The Cancer Institute is a leader in cutting-edge treatments. Using a truly multidisciplinary approach, patients have access to advanced diagnostics, minimally invasive surgical interventions, and personalized genomic and immune-oncologic treatment options. Our team of cancer specialists – many of whom completed fellowships and specialty training at prestigious academic centers – offers comprehensive services for individuals with a cancer diagnosis.

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Submissions from 2020

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Response to radiotherapy in pancreatic ductal adenocarcinoma is enhanced by inhibition of myeloid-derived suppressor cells using STAT3 anti-sense oligonucleotide., Ayman J Oweida, Adam C Mueller, Miles Piper, Dallin Milner, Benjamin Van Court, Shilpa Bhatia, Andy Phan, Thomas Bickett, Kimberly Jordan, Theresa Proia, Richard Schulick, Wells A Messersmith, Marco Del Chiaro, Eric Clambey, Michael J. Gough, Jason Williams, Kirk Hansen, Karyn Goodman, and Sana D Karam

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Prevalence of class I-III BRAF mutations among 114,662 cancer patients in a large genomic database., Jeff Owsley, Matthew K Stein, Jason Porter, Gino K In, Mohamed Salem, Steven O'Day, Andrew Elliott, Kelsey Poorman, Geoffrey Gibney, and Ari VanderWalde

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Rapid Donor Identification Improves Survival in High-Risk First-Remission Patients With Acute Myeloid Leukemia., John M Pagel, Megan Othus, Guillermo Garcia-Manero, Min Fang, Jerald P Radich, David A Rizzieri, Guido Marcucci, Stephen A Strickland, Mark R Litzow, M Lynn Savoie, Stephen R Spellman, Dennis L Confer, Jeffrey W Chell, Maria Brown, Bruno C Medeiros, Mikkael A Sekeres, Tara L Lin, Geoffrey L Uy, Bayard L Powell, Ruthee-Lu Bayer, Richard A Larson, Richard M Stone, David Claxton, James Essell, Selina M Luger, Sanjay R Mohan, Anna Moseley, Harry P Erba, and Frederick R Appelbaum

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Antiproliferative and apoptotic effects of indole derivative, N-(2-hydroxy-5-nitrophenyl (4'-methylphenyl) methyl) indoline in breast cancer cells., Suresh Palanivel, Akshaya Murugesan, Kumar Subramanian, Olli Yli-Harja, and Meenakshisundaram Kandhavelu

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Anticancer activity of THMPP: Downregulation of PI3K/ S6K1 in breast cancer cell line., Suresh Palanivel, Akshaya Murugesan, Olli Yli-Harja, and Meenakshisundaram Kandhavelu

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Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19?, Dipak Panigrahy, Molly M Gilligan, Sui Huang, Allison Gartung, Irene Cortés-Puch, Patricia J Sime, Richard P Phipps, Charles N Serhan, and Bruce D Hammock

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Use of the IL-6R Antagonist Tocilizumab in Hospitalized COVID-19 Patients., Krish Patel, Ted A Gooley, Neil Bailey, Megumi Bailey, Livia Hegerova, Ami Batchelder, Heather Holdread, Vanessa Dunleavy, Tyler Downey, Jens Frisvold, Samantha Megrath, Krystle Pagarigan, Jennie Szeto, Justin Rueda, Adel Islam, Cynthia L Maree, Sonam Nyatsatsang, Sarah E Bork, Anne B Lipke, D Shane O'Mahony, Teresa E Wagner, Juan Pulido, John Mignone, Samuel Youssef, Matthew Hartman, Jason D Goldman, and John M Pagel

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Health Care Coach Support in Reducing Acute Care Use in Patients With Cancer, Manali I. Patel, Kim Smith, Etsegenet Sisay, and David J. Park

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Progesterone receptor membrane component 1 promotes the growth of breast cancers by altering the phosphoproteome and augmenting EGFR/PI3K/AKT signalling., Diego A Pedroza, Venkatesh Rajamanickam, Ramadevi Subramani, Alejandra Bencomo, Adriana Galvez, and Rajkumar Lakshmanaswamy

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Neoantigen-specific CD4(+) T-cell response is critical for the therapeutic efficacy of cryo-thermal therapy, Peng Peng, Hong-Ming Hu, Ping Liu, and Lisa X Xu

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Discrimination of benign from malignant breast lesions in dense breasts with model-based analysis of regions-of-interest using directional diffusion-weighted images., Alan I Penn, Milica Medved, Vandana Dialani, Etta D Pisano, Elodia B Cole, David Brousseau, Gregory S Karczmar, Guimin Gao, Barry D Reich, and Hiroyuki Abe

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Pixantrone plus rituximab versus gemcitabine plus rituximab in patients with relapsed aggressive B-cell non-Hodgkin lymphoma not eligible for stem cell transplantation: a phase 3, randomized, multicentre trial (PIX306)., Ruth Pettengell, Monika Długosz-Danecka, David Andorsky, David Belada, Pencho Georgiev, Donald Quick, Jack W Singer, Simran B Singh, Athanasios Pallis, Anton Egorov, and Gilles Salles

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Enabling Scalable Comprehensive Genomic Profiling from FFPE Samples, Brian D. Piening

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Ageotypes: Distinct Biomolecular Trajectories in Human Aging., Brian D. Piening, Jennifer Lovejoy, and John C Earls

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AML risk stratification models utilizing ELN-2017 guidelines and additional prognostic factors: a SWOG report., Era L Pogosova-Agadjanyan, Anna Moseley, Megan Othus, Frederick R Appelbaum, Thomas R Chauncey, I-Ming L Chen, Harry P Erba, John E Godwin, Isaac C Jenkins, Min Fang, Mike Huynh, Kenneth J Kopecky, Alan F List, Jasmine Naru, Jerald P Radich, Emily Stevens, Brooke E Willborg, Cheryl L Willman, Brent L Wood, Qing Zhang, Soheil Meshinchi, and Derek L Stirewalt

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Comprehensive Immune Profiling of Medullary Thyroid Cancer., Nikita Pozdeyev, Timothy A Erickson, Lian Zhang, Kim Ellison, Christopher J Rivard, Sharon Sams, Fred R Hirsch, Bryan R Haugen, and Jena D French

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Association of BRAF V600E/K Mutation Status and Prior BRAF/MEK Inhibition With Pembrolizumab Outcomes in Advanced Melanoma: Pooled Analysis of 3 Clinical Trials., Igor Puzanov, Antoni Ribas, Caroline Robert, Jacob Schachter, Marta Nyakas, Adil Daud, Ana Arance, Matteo S Carlino, Steven J O'Day, Georgina V Long, Kim A Margolin, Reinhard Dummer, Dirk Schadendorf, Jose Lutzky, Paolo A Ascierto, Ahmad Tarhini, Jianxin Lin, Robin Mogg, Blanca Homet Moreno, Nageatte Ibrahim, and Omid Hamid

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Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma., Na Qin, Yuancheng Li, Cheng Wang, Meng Zhu, Juncheng Dai, Tongtong Hong, Demetrius Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Gary E Goodman, Stig E Bojesen, Maria Teresa Landi, Mattias Johansson, Angela Risch, H-Erich Wichmann, Heike Bickeboller, Gadi Rennert, Susanne Arnold, Paul Brennan, John K Field, Sanjay Shete, Loic Le Marchand, Olle Melander, Hans Brunnstrom, Geoffrey Liu, Rayjean J Hung, Angeline Andrew, Lambertus A Kiemeney, Shan Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Penella Woll, Philip Lazarus, Matthew B Schabath, Melinda C Aldrich, Victoria L Stevens, Guangfu Jin, David C Christiani, Zhibin Hu, Christopher I Amos, Hongxia Ma, and Hongbing Shen

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Brain Structure in Bilingual Compared to Monolingual Individuals with Alzheimer's Disease: Proof of Concept., Cyrus A Raji, Somayeh Meysami, David A Merrill, Verna R Porter, and Mario F Mendez

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Upregulation of Cell Surface GD3 Ganglioside Phenotype is Associated with Human Melanoma Brain Metastasis., Romela Irene Ramos, Matias Bustos, Jinfeng Wu, Peter Jones, Shu Ching Chang, Eiji Kiyohara, Kevin Tran, Xiaoqing Zhang, Stacey L Stern, Sivan Izraely, Orit Sagi-Assif, Isaac P Witz, Michael A Davies, Gordon B Mills, Daniel F Kelly, Reiko F Irie, and Dave S B Hoon

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Genetic Variants in Immune Related Genes as Predictors of Responsiveness to BCG Immunotherapy in Metastatic Melanoma Patients., Romela Irene Ramos, Misa A Shaw, Leland J Foshag, Stacey L Stern, Negin Rahimzadeh, David Elashoff, and Dave Hoon

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Genetic Variants in Immune Related Genes as Predictors of Responsiveness to BCG Immunotherapy in Metastatic Melanoma Patients., Romela Irene Ramos, Misa A Shaw, Leland Foshag, Stacey L Stern, Negin Rahimzadeh, David Elashoff, and Dave Hoon

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Nivolumab Monotherapy and Nivolumab Plus Ipilimumab in Recurrent Small Cell Lung Cancer: Results From the CheckMate 032 Randomized Cohort., Neal E Ready, Patrick A Ott, Matthew D Hellmann, Jon Zugazagoitia, Christine L Hann, Filippo de Braud, Scott J Antonia, Paolo A Ascierto, Victor Moreno, Akin Atmaca, Stefania Salvagni, Matthew H Taylor, Asim Amin, D Ross Camidge, Leora Horn, Emiliano Calvo, Ang Li, Wen Hong Lin, Margaret K Callahan, and David R Spigel

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Confirmatory Tissue Sampling in Clinical Stage I Sarcoidosis., Jerome M Reich

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Response to Grannis FW. Current Controversies in Cardiothoracic Imaging: Overdiagnosis at Lung Cancer Screening-No So Bad After All-Counterpoint., Jerome M Reich and Jong S Kim

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P0357 (S1601). - Malignant Melanoma of the Gallbladder Masquerading as Cholangitis and Cholecystitis, Medora Rodrigues, Sanjay Logani, Juan Mejia, Wichit Srikureja, and Nishant Puri

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451 Combining Bempegaldesleukin (CD122-preferential IL-2 pathway agonist) and NKTR-262 (TLR7/8 agonist) pairs local innate activation with systemic CD8+ T cell expansion to enhance anti-tumor immunity, Annah S Rolig, Daniel Rose, Saul Kivimae, Werner Rubas, and William L. Redmond

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451 Combining Bempegaldesleukin (CD122-preferential IL-2 pathway agonist) and NKTR-262 (TLR7/8 agonist) pairs local innate activation with systemic CD8+ T cell expansion to enhance anti-tumor immunity, Annah S Rolig, Daniel Rose, Saul Kivimae, Werner Rubas, and William L. Redmond

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A Multi-Institutional Analysis of the Effect of Positive Surgical Margins Following Robot-Assisted Partial Nephrectomy on Oncologic Outcomes., Michael Rothberg, David J Paulucci, Kennedy E Okhawere, Christopher Reynolds, Ketan K Badani, Ronney Abaza, Daniel Eun, Akshay Bhandari, James R Porter, and Ashok Hemal

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Assessing Time from Door-to-Antibiotic Administration for Adult Cancer Patients with Neutropenic Fever in the Emergency Department, Sarah Roy and Tina Magsarili

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Part Two: 24. Skin Cancer, Krista M. Rubin Ed. and Christine Boley Ed.

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Facebook Live: Lung Cancer awareness and da Vinci robotic surgery, Cheri Russum, Kimberly E Costas, and Luis F Alberton

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Society for Immunotherapy of Cancer clinical and biomarkers data sharing resource document: Volume I-conceptual challenges., Sergio Rutella, Michael A Cannarile, Sacha Gnjatic, Bruno Gomes, Justin Guinney, Vaios Karanikas, Mohan Karkada, John M Kirkwood, Beatrix Kotlan, Giuseppe V Masucci, Els Meeusen, Anne Monette, Aung Naing, Vésteinn Thorsson, Nicholas Tschernia, Ena Wang, Daniel K Wells, Timothy L Wyant, and Alessandra Cesano

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Parathyroidectomy and Hypertension-Reply., Meena Said

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Complex Oncological Decision-Making Utilizing Fast-and-Frugal Trees in a Community Setting-Role of Academic and Hybrid Modeling., Ravi Salgia, Isa Mambetsariev, Tingting Tan, Amanda Schwer, Daryl Pearlstein, Hazem Chehabi, Angel Baroz, Jeremy Fricke, Rebecca Pharaon, Hannah Romo, Thomas Waddington, Razmig Babikian, Linda Buck, Prakash Kulkarni, Mary Cianfrocca, Benjamin Djulbegovic, and Sumanta K Pal

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405 CDX1140–01, a phase 1 dose-escalation/expansion study of CDX-1140 alone (Part 1) and in combination with CDX-301 (Part 2) or pembrolizumab (Part 3), Rachel E Sanborn, Ralph Hauke, Nashat Gabrail, Mark O'Hara, Nina Bhardwaj, Rodolfo Bordoni, Michael Gordon, Danny Khalil, Maen Abdelrahim, Thomas Marron, Thomas Hawthorne, Lawrence Thomas, Tracey Rawls, Diego Alavardo, Laura Vitale, Tibor Keler, and Michael Yellin

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405 CDX1140–01, a phase 1 dose-escalation/expansion study of CDX-1140 alone (Part 1) and in combination with CDX-301 (Part 2) or pembrolizumab (Part 3), Rachel E Sanborn, Ralph Hauke, Nashat Gabrail, Mark O'Hara, Nina Bhardwaj, Rodolfo Bordoni, Michael Gordon, Danny Khalil, Maen Abdelrahim, Thomas Marron, Thomas Hawthorne, Lawrence Thomas, Tracey Rawls, Mark Rogalski, Diego Alvarado, Laura Vitale, Tibor Keler, and Michael Yellin

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Concordance of multispectral immunofluorescence (mIF) with programmed death ligand 1 (PD-L1) and stromal tumor infiltrating lymphocyte (sTILs) clinical assays in early-stage breast cancer (BC)., Katherine Sanchez, Shu-Ching Chang, Isaac Kim, Maritza Martel, Yaping Wu, William L. Redmond, Zhaoyu Sun, Dottie Waddell, Deborah R. Laxague, Brady Bernard, Monil Shah, Walter Urba, and David B. Page

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Part One: 11. Clinical Trials and Research Protocols, Marlon G Saria Ed. and Santosh Kesari Ed.

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Part Two: 9. Precision Medicine, Marlon G Saria Ed. and Santosh Kesari Ed.

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Complementary and Alternative Medicine Attitudes and Use in Caregivers of Patients with Lung Cancer, Trisha Saul, Lorraine Evangelista, Jung-Ah Lee, Sangyhuk Shin, and Michelle Fortier

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Inaccurate pretreatment staging can impact survival in early stage esophageal adenocarcinoma., Anthony J Scholer, Abhineet Uppal, Shu-Ching Chang, Debopriya Ghosh, Mary Garland-Kledzik, Juan A Santamaria-Barria, Adam Khader, Ahmed Dehal, Trevan D Fischer, and Melanie Goldfarb

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Clinical application of next generation sequencing in lymphoma., Anthony J Scott, Molly C Tokaz, Maryann M Shango, Sumana Devata, Shannon A Carty, Mark S Kaminski, Arul M Chinnaiyan, Tycel J Phillips, and Ryan A Wilcox

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Lisocabtagene maraleucel (liso-cel) for treatment of second-line (2L) transplant noneligible (TNE) relapsed/refractory (R/R) aggressive large B-cell non-Hodgkin lymphoma (NHL): Updated results from the PILOT study., Alison R. Sehgal, Gerhard Hildebrandt, Nilanjan Ghosh, John E Godwin, Nina D. Wagner-Johnston, Daanish Hoda, Edward J. Licitra, Javier Munoz, Nikolaus S. Trede, Lei Wang, Jerill Thorpe, and Leo I. Gordon

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Interim subgroup analysis for response by PD-L1 status of CLASSICAL-Lung, a phase Ib/II study of pepinemab (VX15/2503) in combination with avelumab in advanced NSCLC., Michael Rahman Shafique, Terrence Lee Fisher, Elizabeth E. Evans, John E. Leonard, Desa Rae Electa Pastore, Crystal L. Mallow, Ernest Smith, Andreas Schroder, Kevin M. Chin, Joseph Thaddeus Beck, Megan Ann Baumgart, Ramaswamy Govindan, Nashat Y. Gabrail, Rachel E Sanborn, Alexander I. Spira, Nagashree Seetharamu, Yanyan Lou, Aaron Scott Mansfield, Jonathan Wade Goldman, and Maurice Zauderer

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Interim results from a phase Ib/II study of pepinemab in combination with avelumab in advanced NSCLC patients following progression on prior systemic and/or anti-PDx therapies., Michael Rahman Shafique, Terrence Lee Fisher, Elizabeth E. Evans, John E. Leonard, Desa Rae Electa Pastore, Crystal L. Mallow, Ernest Smith, Andreas Schroder, Kevin M. Chin, J Thaddeus Beck, Megan Ann Baumgart, Ramaswamy Govindan, Nashat Y. Gabrail, Rachel E Sanborn, Alexander I. Spira, Nagashree Seetharamu, Yan Yan Lou, Aaron Scott Mansfield, Jonathan Wade Goldman, and Maurice Zauderer

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Interim results from a phase Ib/II study of pepinemab in combination with avelumab in advanced NSCLC patients following progression on prior systemic and/or anti-PDx therapies., Michael Rahman Shafique, Terrence Lee Fisher, Elizabeth E. Evans, John E. Leonard, Desa Rae Electa Pastore, Crystal L. Mallow, Ernest Smith, Andreas Schroder, Kevin M. Chin, J Thaddeus Beck, Megan Ann Baumgart, Ramaswamy Govindan, Nashat Y. Gabrail, Rachel E Sanborn, Alexander I. Spira, Nagashree Seetharamu, Yanyan Lou, Aaron Scott Mansfield, Jonathan Wade Goldman, and Maurice Zauderer

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1020O A phase I, first-in-human, open-label, dose escalation study of MGD019, an investigational bispecific PD-1 x CTLA-4 DART® molecule in patients with advanced solid tumours, M Sharma, Rachel E Sanborn, GM Cote, JC Bendell, S Kaul, F Chen, A Berezhnoy, P Moore, E Bonvini, BJ Sumrow, and JJ Luke

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Acalabrutinib with or without obinutuzumab versus chlorambucil and obinutuzmab for treatment-naive chronic lymphocytic leukaemia (ELEVATE TN): a randomised, controlled, phase 3 trial., Jeff P Sharman, Miklos Egyed, Wojciech Jurczak, Alan Skarbnik, John M Pagel, Ian W Flinn, Manali Kamdar, Talha Munir, Renata Walewska, Gillian Corbett, Laura Maria Fogliatto, Yair Herishanu, Versha Banerji, Steven Coutre, George Follows, Patricia Walker, Karin Karlsson, Paolo Ghia, Ann Janssens, Florence Cymbalista, Jennifer A Woyach, Gilles Salles, William G Wierda, Raquel Izumi, Veerendra Munugalavadla, Priti Patel, Min Hui Wang, Sofia Wong, and John C Byrd

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Circulating MicroRNAs and Extracellular Vesicle-Containing MicroRNAs as Response Biomarkers of Anti-programmed Cell Death Protein 1 or Programmed Death-Ligand 1 Therapy in NSCLC., Takehito Shukuya, Vikas Ghai, Joseph M Amann, Tamio Okimoto, Konstantin Shilo, Taek-Kyun Kim, Kai Wang, and David P Carbone

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407 Preliminary safety, pharmacokinetics/pharmacodynamics, and antitumor activity of XmAb20717, a PD-1 x CTLA-4 bispecific antibody, in patients with advanced solid tumors, Elaine Shum, Adil Daud, Matthew Reilley, Yana Najjar, John Thompson, Joaquina Baranda, R Donald Harvey, Rom Leidner, Anthony Shields, Ezra Cohen, Roger Cohen, Alain Mita, Shubham Pant, Mark Stein, Bartosz Chmielowski, Siwen Hu-Lieskovan, Catherine Fleener, Ying Ding, Sowmya Chollate, Hector Avina, Jolene Shorr, Raphael Clynes, and Barbara Hickingbottom

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407 Preliminary safety, pharmacokinetics/pharmacodynamics, and antitumor activity of XmAb20717, a PD-1 x CTLA-4 bispecific antibody, in patients with advanced solid tumors, Elaine Shum, Adil Daud, Matthew Reilley, Yana Najjar, John Thompson, Joaquina Baranda, R Donald Harvey, Rom Leidner, Anthony Shields, Ezra Cohen, Alain Mita, Shubham Pant, Mark Stein, Bartosz Chmielowski, Siwen Hu-Lieskovan, Catherine Fleener, Ying Ding, Sowmya Chollate, Hector Avina, Jolene Shorr, Raphael Clynes, and Barbara Hickingbottom

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Pomalidomide, dexamethasone, and daratumumab in relapsed refractory multiple myeloma after lenalidomide treatment., David S Siegel, Gary J Schiller, Christy Samaras, Michael Sebag, Jesus Berdeja, Siddhartha Ganguly, Jeffrey Matous, Kevin Song, Christopher S Seet, Giampaolo Talamo, Mirelis Acosta-Rivera, Michael Bar, Donald Quick, Bertrand Anz, Gustavo Fonseca, Donna Reece, William E Pierceall, Weiyuan Chung, Faiza Zafar, Amit Agarwal, and Nizar J Bahlis

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Review of Procedures and Outcomes of Video-Assisted Thoracic Surgery for the Treatment of Non-Small Cell Lung Cancer in 45 Patients Undergoing Segmentectomy., Rachel Sier and Osita Onugha

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Elevating your breast program to the next level., Melvin J Silverstein

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Empowering Clinical Nurses: Decreasing Clostridium Difficile, Danielle N. Sloane and Michelle McSherry

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Low-dose adjuvant vaginal cylinder brachytherapy for early-stage non-endometrioid endometrial cancer: recurrence risk and survival outcomes., Alicia Smart, Daniela Buscariollo, Gabriela Alban, Ivan Buzurovic, Teresa Cheng, Jennifer Pretz, Betty Krechmer, Martin King, and Larissa Lee

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A phase 1/2 study of the oral FLT3 inhibitor pexidartinib in relapsed/refractory FLT3-ITD-mutant acute myeloid leukemia., Catherine C Smith, Mark J Levis, Olga Frankfurt, John M Pagel, Gail J Roboz, Richard M Stone, Eunice S Wang, Paul L Severson, Brian L West, Mai H Le, Sabine Kayser, Bao Lam, Henry H Hsu, Chao Zhang, Gideon Bollag, and Alexander E Perl

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Surgical Management of Non-Small Cell Lung Cancer Invading the Fissure: Less Is More?, Shane P Smith, Adam J Bograd, Gal Levy, Shu-Ching Chang, Alexander S Farivar, Ralph W Aye, Brian Louie, and Eric Vallieres

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Nanoparticle Albumin-bound Paclitaxel Plus Carboplatin Induction Followed by Nanoparticle Albumin-bound Paclitaxel Maintenance in Squamous Non-Small-cell Lung Cancer (ABOUND.sqm): A Phase III Randomized Clinical Trial., David R Spigel, Robert M Jotte, Santiago Ponce Aix, Laurent Gressot, Daniel Morgensztern, Michael McCleod, Mark A Socinski, Davey Daniel, Oscar Juan-Vidal, Kathryn F Mileham, Howard J. West, Ray Page, Niels Reinmuth, Jeanna Knoble, Tianlei Chen, Rafia Bhore, Marianne Wolfsteiner, Teng Jin Ong, Cesare Gridelli, and Michael Thomas

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What is the Cost-Effective Treatment for Melanoma Patients with a Positive Sentinel Node?, Hayley Standage, Alyssa R Hersh, Aaron Caughey, Matthew H Taylor, John Vetto, and Dale Han

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Hodgkin lymphoma arising in patients with chronic lymphocytic leukemia: outcomes from a large multi-center collaboration., Deborah M Stephens, Ken Boucher, Elizabeth Kander, Sameer A Parikh, Erin M Parry, Mazyar Shadman, John M Pagel, Jennifer Cooperrider, Joanna Rhodes, Anthony Mato, Allison Winter, Brian Hill, Sameh Gaballa, Alexey Danilov, Tycel Phillips, Danielle M Brander, Sonali M Smith, Matthew Davids, Kerry Rogers, Martha J Glenn, and John C Byrd

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An exercise oncology clinical pathway: Screening and referral for personalized interventions., Nicole L Stout, Justin C Brown, Anna L Schwartz, Timothy F Marshall, Anna M Campbell, Larissa Nekhlyudov, David S Zucker, Karen M Basen-Engquist, Grace Campbell, Jeffrey Meyerhardt, Andrea L Cheville, Kelley R Covington, Jennifer A Ligibel, Jonas M Sokolof, Kathryn H Schmitz, and Catherine M Alfano

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Response to anti-PD-1 and anti-LAG-3 immune checkpoint blockade (ICB) is associated with induction of pro-inflammatory Tregs, Elizabeth Sturgill, Courtney Mick, Johanna K. Kaufmann, and William L. Redmond

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Clinical activity of the RET inhibitor pralsetinib (BLU-667) in patients with RET fusion+ solid tumors., Vivek Subbiah, Mini I-Nan Hu, Justin F. Gainor, Aaron Scott Mansfield, Guzman Alonso, Matthew H Taylor, Viola Weijia Zhu, Pilar Garrido Lopez, Alessio Amatu, Robert C. Doebele, Philippe Alexandre Cassier, Bhumsuk Keam, Martin H. Schuler, Hui Zhang, Corinne Clifford, Michael Palmer, Jennifer Green, Christopher D. Turner, and Giuseppe Curigliano

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Demonstration of reciprocal diurnal variation in human serum T3 and rT3 concentration demonstrated by mass spectrometric analysis and establishment of thyroid hormone reference intervals., Qian Sun, Lívia Avallone, Brian Stolze, Katherine A Araque, Yesim Özarda, Jacqueline Jonklaas, Toral Parikh, Kerry Welsh, Likhona Masika, and Steven J Soldin

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Integration of multiomic annotation data to prioritize and characterize inflammation and immune-related risk variants in squamous cell lung cancer., Ryan Sun, Miao Xu, Xihao Li, Sheila Gaynor, Hufeng Zhou, Zilin Li, Yohan Bossé, Stephen Lam, Ming-Sound Tsao, Adonina Tardon, Chu Chen, Jennifer Doherty, Gary E Goodman, Stig E Bojesen, Maria T Landi, Mattias Johansson, John K Field, Heike Bickeböller, H-Erich Wichmann, Angela Risch, Gadi Rennert, Suzanne Arnold, Xifeng Wu, Olle Melander, Hans Brunnström, Loic Le Marchand, Geoffrey Liu, Angeline Andrew, Eric Duell, Lambertus A Kiemeney, Hongbing Shen, Aage Haugen, Mikael Johansson, Kjell Grankvist, Neil Caporaso, Penella Woll, M Dawn Teare, Ghislaine Scelo, Yun-Chul Hong, Jian-Min Yuan, Philip Lazarus, Matthew B Schabath, Melinda C Aldrich, Demetrios Albanes, Raymond Mak, David Barbie, Paul Brennan, Rayjean J Hung, Christopher I Amos, David C Christiani, and Xihong Lin

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An introduction to the Cyrcadia Breast Monitor: A wearable breast health monitoring device., Vinitha Sree S, Rob Royea, Kevin J Buckman, Matt Benardis, Jim Holmes, Ronald L Fletcher, Ng Eyk, U Rajendra Acharya, and Joshua D I Ellenhorn

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Sequential Complications of Hypercalcemia, Necrotizing Granulomatous Vasculitis, and Aplastic Anemia Occurring in One Patient with Angioimmunoblastic T-cell Lymphoma., Sriman Swarup, Jonathan Kopel, Kyaw Zin Thein, Kaiser Tarafdar, Khatrina Swarup, Seshadri Thirumala, and Donald P Quick

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Spontaneous heparin induced thrombocytopenia (HIT) following curettage and bone graft of femur in a patient with monostotic fibrous dysplasia., Sriman Swarup, Jonathan Kopel, Rachana Yendala, Seshadri Thirumala, and Donald Quick

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560 Alpha-tocopheryloxyacetic acid induces apoptosis of murine rhabdomyosarcoma in vitro while modulating innate and adaptive immune responses in vivo, Fernanda Szewc, Longzhen Song, Sean Rinella, Christopher Dubay, Emmanuel Akporiaye, William L. Redmond, and Christian Capitini

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560 Alpha-tocopheryloxyacetic acid induces apoptosis of murine rhabdomyosarcoma in vitro while modulating innate and adaptive immune responses in vivo, Fernanda Szewc, Longzhen Song, Sean Rinella, Christopher Dubay, Emmanuel Akporiaye, William L. Redmond, and Christian Capitini

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The Society for Immunotherapy of Cancer statement on best practices for multiplex immunohistochemistry (IHC) and immunofluorescence (IF) staining and validation., Janis M Taube, Guray Akturk, Michael Angelo, Elizabeth L Engle, Sacha Gnjatic, Shirley Greenbaum, Noah F Greenwald, Cyrus V Hedvat, Travis J Hollmann, Jonathan Juco, Edwin R Parra, Marlon C Rebelatto, David L Rimm, Jaime Rodriguez-Canales, Kurt A Schalper, Edward C Stack, Cláudia S Ferreira, Konstanty Korski, Ana Lako, Scott J Rodig, Emanuel Schenck, Keith E Steele, Michael J Surace, Michael T Tetzlaff, Katharina von Loga, Ignacio I Wistuba, Carlo Bifulco, and Society for Immunotherapy of Cancer (SITC) Pathology Task Force.

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A mutation-specific, single-arm, phase 2 study of dovitinib in patients with advanced malignancies., Matthew H Taylor, Ajjai S Alva, Timothy Larson, Sebastian Szpakowski, Das Purkaystha, Alpesh Amin, Linda Karpiak, and Sarina A Piha-Paul

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Phase IB/II Trial of Lenvatinib Plus Pembrolizumab in Patients With Advanced Renal Cell Carcinoma, Endometrial Cancer, and Other Selected Advanced Solid Tumors., Matthew H Taylor, Chung-Han Lee, Vicky Makker, Drew Rasco, Corina E Dutcus, Jane Wu, Daniel E Stepan, Robert C Shumaker, and Robert J Motzer

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The LEAP program: lenvatinib plus pembrolizumab for the treatment of advanced solid tumors., Matthew H Taylor, Emmett V Schmidt, Corina Dutcus, Elaine M Pinheiro, Yasuhiro Funahashi, Gregory Lubiniecki, and Drew Rasco

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Implications of Prolonged Time to Pancreaticoduodenectomy After Neoadjuvant Chemoradiation., Annabelle Teng, Trang Nguyen, Anton J Bilchik, Victoria O'Connor, and David Y Lee

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Bevacizumab plus fosbretabulin in recurrent ovarian cancer: Overall survival and exploratory analyses of a randomized phase II NRG oncology/gynecologic oncology group study., Krishnansu S Tewari, Michael W Sill, Robert L Coleman, Carol Aghajanian, Robert Mannel, Paul A DiSilvestro, Matthew Powell, Leslie M Randall, John Farley, Stephen C Rubin, and Bradley J Monk

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Minimally invasive surgical treatment of intracranial meningiomas in elderly patients (≥ 65 years): outcomes, readmissions, and tumor control., Jai Deep Thakur, Regin Jay Mallari, Alex Corlin, Samantha Yawitz, Weichao Huang, Amy Eisenberg, Walavan Sivakumar, Howard Krauss, Chester Griffiths, Garni Barkhoudarian, and Daniel F Kelly

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172 Increasing activation of human tumor-reactive T cells (CD39+CD103+CD8+) by gene silencing of PD1 with self-delivering RNAi INTASYL(TM), Colin Thalhofer, Ryan Montler, Melissa Maxwell, Dingxue Yan, James Cardia, Simon Fricker, Jacob Moses, Joshua Rios, Tarsem Moudgil, Bernard A Fox, Nick Morris, Richard Bryan Bell, and Andrew Weinberg

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172 Increasing activation of human tumor-reactive T cells (CD39+CD103+CD8+) by gene silencing of PD1 with self-delivering RNAi INTASYL(TM), Colin Thalhofer, Ryan Montler, Melissa Maxwell, Dingxue Yan, James Cardia, Simon Fricker, Jacob Moses, Joshua Rios, Tarsem Moudgil, Bernard A Fox, Nick Morris, Richard Bryan Bell, and Andrew D Weinberg

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Impact of Primary Ambulatory Thromboprophylaxis (PATP) with Low-Molecular Weight Heparins (LMWHs) on Survival in Patients with Lung Cancer Receiving Chemotherapy., Kyaw Zin Thein, Donald Quick, Thura Win Htut, Lukman Tijani, and Thein Hlaing Oo

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Bilateral pulmonary metastases of papillary thyroid carcinoma in a 12-year-old child-A case report and review of the literature., V Thirumala, C O'Souji, and S Thirumala

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PROCLAIM-CX-072: Analysis of patients with advanced solid tumors receiving long-term treatment with CX-072, a PD-L1 probody therapeutic, as a single agent or in combination with ipilimumab., Fiona Thistlethwaite, Aung Naing, Marta Gil-Martin, Patricia LoRusso, Manreet Randhawa, Ferry Eskens, Rachel E Sanborn, Nataliya Volodymyrivna Uboha, Daniel C. Cho, Alexander I. Spira, Igor Bondarenko, Elizabeth Ruth Plummer, Javier Garcia-Corbacho, Ivan Victoria, Javier Lavernia, Ignacio Melero, Elisabeth De Vries, William Garner, Hendrik-Tobias Arkenau, and Johanna C. Bendell

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New Landscape: Physician Compensation., Christian A Thomas, Allison M Hirschorn, Julia E Tomkins, Walter E Birch, Linda D Bosserman, Debra A Patt, Dhimant R Patel, Michael Diaz, Thomas A Marsland, Mary M Klix, Edward P Balaban, Elizabeth M Blanchard, Gregg E Franklin, Rahul Seth, and Andrew Norden

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An interferon-gamma release assay as a novel biomarker in systemic lupus erythematosus., Jenna L Thomason, Uchechukwu M Obih, David M Koelle, Christian Lood, and And Grant Hughes

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Urelumab alone or in combination with rituximab in patients with relapsed or refractory B-cell lymphoma., John Timmerman, Charles Herbaux, Vincent Ribrag, Andrew D Zelenetz, Roch Houot, Sattva S Neelapu, Theodore Logan, Izidore S Lossos, Walter Urba, Gilles Salles, Radhakrishnan Ramchandren, Caron Jacobson, John Godwin, Cecilia Carpio, Deanne Lathers, Yali Liu, Jaclyn Neely, Satyendra Suryawanshi, Yoshinobu Koguchi, and Ronald Levy

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Evaluation of Cyclophosphamide/GVAX Pancreas Followed by Listeria-mesothelin (CRS-207) With or Without Nivolumab in Patients with Pancreatic Cancer., Takahiro Tsujikawa, Todd S Crocenzi, Jennifer N Durham, Elizabeth A Sugar, Annie A Wu, Beth Onners, Julie M Nauroth, Robert A Anders, Elana J Fertig, Daniel A Laheru, Kim Reiss, Robert H Vonderheide, Andrew H Ko, Margaret A Tempero, George A Fisher, Michael Considine, Ludmila Danilova, Dirk G Brockstedt, Lisa M Coussens, Elizabeth M Jaffee, and Dung T Le

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Yttrium-90 Anti-CD45 Immunotherapy Followed by Autologous Hematopoietic Cell Transplantation for Relapsed or Refractory Lymphoma., Sherilyn A Tuazon, Ryan D Cassaday, Theodore A Gooley, Brenda M Sandmaier, Leona A Holmberg, Stephen D Smith, David G Maloney, Brian G Till, Daniel B Martin, Victor A Chow, Joseph G Rajendran, Darrell R Fisher, Manuela C Matesan, Sally J Lundberg, Damian J Green, John M Pagel, Oliver W Press, and Ajay K Gopal

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90 Y-labeled anti-CD45 antibody allogeneic hematopoietic cell transplantation for high-risk multiple myeloma, Sherilyn A Tuazon, Brenda M Sandmaier, Theodore A Gooley, Darrell R Fisher, Leona A Holmberg, Pamela S Becker, Sally J Lundberg, Johnnie J Orozco, Ajay K Gopal, Brian G Till, David G Coffey, Margaret E Nartea, Manuela C Matesan, John M Pagel, Joseph G Rajendran, Oliver W Press, William Bensinger, and Damian J Green

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The Impact of Age on Survival in CLL Patients Receiving Ibrutinib as Initial Therapy., Chaitra Ujjani, Anthony Mato, Brian T Hill, John N Allan, Frederick Lansigan, Ryan Jacobs, Alan Skarbnik, Hande Tuncer, John M Pagel, Danielle Brander, Bruce Cheson, Paul Barr, Lindsey E Roeker, Jeffrey Pu, Nirav N Shah, Andre Goy, Stephen J Schuster, Nicole Lamanna, Alison Sehgal, Constantine S Tam, and Mazyar Shadman

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Evaluating the Regional Uptake of Minimally Invasive Colorectal Surgery: a Report from the Surgical Care Outcomes Assessment Program., Kenley R Unruh, Amir Bastawrous, Greta V Bernier, David R Flum, Anjali S Kumar, Ravi Moonka, Richard C Thirlby, and Vlad V Simianu

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Flotetuzumab as Salvage Immunotherapy for Refractory Acute Myeloid Leukemia., Geoffrey L Uy, Ibrahim Aldoss, Matthew C Foster, Peter H Sayre, Matthew J Wieduwilt, Anjali S Advani, John E Godwin, Martha L Arellano, Kendra Sweet, Ashkan Emadi, Farhad Ravandi, Harry P Erba, Michael Byrne, Laura C Michaelis, Max S Topp, Norbert Vey, Fabio Ciceri, Matteo Giovanni Carrabba, Stefania Paolini, Gerwin Huls, Mojca Jongen-Lavrencic, Martin Wermke, Patrice Chevallier, Emmanuel Gyan, Christian Récher, Patrick Stiff, Kristen Pettit, Bob Löwenberg, Sarah Church, Erica Katherine Anderson, Jayakumar Vadakekolathu, Marianne T Santaguida, Michael P Rettig, John Muth, Teia Curtis, Erin Fehr, Kuo Guo, Jian Zhao, Ouiam Bakkacha, Kenneth Jacobs, Kathy Tran, Patrick Kaminker, Maya Kostova, Ezio Bonvini, Roland B Walter, Jan Kenneth Davidson-Moncada, Sergio Rutella, and John F DiPersio

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Prophylactic Ruxolitinib for Cytokine Release Syndrome in Relapse/Refractory AML Patients Treated with Flotetuzumab., Geoffrey L. Uy, Michael P. Rettig, Stephanie Christ, Ibrahim Aldoss, Michael T. Byrne, Harry P. Erba, Martha L. Arellano, Matthew C. Foster, John E Godwin, Farhad Ravandi, Peter H. Sayre, Anjali S. Advani, Matthew J. Wieduwilt, Ashkan Emadi, Laura C. Michaelis, Patrick J. Stiff, Martin Wermke, Norbert Vey, Patrice Chevalier, Emmanuel Gyan, Christian Recher, Fabio Ciceri, Matteo Giovanni Carrabba, Antonio Curti, Geert Huls, Max S. Topp, Mojca Jongen-Lavrencic, John Muth, Teia Curtis, Mary Beth Collins, Erin Timmeny, Kuo Guo, Jian Zhao, Kathy Tran, Patrick Kaminker, Priyanka Patel, Ouiam Bakkacha, Kenneth Jacobs, Maya Kostova, Jennifer Seiler, Bob Lowenberg, Sergio Rutella, Roland B. Walter, Ezio Bonvini, Jan K. Davidson-Moncada, and John F. DiPersio

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TP53 abnormalities correlate with immune infiltration and associate with response to flotetuzumab immunotherapy in AML., Jayakumar Vadakekolathu, Catherine Lai, Stephen Reeder, Sarah E Church, Tressa Hood, Anbarasu Lourdusamy, Michael P Rettig, Ibrahim Aldoss, Anjali S Advani, John E Godwin, Matthew J Wieduwilt, Martha Arellano, John Muth, Tung On Yau, Farhad Ravandi, Kendra Sweet, Heidi Altmann, Gemma A Foulds, Friedrich Stölzel, Jan Moritz Middeke, Marilena Ciciarello, Antonio Curti, Peter J M Valk, Bob Löwenberg, Ivana Gojo, Martin Bornhäuser, John F DiPersio, Jan K Davidson-Moncada, and Sergio Rutella

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TP53 abnormalities correlate with immune infiltration and associate with response to flotetuzumab immunotherapy in AML., Jayakumar Vadakekolathu, Catherine Lai, Stephen Reeder, Sarah E Church, Tressa Hood, Anbarasu Lourdusamy, Michael P Rettig, Ibrahim Aldoss, Anjali S Advani, John E Godwin, Matthew J Wieduwilt, Martha Arellano, John Muth, Tung On Yau, Farhad Ravandi, Kendra Sweet, Heidi Altmann, Gemma A Foulds, Friedrich Stölzel, Jan Moritz Middeke, Marilena Ciciarello, Antonio Curti, Peter J M Valk, Bob Löwenberg, Ivana Gojo, Martin Bornhäuser, John F DiPersio, Jan K Davidson-Moncada, and Sergio Rutella

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Immune Senescence and Exhaustion Correlate with Response to Flotetuzumab, an Investigational CD123×CD3 Bispecific Dart® Molecule, in Acute Myeloid Leukemia, Jayakumar Vadakekolathu, Tung On Yau, Sarah E. Church, Michael P. Rettig, Ibarhim Aldoss, Geoffrey L. Uy, Norbert Vey, Ashkan Emadi, Peter H. Sayre, Roland B. Walter, Matthew C. Foster, Martha L. Arellano, John E Godwin, Matthew J. Wieduwilt, Michael T. Byrne, Laura C. Michaelis, Patrick J. Stiff, Matteo Giovanni Carrabba, Patrice Chevalier, Emmanuel Gyan, Christian Recher, Anjali S. Advani, Martin Wermke, Harry P. Erba, Fabio Ciceri, Geert Huls, Mojca Jongen-Lavrencic, Farhad Ravandi, Antonio Curti, Max S. Topp, John Muth, Patrick Kaminker, Bob Lowenberg, Ivana Gojo, Leo Luznik, John F. DiPersio, Jan K. Davidson-Moncada, and Sergio Rutella

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Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomised clinical trial., Jayant S Vaidya, Max Bulsara, Michael Baum, Frederik Wenz, Samuele Massarut, Steffi Pigorsch, Michael Alvarado, Michael Douek, Christobel Saunders, Henrik L Flyger, Wolfgang Eiermann, Chris Brew-Graves, Norman R Williams, Ingrid Potyka, Nicholas Roberts, Marcelle Bernstein, Douglas Brown, Elena Sperk, Siobhan Laws, Marc Sütterlin, Tammy Corica, Steinar Lundgren, Dennis R Holmes, Lorenzo Vinante, Fernando Bozza, Montserrat Pazos, Magali Le Blanc-Onfroy, Günther Gruber, Wojciech Polkowski, Konstantin J Dedes, Marcus Niewald, Jens Blohmer, David McCready, Richard Hoefer, Pond Kelemen, Gloria Petralia, Mary Falzon, David J Joseph, and Jeffrey S Tobias

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Effect of Delayed Targeted Intraoperative Radiotherapy vs Whole-Breast Radiotherapy on Local Recurrence and Survival: Long-term Results From the TARGIT-A Randomized Clinical Trial in Early Breast Cancer., Jayant S Vaidya, Max Bulsara, Christobel Saunders, Henrik Flyger, Jeffrey S Tobias, Tammy Corica, Samuele Massarut, Frederik Wenz, Steffi Pigorsch, Michael Alvarado, Michael Douek, Wolfgang Eiermann, Chris Brew-Graves, Norman Williams, Ingrid Potyka, Nicholas Roberts, Marcelle Bernstein, Douglas Brown, Elena Sperk, Siobhan Laws, Marc Sütterlin, Steinar Lundgren, Dennis R Holmes, Lorenzo Vinante, Fernando Bozza, Montserrat Pazos, Magali Le Blanc-Onfroy, Günther Gruber, Wojciech Polkowski, Konstantin J Dedes, Marcus Niewald, Jens Blohmer, David McCready, Richard Hoefer, Pond Kelemen, Gloria Petralia, Mary Falzon, Michael Baum, and David Joseph

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Efficacy and safety of first-line avelumab in patients with advanced non-small cell lung cancer: results from a phase Ib cohort of the JAVELIN Solid Tumor study., Claire F Verschraegen, Guy Jerusalem, Edward F McClay, Nicholas Iannotti, Charles H Redfern, Jaafar Bennouna, Franklin L Chen, Karen Kelly, Janice Mehnert, John C Morris, Matthew H Taylor, David Spigel, Ding Wang, Hans Juergen Grote, Dongli Zhou, Neru Munshi, Marcis Bajars, and James L Gulley