The Cancer Institute is a leader in cutting-edge treatments. Using a truly multidisciplinary approach, patients have access to advanced diagnostics, minimally invasive surgical interventions, and personalized genomic and immune-oncologic treatment options. Our team of cancer specialists – many of whom completed fellowships and specialty training at prestigious academic centers – offers comprehensive services for individuals with a cancer diagnosis.

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Submissions from 2020

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A mutation-specific, single-arm, phase 2 study of dovitinib in patients with advanced malignancies., Matthew H Taylor, Ajjai S Alva, Timothy Larson, Sebastian Szpakowski, Das Purkaystha, Alpesh Amin, Linda Karpiak, and Sarina A Piha-Paul

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Phase IB/II Trial of Lenvatinib Plus Pembrolizumab in Patients With Advanced Renal Cell Carcinoma, Endometrial Cancer, and Other Selected Advanced Solid Tumors., Matthew H Taylor, Chung-Han Lee, Vicky Makker, Drew Rasco, Corina E Dutcus, Jane Wu, Daniel E Stepan, Robert C Shumaker, and Robert J Motzer

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The LEAP program: lenvatinib plus pembrolizumab for the treatment of advanced solid tumors., Matthew H Taylor, Emmett V Schmidt, Corina Dutcus, Elaine M Pinheiro, Yasuhiro Funahashi, Gregory Lubiniecki, and Drew Rasco

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Implications of Prolonged Time to Pancreaticoduodenectomy After Neoadjuvant Chemoradiation., Annabelle Teng, Trang Nguyen, Anton J Bilchik, Victoria O'Connor, and David Y Lee

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Loss of switch/sucrose non-fermenting complex protein expression in undifferentiated gastrointestinal and pancreatic carcinomas., Basile Tessier-Cloutier, David F Schaeffer, Julinor Bacani, Celia E Marginean, Steve Kalloger, Martin Köbel, and Cheng-Han Lee

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Bevacizumab plus fosbretabulin in recurrent ovarian cancer: Overall survival and exploratory analyses of a randomized phase II NRG oncology/gynecologic oncology group study., Krishnansu S Tewari, Michael W Sill, Robert L Coleman, Carol Aghajanian, Robert Mannel, Paul A DiSilvestro, Matthew Powell, Leslie M Randall, John Farley, Stephen C Rubin, and Bradley J Monk

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Minimally invasive surgical treatment of intracranial meningiomas in elderly patients (≥ 65 years): outcomes, readmissions, and tumor control., Jai Deep Thakur, Regin Jay Mallari, Alex Corlin, Samantha Yawitz, Weichao Huang, Amy Eisenberg, Walavan Sivakumar, Howard Krauss, Chester Griffiths, Garni Barkhoudarian, and Daniel F Kelly

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172 Increasing activation of human tumor-reactive T cells (CD39+CD103+CD8+) by gene silencing of PD1 with self-delivering RNAi INTASYL(TM), Colin Thalhofer, Ryan Montler, Melissa Maxwell, Dingxue Yan, James Cardia, Simon Fricker, Jacob Moses, Joshua Rios, Tarsem Moudgil, Bernard A Fox, Nick Morris, Richard Bryan Bell, and Andrew Weinberg

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172 Increasing activation of human tumor-reactive T cells (CD39+CD103+CD8+) by gene silencing of PD1 with self-delivering RNAi INTASYL(TM), Colin Thalhofer, Ryan Montler, Melissa Maxwell, Dingxue Yan, James Cardia, Simon Fricker, Jacob Moses, Joshua Rios, Tarsem Moudgil, Bernard A Fox, Nick Morris, Richard Bryan Bell, and Andrew D Weinberg

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Impact of Primary Ambulatory Thromboprophylaxis (PATP) with Low-Molecular Weight Heparins (LMWHs) on Survival in Patients with Lung Cancer Receiving Chemotherapy., Kyaw Zin Thein, Donald Quick, Thura Win Htut, Lukman Tijani, and Thein Hlaing Oo

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Bilateral pulmonary metastases of papillary thyroid carcinoma in a 12-year-old child-A case report and review of the literature., V Thirumala, C O'Souji, and S Thirumala

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PROCLAIM-CX-072: Analysis of patients with advanced solid tumors receiving long-term treatment with CX-072, a PD-L1 probody therapeutic, as a single agent or in combination with ipilimumab., Fiona Thistlethwaite, Aung Naing, Marta Gil-Martin, Patricia LoRusso, Manreet Randhawa, Ferry Eskens, Rachel E Sanborn, Nataliya Volodymyrivna Uboha, Daniel C. Cho, Alexander I. Spira, Igor Bondarenko, Elizabeth Ruth Plummer, Javier Garcia-Corbacho, Ivan Victoria, Javier Lavernia, Ignacio Melero, Elisabeth De Vries, William Garner, Hendrik-Tobias Arkenau, and Johanna C. Bendell

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New Landscape: Physician Compensation., Christian A Thomas, Allison M Hirschorn, Julia E Tomkins, Walter E Birch, Linda D Bosserman, Debra A Patt, Dhimant R Patel, Michael Diaz, Thomas A Marsland, Mary M Klix, Edward P Balaban, Elizabeth M Blanchard, Gregg E Franklin, Rahul Seth, and Andrew Norden

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An interferon-gamma release assay as a novel biomarker in systemic lupus erythematosus., Jenna L Thomason, Uchechukwu M Obih, David M Koelle, Christian Lood, and And Grant Hughes

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Urelumab alone or in combination with rituximab in patients with relapsed or refractory B-cell lymphoma., John Timmerman, Charles Herbaux, Vincent Ribrag, Andrew D Zelenetz, Roch Houot, Sattva S Neelapu, Theodore Logan, Izidore S Lossos, Walter Urba, Gilles Salles, Radhakrishnan Ramchandren, Caron Jacobson, John Godwin, Cecilia Carpio, Deanne Lathers, Yali Liu, Jaclyn Neely, Satyendra Suryawanshi, Yoshinobu Koguchi, and Ronald Levy

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Targeting MerTK Enhances Adaptive Immune Responses After Radiation Therapy., Garth W Tormoen, Tiffany C Blair, Shelly Bambina, Gwen Kramer, Jason Baird, Ramtin Rahmani, John M Holland, Owen J T McCarty, Michael J Baine, Vivek Verma, Nima Nabavizadeh, Michael J Gough, and Marka Crittenden

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Evaluation of Cyclophosphamide/GVAX Pancreas Followed by Listeria-mesothelin (CRS-207) With or Without Nivolumab in Patients with Pancreatic Cancer., Takahiro Tsujikawa, Todd S Crocenzi, Jennifer N Durham, Elizabeth A Sugar, Annie A Wu, Beth Onners, Julie M Nauroth, Robert A Anders, Elana J Fertig, Daniel A Laheru, Kim Reiss, Robert H Vonderheide, Andrew H Ko, Margaret A Tempero, George A Fisher, Michael Considine, Ludmila Danilova, Dirk G Brockstedt, Lisa M Coussens, Elizabeth M Jaffee, and Dung T Le

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Yttrium-90 Anti-CD45 Immunotherapy Followed by Autologous Hematopoietic Cell Transplantation for Relapsed or Refractory Lymphoma., Sherilyn A Tuazon, Ryan D Cassaday, Theodore A Gooley, Brenda M Sandmaier, Leona A Holmberg, Stephen D Smith, David G Maloney, Brian G Till, Daniel B Martin, Victor A Chow, Joseph G Rajendran, Darrell R Fisher, Manuela C Matesan, Sally J Lundberg, Damian J Green, John M Pagel, Oliver W Press, and Ajay K Gopal

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90 Y-labeled anti-CD45 antibody allogeneic hematopoietic cell transplantation for high-risk multiple myeloma, Sherilyn A Tuazon, Brenda M Sandmaier, Theodore A Gooley, Darrell R Fisher, Leona A Holmberg, Pamela S Becker, Sally J Lundberg, Johnnie J Orozco, Ajay K Gopal, Brian G Till, David G Coffey, Margaret E Nartea, Manuela C Matesan, John M Pagel, Joseph G Rajendran, Oliver W Press, William Bensinger, and Damian J Green

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The Impact of Age on Survival in CLL Patients Receiving Ibrutinib as Initial Therapy., Chaitra Ujjani, Anthony Mato, Brian T Hill, John N Allan, Frederick Lansigan, Ryan Jacobs, Alan Skarbnik, Hande Tuncer, John M Pagel, Danielle Brander, Bruce Cheson, Paul Barr, Lindsey E Roeker, Jeffrey Pu, Nirav N Shah, Andre Goy, Stephen J Schuster, Nicole Lamanna, Alison Sehgal, Constantine S Tam, and Mazyar Shadman

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Evaluating the Regional Uptake of Minimally Invasive Colorectal Surgery: a Report from the Surgical Care Outcomes Assessment Program., Kenley R Unruh, Amir Bastawrous, Greta V Bernier, David R Flum, Anjali S Kumar, Ravi Moonka, Richard C Thirlby, and Vlad V Simianu

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Flotetuzumab as Salvage Immunotherapy for Refractory Acute Myeloid Leukemia., Geoffrey L Uy, Ibrahim Aldoss, Matthew C Foster, Peter H Sayre, Matthew J Wieduwilt, Anjali S Advani, John E Godwin, Martha L Arellano, Kendra Sweet, Ashkan Emadi, Farhad Ravandi, Harry P Erba, Michael Byrne, Laura C Michaelis, Max S Topp, Norbert Vey, Fabio Ciceri, Matteo Giovanni Carrabba, Stefania Paolini, Gerwin Huls, Mojca Jongen-Lavrencic, Martin Wermke, Patrice Chevallier, Emmanuel Gyan, Christian Récher, Patrick Stiff, Kristen Pettit, Bob Löwenberg, Sarah Church, Erica Katherine Anderson, Jayakumar Vadakekolathu, Marianne T Santaguida, Michael P Rettig, John Muth, Teia Curtis, Erin Fehr, Kuo Guo, Jian Zhao, Ouiam Bakkacha, Kenneth Jacobs, Kathy Tran, Patrick Kaminker, Maya Kostova, Ezio Bonvini, Roland B Walter, Jan Kenneth Davidson-Moncada, Sergio Rutella, and John F DiPersio

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Prophylactic Ruxolitinib for Cytokine Release Syndrome in Relapse/Refractory AML Patients Treated with Flotetuzumab., Geoffrey L. Uy, Michael P. Rettig, Stephanie Christ, Ibrahim Aldoss, Michael T. Byrne, Harry P. Erba, Martha L. Arellano, Matthew C. Foster, John E Godwin, Farhad Ravandi, Peter H. Sayre, Anjali S. Advani, Matthew J. Wieduwilt, Ashkan Emadi, Laura C. Michaelis, Patrick J. Stiff, Martin Wermke, Norbert Vey, Patrice Chevalier, Emmanuel Gyan, Christian Recher, Fabio Ciceri, Matteo Giovanni Carrabba, Antonio Curti, Geert Huls, Max S. Topp, Mojca Jongen-Lavrencic, John Muth, Teia Curtis, Mary Beth Collins, Erin Timmeny, Kuo Guo, Jian Zhao, Kathy Tran, Patrick Kaminker, Priyanka Patel, Ouiam Bakkacha, Kenneth Jacobs, Maya Kostova, Jennifer Seiler, Bob Lowenberg, Sergio Rutella, Roland B. Walter, Ezio Bonvini, Jan K. Davidson-Moncada, and John F. DiPersio

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TP53 abnormalities correlate with immune infiltration and associate with response to flotetuzumab immunotherapy in AML., Jayakumar Vadakekolathu, Catherine Lai, Stephen Reeder, Sarah E Church, Tressa Hood, Anbarasu Lourdusamy, Michael P Rettig, Ibrahim Aldoss, Anjali S Advani, John E Godwin, Matthew J Wieduwilt, Martha Arellano, John Muth, Tung On Yau, Farhad Ravandi, Kendra Sweet, Heidi Altmann, Gemma A Foulds, Friedrich Stölzel, Jan Moritz Middeke, Marilena Ciciarello, Antonio Curti, Peter J M Valk, Bob Löwenberg, Ivana Gojo, Martin Bornhäuser, John F DiPersio, Jan K Davidson-Moncada, and Sergio Rutella

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TP53 abnormalities correlate with immune infiltration and associate with response to flotetuzumab immunotherapy in AML., Jayakumar Vadakekolathu, Catherine Lai, Stephen Reeder, Sarah E Church, Tressa Hood, Anbarasu Lourdusamy, Michael P Rettig, Ibrahim Aldoss, Anjali S Advani, John E Godwin, Matthew J Wieduwilt, Martha Arellano, John Muth, Tung On Yau, Farhad Ravandi, Kendra Sweet, Heidi Altmann, Gemma A Foulds, Friedrich Stölzel, Jan Moritz Middeke, Marilena Ciciarello, Antonio Curti, Peter J M Valk, Bob Löwenberg, Ivana Gojo, Martin Bornhäuser, John F DiPersio, Jan K Davidson-Moncada, and Sergio Rutella

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Immune Senescence and Exhaustion Correlate with Response to Flotetuzumab, an Investigational CD123×CD3 Bispecific Dart® Molecule, in Acute Myeloid Leukemia, Jayakumar Vadakekolathu, Tung On Yau, Sarah E. Church, Michael P. Rettig, Ibarhim Aldoss, Geoffrey L. Uy, Norbert Vey, Ashkan Emadi, Peter H. Sayre, Roland B. Walter, Matthew C. Foster, Martha L. Arellano, John E Godwin, Matthew J. Wieduwilt, Michael T. Byrne, Laura C. Michaelis, Patrick J. Stiff, Matteo Giovanni Carrabba, Patrice Chevalier, Emmanuel Gyan, Christian Recher, Anjali S. Advani, Martin Wermke, Harry P. Erba, Fabio Ciceri, Geert Huls, Mojca Jongen-Lavrencic, Farhad Ravandi, Antonio Curti, Max S. Topp, John Muth, Patrick Kaminker, Bob Lowenberg, Ivana Gojo, Leo Luznik, John F. DiPersio, Jan K. Davidson-Moncada, and Sergio Rutella

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Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomised clinical trial., Jayant S Vaidya, Max Bulsara, Michael Baum, Frederik Wenz, Samuele Massarut, Steffi Pigorsch, Michael Alvarado, Michael Douek, Christobel Saunders, Henrik L Flyger, Wolfgang Eiermann, Chris Brew-Graves, Norman R Williams, Ingrid Potyka, Nicholas Roberts, Marcelle Bernstein, Douglas Brown, Elena Sperk, Siobhan Laws, Marc Sütterlin, Tammy Corica, Steinar Lundgren, Dennis R Holmes, Lorenzo Vinante, Fernando Bozza, Montserrat Pazos, Magali Le Blanc-Onfroy, Günther Gruber, Wojciech Polkowski, Konstantin J Dedes, Marcus Niewald, Jens Blohmer, David McCready, Richard Hoefer, Pond Kelemen, Gloria Petralia, Mary Falzon, David J Joseph, and Jeffrey S Tobias

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Effect of Delayed Targeted Intraoperative Radiotherapy vs Whole-Breast Radiotherapy on Local Recurrence and Survival: Long-term Results From the TARGIT-A Randomized Clinical Trial in Early Breast Cancer., Jayant S Vaidya, Max Bulsara, Christobel Saunders, Henrik Flyger, Jeffrey S Tobias, Tammy Corica, Samuele Massarut, Frederik Wenz, Steffi Pigorsch, Michael Alvarado, Michael Douek, Wolfgang Eiermann, Chris Brew-Graves, Norman Williams, Ingrid Potyka, Nicholas Roberts, Marcelle Bernstein, Douglas Brown, Elena Sperk, Siobhan Laws, Marc Sütterlin, Steinar Lundgren, Dennis R Holmes, Lorenzo Vinante, Fernando Bozza, Montserrat Pazos, Magali Le Blanc-Onfroy, Günther Gruber, Wojciech Polkowski, Konstantin J Dedes, Marcus Niewald, Jens Blohmer, David McCready, Richard Hoefer, Pond Kelemen, Gloria Petralia, Mary Falzon, Michael Baum, and David Joseph

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Efficacy and safety of first-line avelumab in patients with advanced non-small cell lung cancer: results from a phase Ib cohort of the JAVELIN Solid Tumor study., Claire F Verschraegen, Guy Jerusalem, Edward F McClay, Nicholas Iannotti, Charles H Redfern, Jaafar Bennouna, Franklin L Chen, Karen Kelly, Janice Mehnert, John C Morris, Matthew H Taylor, David Spigel, Ding Wang, Hans Juergen Grote, Dongli Zhou, Neru Munshi, Marcis Bajars, and James L Gulley

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Transoral robotic surgery and neck dissection for HPV-positive oropharyngeal carcinoma: Importance of nodal count in survival., Chi T Viet, Eric J Dierks, Allen C Cheng, Ashish Patel, Shu-Ching Chang, Marcus Couey, Amber L Watters, Thien Hoang, Hong D Xiao, Marka R Crittenden, Rom Leidner, Steven K Seung, Kristina H Young, and Richard Bryan Bell

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Erratum: Viswanathan, A., et al. Battling Glioblastoma: A Novel Tyrosine Kinase Inhibitor with Multi-Dimensional Anti-Tumor Effect (Running Title: Cancer Cells Death Signalling Activation)., Anisha Viswanathan, Aliyu Musa, Akshaya Murugesan, João R Vale, Carlos A M Afonso, Saravanan Konda Mani, Olli Yli-Harja, Nuno R Candeias, and Meenakshisundaram Kandhavelu

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Activity of tepotinib in brain metastases (BM): Preclinical models and clinical data from patients (pts) with MET exon 14 (METex14) skipping NSCLC, S Viteri, J Mazieres, R Veillon, E Felip, X Le, MC Garassino, Thomas Stanton, M Morise, J Lee, S Matsumoto, F De Marinis, T Wehler, A Clark, M Friese-Hamim, C Stroh, R Bruns, G Otto, and PK Paik

Activity of tepotinib in brain metastases (BM): Preclinical models and clinical data from patients (pts) with MET exon 14 (METex14) skipping NSCLC, S Viteri, J Mazieres, R Veillon, E Felip, X Le, MC Garassino, Thomas Stanton, M Morise, J Lee, S Matsumoto, F De Marinis, T Wehler, A Clark, M Friese-Hamim, C Stroh, R Bruns, G Otto, and PK Paik

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Breaking Down the Blood Brain Barrier., Naveed Wagle and Santosh Kesari

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Characterization of molecular pathways for targeting therapy in glioblastoma., Naveed Wagle, Minhdan Nguyen, Jose Carrillo, Judy D Truong, Lucia Dobrawa, and Santosh Kesari

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NKTR-214 immunotherapy synergizes with radiotherapy to stimulate systemic CD8, Joshua M Walker, Annah S Rolig, Deborah H Charych, Ute Hoch, Melissa Kasiewicz, Daniel Rose, Michael J McNamara, Ian F Hilgart-Martiszus, and William L. Redmond

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KTE-X19 CAR T-Cell Therapy in Relapsed or Refractory Mantle-Cell Lymphoma., Michael Wang, Javier Munoz, Andre Goy, Frederick L Locke, Caron A Jacobson, Brian T Hill, John M Timmerman, Houston Holmes, Samantha Jaglowski, Ian W Flinn, Peter A McSweeney, David B Miklos, John M Pagel, Marie-Jose Kersten, Noel Milpied, Henry Fung, Max S Topp, Roch Houot, Amer Beitinjaneh, Weimin Peng, Lianqing Zheng, John M Rossi, Rajul K Jain, Arati V Rao, and Patrick M Reagan

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PANEL DISCUSSION: Vaccine Development for COVID-19, Nathaniel Wang, Andrew J. Geall, and Andrew D Weinberg

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Downregulation of the Ubiquitin-E3 Ligase RNF123 Promotes Upregulation of the NF-κB1 Target SerpinE1 in Aggressive Glioblastoma Tumors., Xiaowen Wang, Matias A Bustos, Xiaoqing Zhang, Romela Irene Ramos, Cong Tan, Yuuki Iida, Shu-Ching Chang, Matthew P Salomon, Kevin Tran, Rebecca Gentry, Yelena Kravtsova-Ivantsiv, Daniel F Kelly, Gordon B Mills, Aaron Ciechanover, Ying Mao, and Dave S B Hoon

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Circulating activated lymphocyte subsets as potential blood biomarkers of cancer progression., Ying-Yi Wang, Na Zhou, Hong-Sheng Liu, Xiao-Lei Gong, Rui Zhu, Xiao-Yuan Li, Zhao Sun, Xu-Hong Zong, Ning-Ning Li, Chang-Ting Meng, Chun-Mei Bai, and Tai-Sheng Li

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Association Analysis of Driver Gene-Related Genetic Variants Identified Novel Lung Cancer Susceptibility Loci with 20,871 Lung Cancer Cases and 15,971 Controls., Yuzhuo Wang, Olga Y Gorlova, Ivan P Gorlov, Meng Zhu, Juncheng Dai, Demetrius Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Gary E Goodman, Stig E Bojesen, Maria Teresa Landi, Mattias Johansson, Angela Risch, Heunz-Erich Wichmann, Heike Bickeboller, David C Christiani, Gad Rennert, Susanne M Arnold, Paul Brennan, John K Field, Sanjay Shete, Loïc Le Marchand, Olle Melander, Hans Brunnstrom, Geoffrey Liu, Rayjean J Hung, Angeline S Andrew, Lambertus A Kiemeney, Shanbeh Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil E Caporaso, Penella J Woll, Philip Lazarus, Matthew B Schabath, Melinda C Aldrich, Victoria L Stevens, Hongxia Ma, Guangfu Jin, Zhibin Hu, Christopher I Amos, and Hongbing Shen

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Single-Cell Sequencing-Enabled Hexokinase 2 Assay for Noninvasive Bladder Cancer Diagnosis and Screening by Detecting Rare Malignant Cells in Urine., Zhuo Wang, Jie Chen, Liu Yang, Mingzhe Cao, Yanlan Yu, Rulin Zhang, Heng Quan, Qi Jiang, Yingqi Hua, Wei Wei, Peihua Lu, Jun Wu, and Qihui Shi

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Updates to the ASCO Patient-Centered Oncology Payment Model., Jeffery C Ward, Brian R Bourbeau, Alexander L Chin, Ray D Page, Stephen S Grubbs, Deborah Y Kamin, Sybil R Green, and Mary Rappaport

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Agonist Abs to TNF Receptor Family Members, Andrew D Weinberg

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Can OX40 Agonists Increase the Potency of COVID-19 Vaccines?, Andrew D Weinberg

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Identifying Tumor-Reactive CD8 TIL in Patients with Solid Malignancies: Clinical Implications, Andrew D Weinberg

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Nab-paclitaxel in older patients with non-small cell lung cancer who have developed disease progression after platinum-based doublet chemotherapy., Jared M Weiss, Nathan Pennell, Allison M Deal, Daniel Morgensztern, Daniel S Bradford, Jeffrey Crane, Howard J. West, Carrie Lee, Chad Pecot, James P Stevenson, William Irvin, Mark Socinski, Tom Stinchcombe, Liza C Villaruz, and Hyman B Muss

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Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction., Daniel K Wells, Marit M van Buuren, Kristen K Dang, Vanessa M Hubbard-Lucey, Kathleen C F Sheehan, Katie M Campbell, Andrew Lamb, Jeffrey P Ward, John Sidney, Ana B Blazquez, Andrew J Rech, Jesse M Zaretsky, Begonya Comin-Anduix, Alphonsus H C Ng, William Chour, Thomas V Yu, Hira Rizvi, Jia M Chen, Patrice Manning, Gabriela M Steiner, Xengie C Doan, Taha Merghoub, Justin Guinney, Adam Kolom, Cheryl Selinsky, Antoni Ribas, Matthew D Hellmann, Nir Hacohen, Alessandro Sette, James R Heath, Nina Bhardwaj, Fred Ramsdell, Robert D Schreiber, Ton N Schumacher, Pia Kvistborg, and Nadine A Defranoux

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Somatic mismatch repair testing in evaluation of Lynch syndrome: The gap between preferred and current practices., Danielle Williams, Eduardo Vilar, S Shakrukh Hashmi, Meagan Choates, Sarah Noblin, and Maureen Mork

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Association between Tunneled Pleural Catheter Use and Infection in Patients Immunosuppressed from Antineoplastic Therapy: A Multicenter Study., Candice Wilshire, Shu-Ching Chang, Christopher R Gilbert, Jason A Akulian, Mohammed K AlSarraj, Rachelle Asciak, Benjamin T Bevill, Kevin R Davidson, Ashley Delgado, Horiana B Grosu, Felix J F Herth, Hans J Lee, Justin E Lewis, Fabien Maldonado, David E Ost, Nicholas J Pastis, Najib M Rahman, Chakravarthy B Reddy, Lance J Roller, Trinidad M Sanchez, Samira Shojaee, Henry Steer, Jeffrey Thiboutot, Momen M Wahidi, Amber N Wright, Lonny B Yarmus, and Jed A Gorden

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Electronic Medical Record Inaccuracies: Multicenter Analysis of Challenges with Modified Lung Cancer Screening Criteria., Candice Wilshire, Carson C Fuller, Christopher R Gilbert, John R Handy, Kimberly E Costas, Brian Louie, Ralph W Aye, Alexander S Farivar, Eric Vallières, and Jed A Gorden

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Not following the rules in guideline care for lung cancer diagnosis and staging has negative impact., Candice Wilshire, Joshua R Rayburn, Shu-Ching Chang, Christopher R Gilbert, Brian Louie, Ralph W Aye, Alexander S Farivar, Adam J Bograd, Eric Vallières, and Jed A Gorden

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Tumor infiltrating lymphocytes after neoadjuvant IRX-2 immunotherapy in oral squamous cell carcinoma: Interim findings from the INSPIRE trial., Gregory T Wolf, Siyu Liu, Emily Bellile, Maureen Sartor, Laura Rozek, Dafydd Thomas, Ariane Nguyen, Katie Zarins, Jonathan B McHugh, INSPIRE Trial Clinical Investigators, and R Bryan Bell

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Cost-effectiveness of niraparib, rucaparib, and olaparib for treatment of platinum-resistant, recurrent ovarian carcinoma., Juliet E Wolford, Jiaru Bai, Kathleen N Moore, Rebecca Kristeleit, Bradley J Monk, and Krishnansu S Tewari

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The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View., Joao B Xavier, Vincent B Young, Joseph Skufca, Fiona Ginty, Traci Testerman, Alexander T Pearson, Paul Macklin, Amir Mitchell, Ilya Shmulevich, Lei Xie, J Gregory Caporaso, Keith A Crandall, Nicole L Simone, Filipa Godoy-Vitorino, Timothy J Griffin, Katrine L Whiteson, Heather H Gustafson, Daniel J Slade, Thomas M Schmidt, Marina R S Walther-Antonio, Tal Korem, Bobbie-Jo M Webb-Robertson, Mark P Styczynski, W Evan Johnson, Christian Jobin, Jason M Ridlon, Andrew Y Koh, Michael Yu, Libusha Kelly, and Jennifer A Wargo

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Correction to: Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy., Ke Xu, Dongkyoo Park, Andrew T Magis, Jun Zhang, Wei Zhou, Gabriel L Sica, Suresh S Ramalingam, Walter J Curran, and Xingming Deng

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The association between facility volume and overall survival in patients with Merkel cell carcinoma., Emi J Yoshida, Michael Luu, Morganna Freeman, Richard Essner, Nima M Gharavi, Stephen L Shiao, Jon Mallen-St Clair, Omid Hamid, Allen S Ho, and Zachary S Zumsteg

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Introduction to the Immune System, Anti-tumor Immunity, and Immunotherapy., Kristina H Young

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Transducin β-like protein 1 controls multiple oncogenic networks in diffuse large B-cell lymphoma., Youssef Youssef, Vrajesh Karkhanis, Wing Keung Chan, Frankie Jeney, Alessandro Canella, Xiaoli Zhang, Shelby Sloan, Alexander Prouty, JoBeth Helmig-Mason, Liudmyla Tsyba, Walter Hanel, Xuguang Zheng, Pu Zhang, Ji-Hyun Chung, David M Lucas, Zachary Kauffman, Karilyn Larkin, Anne M Strohecker, Hatice G Ozer, Rosa Lapalombella, Hui Zhou, Zijun Y Xu-Monette, Ken H Young, Ruolan Han, Elmar Nurmemmedov, Gerard Nuovo, Kami Maddocks, John C Byrd, Robert A Baiocchi, and Lapo Alinari

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Advances in targeted therapy for acute myeloid leukemia., Jifeng Yu, Peter Y Z Jiang, Hao Sun, Xia Zhang, Zhongxing Jiang, Yingmei Li, and Yongping Song

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Transcriptional Upregulation of NLRC5 by Radiation Drives STING- and Interferon-Independent MHC-I Expression on Cancer Cells and T Cell Cytotoxicity., Lauren Zebertavage, Alejandro F Alice, Marka R Crittenden, and Michael J. Gough

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CDCA2 Inhibits Apoptosis and Promotes Cell Proliferation in Prostate Cancer and Is Directly Regulated by HIF-1α Pathway., Yixiang Zhang, Yingduan Cheng, Zhaoxia Zhang, Zhongyuan Bai, Hongtao Jin, Xiaojing Guo, Xiaoyan Huang, Meiqi Li, Maolin Wang, Xing-Sheng Shu, Yeqing Yuan, and Ying Ying

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Predictors of survival following surgical resection of limited-stage small cell lung cancer., Nicolas Zhou, Matthew Bott, Bernard J Park, Eric Vallieres, Candice Wilshire, Kazuhiro Yasufuku, Jonathan D Spicer, David R Jones, Boris Sepesi, and Small Cell Lung Cancer Working Group

Predictors of overall survival following surgical resection of small cell lung cancer, N Zhou, KG Mitchell, EM Corsini, DR Jones, MJ Bott, CL Wilshire, SG Swisher, MB Antonoff, DC Rice, GL Walsh, RJ Mehran, WL Hofstetter, JA Roth, and See additional authors in comments

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Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP., Yi Zhou, Mingjian Fei, Gu Zhang, Wei-Ching Liang, WeiYu Lin, Yan Wu, Robert Piskol, John Ridgway, Erin McNamara, Haochu Huang, Juan Zhang, Jaehak Oh, Jaina M Patel, Diana Jakubiak, Jeff Lau, Beth Blackwood, Daniel D Bravo, Yongchang Shi, Jianyong Wang, Hong-Ming Hu, Wyne P Lee, Rajiv Jesudason, Dewakar Sangaraju, Zora Modrusan, Keith R Anderson, Søren Warming, Merone Roose-Girma, and Minhong Yan

Submissions from 2019

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Genomic characteristics of deleterious BRCA1 and BRCA2 alterations and associations with baseline clinical factors in patients with metastatic castration-resistant prostate cancer (mCRPC) enrolled in TRITON2, Wassim Abida, Alan Haruo Bryce, Nicholas J. Vogelzang, Robert J. Amato, Ivor John Percent, Jeremy David Shapiro, Raymond S. McDermott, Arif Hussain, Akash Patnaik, Daniel Peter Petrylak, Charles J. Ryan, Thomas Stanton, Jingsong Zhang, Andrea Loehr, Andrew Simmons, Darrin Despain, Anthony A. Golsorkhi, Simon Paul Watkins, Howard I. Scher, and Simon Chowdhury

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Brain metastases., Achal Singh Achrol, Robert C Rennert, Carey Anders, Riccardo Soffietti, Manmeet S Ahluwalia, Lakshmi Nayak, Solange Peters, Nils D Arvold, Griffith R Harsh, Patricia S Steeg, and Steven D Chang

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Current Landscape of Immunotherapy in Breast Cancer: A Review., Sylvia Adams, Margaret E Gatti-Mays, Kevin Kalinsky, Larissa A Korde, Elad Sharon, Laleh Amiri-Kordestani, Harry Bear, Heather L McArthur, Elizabeth Frank, Jane Perlmutter, David B Page, Benjamin Vincent, Jennifer F Hayes, James L Gulley, Jennifer K Litton, Gabriel N Hortobagyi, Stephen Chia, Ian Krop, Julia White, Joseph Sparano, Mary L Disis, and Elizabeth A Mittendorf

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Correction to: Unintended consequences of decreased PSA-based prostate cancer screening., Thomas Ahlering, Linda My Huynh, Kamaljot S Kaler, Stephen Williams, Kathryn Osann, Jean Joseph, David Lee, John W Davis, Ronney Abaza, Jihad Kaouk, Vipul Patel, Isaac Yi Kim, James R Porter, and Jim C Hu

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False-positive screening events and worry influence decisions about surgery among high-risk women., M Robyn Andersen, Beth Y Karlan, Charles W Drescher, Pamela Paley, Sarah Hawley, Melanie Palomares, Mary B Daly, and Nicole Urban

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Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer., Carryn M Anderson, Christopher M Lee, Deborah P Saunders, Amarinthia Curtis, Neal Dunlap, Chaitali Nangia, Arielle S Lee, Sharon M Gordon, Philip Kovoor, Roberto Arevalo-Araujo, Voichita Bar-Ad, Abhinand Peddada, Kyle Colvett, Douglas Miller, Anshu K Jain, James Wheeler, Dukagjin Blakaj, Marcelo Bonomi, Sanjiv S Agarwala, Madhur Garg, Francis Worden, Jon Holmlund, Jeffrey M Brill, Matt Downs, Stephen T Sonis, Sanford Katz, and John M Buatti

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Viral Targeting of Non-Muscle-Invasive Bladder Cancer and Priming of Antitumor Immunity Following Intravesical Coxsackievirus A21., Nicola E Annels, David Mansfield, Mehreen Arif, Carmen Ballesteros-Merino, Guy R Simpson, Mick Denyer, Sarbjinder S Sandhu, Alan A Melcher, Kevin J Harrington, Bronwyn Davies, Gough Au, Mark Grose, Izhar Bagwan, Bernard A Fox, Richard Vile, Hugh Mostafid, Darren Shafren, and Hardev S Pandha

Incidence of incidental findings and the rate of downstream interventions in lung cancer screening: A multistate, community-based healthcare network experience, SE Anton, LC Horslen, CA Henson, CL Wilshire, CR Gilbert, KM Spiegel, JR Rayburn, AS Carlson, CC Fuller, and M Bretta

High variability in radiologist reporting of incidental findings during lung cancer screening in a community-based healthcare network The American, SE Anton, CL Wilshire, See all authors in comments, and CR Gilbert

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Hypothalamic Vasopressin-Producing Tumors: Often Inappropriate Diuresis But Occasionally Cushing Disease., Sylvia L Asa, Shereen Ezzat, Daniel F Kelly, Pejman Cohan, Yuki Takasumi, Garni Barkhoudarian, Anthony P Heaney, Rowena Ridout, Constance L Chik, Lester D R Thompson, Fred Gentili, and Ozgur Mete

Perspectives in immunotherapy: meeting report from the "Immunotherapy Bridge 2018" (28-29 November, 2018, Naples, Italy)., Paolo A Ascierto, Carlo Bifulco, Luigi Buonaguro, Leisha A Emens, Robert L Ferris, Bernard A Fox, Greg M Delgoffe, Jérôme Galon, Cesare Gridelli, Marco Merlano, Paul Nathan, Kunle Odunsi, Hideho Okada, Chrystal M Paulos, Sandro Pignata, Kurt A Schalper, Stefani Spranger, Giampaolo Tortora, Hassane Zarour, Lisa H Butterfield, and Igor Puzanov

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Pre-Analytic Variables and Tissue Stewardship for Reliable Next-Generation Sequencing (NGS) Clinical Analysis., Paolo A Ascierto, Carlo Bifulco, Giuseppe Palmieri, Solange Peters, and Nikoletta Sidiropoulos

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Evaluating the effectiveness and implementation of evidence-based treatment: A multisite hybrid design., Jamile A Ashmore, Kirk W Ditterich, Claire C Conley, Melissa R Wright, Peggy S Howland, Kelly L Huggins, Jena Cooreman, Priscilla S Andrews, Donald R Nicholas, Lind Roberts, Larissa Hewitt, Joan N Scales, Jenny K Delap, Christine A Gray, Lynelle A Tyler, Charlotte Collins, Catherine M Whiting, Brittany M Brothers, Marlena M Ryba, and Barbara L Andersen

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Advances in Radiation Oncology, Robert Ash

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Acalabrutinib monotherapy in patients with chronic lymphocytic leukemia who are intolerant to ibrutinib., Farrukh T Awan, Anna Schuh, Jennifer R Brown, Richard R Furman, John M Pagel, Peter Hillmen, Deborah M Stephens, Jennifer Woyach, Elena Bibikova, Prista Charuworn, Melanie M Frigault, Ahmed Hamdy, Raquel Izumi, Bolan Linghu, Priti Patel, Min Hui Wang, and John C Byrd

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Pituitary Apoplexy., Garni Barkhoudarian and Daniel F Kelly

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Pituitary Apoplexy., Garni Barkhoudarian and Daniel F Kelly

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Intraoperative Opioid Administration Among Cancer Patients., Amanda Barrett and Kenn Daratha

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Intraoperative Opioid Administration Among Cancer Patients, Amanda Barrett and Kenn B Daratha

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Incidence, associated risk factors, and impact of conversion to laparotomy in elective minimally invasive sigmoidectomy for diverticular disease., Amir Bastawrous, Ron G Landmann, Yuki Liu, Emelline Liu, and Robert K Cleary

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A Mother in Jeopardy: The Ethics of Pregnancy and Chemotherapy., Steven J Baumrucker, Wendy H Vogel, Robert M Stolick, Russell W Adkins, Heather Holland, Gregg VandeKieft, and Angela Eastridge

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Cranial and intra-axial metastasis originating from a primary ovarian Dysgerminoma., Tiffany L Beck, Hitomi Momose, Jeffrey M Dym, Vikas Y Rao, Randy Bohart, and Bram H Goldstein

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Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop., Davide Bedognetti, Michele Ceccarelli, Lorenzo Galluzzi, Rongze Lu, Karolina Palucka, Josue Samayoa, Stefani Spranger, Sarah Warren, Kwok-Kin Wong, Elad Ziv, Diego Chowell, Lisa M Coussens, Daniel D De Carvalho, David G DeNardo, Jérôme Galon, Howard L Kaufman, Tomas Kirchhoff, Michael T Lotze, Jason J Luke, Andy J Minn, Katerina Politi, Leonard D Shultz, Richard Simon, Vésteinn Thórsson, Joanne B Weidhaas, Maria Libera Ascierto, Paolo Antonio Ascierto, James M Barnes, Valentin Barsan, Praveen K Bommareddy, Adrian Bot, Sarah E Church, Gennaro Ciliberto, Andrea De Maria, Dobrin Draganov, Winson S Ho, Heather M McGee, Anne Monette, Joseph F Murphy, Paola Nisticò, Wungki Park, Maulik Patel, Michael Quigley, Laszlo Radvanyi, Harry Raftopoulos, Nils-Petter Rudqvist, Alexandra Snyder, Randy F Sweis, Sara Valpione, Lisa H Butterfield, Mary L Disis, Bernard A Fox, Alessandra Cesano, and Francesco M Marincola

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Correction to: Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop., Davide Bedognetti, Michele Ceccarelli, Lorenzo Galluzzi, Rongze Lu, Karolina Palucka, Josue Samayoa, Stefani Spranger, Sarah Warren, Kwok-Kin Wong, Elad Ziv, Diego Chowell, Lisa M Coussens, Daniel D De Carvalho, David G DeNardo, Jérôme Galon, Howard L Kaufman, Tomas Kirchhoff, Michael T Lotze, Jason J Luke, Andy J Minn, Katerina Politi, Leonard D Shultz, Richard Simon, Vésteinn Thorsson, Joanne B Weidhaas, Maria Libera Ascierto, Paolo Antonio Ascierto, James M Barnes, Valentin Barsan, Praveen K Bommareddy, Adrian Bot, Sarah E Church, Gennaro Ciliberto, Andrea De Maria, Dobrin Draganov, Winson S Ho, Heather M McGee, Anne Monette, Joseph F Murphy, Paola Nisticò, Wungki Park, Maulik Patel, Michael Quigley, Laszlo Radvanyi, Harry Raftopoulos, Nils-Petter Rudqvist, Alexandra Snyder, Randy F Sweis, Sara Valpione, Roberta Zappasodi, Lisa H Butterfield, Mary L Disis, Bernard A Fox, Alessandra Cesano, and Francesco M Marincola

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Effect of Exercise on Taxane Chemotherapy-Induced Peripheral Neuropathy in Women With Breast Cancer: A Randomized Controlled Trial., Kelcey A Bland, Amy A Kirkham, Joshua Bovard, Tamara Shenkier, David S Zucker, Donald C McKenzie, Margot K Davis, Karen A Gelmon, and Kristin L Campbell

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Body mass index and prostate cancer risk in the Carotene and Retinol Efficacy Trial., Stephanie E Bonn, Matt J Barnett, Mark Thornquist, Gary E Goodman, and Marian L Neuhouser

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Transcriptome-wide association study reveals candidate causal genes for lung cancer., Yohan Bossé, Zhonglin Li, Jun Xia, Venkata Manem, Robert Carreras-Torres, Aurélie Gabriel, Nathalie Gaudreault, Demetrius Albanes, Melinda C Aldrich, Angeline Andrew, Susanne Arnold, Heike Bickeböller, Stig E Bojesen, Paul Brennan, Hans Brunnstrom, Neil Caporaso, Chu Chen, David C Christiani, John K Field, Gary E Goodman, Kjell Grankvist, Richard Houlston, Mattias Johansson, Mikael Johansson, Lambertus A Kiemeney, Stephen Lam, Maria T Landi, Philip Lazarus, Loic Le Marchand, Geoffrey Liu, Olle Melander, Gadi Rennert, Angela Risch, Susan M Rosenberg, Matthew B Schabath, Sanjay Shete, Zhuoyi Song, Victoria L Stevens, Adonina Tardon, H-Erich Wichmann, Penella Woll, Shan Zienolddiny, Ma'en Obeidat, Wim Timens, Rayjean J Hung, Philippe Joubert, Christopher I Amos, and James D McKay

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Erratum: Author Correction: Surgical Standards for Management of the Axilla in Breast Cancer Clinical Trials with Pathological Complete Response Endpoint., Judy C Boughey, Michael D Alvarado, Rachael B Lancaster, W Fraser Symmans, Rita Mukhtar, Jasmine M Wong, Cheryl A Ewing, David A Potter, Todd M Tuttle, Tina J Hieken, Jodi M Carter, James W Jakub, Henry G Kaplan, Claire L Buchanan, Nora T Jaskowiak, Husain A Sattar, Jeffrey Mueller, Rita Nanda, Claudine J Isaacs, Paula R Pohlmann, Filipa Lynce, Eleni A Tousimis, Jay C Zeck, M Catherine Lee, Julie E Lang, Paulette Mhawech-Fauceglia, Roshni Rao, Bret Taback, Constantine Goodellas, Margaret Chen, Kevin M Kalinsky, Hanina Hibshoosh, Brigid Killelea, Tara Sanft, Gillian L Hirst, Smita Asare, Jeffrey B Matthews, Jane Perlmutter, and Laura J Esserman

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Targeting DNA repair in Metastatic Castration-Resistant Prostate Cancer (mCRPC): Genomic Screening for a Clinical Trial of Rucaparib, Alan Bryce, Mitchell E. Gross, Charles Redfern, Nicholas Vogelzang, Matthew Rettig, Thomas Stanton, Julie N. Graff, Sandhya Srinivas, Andrea Loehr, and Wassim Abida

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Staying Well with Survivorship Wellness, Janni Buaiz

Therapy with high-dose Interleukin-2 (HD IL-2) in metastatic melanoma and renal cell carcinoma following PD1 or PDL1 inhibition., Elizabeth I Buchbinder, Janice P Dutcher, Gregory A Daniels, Brendan Curti, Sapna P Patel, Shernan G Holtan, Gerald P Miletello, Mayer N Fishman, Rene Gonzalez, Joseph I Clark, John M Richart, Christopher D Lao, Scott S Tykodi, Ann W Silk, and David F McDermott

Rib plating offers favourable outcomes in patients with chronic non-union of prior rib fractures, KE Buehler, CL Wilshire, AJ Bograd, and E Vallières

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Advances in drug delivery for post-surgical cancer treatment., Lin-Lin Bu, Junjie Yan, Zejun Wang, Huitong Ruan, Qian Chen, Vivienne Gunadhi, Richard Bryan Bell, and Zhen Gu

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Prolactinomas and nonfunctioning adenomas: preoperative diagnosis of tumor type using serum prolactin and tumor size., William T Burke, David L Penn, Joseph P Castlen, Daniel A Donoho, Caroline S Repetti, Sherry Iuliano, Garni Barkhoudarian, and Edward R Laws

“Interleukin-enhancer binding factor 2 expression associates with chemotherapy response in triple-negative breast cancer, MA Bustos, X Zhang, and DSB Hoon