The Cancer Institute is a leader in cutting-edge treatments. Using a truly multidisciplinary approach, patients have access to advanced diagnostics, minimally invasive surgical interventions, and personalized genomic and immune-oncologic treatment options. Our team of cancer specialists – many of whom completed fellowships and specialty training at prestigious academic centers – offers comprehensive services for individuals with a cancer diagnosis.

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Submissions from 2022

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The impact of mentoring on early career faculty: Assessment of a virtual mentoring program., Akanksha Sharma, Heather Leeper, Soo Bang, Donna Molaie, and Alyx B. Porter

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Advances in the Diagnosis and Treatment of Leptomeningeal Disease., Akanksha Sharma, Justin T Low, and Priya Kumthekar

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Comparison of perioperative outcomes following transperitoneal versus retroperitoneal robot-assisted partial nephrectomy: a propensity-matched analysis of VCQI database., Gopal Sharma, Milap Shah, Puneet Ahluwalia, Prokar Dasgupta, Benjamin J Challacombe, Mahendra Bhandari, Rajesh Ahlawat, Sudhir Rawal, Nicolo M Buffi, Ananthkrishnan Sivaraman, James R Porter, Craig Rogers, Alexandre Mottrie, Ronney Abaza, Khoon Ho Rha, Daniel Moon, Thyavihally B Yuvaraja, Dipen J Parekh, Umberto Capitanio, Kris K Maes, Francesco Porpiglia, Levent Turkeri, and Gagan Gautam

772 A phase 1/2 dose escalation/expansion study evaluating the safety, pharmacokinetics, pharmacodynamics, and antitumor activity of E-602, a bi-sialidase fusion protein, in advanced cancer (GLIMMER-01), Manish Sharma, Brendan Curti, and See all authors in comments

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Efficacy and safety in a 4-year follow-up of the ELEVATE-TN study comparing acalabrutinib with or without obinutuzumab versus obinutuzumab plus chlorambucil in treatment-naïve chronic lymphocytic leukemia., Jeff P Sharman, Miklos Egyed, Wojciech Jurczak, Alan Skarbnik, John M Pagel, Ian W Flinn, Manali Kamdar, Talha Munir, Renata Walewska, Gillian Corbett, Laura Maria Fogliatto, Yair Herishanu, Versha Banerji, Steven Coutre, George Follows, Patricia Walker, Karin Karlsson, Paolo Ghia, Ann Janssens, Florence Cymbalista, Jennifer A Woyach, Emmanuelle Ferrant, William G Wierda, Veerendra Munugalavadla, Ting Yu, Min Hui Wang, and John C Byrd

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Immunotherapy in head and neck squamous cell carcinoma: a narrative review., Shay Sharon and R Bryan Bell

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The immune landscape of solid pediatric tumors., Shimaa Sherif, Jessica Roelands, William Mifsud, Eiman I Ahmed, Christophe M Raynaud, Darawan Rinchai, Abbirami Sathappan, Ata Maaz, Ayman Saleh, Erdener Ozer, Khalid A Fakhro, Borbala Mifsud, Vésteinn Thorsson, Davide Bedognetti, and Wouter R L Hendrickx

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Effect of 3-Dimensional, Virtual Reality Models for Surgical Planning of Robotic Prostatectomy on Trifecta Outcomes: A Randomized Clinical Trial., Joseph D Shirk, Robert Reiter, Eric M Wallen, Ray Pak, Thomas Ahlering, Ketan K Badani, and James R Porter

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Efficacy and safety of trifluridine/tipiracil in older and younger patients with metastatic gastric or gastroesophageal junction cancer: subgroup analysis of a randomized phase 3 study (TAGS)., Kohei Shitara, Toshihiko Doi, Hisashi Hosaka, Peter Thuss-Patience, Armando Santoro, Federico Longo, Ozgur Ozyilkan, Irfan Cicin, David J Park, Aziz Zaanan, Carles Pericay, Mustafa Özgüroğlu, Maria Alsina, Lukas Makris, Karim A Benhadji, and David H Ilson

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Abstract A27: Impact of a validated composite comorbidity score on outcomes in patients treated with CAR T-cell therapy for diffuse large B cell lymphoma (DLBCL): A multicenter real-world evidence (RWE) study, Geoffrey Shouse, Neil Bailey, Krish Patel, and See all authors in comments

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Impact of a Validated Composite Comorbidity Score on Outcomes in Patients Treated with CAR T-Cell Therapy for Diffuse Large B Cell Lymphoma (DLBCL): A Multicenter Real-World Evidence (RWE) Study, Geoffrey Shouse, Neil Bailey, Krish Patel, and See all authors in comments

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Amivantamab and lazertinib in patients with EGFR-mutant non–small cell lung (NSCLC) after progression on osimertinib and platinum-based chemotherapy: Updated results from CHRYSALIS-2., Catherine A. Shu, Rachel E Sanborn, and See full list of authors in comments

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A phase 1b single-arm trial of intratumoral oncolytic virus V937 in combination with pembrolizumab in patients with advanced melanoma: results from the CAPRA study., Ann W Silk, Steven O'Day, Howard L Kaufman, Jennifer Bryan, Jacqueline T Norrell, Casey Imbergamo, Daniella Portal, Edwin Zambrano-Acosta, Marisa Palmeri, Seymour Fein, Cai Wu, Leslie Guerreiro, Daniel Medina, Praveen K Bommareddy, Andrew Zloza, Bernard A Fox, Carmen Ballesteros-Merino, Yixin Ren, Darren Shafren, Mark Grose, Joshua A Vieth, and Janice M Mehnert

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ASO Visual Abstract: Recurrence and Survival Rates for 1400 Early Breast Tumors Treated with Intraoperative Radiation Therapy (IORT)., Melvin J Silverstein, Melinda Epstein, Peter Chen, Kevin Lin, Sadia Khan, Lincoln Snyder, Colleen Coleman, Lisa Guerra, Farideh Dehkordi-Vakil, and Brian Kim

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Psychometric Characteristics and Validity of the PROMIS Cancer Function Brief 3D Profile, Sean R. Smith, Mary Vargo, David S Zucker, Samman Shahpar, Lynn Gerber, Maryanne Henderson, Gina Jay, Minji Lee, and Andrea Cheville

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Psychometric Characteristics and Validity of the PROMIS Cancer Function Brief 3D Profile, Sean R. Smith, Mary Vargo, David S Zucker, Samman Shahpar, Lynn Gerber, Maryanne Henderson, Gina Jay, Minji Lee, and Andrea Cheville

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Responsiveness and interpretation of the PROMIS Cancer Function Brief 3D Profile., Sean R Smith, Mary Vargo, David S Zucker, Samman Shahpar, Lynn H Gerber, Maryanne Henderson, Gina Jay, and Andrea L Cheville

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Contemporary, national patterns of surgery after preoperative therapy for stage II/III rectal adenocarcinoma., Celine Soriano, Henry T Bahnson, Jennifer A Kaplan, Bruce Lin, Ravi Moonka, Huong T Pham, Hagen F Kennecke, and Vlad Simianu

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Clinical Oncology Nurse Best Practices: Palliative Care and End-of-Life Conversations., Kellie Spine, Anne Skwira-Brown, Deanna Schlifke, and Ellen Carr

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Exploring approaches for predictive cancer patient digital twins: Opportunities for collaboration and innovation., Eric A Stahlberg, Mohamed Abdel-Rahman, Boris Aguilar, Alireza Asadpoure, Robert A Beckman, Lynn L Borkon, Jeffrey N Bryan, Colleen M Cebulla, Young Hwan Chang, Ansu Chatterjee, Jun Deng, Sepideh Dolatshahi, Olivier Gevaert, Emily J Greenspan, Wenrui Hao, Tina Hernandez-Boussard, Pamela R Jackson, Marieke Kuijjer, Adrian Lee, Paul Macklin, Subha Madhavan, Matthew D McCoy, Navid Mohammad Mirzaei, Talayeh Razzaghi, Heber L Rocha, Leili Shahriyari, Ilya Shmulevich, Daniel G Stover, Yi Sun, Tanveer Syeda-Mahmood, Jinhua Wang, Qi Wang, and Ioannis Zervantonakis

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Severe breakthrough COVID-19 with a heavily mutated variant in a multiple myeloma patient 10 weeks after vaccination., Samuel D Stampfer, Marissa-Skye Goldwater, Sean Bujarski, Bernard Regidor, Wenjuan Zhang, Aaron J Feinstein, Regina Swift, Shahrooz Eshaghian, Eric Vail, and James R Berenson

A phase I dose escalation study of STEMVAC, a multi-antigen, multi-epitope Th1 selective plasmid-based vaccine, targeting stem cell associated proteins in patients with advanced breast cancer, S Stanton

Systemic therapy strategies in triple negative breast cancer, S Stanton

Neoadjuvant survivin-targeted immunotherapy maveropepimut-S (MVP-S) to increase Th1 immune response in Ki67-high hormone receptor-positive (HR+) early-stage breast cancer (ESBC)., Sasha Stanton

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549 Booster vaccination of a HER2 helper T-cell vaccine increased HER2 immunity in metastatic HER2 positive breast cancer., Sasha Stanton, Jennifer Childs, Doreen Higgins, Angela Kask, Yi Yang, and Mary Disis

Phase I trial of the safety and immunogenicity of a tri-antigen vaccine targeting HER2, IGFBP-2, and IGF-IR in patients with non-metastatic breast cancer, Sasha E. Stanton and See all authors in comments

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Neoadjuvant survivin-targeted immunotherapy maveropepimut-S (MVP-S) to increase Th1 immune response in Ki67-high hormone receptor-positive (HR+) early-stage breast cancer (ESBC)., Sasha Stanton, Lisa Diana MacDonald, Staci Mellinger, Nikki Moxon, Tracy L. Kelly, Heather Ann Hirsch, Stephan Fiset, Kristina H Young, and David B Page

646 Neoadjuvant immunotherapy combining maveropepimut-S (MVP-S) with letrozole decreases Ki67 and increases Th1 immune response in hormone receptor positive (HR+) early-stage breast cancer (ESBC), Sasha Stanton, David Page, Kristina Young, and See all authors in comments

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Abstract PR007: Candidate antigens for a ductal carcinoma in situ vaccine, essential for breast cancer cell survival across multiple subtypes, are immunogenic in DCIS and IBC, Sasha Stanton, Jason Schlumbohm, and Mary L. Disis

Neoadjuvant survivin-targeted immunotherapy maveropepimut-S (MVP-S) to increase Th1 immune response in Ki67-high hormone receptor-positive (HR+) early-stage breast cancer (ESBC), Sasha Stanton and See all authors in comments

Phase I trial of the safety and immunogenicity of a tri-antigen vaccine targeting HER2, IGFBP-2, and IGF-IR in patients with non-metastatic breast cancer, Sasha Stanton and See all authors in comments

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3380 / 8 - Seven autoantibody panel, validated in two independent patient serum collections, can detect women with DCIS and invasive breast cancer, Sasha Stanton and See full list of authors in comments

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Neoadjuvant survivin-targeted immunotherapy maveropepimut-S (MVP-S) to increase Th1 immune response in Ki67-high hormone receptor-positive (HR+) early-stage breast cancer (ESBC)., Sasha Stanton, Kristina H Young, David B Page, and See all authors in comments

Immunology 101, SE Stanton

647 Phase I studies of AgenT-797, a novel allogeneic invariant natural killer T (iNKT) cell therapy, for the treatment of patients with solid tumors or multiple myeloma, Don Stevens, Rachel Sanborn, and See all authors in comments

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Risk factors for reduced function in women with a history of breast cancer., Nicholas Stoyles, Andrea Cheville, David S Zucker, Blair Richards, Mary Vargo, Lynn Gerber, Samman Shahpar, Maryanne Henderson, Gina Jay, and Sean R Smith

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Malignant Pilomatricoma of the Lower Extremity: A Difficult and Rare Diagnosis., Chaitra Subramanyam, Paige Dyrek, Xu Yao, and Martin H Kay

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Blockade of interleukin 10 potentiates antitumour immune function in human colorectal cancer liver metastases., Kevin M Sullivan, Xiuyun Jiang, Prajna Guha, Christopher Lausted, Jason A Carter, Cynthia Hsu, Kevin P Labadie, Karan Kohli, Heidi L Kenerson, Sara K Daniel, Xiaowei Yan, Changting Meng, Arezou Abbasi, Marina Chan, Y David Seo, James O Park, Ian Nicholas Crispe, Raymond S Yeung, Teresa S Kim, Taranjit S Gujral, Qiang Tian, Steven C Katz, and Venu G Pillarisetty

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Anomaly Detection Framework for Wearables Data: A Perspective Review on Data Concepts, Data Analysis Algorithms and Prospects., Jithin S Sunny, C Pawan K Patro, Khushi Karnani, Sandeep C Pingle, Feng Lin, Misa Anekoji, Lawrence D Jones, Santosh Kesari, and Shashaanka Ashili

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Multiple Early Factors Anticipate Post-Acute COVID-19 Sequelae, Yapeng Su, Dan Yuan, Daniel G. Chen, Rachel H. Ng, Kai Wang, Jongchan Choi, Sarah Li, Sunga Hong, Rongyu Zhang, Jingyi Xie, Sergey A Kornilov, Kelsey Scherler, Ana Jimena Pavlovitch-Bedzyk, Shen Dong, Christopher Lausted, Inyoul Lee, Shannon Fallen, Chengzhen L Dai, Priyanka Baloni, Brett Smith, Venkata R Duvvuri, Kristin G. Anderson, Jing Li, Fan Yang, Caroline J. Duncombe, Denise J. McCulloch, Clifford Rostomily, Pamela Troisch, Jing Zhou, Sean Mackay, Quinn DeGottardi, Damon H. May, Ruth Taniguchi, Rachel M. Gittelman, Mark Klinger, Thomas M. Snyder, Ryan Roper, Gladys Wojciechowska, Kim Murray, Rick Edmark, Simon Evans, Lesley Jones, Yong Zhou, Lee Rowen, Rachel Liu, William Chour, Heather A Algren, William R Berrington, Julie A Wallick, Rebecca A. Cochran, Mary Micikas, ISB-Swedish COVID19 Biobanking Unit, Terri Wrin, Christos J. Petropoulos, Hunter R. Cole, Trevan D Fischer, Wei Wei, Dave SB Hoon, Nathan D Price, Naeha Subramanian, Joshua A. Hill, Jennifer J Hadlock, Andrew T. Magis, Antoni Ribas, Lewis L. Lanier, Scott D. Boyd, Jeffrey A. Bluestone, Helen Chu, Leroy Hood, Raphael Gottardo, Philip D. Greenberg, Mark M. Davis, Jason D Goldman, and James R. Heath

Cabozantinib in combination with atezolizumab as a first-line therapy in patients with radioiodinerefractory differentiated thyroid cancer: Results from cohort 18 of the phase 1b COSMIC-21 study., M Taylor

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Health-related quality-of-life analyses from a multicenter, randomized, double-blind phase 2 study of patients with differentiated thyroid cancer treated with lenvatinib 18 or 24 mg/day., Matthew H. Taylor, Sophie Leboulleux, Yury Panaseykin, Bhavana Konda, Christelle de La Fouchardiere, Brett G M Hughes, Andrew G Gianoukakis, Young Joo Park, Ilia Romanov, Monika K Krzyzanowska, Diana Garbinsky, Bintu Sherif, Jie Janice Pan, Terri A Binder, Nicholas Sauter, Ran Xie, and Marcia S Brose

IO in Thyroid Cancer, Michael Taylor

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SL-Cloud: A Cloud-based resource to support synthetic lethal interaction discovery., Bahar Tercan, Guangrong Qin, Taek-Kyun Kim, Boris Aguilar, John Phan, William Longabaugh, David Pot, Christopher J Kemp, Nyasha Chambwe, and Ilya Shmulevich

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Survival with Cemiplimab in Recurrent Cervical Cancer., Krishnansu S Tewari, Bradley J Monk, Ignace Vergote, Austin Miller, Andreia C de Melo, Hee-Seung Kim, Yong Man Kim, Alla Lisyanskaya, Vanessa Samouëlian, Domenica Lorusso, Fernanda Damian, Chih-Long Chang, Evgeniy A Gotovkin, Shunji Takahashi, Daniella Ramone, Joanna Pikiel, Beata Maćkowiak-Matejczyk, Eva M Guerra Alía, Nicoletta Colombo, Yulia Makarova, Danny Rischin, Stephanie Lheureux, Kosei Hasegawa, Keiichi Fujiwara, Jingjin Li, Shaheda Jamil, Vladimir Jankovic, Chieh-I Chen, Frank Seebach, David M Weinreich, George D Yancopoulos, Israel Lowy, Melissa Mathias, Matthew G Fury, Ana Oaknin, and Investigators for GOG Protocol 3016 and ENGOT Protocol En-Cx9

TP022/#1424 A phase I/II study evaluating intraperitoneal GEN-1 in combination with neoadjuvant chemotherapy in patients newly diagnosed with advanced epithelial ovarian cancer, Premal Thaker, Melanie Bergman, and See all authors in comments

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Critical appraisal of minimally invasive keyhole surgery for intracranial meningioma in a large case series., Jai Deep Thakur, Regin Jay Mallari, Alex Corlin, Samantha Yawitz, Amy Eisenberg, John Rhee, Walavan Sivakumar, Howard Krauss, Neil A Martin, Chester Griffiths, Garni Barkhoudarian, and Daniel F Kelly

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409 Manufacturing of a clinical scale CD8 TIL product, AGX148, with and without gene silencing of PD-1 using self-delivering RNAi INTASYLTM PH-762, Colin Thalhofer, Tarsem Moudgil, Bernard A Fox, Nelson Sanjuan Silva, Eric Tran, and See all authors in comments

Enriching for tumor-reactive CD8 TIL (AGX148) leads to effective tumor clearance in a patient-derived xenograft model, C Thalhofer, Andrew D Weinberg, and See full list of authors in comments

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Association of PD-L1 expression, tumor mutational burden and immunotherapy with venous thrombosis in patients with solid organ malignancies., Rajat Thawani, Thomas Kartika, Benjamin Elstrott, Elizabeth Batiuk, Derrick L Tao, Sonia Gowda, Lilian Chen, Corinne Lavasseur, Nattapron Tun, Nicholas F Taflin, and Joseph Shatzel

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Outcomes of Therapies and Resistance Mutations Following Non-Covalent Bruton's Tyrosine Kinase Inhibitor Treatment for Patients with Chronic Lymphocytic Leukemia and Richter Transformation, Meghan C. Thompson, Krish Patel, Neil Bailey, and See all authors in comments

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Circulating Tumor DNA Identifies Diverse Landscape of Acquired Resistance to Anti-Epidermal Growth Factor Receptor Therapy in Metastatic Colorectal Cancer., James T Topham, Chris J O'Callaghan, Harriet Feilotter, Hagen F Kennecke, Young S Lee, Weimin Li, Kimberly C Banks, Katie Quinn, Daniel J Renouf, Derek J Jonker, Dongsheng Tu, Eric X Chen, and Jonathan M Loree

Cell transfer therapy targeting mutated neoantigens in epithelial cancer, E Tran

Targeting mutant KRAS with adoptive T-cell therapy, E Tran

Targeting mutant KRAS with TCR-gene therapy, E Tran

TCR-gene therapy targeting mutant KRAS, E Tran

Targeting mutant KRAS with TCR-gene therapy, Eric Tran

TILs Update, Eric Tran

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Neoantigen T-Cell Receptor Gene Therapy in Pancreatic Cancer. Reply., Eric Tran, Walter Urba, and Rom Leidner

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Routine frozen section during pancreaticoduodenectomy does not improve value-based care, Abhineet Uppal, Wade O Christopher, Trang Nguyen, Brooke Vuong, Stacey Stern, Juan Mejia, Roshanthi Weerasinghe, Evan Ong, and Anton J Bilchik

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The TARGIT-A Randomized Trial: TARGIT-IORT Versus Whole Breast Radiation Therapy: Long-Term Local Control and Survival., Jayant S Vaidya, Max Bulsara, Frederik Wenz, Elena Sperk, Samuele Massarut, Michael Alvarado, Norman R Williams, Chris Brew-Graves, Marcelle Bernstein, Dennis Holmes, Lorenzo Vinante, Steffi Pigorsch, Steinar Lundgren, Valery Uhl, David Joseph, Jeffrey S Tobias, and TARGIT-A authors

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Editorial: Mechanisms of Lymphocyte Exclusion in the Tumor Microenvironment., Rieneke van de Ven, Carlo Bifulco, Jason J Luke, and Sarah E Church

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Neoantigen-specific CD4 + T cells in human melanoma have diverse differentiation states and correlate with CD8 + T cell, macrophage, and B cell function, Joshua R Veatch, Sylvia M Lee, Carolyn Shasha, Naina Singhi, Julia L Szeto, Ata S Moshiri, Teresa S Kim, Kimberly Smythe, Paul Kong, Matthew Fitzgibbon, Brenda Jesernig, Shailender Bhatia, Scott S Tykodi, Evan T Hall, David R Byrd, John A Thompson, Venu G Pillarisetty, Thomas Duhen, A McGarry Houghton, Evan Newell, Raphael Gottardo, and Stanley R Riddell

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Robotic vs laparoscopic nephroureterectomy for upper tract urothelial carcinoma: a multicenter propensity-score matched pair "tetrafecta" analysis (ROBUUST collaborative group)., Alessandro Veccia, Umberto Carbonara, Hooman Djaladat, Reza Mehrazin, Daniel Eun, Adam C Reese, Xiaosong Meng, Robert Uzzo, Abhishek Srivastava, James R Porter, Jason Farrow, Marcus Jamil, Giuseppe Rosiello, Riccardo Tellini, Andrea Mari, Ali Al-Qathani, Koon Ho Rha, Linhui Wang, Riccardo Mastroianni, Matteo Ferro, Ottavio De Cobelli, Kevin Hakimi, Fabio Crocerossa, Alireza Ghoreifi, Giovanni Cacciamani, Amit Amit S Bhattu, Alexandre Mottrie, Firas Abdollah, Andrea Minervini, Zhenjie Wu, Giuseppe Simone, Ithaar H Derweesh, Mark L Gonzalgo, Vitaly Margulis, Chandru P Sundaram, and Riccardo Autorino

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CTNI-51. FEASIBILITY AND SAFETY OF NEUROSURGICAL RESECTION AND INTRA-OPERATIVE RADIATION THERAPY USING THE XOFT AXXENT ELECTRONIC BRACHYTHERAPY SYSTEM AND BEVACIZUMAB IN RECURRENT GLIOBLASTOMA, Naveed Wagle, Garni Barkhoudarian, Lisa Chaiken, Robert Wollman, Akanksha Sharma, Jose Carrillo, Minhdan Nguyen, Judy D Truong, Jared Chow, Emma Chacon, and Santosh Kesari

Geno4ME: establishment of an equitable whole-genome sequencing-based platform for clinical screening in a large healthcare system, Josiah Wagner, I A. Lucas-Beckett, K R. Emery, B A. Cosgrove, John T. Welle, K Jade, N D. Wagner, J Rinaldi, Lindsay Dickey, K G. Jones, L Yuan, E M. Shull, J Clemens, Keri Vartanian, A T. Magis, M B. Campbell, Brian Piening, Carlo Bifulco, and Ora K. Gordon

Clinical Performance of Comprehensive Genomic Profiling Using a Wide Range of Input Quantities and Solid Tumor Tissue Types, Josiah Wagner, S Reynolds, A Dowdell, E Shull, J Welle, M Pukay, R Rattray, C Moung-Wen, T Ward, M Campbell, C Bifulco, and B Piening

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Novel Therapeutics and Treatment Strategies for Medullary Thyroid Cancer., Evan Walgama, Naifa Busaidy, and Mark Zafereo

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Three-Year Follow-Up of KTE-X19 in Patients With Relapsed/Refractory Mantle Cell Lymphoma, Including High-Risk Subgroups, in the ZUMA-2 Study., Michael Wang, Javier Munoz, Andre Goy, Frederick L Locke, Caron A Jacobson, Brian T Hill, John M Timmerman, Houston Holmes, Samantha Jaglowski, Ian W Flinn, Peter A McSweeney, David B Miklos, John M Pagel, Marie José Kersten, Krimo Bouabdallah, Rashmi Khanal, Max S Topp, Roch Houot, Amer Beitinjaneh, Weimin Peng, Xiang Fang, Rhine R Shen, Rubina Siddiqi, Ioana Kloos, and Patrick M Reagan

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Why so Shocky?? A case of refractory shock, Brittney Ward, Cicily Hummer, and Joseph Bell

Streamlining Solid Tumor Comprehensive Genomic Profiling Workflows Using Learned Variant and Sequencing Noise Autoclassification, Thomas Ward, S Reynolds, J Wagner, N Naidoo, E Shull, John Welle, R Rattray, C Moung-Wen, Mary Campbell, Brian Piening, and Carlo Bifulco

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Identification of clinically actionable biomarkers via routine comprehensive genomic profiling across a large community health system, Roshanthi Weerasinghe, Ryan Meng, Alexa K Dowdell, Bela Bapat, Ann Vita, Brock Schroeder, Alisha Stein, Lauren Harold, Mark Schmidt, Shu-Ching Chang, Thomas R. Ward, Josiah T Wagner, Stanley Piotrowski, Phillip G. Febbo, Carlo Bifulco, and Brian D. Piening

Identification of clinically actionable biomarkers via routine comprehensive genomic profiling across a large community health system., Rosohanthi K. Weersinghe, Ryan Meng, Alexa K. Dowdell, Bela Bapat, Ann Vita, Brock Schroeder, Alisha Stein, Lauren Harold, Mark Schmidt, Shu-Ching Chang, Thomas Ward, Josiah Wagner, Stanley Piotrowski, Phillip G. Febbo, Carlo Bifulco, and Brian Piening

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Germline biomarkers predict toxicity to anti-PD1/PDL1 checkpoint therapy., Joanne Weidhaas, Nicholas Marco, Aaron W Scheffler, Anusha Kalbasi, Kirk Wilenius, Emily Rietdorf, Jaya Mini Gill, Mara Heilig, Caroline Desler, Robert K Chin, Tania Kaprealian, Susan McCloskey, Ann Raldow, Naga P Raja, Santosh Kesari, Jose Carrillo, Alexandra Drakaki, Mark Scholz, and Donatello Telesca

Enriching for tumor-reactive CD8 TIL using CD39/103 markers: Clinical implications, A Weinberg

Isolating/Expanding the Entire TIL Repertoire of Tumor-Reactive CD8 T Cells for Cell Therapy in H&N Cancer, Andrew Weinberg

Identifying tumor-reactive CD8+ TIL in patients with solid malignancies: clinical implications, Andrew D Weinberg

T Cell Agonists, Andrew D Weinberg

Accepting social e-cigarette behaviors among fraternity members found utilizing egocentric network analysis, AC Welch, MS Patterson, CL Wilshire, H Kathuria, CR Gilbert, and JA Gorden

The role of ego networks for college fraternity members who use e-cigarettes, AC Welch, MS Patterson, CL Wilshire, H Kathuria, CR Gilbert, and JA Gorden

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Design and Validation of a Whole-Genome Sequencing- Based Assay for Population Health, John Welle, Brian D. Piening, Josiah T Wagner, Isabelle Lucas-Beckett, T Ward, Benjamin Cosgrove, Eric Shull, R Rattray, Marina Pukay, M Ricks, Kimberly K Childers, Jennifer M Linehan, Mary Campbell, Ora K Gordon, and Carlo Bifulco

Design and Validation of a Whole-Genome SequencingBased Assay for Population Health, John Welle, Brian Piening, Josiah Wagner, I Lucas-Beckett, Thomas Ward, B Cosgrove, Eric Shull, R Rattray, Marina Pukay, Milena Ricks, K Childers, J Linehan, M Campbell, Ora Gordon, and Carlo Bifulco

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Adipocytes Encapsulating Telratolimod Recruit and Polarize Tumor-Associated Macrophages for Cancer Immunotherapy., Di Wen, Tingxizi Liang, Guojun Chen, Hongjun Li, Zejun Wang, Jinqiang Wang, Ruxing Fu, Xiao Han, Tianyuan Ci, Yuqi Zhang, Peter Abdou, Ruoxin Li, Linlin Bu, Gianpietro Dotti, and Zhen Gu

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778 Botensilimab, a novel innate/adaptive immune activator, plus or minus balstilimab (anti-PD-1) in “cold” and I-O refractory metastatic solid tumors, Breelyn Wilky, Kim Margolin, Rachel E Sanborn, Steven O'Day, and See full list of authors in comments

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Comparing Initial Surgery versus Fibrinolytics for Pleural Space Infections: A Retrospective Multicenter Cohort Study., Candice Wilshire, Anee Sophia Jackson, Austin M Meggyesy, Kerrie E Buehler, Shu-Ching Chang, Leah C Horslen, Joshua R Rayburn, Carson C Fuller, Alexander S Farivar, Adam J Bograd, Brian Louie, Eric Vallieres, Ralph W Aye, Christopher R Gilbert, and Jed A Gorden

Lower paraspinous muscle index at first thoracentesis is associated with poor survival in non-small cell lung cancer, CL Wilshire, AM Meggyesy, JA Gorden, and CR Gilbert

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Early experience with UGN-101 for the treatment of upper tract urothelial cancer - A multicenter evaluation of practice patterns and outcomes., Solomon L Woldu, Craig Labbate, Katie S Murray, Kyle Rose, Wade Sexton, Isamu Tachibana, Hristos Kaimakliotis, Joseph Jacob, Rian Dickstein, Jennifer Linehan, Alan Nieder, Marc A Bjurlin, Mitchell Humphreys, Saum Ghodoussipor, Marcus L Quek, Michael O'Donnell, Brian H Eisner, Adam S Feldman, Surena F Matin, and Yair Lotan

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Current Clinical Trial Landscape of OX40 Agonists., Rashi Yadav and William L. Redmond

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Galunisertib plus neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer: a single-arm, phase 2 trial., Tomoko Yamazaki, Andrew J Gunderson, Miranda Gilchrist, Mark Whiteford, Maria X Kiely, Amanda Hayman, David O'Brien, Rehan Ahmad, Jeffrey V Manchio, Nathaniel E Fox, Kayla McCarty, Michaela Phillips, Evelyn Brosnan, Gina Vaccaro, Rui Li, Miklos Simon, Eric Bernstein, Mary McCormick, Lena Yamasaki, Yaping Wu, Ashley Drokin, Trevor Carnahan, Yy To, William L. Redmond, Brian Lee, Jeannie Louie, Eric Hansen, Matthew C Solhjem, Julie Cramer, Walter Urba, Michael J. Gough, Marka R Crittenden, and Kristina H Young

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Nivolumab Plus Cabozantinib With or Without Ipilimumab for Advanced Hepatocellular Carcinoma: Results From Cohort 6 of the CheckMate 040 Trial., Thomas Yau, Vittorina Zagonel, Armando Santoro, Mirelis Acosta-Rivera, Su Pin Choo, Ana Matilla, Aiwu Ruth He, Antonio Cubillo Gracian, Anthony B El-Khoueiry, Bruno Sangro, Tarek E Eldawy, Jordi Bruix, Giovanni Luca Frassineti, Gina Vaccaro, Marina Tschaika, Christian Scheffold, Petra Koopmans, Jaclyn Neely, and Fabio Piscaglia

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Daratumumab, cyclophosphamide, bortezomib, and dexamethasone for multiple myeloma: final results of the LYRA study., Habte Yimer, Jason Melear, Edward Faber, William Bensinger, John M Burke, Mohit Narang, Don Stevens, Kathleen S Gray, Yana Lutska, Padma Bobba, Keqin Qi, Daniela Hoehn, Ming Qi, Thomas S Lin, and Robert M Rifkin

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The landscape of brain tumor mimics in neuro-oncology practice., Lalanthica V Yogendran, Tuba Kalelioglu, Joseph H Donahue, Haroon Ahmad, Kester A Phillips, Nicole M Calautti, Maria-Beatriz Lopes, Ashok R Asthagiri, Benjamin Purow, David Schiff, Sohil H Patel, and Camilo E Fadul

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Identification of Patients With Ovarian Cancer Experiencing the Highest Benefit From Bevacizumab in the First-Line Setting on the Basis of Their Tumor-Intrinsic Chemosensitivity (KELIM): The GOG-0218 Validation Study., Benoit You, Christopher Purdy, Larry J Copeland, Elizabeth M Swisher, Michael A Bookman, Gini Fleming, Robert Coleman, Leslie M Randall, Krishnansu S Tewari, Bradley J Monk, Robert S Mannel, Joan L Walker, Fabio Cappuccini, David Cohn, Mahvish Muzaffar, David Mutch, Andrea Wahner-Hendrickson, Lainie Martin, Olivier Colomban, and Robert A Burger

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A phase II trial of TGFβ type I receptor inhibitor, galunisertib, plus neoadjuvant chemoradiation in patients with locally advanced rectal cancer., Kristina H Young, Walter Urba, Michael J. Gough, Marka R Crittenden, and See full list of authors in comments

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Surgical approach to pediatric mediastinal masses based on imaging characteristics., Stephanie Young, R Luke Rettig, Ian V Hutchinson, Michael G Sutcliffe, and Roman M Sydorak

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1171 CAN1012: a selective and potent TLR7 agonist with strong antitumoral properties mediated by localized innate immune activation, Henry Yu, William L. Redmond, Yoshinobu Koguchi, and See all authors in comments

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Transcriptomic profiles of neoantigen-reactive T cells in human gastrointestinal cancers., Chunhong Zheng, Joseph N Fass, Yi-Ping Shih, Andrew J Gunderson, Nelson Sanjuan Silva, Huayu Huang, Brady M Bernard, Venkatesh Rajamanickam, Joseph Slagel, Carlo B Bifulco, Brian Piening, Pippa H A Newell, Paul D Hansen, and Eric Tran

Submissions from 2021

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Transition Therapy: Tackling the Ecology of Tumor Phenotypic Plasticity., Guim Aguadé-Gorgorió, Stuart Kauffman, and Ricard Solé

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Listeria monocytogenes-infected human monocytic derived dendritic cells activate Vγ9Vδ2 T cells independently of HMBPP production., Alejandro F Alice, Gwen Kramer, Shelly Bambina, Keith S Bahjat, Michael J Gough, and Marka R Crittenden

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Phase 1b dose-escalation study of the selective, noncovalent, reversible Bruton's tyrosine kinase inhibitor vecabrutinib in B-cell malignancies., John N Allan, Javier Pinilla-Ibarz, Douglas E Gladstone, Krish Patel, Jeff P Sharman, William G Wierda, Michael Y Choi, Susan M O'Brien, Mazyar Shadman, Matthew S Davids, John M Pagel, Habte A Yimer, Renee Ward, Gary Acton, Pietro Taverna, Daniel L Combs, Judith A Fox, Richard R Furman, and Jennifer R Brown