whisenant, H Wakelee, K L Reckamp, H Qiao, L Du, J Hernandez, V Huang, S N Waqar, S Patel, R E Sanborn, T Shaffer, K Garg, A Holzhausen, K Harrow, C Liang, L P Lim, M Li, and C M Lovly

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Future Research Goals in Immunotherapy., Tyler W Hulett, Bernard A Fox, David J Messenheimer, Sebastian Marwitz, Tarsem Moudgil, Michael E Afentoulis, Keith W Wegman, Carmen Ballesteros-Merino, and Shawn M. Jensen

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Safety and Efficacy of Durvalumab and Tremelimumab Alone or in Combination in Patients with Advanced Gastric and Gastroesophageal Junction Adenocarcinoma., Ronan J Kelly, Jeeyun Lee, Yung-Jue Bang, Khaldoun Almhanna, Mariela Blum Murphy, Daniel V T Catenacci, Hyun Cheol Chung, Zev A Wainberg, Michael K Gibson, Keun-Wook Lee, Johanna C Bendell, Crystal S Denlinger, Cheng Ean Chee, Takeshi Omori, Rom Leidner, Heinz-Josef Lenz, Yee Chao, Marlon C Rebelatto, Philip Brohawn, Peng He, Jennifer McDevitt, Siddharth Sheth, Judson M Englert, and Geoffrey Y Ku

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Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer., Winifred Lo, Maria Parkhurst, Paul F Robbins, Eric Tran, Yong-Chen Lu, Li Jia, Jared J Gartner, Anna Pasetto, Drew Deniger, Parisa Malekzadeh, Thomas E Shelton, Todd Prickett, Satyajit Ray, Scott Kivitz, Biman C Paria, Isaac Kriley, David S Schrump, and Steven A Rosenberg

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Addressing current challenges and future directions in immuno-oncology: expert perspectives from the 2017 NIBIT Foundation Think Tank, Siena, Italy., Michele Maio, George Coukos, Soldano Ferrone, Bernard A Fox, Wolf H Fridman, Patrick L Garcia, Michael Lahn, Olivier Provendier, Vincenzo Russo, Dominik Rüttinger, Aiman Shalabi, Zlatko Trajanoski, Jean Viallet, Jedd D Wolchok, and Ramy Ibrahim

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Neoantigen screening identifies broad TP53 mutant immunogenicity in patients with epithelial cancers., Parisa Malekzadeh, Anna Pasetto, Paul F Robbins, Maria R Parkhurst, Biman C Paria, Li Jia, Jared J Gartner, Victoria Hill, Zhiya Yu, Nicholas P Restifo, Abraham Sachs, Eric Tran, Winifred Lo, Robert Pt Somerville, Steven A Rosenberg, and Drew C Deniger

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Neoantigen screening identifies broad TP53 mutant immunogenicity in patients with epithelial cancers., Parisa Malekzadeh, Anna Pasetto, Paul F Robbins, Maria R Parkhurst, Biman C Paria, Li Jia, Jared J Gartner, Victoria Hill, Zhiya Yu, Nicholas P Restifo, Abraham Sachs, Eric Tran, Winifred Lo, Robert Pt Somerville, Steven A Rosenberg, and Drew C Deniger

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Activating the Nucleic Acid-Sensing Machinery for Anticancer Immunity., Terry R Medler, Jaina M Patel, Alejandro Alice, Jason R Baird, Hong-Ming Hu, and Michael J Gough

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Anti-PD-1 monoclonal antibody MEDI0680 in a phase I study of patients with advanced solid malignancies., Aung Naing, Jeffrey Infante, Sanjay Goel, Howard Burris, Chelsea Black, Shannon Marshall, Ikbel Achour, Susannah Barbee, Rena May, Chris Morehouse, Kristen Pollizzi, Xuyang Song, Keith Steele, Nairouz Elgeioushi, Farzana Walcott, Joyson Karakunnel, Patricia LoRusso, Amy Weise, Joseph Eder, Brendan Curti, and Michael Oberst

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Use of "Research Techniques Made Simple" Series in Translational Topics Training in Dermatology at Oregon Health & Science University., Solveig Ophaug and Terry R Medler

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A phase Ib study of pre-operative, locoregional IRX-2 cytokine immunotherapy to prime immune responses in patients with early stage breast cancer., David B Page, Joanna Pucilowska, Katherine G Sanchez, Alison K Conlin, Anupama Acheson, Kelly S Perlewitz, James H Imatani, Shagheyegh Aliabadi-Wahle, Nikki Moxon, Staci Mellinger, Amanda Y Seino, Maritza Martel, Yaping Wu, Zhaoyu Sun, William L. Redmond, Valerie Conrad, Venkatesh Rajamanickam, Dottie Waddell, Deborah Laxague, Monil Shah, Shu-Ching Chang, and Walter Urba

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First-In-Human Study of Cemiplimab Alone or In Combination with Radiotherapy and/or Low Dose Cyclophosphamide in Patients with Advanced Malignancies., Kyriakos P Papadopoulos, Melissa L Johnson, Albert Craig Lockhart, Kathleen N Moore, Gerald S Falchook, Silvia C Formenti, Aung Naing, Richard D Carvajal, Lee S Rosen, Glen J Weiss, Rom Leidner, Jingjin Li, Anne Paccaly, Minjie Feng, Elizabeth Stankevich, Israel Lowy, Matthew G Fury, and Marka R Crittenden

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Unique Neoantigens Arise from Somatic Mutations in Patients with Gastrointestinal Cancers., Maria R Parkhurst, Paul F Robbins, Eric Tran, Todd D Prickett, Jared J Gartner, Li Jia, Gabriel Ivey, Yong F Li, Mona El-Gamil, Almin Lalani, Jessica S Crystal, Abraham Sachs, Eric Groh, Satyajit Ray, Lien T Ngo, Scott Kivitz, Anna Pasetto, Rami Yossef, Frank J Lowery, Stephanie L Goff, Winifred Lo, Gal Cafri, Drew C Deniger, Parisa Malekzadeh, Mojgan Ahmadzadeh, John R Wunderlich, Robert P T Somerville, and Steven A Rosenberg

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Peritumoral administration of DRibbles-pulsed antigen-presenting cells enhances the antitumor efficacy of anti-GITR and anti-PD-1 antibodies via an antigen presenting independent mechanism., Jaina M Patel, Zhihua Cui, Zhi-Fa Wen, Catherine T Dinh, and Hong-Ming Hu

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Blockade of TGF-β signaling to enhance the antitumor response is accompanied by dysregulation of the functional activity of CD4, Magdalena J Polanczyk, Edwin Walker, Daniel Haley, Bella S Guerrouahen, and Emmanuel T Akporiaye

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OX40 Agonist Tumor Immunotherapy Does Not Impact Regulatory T Cell Suppressive Function., Fanny Polesso, Minhaz Sarker, Andrew D Weinberg, Susan E Murray, and Amy E Moran

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OX40 Agonist Tumor Immunotherapy Does Not Impact Regulatory T Cell Suppressive Function., Fanny Polesso, Minhaz Sarker, Andrew D Weinberg, Susan E Murray, and Amy E Moran

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Immunological Complexity of the Prostate Cancer Microenvironment Influences the Response to Immunotherapy., Nataliya Prokhnevska, Dana A Emerson, Haydn T Kissick, and William L. Redmond

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Non-TB Mycobacterial Infection-Bronchiectasis Nexus., Jerome M Reich

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Non-TB Mycobacterial Infection-Bronchiectasis Nexus., Jerome M Reich

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Two Radiographic Features Favoring Radiation Pneumonitis in the Differential Diagnosis., Jerome M Reich

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Current Controversies in Cardiothoracic Imaging: Low-dose Computerized Tomographic Overdiagnosis of Lung Cancer is Substantial; Its Consequences are Underappreciated-Point., Jerome M Reich and Jong S Kim

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Earlier Diagnosis Not Self-Evidently Beneficial: Natural History of Subcentimeter Lung Cancers., Jerome M Reich and Jong S Kim

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Immunotherapy Toxicities., Katherine Sanchez, David B Page, and Walter Urba

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High-Dose Ipilimumab and High-Dose Interleukin-2 for Patients With Advanced Melanoma., Ann W Silk, Howard L Kaufman, Brendan Curti, Janice M Mehnert, Kim Margolin, David McDermott, Joseph Clark, Jenna Newman, Praveen K Bommareddy, Lisa Denzin, Saltanat Najmi, Azra Haider, Weichung Shih, Michael P Kane, and Andrew Zloza

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Immunotherapy for Head and Neck Cancer., Felix Sim, Rom Leidner, and Richard Bryan Bell

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Immunotherapy for Head and Neck Cancer., Felix Sim, Rom Leidner, and Richard Bryan Bell

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Immunotherapy for Head and Neck Cancer., Felix Sim, Rom Leidner, and Richard Bryan Bell

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Major pathologic response on biopsy (MPRbx) in patients with advanced melanoma treated with anti-PD-1: evidence for an early, on-therapy biomarker of response., J E Stein, A Soni, L Danilova, T R Cottrell, T F Gajewski, F S Hodi, S Bhatia, W J Urba, W H Sharfman, M Wind-Rotolo, R Edwards, E J Lipson, and J M Taube

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Subcellular compartmentalization of PKM2 identifies anti-PKM2 therapy response in vitro and in vivo mouse model of human non-small-cell lung cancer., Akiko Suzuki, Sachin Puri, Pamela Leland, Ankit Puri, Tarsem Moudgil, Bernard A Fox, Raj K Puri, and Bharat H Joshi

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Prevalence of trismus in patients with head and neck cancer: A systematic review with meta-analysis., Amber L Watters, Shane Cope, Meir N Keller, Mariela Padilla, and Reyes Enciso

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Multispectral Fluorescence Imaging Allows for Distinctive Topographic Assessment and Subclassification of Tumor-Infiltrating and Surrounding Immune Cells., Claudia Wickenhauser, Daniel Bethmann, Zipei Feng, Shawn M. Jensen, Carmen Ballesteros-Merino, Chiara Massa, Andre Steven, Marcus Bauer, Peter Kaatzsch, Nikolaos Pazaitis, Georgiana Toma, Carlo Bifulco, Bernard A Fox, and Barbara Seliger

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A microbial-based cancer vaccine for induction of EGFRvIII-specific CD8+ T cells and anti-tumor immunity., Lauren Zebertavage, Shelly Bambina, Jessica Shugart, Alejandro Alice, Kyra D Zens, Peter Lauer, Bill Hanson, Michael J. Gough, Marka R Crittenden, and Keith S Bahjat

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Longitudinal multi-omics of host-microbe dynamics in prediabetes., Wenyu Zhou, M Reza Sailani, Kévin Contrepois, Yanjiao Zhou, Sara Ahadi, Shana R Leopold, Martin J Zhang, Varsha Rao, Monika Avina, Tejaswini Mishra, Jethro Johnson, Brittany Lee-McMullen, Songjie Chen, Ahmed A Metwally, Thi Dong Binh Tran, Hoan Nguyen, Xin Zhou, Brandon Albright, Bo-Young Hong, Lauren Petersen, Eddy Bautista, Blake Hanson, Lei Chen, Daniel Spakowicz, Amir Bahmani, Denis Salins, Benjamin Leopold, Melanie Ashland, Orit Dagan-Rosenfeld, Shannon Rego, Patricia Limcaoco, Elizabeth Colbert, Candice Allister, Dalia Perelman, Colleen Craig, Eric Wei, Hassan Chaib, Daniel Hornburg, Jessilyn Dunn, Liang Liang, Sophia Miryam Schüssler-Fiorenza Rose, Kim Kukurba, Brian D. Piening, Hannes Rost, David Tse, Tracey McLaughlin, Erica Sodergren, George M Weinstock, and Michael Snyder

Submissions from 2018

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Clinical Development of Novel Drug-Radiotherapy Combinations., Saif S Ahmad, Marka R Crittenden, Phuoc T Tran, Paul G Kluetz, Gideon M Blumenthal, Helen Bulbeck, Richard D Baird, Kaye J Williams, Tim Illidge, Stephen M Hahn, Theodore S Lawrence, Patricia A Spears, Amanda J Walker, and Ricky A Sharma

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Amplifying IFN-γ Signaling in Dendritic Cells by CD11c-Specific Loss of SOCS1 Increases Innate Immunity to Infection while Decreasing Adaptive Immunity., Alejandro F Alice, Gwen Kramer, Shelly Bambina, Jason R Baird, Keith S Bahjat, Michael J Gough, and Marka R Crittenden

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Perspectives in immunotherapy: meeting report from the Immunotherapy Bridge (29-30 November, 2017, Naples, Italy)., Paolo A Ascierto, James Brugarolas, Luigi Buonaguro, Lisa H Butterfield, David Carbone, Bruno Daniele, Robert Ferris, Bernard A Fox, Jérôme Galon, Cesare Gridelli, Howard L Kaufman, Christopher A Klebanoff, Ignacio Melero, Paul Nathan, Chrystal M Paulos, Marco Ruella, Ryan Sullivan, Hassane Zarour, and Igor Puzanov

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Perspectives in melanoma: Meeting report from the Melanoma Bridge (30 November-2 December, 2017, Naples, Italy)., Paolo A Ascierto, Igor Puzanov, Sanjiv S Agarwala, Carlo Bifulco, Gerardo Botti, Corrado Caracò, Gennaro Ciliberto, Michael A Davies, Reinhard Dummer, Soldano Ferrone, Thomas F Gajewski, Claus Garbe, Jason J Luke, Francesco M Marincola, Giuseppe Masucci, Janice M Mehnert, Nicola Mozzillo, Giuseppe Palmieri, Michael A Postow, Stephen P Schoenberger, Ena Wang, and Magdalena Thurin

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MV-626, a potent and selective inhibitor of ENPP1 enhances STING activation and augments T-cell mediated anti-tumor activity in vivo, Jason Baird, Gregory Dietsch, Vincent Florio, Michael Gallatin, Clayton Knox, Joshua Odingo, Marka Crittenden, and Michael J. Gough

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Evaluation of explant responses to STING ligands: personalized immunosurgical therapy for head and neck squamous cell carcinoma., Jason R Baird, R Bryan Bell, Victoria Troesch, David J Friedman, Shelly Bambina, Gwen Kramer, Tiffany Blair, Terry R Medler, Yaping Wu, Zhaoyu Sun, Tanja D de Gruijl, Rieneke van de Ven, Rom Leidner, Marka R Crittenden, and Michael J. Gough

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Integrative spatially-resolved, high-plex digital profiling enables characterization of complex immune biology in the tumor microenvironment of mesothelioma, Carmen Ballesteros-Merino, Moritz Widmaier, Sarah Church, Thomas Herz, Alexei Budco, Das Medrikova, Ivan Kanchev, Andrew White, Douglas Hinerfeld, Shawn Jensen, John Handy, Rachel Sanborn, Carlo Bifulco, Sarah Warren, Joseph Beechem, and Bernard .. Fox

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SITC 2018 workshop report: Immuno-Oncology Biomarkers: State of the Art., Lisa H Butterfield, Mary L Disis, Bernard A Fox, David R Kaufman, Samir N Khleif, and Ena Wang

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A Phase II Study of Celecoxib With Irinotecan, 5-Fluorouracil, and Leucovorin in Patients With Previously Untreated Advanced or Metastatic Colorectal Cancer., Emerson Y Chen, Charles D Blanke, Daniel G Haller, Al B Benson, Tomislav Dragovich, Heinz-Josef Lenz, Carlos Robles, Hong Li, Motomi Mori, Nora Mattek, Rachel E Sanborn, and Charles D Lopez

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Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity., Hui-Ming Chen, William van der Touw, Yuan Shuo Wang, Kyeongah Kang, Sunny Mai, Jilu Zhang, Dayanira Alsina-Beauchamp, James A Duty, Sathish Kumar Mungamuri, Bin Zhang, Thomas Moran, Richard Flavell, Stuart Aaronson, Hong-Ming Hu, Hisashi Arase, Suresh Ramanathan, Raja Flores, Ping-Ying Pan, and Shu-Hsia Chen

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Phase IIIb safety results from an expanded-access protocol of talimogene laherparepvec for patients with unresected, stage IIIB-IVM1c melanoma., Jason Chesney, Sanjay Awasthi, Brendan Curti, Laura Hutchins, Gerald Linette, Pierre Triozzi, Marcus C B Tan, Russell E Brown, John Nemunaitis, Eric Whitman, Christopher Windham, Jose Lutzky, Gerald F Downey, Nicolas Batty, and Thomas Amatruda

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A multi-center phase II study of high dose interleukin-2 sequenced with vemurafenib in patients with BRAF-V600 mutation positive metastatic melanoma., Joseph I Clark, Jatinder Singh, Marc S Ernstoff, Christopher D Lao, Lawrence E Flaherty, Theodore F Logan, Brendan Curti, Sanjiv S Agarwala, Bret Taback, Lee Cranmer, Jose Lutzky, Theresa L Luna, Sandra Aung, and David H Lawson

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Implementation and Validation of an Automated Flow Cytometry Analysis Pipeline for Human Immune Profiling., Valerie Conrad, Christopher Dubay, Mehrnoush Malek, Ryan R Brinkman, Yoshinobu Koguchi, and William L. Redmond

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Delayed immune-related events after discontinuation of immunotherapy – DIRE syndrome?, Marcus Couey, R. Bryan Bell, Ashish Patel, Marka R Crittenden, Brendan Curti, and Rom Leidner

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Tumor cure by radiation therapy and checkpoint inhibitors depends on pre-existing immunity., Marka R Crittenden, Lauren Zebertavage, Gwen Kramer, Shelly Bambina, David Friedman, Victoria Troesch, Tiffany Blair, Jason R Baird, Alejandro F Alice, and Michael J Gough

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Immunotherapy in Advanced Renal Cancer - Is Cure Possible?, Brendan D Curti