The Cancer Institute is a leader in cutting-edge treatments. Using a truly multidisciplinary approach, patients have access to advanced diagnostics, minimally invasive surgical interventions, and personalized genomic and immune-oncologic treatment options. Our team of cancer specialists – many of whom completed fellowships and specialty training at prestigious academic centers – offers comprehensive services for individuals with a cancer diagnosis.

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Submissions from 2022

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A single-arm, phase 2 study of perioperative ipilimumab, nivolumab, and cryoablation in women with hormone receptor-negative, HER2-negative, early-stage/resectable breast cancer., Heather L. McArthur, David B Page, and See full list of authors in comments

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Neoadjuvant HER2-targeted therapy +/- immunotherapy with pembrolizumab (neoHIP): An open-label randomized phase II trial., Heather L. McArthur, David B Page, and See full list of authors in comments

A Single Arm Phase 2 Study of Peri-Operative Checkpoint-Mediated Immune Therapy and Cryoablation in Women with Hormone Receptor-Negative, HER2-Negative Early Stage/Resectable Breast Cancer, Heather McArthur, David B. Page, Staci Mellinger, Nicole Fredrich, Nicole Moxon, and See all authors in comments

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Recurrence and Mortality Risk of Merkel Cell Carcinoma by Cancer Stage and Time From Diagnosis., Aubriana M McEvoy, Kristina Lachance, Daniel S Hippe, Kelsey Cahill, Yasman Moshiri, Christopher W Lewis, Neha Singh, Song Y Park, Zoe Thuesmunn, Maclean M Cook, Nora A Alexander, Lauren Zawacki, Hannah Thomas, Kelly G Paulson, and Paul Nghiem

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Patient-reported tolerability of adjuvant ipilimumab (3 or 10 mg/kg) versus high-dose interferon alfa-2b for resected high-risk stage III-IV melanoma in phase III trial E1609., Laurie E McLouth, Yue Zheng, Stephanie Smith, F Stephen Hodi, Uma N Rao, Gary I Cohen, Thomas T Amatruda, Shaker R Dakhil, Brendan D Curti, Ibrahim Nakhoul, Sreenivasa R Chandana, Charles L Bane, David E Marinier, Sandra J Lee, Vernon K Sondak, John M Kirkwood, Ahmad A Tarhini, and Lynne I Wagner

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ATF6-mediated signaling contributes to PARP Inhibitor Resistance in Ovarian Cancer., Alexandra McMellen, Tomomi M Yamamoto, Lubna Qamar, Brooke E Sanders, Lily L Nguyen, Daniela Ortiz Chavez, Jaidev Bapat, Amber Berning, Miriam D Post, Joshua Johnson, Kian Behbakht, Elmar Nurmemmedov, Edward B Chuong, and Benjamin G Bitler

Lower paraspinous muscle cross-sectional area is associated with shorter survival in patients with a malignant pleural effusion The American Thoracic Society San Francisco, California, AM Meggyesy, CL Wilshire, and See all authors in comments

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Utilization of palliative care resource remains low, consuming potentially avoidable hospital admissions in stage IV non-small cell lung cancer: a community-based retrospective review., Austin M Meggyesy, Kerrie E Buehler, Candice Wilshire, Shih-Ting Chiu, Shu-Ching Chang, Joshua R Rayburn, Christopher R Gilbert, and Jed A Gorden

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Outcomes by tobacco history in E3311, a phase II trial of transoral surgery (TOS) followed by pathology-based adjuvant treatment in HPV-associated (HPV+) oropharynx cancer (OPC): A trial of the ECOG-ACRIN Cancer Research Group., Ranee Mehra, Richard Bryan Bell, and See full list of authors in comments

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Learning from the past: a century of accuracy, aspirations, and aspersions in brachytherapy., Christopher S Melhus, Samantha J Simiele, Manik Aima, and Susan Richardson

Immunological profiling of tumor-infiltrating CD8+ T lymphocytes in primary non-small cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC), breast cancer (BCa), and renal cell cancers (RCC)., W Miller, William L. Redmond, and See full list of authors in comments

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CT041 - Monotherapy dose escalation of davoceticept (ALPN-202), a conditional CD28 costimulator and dual checkpoint inhibitor, in advanced malignancies (NEON-1), Michael Millward, Rachel E Sanborn, and See full list of authors in comments

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Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study., Bernhard Mlecnik, Toshihiko Torigoe, Gabriela Bindea, Boryana Popivanova, Mingli Xu, Tomonobu Fujita, Shoichi Hazama, Nobuaki Suzuki, Hiroaki Nagano, Kiyotaka Okuno, Yoshihiko Hirohashi, Tomohisa Furuhata, Ichiro Takemasa, Prabhudas Patel, Hemangini Vora, Birva Shah, Jayendrakumar B Patel, Kruti N Rajvik, Shashank J Pandya, Shilin N Shukla, Yili Wang, Guanjun Zhang, Takayuki Yoshino, Hiroya Taniguchi, Carlo Bifulco, Alessandro Lugli, Jiun-Kae Jack Lee, Inti Zlobec, Tilman T Rau, Martin D Berger, Iris D Nagtegaal, Elisa Vink-Börger, Arndt Hartmann, Carol I Geppert, Julie Kolwelter, Susanne Merkel, Robert Grützmann, Marc Van den Eynde, Anne Jouret-Mourin, Alex Kartheuser, Daniel Léonard, Christophe Remue, Julia Wang, Prashant Bavi, Michael H A Roehrl, Pamela S Ohashi, Linh T Nguyen, SeongJun Han, Heather L MacGregor, Sara Hafezi-Bakhtiari, Bradly G Wouters, Giuseppe V Masucci, Emilia Andersson, Eva Zavadova, Michal Vocka, Jan Spacek, Lubos Petruzelka, Bohuslav Konopasek, Pavel Dundr, Helena Skalova, Kristyna Nemejcova, Gerardo Botti, Fabiana Tatangelo, Paolo Delrio, Gennaro Ciliberto, Michele Maio, Luigi Laghi, Fabio Grizzi, Florence Marliot, Tessa Fredriksen, Bénédicte Buttard, Lucie Lafontaine, Pauline Maby, Amine Majdi, Assia Hijazi, Carine El Sissy, Amos Kirilovsky, Anne Berger, Christine Lagorce, Christopher Paustian, Carmen Ballesteros-Merino, Jeroen Dijkstra, Carlijn Van de Water, Shannon van Lent-van Vliet, Nikki Knijn, Ana-Maria Mușină, Dragos-Viorel Scripcariu, Francesco M Marincola, Paolo A Ascierto, Bernard A Fox, Franck Pagès, Yutaka Kawakami, and Jérôme Galon

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Synthetic lethal kinases in Ras/p53 mutant squamous cell carcinoma., Russell Moser, Kay E Gurley, Olga Nikolova, Guangrong Qin, Rashmi Joshi, Eduardo Mendez, Ilya Shmulevich, Amanda Ashley, Carla Grandori, and Christopher J Kemp

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Lenvatinib dose, efficacy, and safety in the treatment of multiple malignancies., Robert J Motzer, Matthew H Taylor, Thomas R Jeffry Evans, Takuji Okusaka, Hilary Glen, Gregory M Lubiniecki, Corina Dutcus, Alan D Smith, Chinyere E Okpara, Ziad Hussein, Seiichi Hayato, Toshiyuki Tamai, and Vicky Makker

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Radiotherapy for Plantar Fibromas (Ledderhose Disease)., John D Mozena, Eric K Hansen, and Paul Clint Jones

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Therapeutic Value of Sentinel Lymph Node Biopsy in Patients With Melanoma: A Randomized Clinical Trial., Multicenter Selective Lymphadenectomy Trials Study Group, Jessica S Crystal, John F Thompson, John Hyngstrom, Corrado Caracò, Jonathan S Zager, Tiina Jahkola, Tawnya L Bowles, Elisabetta Pennacchioli, Peter D Beitsch, Harald J Hoekstra, Marc Moncrieff, Christian Ingvar, Alexander van Akkooi, Michael S Sabel, Edward A Levine, Doreen Agnese, Michael Henderson, Reinhard Dummer, Rogerio I Neves, Carlo Riccardo Rossi, John M Kane, Steven Trocha, Frances Wright, David R Byrd, Maurice Matter, Eddy C Hsueh, Alastair MacKenzie-Ross, Mark Kelley, Patrick Terheyden, Tara L Huston, Jeffrey D Wayne, Heather Neuman, B Mark Smithers, Charlotte E Ariyan, Darius Desai, Jeffrey E Gershenwald, Shlomo Schneebaum, Anja Gesierich, Lisa K Jacobs, James M Lewis, Kelly M McMasters, Cristina O'Donoghue, Andre van der Westhuizen, Armando Sardi, Richard Barth, Robert Barone, J Greg McKinnon, Craig L Slingluff, Jeffrey M Farma, Erwin Schultz, Randall P Scheri, Sergi Vidal-Sicart, Manuel Molina, Alessandro A E Testori, Lee Foshag, Lisa Van Kreuningen, He-Jing Wang, Myung-Shin Sim, Richard A Scolyer, David E Elashoff, Alistair J Cochran, and Mark B Faries

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Trends in treatment patterns and costs of care among patients with advanced stage cervical cancer., Fernanda Musa, Elizabeth Brouwer, Jie Ting, Naomi R M Schwartz, Andy Surinach, Lisa Bloudek, and Scott D Ramsey

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CT250 / 11 - A first-in-human phase 1 study of NL-201 in patients with relapsed or refractory cancer, Aung Naing, Brendan Curti, and See full list of authors in comments

Treatment Utilization/Outcomes for Locally Advanced Rectal Cancer in Elderly Patients: Analysis of the NCDB, S Nassoiy, SC Chang, and See all authors in comments

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Treatment Utilization and Outcomes for Locally Advanced Rectal Cancer in Older Patients., Sean Nassoiy, Wade Christopher, Rebecca Marcus, Jennifer Keller, Jessica Weiss, Shu-Ching Chang, Leland Foshag, Richard Essner, Trevan Fischer, and Melanie Goldfarb

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Evolving management of early stage pancreatic adenocarcinoma in older patients., Sean Nassoiy, Wade O Christopher, Rebecca Marcus, Jennifer Keller, Jessica Weiss, Shu-Ching Chang, Richard Essner, Lee Foshag, Trevan Fischer, and Melanie Goldfarb

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Constraint-Based Reconstruction and Analyses of Metabolic Models: Open-Source Python Tools and Applications to Cancer., Rachel H Ng, Jihoon W Lee, Priyanka Baloni, Christian Diener, James R Heath, and Yapeng Su

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GPR17 Signaling Activation by CHBC Agonist Induced Cell Death via Modulation of MAPK Pathway in Glioblastoma., Phung Nguyen, Phuong Doan, Akshaya Murugesan, Thiyagarajan Ramesh, Tatu Rimpilainen, Nuno R Candeias, Olli Yli-Harja, and Meenakshisundaram Kandhavelu

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Safety and antitumor activity of dostarlimab in patients with advanced or recurrent DNA mismatch repair deficient/microsatellite instability-high (dMMR/MSI-H) or proficient/stable (MMRp/MSS) endometrial cancer: interim results from GARNET-a phase I, single-arm study., Ana Oaknin, Lucy Gilbert, Anna V Tinker, Jubilee Brown, Cara Mathews, Joshua Press, Renaud Sabatier, David M O'Malley, Vanessa Samouelian, Valentina Boni, Linda Duska, Sharad Ghamande, Prafull Ghatage, Rebecca Kristeleit, Charles Leath Iii, Wei Guo, Ellie Im, Sybil Zildjian, Xinwei Han, Tao Duan, Jennifer Veneris, and Bhavana Pothuri

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A comparison of outcomes between transperitoneal and retroperitoneal robotic assisted partial nephrectomy in patients with completely endophytic kidney tumors., Kennedy E Okhawere, Jordan Miller Rich, Burak Ucpinar, Alp Tuna Beksac, Indu Saini, Anthony Deluxe, Laura Zuluaga, Daniel D Eun, Akshay Bhandari, Ashok K Hemal, James Porter, Ronney Abaza, Ahmed Mansour, Michael D Stifelman, Simone Crivellaro, Phillip M Pierorazio, Osama Zaytoun, and Ketan K Badani

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Repeat Revascularization Post Coronary Artery Bypass Grafting: Comparing Minimally Invasive and Traditional Sternotomy Techniques in 1468 Cases., Peter Olson, Michael Cinelli, Hamfreth S Rahming, Thomas Vazzana, Jonathan Spagnola, Emad Barsoum, Marc Assaad, Frank Tamburrino, and James Lafferty

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IFI16-dependent STING signaling is a crucial regulator of anti-HER2 immune response in HER2+ breast cancer., Li-Teng Ong, Wee Chyan Lee, Shijun Ma, Gokce Oguz, Zhitong Niu, Yi Bao, Mubaraka Yusuf, Puay Leng Lee, Jian Yuan Goh, Panpan Wang, Kylie Su Mei Yong, Qingfeng Chen, Wenyu Wang, Adaikalavan Ramasamy, Dave Hoon, Henrik J Ditzel, Ern Yu Tan, Soo Chin Lee, and Qiang Yu

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A Case of Brachial Lymph Node Recurrences after the Resection of Locally Advanced Breast Cancer., Kayono Onishi, Rurina Watanuki, Takamichi Yokoe, Tsuguo Iwatani, Chisako Yamauchi, and Tatsuya Onishi

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Salpingo-oophorectomy or surveillance for ovarian endometrioma in asymptomatic premenopausal women: a cost-effectiveness analysis., Megan S Orlando, Lauren A Cadish, Jonathan P Shepherd, Tommaso Falcone, Olivia H Chang, and Rosanne M Kho

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ASO Author Reflections: Breast-Conserving Therapy: A Safe Option in Young Patients with Early-Stage Breast Cancer., Javier I Orozco, Crystal E Fancher, and Janie Grumley

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ASO Visual Abstract: Machine Learning-Based Epigenetic Classifiers for Axillary Staging of Patients with ER-Positive Early-Stage Breast Cancer., Javier I J Orozco, Julie Le, Miquel Ensenyat-Mendez, Jennifer L Baker, Joanne Weidhaas, Alexandra Klomhaus, Diego M Marzese, and Maggie L DiNome

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ASO Visual Abstract: Impact of Locoregional Treatment on Survival in Young Patients with Early-Stage Breast Cancer Undergoing Upfront Surgery., Javier I Orozco, Jennifer Keller, Shu-Ching Chang, Crystal E Fancher, and Janie Grumley

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Impact of Locoregional Treatment on Survival in Young Patients with Early-Stage Breast Cancer undergoing Upfront Surgery., Javier I Orozco, Jennifer Keller, Shu-Ching Chang, Crystal E Fancher, and Janie Grumley

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ASO Author Reflections: Molecular Signatures May Render Surgical Staging of the Axilla Obsolete., Javier I Orozco, Julie Le, Jennifer L Baker, Diego M Marzese, and Maggie L DiNome

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Machine Learning-Based Epigenetic Classifiers for Axillary Staging of Patients with ER-Positive Early-Stage Breast Cancer., Javier I Orozco, Julie Le, Miquel Ensenyat-Mendez, Jennifer L Baker, Joanne Weidhaas, Alexandra Klomhaus, Diego M Marzese, and Maggie L DiNome

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ToPP: Tumor online prognostic analysis platform for prognostic feature selection and clinical patient subgroup selection., Jian Ouyang, Guangrong Qin, Zhenhao Liu, Xingxing Jian, Tieliu Shi, and Lu Xie

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The Human Tumor Atlas Network's beginning steps toward the future of collaborative multi-omic discovery., David B Page

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Brain radiotherapy, tremelimumab-mediated CTLA-4-directed blockade +/- trastuzumab in patients with breast cancer brain metastases., David B Page, Kathryn Beal, Stefanie N Linch, Kateri Spinelli, Micaela Rodine, Darragh Halpenny, Shanu Modi, Sujata Patil, Robert J Young, Thomas Kaley, Taha Merghoub, David Redmond, Phillip Wong, Christopher A Barker, Adi Diab, Larry Norton, and Heather L McArthur

Applications of statistical regression to improve the TIL score and other immune-based biomarkers in breast cancer, DB Page

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Zandelisib with continuous or intermittent dosing as monotherapy or in combination with rituximab in patients with relapsed or refractory B-cell malignancy: a multicentre, first-in-patient, dose-escalation and dose-expansion, phase 1b trial., John M Pagel, Jacob D Soumerai, Nishitha Reddy, Deepa Jagadeesh, Anastasios Stathis, Adam Asch, Huda Salman, Vaishalee P Kenkre, Alexia Iasonos, Judith Llorin-Sangalang, Joanne Li, and Andrew D Zelenetz

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Molecular alterations associated with improved outcome in patients with glioblastoma treated with Tumor-Treating Fields., Manjari Pandey, Joanne Xiu, Sandeep Mittal, Jia Zeng, Michelle Saul, Santosh Kesari, Amir Azadi, Herbert Newton, Karina Deniz, Katherine Ladner, Ashley Sumrall, W Michael Korn, and Emil Lou

172P Phase I study of JTX-8064, a LILRB2 (ILT4) inhibitor, as monotherapy and combination with pimivalimab (pimi), a PD-1 inhibitor (PD-1i), in patients (pts) with advanced solid tumors, K Papadopoulos, Rachel Sanborn, and See all authors in comments

1296 ­Radiomics-based multi-modal prediction of treatment response to PD-1/PD-L1 immune checkpoint inhibitor (ICI) therapy in stage IV non-small cell lung carcinoma (mNSCLC), Ravi Parikh, Brendan Curti, Roshanthi Weerasinghe, and See all authors in comments

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Chemoradiation therapy alters the PD-L1 score in locoregional recurrent squamous cell carcinomas of the head and neck., Brian J Park, Austin K Mattox, Daniel Clayburgh, Mihir Patel, R Bryan Bell, Bevan Yueh, Rom Leidner, Hong Xiao, Marcus Couey, Shiting Li, Tingting Qin, Maureen A Sartor, Belinda Cairns, Tracy MacDonough, Kyle Halliwill, Daniel Deschler, Derrick T Lin, William C Faquin, Peter M Sadow, and Sara I Pai

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A single-cell based precision medicine approach using glioblastoma patient-specific models., James H Park, Abdullah H Feroze, Samuel N Emerson, Anca B Mihalas, C Dirk Keene, Patrick J Cimino, Adrian Lopez Garcia de Lomana, Kavya Kannan, Wei-Ju Wu, Serdar Turkarslan, Nitin S Baliga, and Anoop P Patel

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Posterior Ischemic Optic Neuropathy Because of Hematologic Malignancy., Ankush U Patel, Uresh S Patel, and Eugene F May

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Effect of a Community Health Worker Intervention on Acute Care Use, Advance Care Planning, and Patient-Reported Outcomes Among Adults With Advanced Stages of Cancer: A Randomized Clinical Trial., Manali I Patel, Kristopher Kapphahn, Marilyn Dewland, Veronica Aguilar, Blanca Sanchez, Etsegenet Sisay, Ariana Murillo, Kim Smith, and David J Park

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#754 A PHASE 1/2 STUDY OF ASP1570 IN PARTICIPANTS WITH LOCALLY ADVANCED OR METASTATIC SOLID TUMORS WHO HAVE PROGRESSED ON, OR ARE INELIGIBLE FOR, ALL AVAILABLE STANDARD THERAPIES, Manish Patel, David J Park, and See full list of authors in comments

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A PHASE 1/2 STUDY OF ASP1570 IN PARTICIPANTS WITH LOCALLY ADVANCED OR METASTATIC SOLID TUMORS WHO HAVE PROGRESSED ON, OR ARE INELIGIBLE FOR, ALL AVAILABLE STANDARD THERAPIES, Manish Patel, David J Park, and See full list of authors in comments

A PHASE 1/2 STUDY OF ASP1570 IN PARTICIPANTS WITH LOCALLY ADVANCED OR METASTATIC SOLID TUMORS WHO HAVE PROGRESSED ON, OR ARE INELIGIBLE FOR, ALL AVAILABLE STANDARD THERAPIES, Manish Patel, David Park, and See all authors in comments

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MTAP loss: a possible therapeutic approach for glioblastoma., C Pawan K Patro, Nupur Biswas, Sandeep C Pingle, Feng Lin, Misa Anekoji, Lawrence D Jones, Santosh Kesari, Feng Wang, and Shashaanka Ashili

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Genetic polymorphisms and correlation with treatment induced cardiotoxicity and prognosis in breast cancer patients., Parvin Peddi, Peter A Fasching, Duan Liu, Emmanuel Quinaux, Nicholas J Robert, Vicente Valero, John Crown, Carla Falkson, Adam Brufsky, Julie M Cunningham, Richard M Weinshilboum, Tadeusz Pienkowski, Wolfgang Eiermann, Miguel Martín, Valerie Bee, Xiaoyan Wang, Liewei Wang, Eric Yang, Dennis J Slamon, and Sara A Hurvitz

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Correction: Phase 1 First-in-Human Dose Escalation and Dose Expansion Study of KLS-1 (64Zinc Aspartate) in Patients With Cancer and Neurodegenerative Diseases., Jesus A Perez, Javier J Lopez, Claudia C Torres Badillo, Jaya Gill, Santosh Kesari, Peter Novak, Max Temnikov, Roman Byshovets, and Oleg Bychkov

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Phase 1 First-in-Human Dose Escalation and Dose Expansion Study of KLS-1 (64Zinc Aspartate) in Patients With Cancer and Neurodegenerative Diseases., Jesus A Perez, Javier J Lopez, Claudia C Torres Badillo, Jaya Gill, Santosh Kesari, Peter Novak, Max Temnikov, Roman Byshovets, and Oleg Bychkov

Real-World Evidence Insights in Cancer Research and Care, Brian D. Piening

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Pathogenic fusion detection in solid malignancies utilizing RNA-DNA based comprehensive genomic profiling (CGP) testing., Brian D. Piening, Alexa K Dowdell, Ryan Meng, Ann Vita, Roshanthi Weerasinghe, Alisha Stein, Bela Bapat, Brock Shroeder, Shu-Ching Chang, Lauren Harold, Mark Schmidt, Thomas R. Ward, Josiah T Wagner, Stanley Piotrowski, Phillip G. Febbo, and Carlo Bifulco

Design and Implementation of a Decentralized Virtual Molecular Tumor Board across a Large, Diverse Community Health System, Brian Piening, Patrick Foley, K Matlock, H Wright, Lauren Harold, Roshanthi Weerasinghe, A Viita, C Moung-Wen, Jacob Abel, Vassil Kaimaktchiev, A Dowdell, Ryan Meng, Walter Urba, G Srinivasa, Philip Gold, Gina Vaccaro, and Carlo Bifulco

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Uncovering potential interventions for pancreatic cancer patients via mathematical modeling., Daniel Plaugher, Boris Aguilar, and David Murrugarra

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Clinical characteristics associated with falls in patients with non-metastatic castration-resistant prostate cancer treated with apalutamide., YaoYao Pollock, Matthew R Smith, Fred Saad, Simon Chowdhury, Stéphane Oudard, Boris Hadaschik, David Olmos, Ji Youl Lee, Hiroji Uemura, Amitabha Bhaumik, Anil Londhe, Brendan Rooney, Sabine D Brookman-May, Peter De Porre, Suneel D Mundle, and Eric J Small

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Adjuvant and Neoadjuvant Therapies in Cutaneous Melanoma., Jay Ponto and Richard Bryan Bell

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The effect of race on treatment patterns and subsequent health-related quality of life outcomes in men undergoing treatment for localized prostate cancer., Natasza M Posielski, Santosh Shanmuga, On Ho, Jiji Jiang, Sally Elsamanoudi, Ryan Speir, Sean Stroup, John Musser, Alexander Ernest, Gregory T Chesnut, Timothy Tausch, John Paul Flores, and Christopher Porter

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Epacadostat Plus Pembrolizumab and Chemotherapy for Advanced Solid Tumors: Results from the Phase I/II ECHO-207/KEYNOTE-723 Study., John D Powderly, Samuel J Klempner, Aung Naing, Johanna Bendell, Ignacio Garrido-Laguna, Daniel V T Catenacci, Matthew H Taylor, James J Lee, Fred Zheng, Feng Zhou, Xiaohua Gong, Hema Gowda, and Gregory L Beatty

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CT209 / 9 - A first-in-human phase 1 trial of IO-108, an antagonist antibody targeting LILRB2 (ILT4), as monotherapy and in combination with pembrolizumab in adult patients with advanced relapsed or refractory solid tumors (NCT05054348), John Powderly, Matthew H Taylor, and See full list of authors in comments

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Randomized Phase III Trial of Paclitaxel and Carboplatin Versus Paclitaxel and Ifosfamide in Patients With Carcinosarcoma of the Uterus or Ovary: An NRG Oncology Trial., Matthew A Powell, Virginia L Filiaci, Martee L Hensley, Helen Q Huang, Kathleen N Moore, Krishnansu S Tewari, Larry J Copeland, Angeles A Secord, David G Mutch, Alessandro Santin, David P Warshal, Nick M Spirtos, Paul A DiSilvestro, Olga B Ioffe, and David S Miller

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AACR Project GENIE: 100,000 cases and beyond., Trevor J Pugh, Jonathan L Bell, Jeff P Bruce, Gary J Doherty, Matthew Galvin, Michelle F Green, Haley Hunter-Zinck, Priti Kumari, Michele L LeNoue-Newton, Marilyn M Li, James Lindsay, Tali Mazor, Andrea Ovalle, Stephen-John Sammut, Nikolaus Schultz, Thomas V Yu, Shawn M Sweeney, Brady Bernard, and Aacr Project Genie Consortium

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Does Residual Invasive Disease in Wide Local Excision after Diagnosis with Partial Biopsy Technique Influence Survival in Melanoma? Matched-Pair Analysis of Multicenter Selective Lymphadenectomy Trial I and II., Judi Anne B Ramiscal, Stacey L Stern, Ana K Wilson, Patrick D Lorimer, Nathaniel A Lee, Melanie R Goldfarb, Leland J Foshag, and Trevan D Fischer

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PTPRD and CNTNAP2 as markers of tumor aggressiveness in oligodendrogliomas., Kirsi J Rautajoki, Serafiina Jaatinen, Aliisa M Tiihonen, Matti Annala, Elisa M Vuorinen, Anni Kivinen, Minna J Rauhala, Kendra K Maass, Kristian W Pajtler, Olli Yli-Harja, Pauli Helén, Joonas Haapasalo, Hannu Haapasalo, Wei Zhang, and Matti Nykter

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Efficacy of oral and topical antioxidants in the prevention and management of oral mucositis in head and neck cancer patients: a systematic review and meta-analyses., Afsheen Raza, Nelli Karimyan, Amber L Watters, Chitra P Emperumal, Kamal Al-Eryani, and Reyes Enciso

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Follow the Data: It Is Time to Incentivize the Use of Drug-Eluting Stents and Balloons., Mahmood K Razavi

Response to aPD-1 + aLAG-3 checkpoint blockade is associated with Treg functional reprogramming and instability, William Redmond

Multimodal single-cell analysis of human TILs across multiple tumor types reveals heterogeneity and potential opportunities for personalized immunotherapy, William L. Redmond

Novel mechanisms to augment the efficacy of cancer immunotherapy, William L. Redmond

Multimodal single-cell analysis of human tumor infiltrating immune cells across multiple tumor types reveals heterogeneity and potential opportunities for personalized immunotherapeutic strategies., William L. Redmond and See full list of authors in comments

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Splenic vein aneurysm: Case report of an exceedingly rare condition, Dave Riesberg

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Combining bempegaldesleukin (CD122-preferential IL-2 pathway agonist) and NKTR-262 (TLR7/8 agonist) improves systemic antitumor CD8, Annah S Rolig, Daniel Rose, Grace Helen McGee, Werner Rubas, Saul Kivimäe, and William L. Redmond

Response to anti-PD-1 and anti-LAG-3 immune checkpoint blockade is associated with induction of pro-inflammatory Tregs., AS Rolig, William L. Redmond, and See full list of authors in comments

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Gene-gene interaction of AhRwith and within the Wntcascade affects susceptibility to lung cancer., Albert Rosenberger, Nils Muttray, Rayjean J Hung, David C Christiani, Neil E Caporaso, Geoffrey Liu, Stig E Bojesen, Loic Le Marchand, Demetrios Albanes, Melinda C Aldrich, Adonina Tardon, Guillermo Fernández-Tardón, Gad Rennert, John K Field, Michael P A Davies, Triantafillos Liloglou, Lambertus A Kiemeney, Philip Lazarus, Bernadette Wendel, Aage Haugen, Shanbeh Zienolddiny, Stephen Lam, Matthew B Schabath, Angeline S Andrew, Eric J Duell, Susanne M Arnold, Gary E Goodman, Chu Chen, Jennifer A Doherty, Fiona Taylor, Angela Cox, Penella J Woll, Angela Risch, Thomas R Muley, Mikael Johansson, Paul Brennan, Maria Teresa Landi, Sanjay S Shete, Christopher I Amos, and Heike Bickeböller

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A Phase III, Multicenter, Randomized Controlled Trial Investigating 1-cm Versus 2-cm Surgical Excision Margins for Stage II Primary Cutaneous Melanoma (MelMarT-II)., Alexander J Rossi, Emily A Verbus, Mark Faries, Marc Moncrieff, Michael Henderson, Jonathan M Hernandez, and Michael C Lowe

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Uterine Sarcomas: How to Navigate an Ever-Growing List of Subtypes., Molly Roy, Fernanda Musa, Sarah E Taylor, and Marilyn Huang

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"Oncologic Safety of Staged Pre-Pectoral Implant Reconstruction Following Nipple-Sparing Mastectomy: a Mean 9-Year Follow-Up.", Arthur H Salibian and Jay K Harness

Novel Combinatorial Approaches with LAG-3, Rachel Sanborn

Targeting OX-40 and LAG-3 to Overcome T-cell Exhaustion, Rachel Sanborn

Vaccines and emerging immunotherapy approaches for NSCLC, Rachel Sanborn

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Safety, tolerability and efficacy of agonist anti-CD27 antibody (varlilumab) administered in combination with anti-PD-1 (nivolumab) in advanced solid tumors., Rachel E Sanborn, Michael J Pishvaian, Margaret K Callahan, Amy Weise, Branimir I Sikic, Osama Rahma, Daniel C Cho, Naiyer A Rizvi, Mario Sznol, Jose Lutzky, Julie E Bauman, Rhonda L Bitting, Alexander Starodub, Antonio Jimeno, David A Reardon, Thomas Kaley, Fabio Iwamoto, Joachim M Baehring, Deepa S Subramaniam, Jeanny B Aragon-Ching, Thomas R Hawthorne, Tracey Rawls, Michael Yellin, and Tibor Keler

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Beyond Checkpoint Inhibitors: Enhancing Antitumor Immune Response in Lung Cancer., Rachel E Sanborn, Famke L Schneiders, Suresh Senan, and Shirish M Gadgeel

Results from a phase 1 study of CDX-1140, a fully human anti-CD40 agonist monoclonal antibody (mAb), in combination with pembrolizumab, Rachel E. Sanborn and See all authors in comments

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Beyond Checkpoint Inhibitors: Enhancing Antitumor Immune Response in Lung Cancer, Rachel E Sanborn and See full list of authors in comments

Candidate antigens for a ductal carcinoma in situ vaccine, essential for breast cancer cell survival across multiple subtypes, are immunogenic in DCIS and IBC, SE Sanborn

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Disparities in the impact of the AJCC 8th edition staging system on differentiated thyroid cancer outcomes., Juan A Santamaria-Barria, Amanda N Graff-Baker, Shu-Ching Chang, Adam Khader, Anthony J Scholer, Mary Garland-Kledzik, and Melanie Goldfarb

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Analytic pipelines to assess the relationship between immune response and germline genetics in human tumors., Rosalyn W Sayaman, Mohamad Saad, Carolina Heimann, Donglei Hu, Khalid Kunji, Jessica Roelands, Denise M Wolf, Scott Huntsman, Michele Ceccarelli, Vésteinn Thorsson, Elad Ziv, and Davide Bedognetti

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Accounting for EGFR Mutations in Epidemiologic Analyses of Non-Small Cell Lung Cancers: Examples Based on the International Lung Cancer Consortium Data., Sabine Schmid, Mei Jiang, M Catherine Brown, Aline Fares, Miguel Garcia, Joelle Soriano, Mei Dong, Sera Thomas, Takashi Kohno, Leticia Ferro Leal, Nancy Diao, Juntao Xie, Zhichao Wang, David Zaridze, Ivana Holcatova, Jolanta Lissowska, Beata Świątkowska, Dana Mates, Milan Savic, Angela S Wenzlaff, Curtis C Harris, Neil E Caporaso, Hongxia Ma, Guillermo Fernandez-Tardon, Matthew J Barnett, Gary E Goodman, Michael P A Davies, Mónica Pérez-Ríos, Fiona Taylor, Eric J Duell, Ben Schoettker, Hermann Brenner, Angeline Andrew, Angela Cox, Alberto Ruano-Ravina, John K Field, Loic Le Marchand, Ying Wang, Chu Chen, Adonina Tardon, Sanjay Shete, Matthew B Schabath, Hongbing Shen, Maria Teresa Landi, Brid M Ryan, Ann G Schwartz, Lihong Qi, Lori C Sakoda, Paul Brennan, Ping Yang, Jie Zhang, David C Christiani, Rui Manuel Reis, Kouya Shiraishi, Rayjean J Hung, Wei Xu, and Geoffrey Liu

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Validating biologic age in selecting elderly patients with pancreatic cancer for surgical resection., Anthony J Scholer, Rebecca Marcus, Mary Garland-Kledzik, Shu-Ching Chang, Adam Khader, Juan Santamaria-Barria, Zeljka Jutric, Ronald Wolf, and Melanie Goldfarb

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Detection of perillyl alcohol and its metabolite perillic acid in postsurgical glioblastoma tissue after intranasal administration of NEO100: illustrative case., Axel H Schönthal, Steve Swenson, Phillip A Bonney, Naveed Wagle, Vincent F Simmon, Anna J Mathew, Kyle M Hurth, and Thomas C Chen

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A Phase II Study Investigating Cabozantinib in Patients with Refractory Metastatic Colorectal Cancer (AGICC 17CRC01)., Aaron J Scott, Atrayee Basu Mallick, Efrat Dotan, Steven J Cohen, Philip J Gold, Howard S Hochster, Somasundaram Subramaniam, Afsaneh Barzi, George S Watts, Patrick J Blatchford, and Wells A Messersmith

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The diverse landscape of dermatologic toxicities of non-immune checkpoint inhibitor monoclonal antibody-based cancer therapy., Riyad N H Seervai, Sarah K Friske, Emily Y Chu, Rhea Phillips, Kelly C Nelson, Auris Huen, Woo Cheal Cho, Phyu P Aung, Carlos A Torres-Cabala, Victor G Prieto, and Jonathan L Curry

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Mechanisms of dermatologic toxicities to immune checkpoint inhibitor cancer therapies., Riyad N H Seervai, Avilasha Sinha, and Rajan P Kulkarni

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Lisocabtagene maraleucel as second-line therapy in adults with relapsed or refractory large B-cell lymphoma who were not intended for haematopoietic stem cell transplantation (PILOT): an open-label, phase 2 study., Alison Sehgal, Daanish Hoda, Peter A Riedell, Nilanjan Ghosh, Mehdi Hamadani, Gerhard C Hildebrandt, John E Godwin, Patrick M Reagan, Nina Wagner-Johnston, James Essell, Rajneesh Nath, Scott R Solomon, Rebecca Champion, Edward Licitra, Suzanne Fanning, Neel Gupta, Ronald Dubowy, Aleco D'Andrea, Lei Wang, Ken Ogasawara, Jerill Thorpe, and Leo I Gordon

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Glioblastoma Embryonic-like Stem Cells Exhibit Immune-Evasive Phenotype., Borja Sesé, Sandra Íñiguez-Muñoz, Miquel Ensenyat-Mendez, Pere Llinàs-Arias, Guillem Ramis, Javier I Orozco, Silvia Fernández de Mattos, Priam Villalonga, and Diego M Marzese

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The impact of mentoring on early career faculty: Assessment of a virtual mentoring program., Akanksha Sharma, Heather Leeper, Soo Bang, Donna Molaie, and Alyx B. Porter