The Cancer Institute is a leader in cutting-edge treatments. Using a truly multidisciplinary approach, patients have access to advanced diagnostics, minimally invasive surgical interventions, and personalized genomic and immune-oncologic treatment options. Our team of cancer specialists – many of whom completed fellowships and specialty training at prestigious academic centers – offers comprehensive services for individuals with a cancer diagnosis.

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Submissions from 2021

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354 Lenvatinib and pembrolizumab in advanced endometrial carcinoma (EC): long-term efficacy and safety update from a phase 1b/2 study, Vicky Makker, Matthew H Taylor, and See full list of authors in comments

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Streamlining brain tumor surgery care during the COVID-19 pandemic: A case-control study., Regin Jay Mallari, Michael B Avery, Alex Corlin, Amalia Eisenberg, Terese C Hammond, Neil A Martin, Garni Barkhoudarian, and Daniel F Kelly

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Endoscopic Endonasal and Supraorbital Removal of Tuberculum Sellae Meningiomas: Anatomic Guides and Operative Nuances for Keyhole Approach Selection., Regin Jay Mallari, Jai Deep Thakur, John H Rhee, Amalia Eisenberg, Howard Krauss, Chester Griffiths, Walavan Sivakumar, Garni Barkhoudarian, and Daniel F Kelly

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Continued proportional age shift of confirmed positive COVID-19 incidence over time to children and young adults: Washington State March-August 2020., Judith Malmgren, Boya Guo, and Henry G Kaplan

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Adjuvant T-DM1 versus trastuzumab in patients with residual invasive disease after neoadjuvant therapy for HER2-positive breast cancer: subgroup analyses from KATHERINE., E P Mamounas, M Untch, M S Mano, C-S Huang, C E Geyer, G von Minckwitz, N Wolmark, X Pivot, S Kuemmel, M P DiGiovanna, B Kaufman, G Kunz, A K Conlin, J C Alcedo, T Kuehn, I Wapnir, A Fontana, J Hackmann, J Polikoff, M Saghatchian, A Brufsky, Y Yang, M Zimovjanova, T Boulet, H Liu, D Tesarowski, L H Lam, C Song, M Smitt, and S Loibl

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Prognostic gene expression signatures of breast cancer are lacking a sensible biological meaning., Kalifa Manjang, Shailesh Tripathi, Olli Yli-Harja, Matthias Dehmer, Galina Glazko, and Frank Emmert-Streib

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Limitations of Explainability for Established Prognostic Biomarkers of Prostate Cancer., Kalifa Manjang, Olli Yli-Harja, Matthias Dehmer, and Frank Emmert-Streib

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A phase I/II study of rovalpituzumab tesirine in delta-like 3-expressing advanced solid tumors., Aaron S Mansfield, David S Hong, Christine L Hann, Anna F Farago, Himisha Beltran, Saiama N Waqar, Andrew E Hendifar, Lowell B Anthony, Matthew H Taylor, Alan H Bryce, Scott T Tagawa, Karl Lewis, Jiaxin Niu, Christine H Chung, James M Cleary, Michael Rossi, Carrianne Ludwig, Ricardo Valenzuela, Yan Luo, and Rahul Aggarwal

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Trifluridine/tipiracil in patients with metastatic gastroesophageal junction cancer: a subgroup analysis from the phase 3 TAGS study., Wasat Mansoor, Hendrik-Tobias Arkenau, Maria Alsina, Kohei Shitara, Peter Thuss-Patience, Sinead Cuffe, Mikhail Dvorkin, David Park, Takayuki Ando, Marc Van Den Eynde, Giordano D Beretta, Alberto Zaniboni, Toshihiko Doi, Josep Tabernero, David H Ilson, Lukas Makris, Karim A Benhadji, and Eric Van Cutsem

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Large polyps: Pearls for the referring and receiving endoscopist., Eric Markarian, Brian M Fung, Mohit Girotra, and James H Tabibian

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Defining Risk Categories for a Significant Decline in Estimated Glomerular Filtration Rate After Robotic Partial Nephrectomy: Implications for Patient Follow-up., Alberto Martini, Ugo Giovanni Falagario, Shivaram Cumarasamy, Ronney Abaza, Daniel D Eun, Akshay Bhandari, James R Porter, Ashok K Hemal, and Ketan K Badani

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Phosphorylation of SMAD3 in immune cells predicts survival of patients with early stage non-small cell lung cancer., Sebastian Marwitz, Carmen Ballesteros-Merino, Shawn M. Jensen, Martin Reck, Christian Kugler, Sven Perner, Daniel Drömann, Torsten Goldmann, and Bernard A Fox

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Durability of Response to Primary Chemoablation of Low-Grade Upper Tract Urothelial Carcinoma Using UGN-101, a Mitomycin-Containing Reverse Thermal Gel: OLYMPUS Trial Final Report., Surena F Matin, Phillip M Pierorazio, Nir Kleinmann, John L Gore, Ahmad Shabsigh, Brian Hu, Karim Chamie, Guilherme Godoy, Scott G Hubosky, Marcelino Rivera, Michael O'Donnell, Marcus Quek, Jay D Raman, John J Knoedler, Douglas Scherr, Christopher Weight, Alon Weizer, Michael Woods, Hristos Kaimakliotis, Angela B Smith, Jennifer M Linehan, Jonathan Coleman, Mitchell R Humphreys, Raymond Pak, David Lifshitz, Michael Verni, Ifat Klein, Marina Konorty, Dalit Strauss-Ayali, Gil Hakim, Elyse Seltzer, Mark Schoenberg, and Seth P Lerner

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Recognizing Unmet Need in the Era of Targeted Therapy for CLL/SLL: "What's Past Is Prologue" (Shakespeare)., Anthony R Mato, Matthew S Davids, Jeff Sharman, Lindsey E Roeker, Neil Kay, Arnon Kater, Kerry Rogers, Meghan C Thompson, Joanna Rhodes, Andre Goy, Alan Skarbnik, Stephen J Schuster, Constantine S Tam, Toby A Eyre, Susan O'Brien, Chadi Nabhan, Nicole Lamanna, Clare Sun, Mazyar Shadman, John M Pagel, Chaitra Ujjani, Danielle Brander, Catherine C Coombs, Nitin Jain, Chan Y Cheah, Jennifer R Brown, John F Seymour, and Jennifer A Woyach

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Pirtobrutinib in relapsed or refractory B-cell malignancies (BRUIN): a phase 1/2 study., Anthony R Mato, Nirav N Shah, Wojciech Jurczak, Chan Y Cheah, John M Pagel, Jennifer A Woyach, Bita Fakhri, Toby A Eyre, Nicole Lamanna, Manish R Patel, Alvaro Alencar, Ewa Lech-Maranda, William G Wierda, Catherine C Coombs, James N Gerson, Paolo Ghia, Steven Le Gouill, David John Lewis, Suchitra Sundaram, Jonathon B Cohen, Ian W Flinn, Constantine S Tam, Minal A Barve, Bryone Kuss, Justin Taylor, Omar Abdel-Wahab, Stephen J Schuster, M Lia Palomba, Katharine L Lewis, Lindsey E Roeker, Matthew S Davids, Xuan Ni Tan, Timothy S Fenske, Johan Wallin, Donald E Tsai, Nora C Ku, Edward Zhu, Jessica Chen, Ming Yin, Binoj Nair, Kevin Ebata, Narasimha Marella, Jennifer R Brown, and Michael Wang

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Vertebral Augmentation of Cancer-Related Spinal Compression Fractures: A Systematic Review and Meta-Analysis., Ryan Mattie, Nick Brar, Jennifer T Tram, Zachary L McCormick, Douglas P Beall, Andrew Fox, and Mikhail Saltychev

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How we approach hemangiomas in infants., Jennifer L R Mayer, Stefanos Intzes, Vikash S Oza, and Francine Blei

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A Microcosm of Disparities in Breast Cancer: Comparison Between a Private Hospital and a Safety-Net County Hospital Within Los Angeles County., Natalie C McClintock, Reed I Ayabe, Ruben D Salas Parra, Amy H Kaji, Javier I Orozco, Diego M Marzese, Estela Samuels, Stacey L Stern, Christine Dauphine, and Junko J Ozao-Choy

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Detection of Human Papillomavirus Integration in Brain Metastases from Oropharyngeal Tumors by Targeted Sequencing., Brian McEllin, Brian C Searle, Lisa DePledge, George Sun, Charles Cobbs, and Mohsen Karimi

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Micro-Loss; Expanding Our Vocabulary to Describe Grief during the Time of Covid., Danielle McLaughlin

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Electronic Charting of Radiation Therapy Planning and Treatment: Report of Task Group 262., James G Mechalakos, Sonja Dieterich, Luis E Fong de Los Santos, Sandra C Fontenla, Joseph Hanley, Vijay A Harwalkar, Linda X Hong, Y Jessica Huang, Grace Gwe-Ya Kim, Susan L Richardson, Steven G Sutlief, Sridhar Yaddanapudi, Sue Merkel, and Mark Parry

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Defining Immunogenic and Radioimmunogenic Tumors., Terry R Medler, Tiffany C Blair, Marka R Crittenden, and Michael J Gough

Complicated pleural space infections are associated with prolonged recovery and reduced work effectiveness Chest 2021 Annual Meeting Orlando, Florida, AM Meggyesy, CL Wilshire, and See all authors in comments

Outpatient thoracentesis for pleural effusion following cardiac surgery appears safe with ongoing anticoagulation and antiplatelet use Chest 2021 Annual Meeting Orlando, Florida, AM Meggyesy, CL Wilshire, and See all authors in comments

Pectoral muscle area correlates with LENT score in non-small cell lung cancer-associated pleural effusion survival prediction The International Association for the Study of Lung Cancer 2020 World Conference on Lung Cancer Worldwide Virtual Event, AM Meggyesy, CL Wilshire, and See all authors in comments

Repeat thoracenteses is associated with an increase in cumulative risk of complications in patients with a malignant pleural effusion The American Thoracic Society San Diego, California, HE Modin, CL Wilshire, and See all authors in comments

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Translational Advances in Cancer Prevention Agent Development (TACPAD) Virtual Workshop on Immunomodulatory Agents: Report., Altaf Mohammed, Roderick H Dashwood, Sally Dickinson, Mary L Disis, Elizabeth M Jaffee, Bryon D Johnson, Samir N Khleif, Michael N Pollak, Jeffrey Schlom, Robert H Shoemaker, Sasha Stanton, Georg T Wondrak, Ming You, Hao Zhu, and Mark Steven Miller

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A Randomized Trial of Fulvestrant, Everolimus, and Anastrozole for the Front-line Treatment of Patients with Advanced Hormone Receptor-positive Breast Cancer, SWOG S1222., Halle C F Moore, William E Barlow, George Somlo, Julie R Gralow, Anne F Schott, Daniel F Hayes, Peter Kuhn, James B Hicks, Lisa Welter, Philip A Dy, Christina H Yeon, Alison Conlin, Ernie Balcueva, Danika L Lew, Debasish Tripathy, Lajos Pusztai, and Gabriel N Hortobagyi

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Atezolizumab, Bevacizumab, and Chemotherapy for Newly Diagnosed Stage III or IV Ovarian Cancer: Placebo-Controlled Randomized Phase III Trial (IMagyn050/GOG 3015/ENGOT-OV39)., Kathleen N Moore, Michael Bookman, Jalid Sehouli, Austin Miller, Charles Anderson, Giovanni Scambia, Tashanna Myers, Cagatay Taskiran, Katina Robison, Johanna Mäenpää, Lyndsay Willmott, Nicoletta Colombo, Jessica Thomes-Pepin, Michalis Liontos, Michael A Gold, Yolanda Garcia, Sudarshan K Sharma, Christopher J Darus, Carol Aghajanian, Aikou Okamoto, Xiaohua Wu, Rustem Safin, Fan Wu, Luciana Molinero, Vidya Maiya, Victor K Khor, Yvonne G Lin, and Sandro Pignata

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HDAC inhibition prevents transgene expression downregulation and loss-of-function in T-cell-receptor-transduced T cells., Tamson V Moore, Gina M Scurti, Matthew DeJong, Siao-Yi Wang, Annika V Dalheim, Courtney R Wagner, Kelli A Hutchens, Jodi J Speiser, Constantine V Godellas, Chris Fountain, Jessica Fleser, Tarsem Moudgil, Mallory Thomas, David Murray, Brendan D Curti, Joseph I Clark, Bernard A Fox, and Michael I Nishimura

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Neoadjuvant Pelvic Radiotherapy in the Management of Rectal Cancer with Synchronous Liver Metastases: Is It Worth It?, Maitham A Moslim, Amir L Bastawrous, and D Rohan Jeyarajah

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Lenvatinib plus Pembrolizumab or Everolimus for Advanced Renal Cell Carcinoma., Robert Motzer, Boris Alekseev, Sun-Young Rha, Camillo Porta, Masatoshi Eto, Thomas Powles, Viktor Grünwald, Thomas E Hutson, Evgeny Kopyltsov, María J Méndez-Vidal, Vadim Kozlov, Anna Alyasova, Sung-Hoo Hong, Anil Kapoor, Teresa Alonso Gordoa, Jaime R Merchan, Eric Winquist, Pablo Maroto, Jeffrey C Goh, Miso Kim, Howard Gurney, Vijay Patel, Avivit Peer, Giuseppe Procopio, Toshio Takagi, Bohuslav Melichar, Frederic Rolland, Ugo De Giorgi, Shirley Wong, Jens Bedke, Manuela Schmidinger, Corina E Dutcus, Alan D Smith, Lea Dutta, Kalgi Mody, Rodolfo F Perini, Dongyuan Xing, Toni K Choueiri, CLEAR Trial Investigators, and Brendan Curti (CLEAR Trial Investigators)

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85 Detection of human angiotensin-converting enzyme 2 receptor (hACE2R) on human cancer cell lines, Tarsem Moudgil, Bernard A Fox, and Hong-Ming Hu

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Induction of ADAM10 by RT drives fibrosis, resistance, and EMT in pancreatic cancer., Adam C Mueller, Miles Piper, Andrew Goodspeed, Shiv Bhuvane, Jason S Williams, Shilpa Bhatia, Andy V Phan, Benjamin Van Court, Kathryn L Zolman, Brisa Peña, Ayman J Oweida, Sara Zakem, Cheryl Meguid, Michael W Knitz, Laurel Darragh, Thomas E Bickett, Jacob Gadwa, Luisa Mestroni, Matthew R G Taylor, Kimberly R Jordan, Peter Dempsey, M Scott Lucia, Martin D McCarter, Marco Del Chiaro, Wells A Messersmith, Richard D Schulick, Karyn A Goodman, Michael J. Gough, Casey S Greene, James C Costello, Antonio Galvao Neto, David Lagares, Kirk C Hansen, Adrie Van Bokhoven, and Sana D Karam

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High Resolution Manometry in a Functioning Fundoplication - Establishing a Standard Profile: Retrospective Chart Review., Dolores T Müller, Brett Parker, Reid Fletcher, Ahmed M Sharata, Daniel Davila Bradley, Steven R DeMeester, Kevin M Reavis, Lee L Swanstrom, and Christy M Dunst

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Regulation of MRE11A by UBQLN4 leads to cisplatin resistance in patients with esophageal squamous cell carcinoma., Tomohiro Murakami, Yoshiaki Shoji, Tomohiko Nishi, Shu-Ching Chang, Ron D Jachimowicz, Sojun Hoshimoto, Shigeshi Ono, Yosef Shiloh, Hiroya Takeuchi, Yuko Kitagawa, Dave Hoon, and Matias Bustos

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Impact of XPO1 mutations on survival outcomes in metastatic non-small cell lung cancer (NSCLC)., Misako Nagasaka, Mohammad Fahad B Asad, Mohammed Najeeb Al Hallak, Md Hafiz Uddin, Ammar Sukari, Yasmine Baca, Joanne Xiu, Dan Magee, Hirva Mamdani, Dipesh Uprety, Chul Kim, Bing Xia, Stephen V Liu, Jorge J Nieva, Gilberto Lopes, Gerold Bepler, Hossein Borghaei, Michael J Demeure, Luis E Raez, Patrick C Ma, Sonam Puri, W Michael Korn, and Asfar S Azmi

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509 A first-in-human phase 1 study of NL-201 in patients with relapsed or refractory cancer, Aung Naing, Brendan Curti, and See full list of authors in comments

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Collagenous Gastritis in Primary Selective IgM Deficiency: Transition to EBV+ Gastric Adenocarcinoma., Tejal Narsai, Houfen Su, David Braxton, and Sudhir Gupta

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Proteogenomic Characterization of Highly Enriched Viable Leukemic Blasts in Acute Myeloid Leukemia: A SWOG Report, Jasmine Naru, John E Godwin, and See full list of authors in comments

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Overall Survival Benefit with Tebentafusp in Metastatic Uveal Melanoma., Paul Nathan, Jessica C Hassel, Piotr Rutkowski, Jean-Francois Baurain, Marcus O Butler, Max Schlaak, Ryan J Sullivan, Sebastian Ochsenreither, Reinhard Dummer, John M Kirkwood, Anthony M Joshua, Joseph J Sacco, Alexander N Shoushtari, Marlana Orloff, Josep M Piulats, Mohammed Milhem, April K S Salama, Brendan Curti, Lev Demidov, Lauris Gastaud, Cornelia Mauch, Melinda Yushak, Richard D Carvajal, Omid Hamid, Shaad E Abdullah, Chris Holland, Howard Goodall, Sophie Piperno-Neumann, and IMCgp100-202 Investigators

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Frequency of Sarcopenia, Sarcopenic Obesity, and Changes in Physical Function in Surgical Oncology Patients Referred for Prehabilitation., An Ngo-Huang, Aliea Herbert, Rhodora C Fontillas, Nathan H Parker, Roan Asumbrado, Naveen Garg, Seyedeh Dibaj, Diane D Liu, Amy H Ng, Ying Guo, Ki Y Shin, Matthew H G Katz, and Eduardo Bruera

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Synthesis and Preclinical Validation of Novel Indole Derivatives as a GPR17 Agonist for Glioblastoma Treatment., Phung Nguyen, Phuong Doan, Tatu Rimpilainen, Saravanan Konda Mani, Akshaya Murugesan, Olli Yli-Harja, Nuno R Candeias, and Meenakshisundaram Kandhavelu

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1665 - QuPath versus InForm: Digital image analysis of multiplex immunofluorescence (mIF) tumor-infiltrating lymphocyte (TIL) outcomes in an immunotherapy clinical trial, Benjamin Nikitin, Brie Chun, Isaac Kim, William L. Redmond, Katherine Sanchez, Zhaoyu Sun, Yaping Wu, and David B Page

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Atezolizumab Plus Chemotherapy for First-Line Treatment of Nonsquamous NSCLC: Results From the Randomized Phase 3 IMpower132 Trial., Makoto Nishio, Fabrice Barlesi, Howard West, Simon Ball, Rodolfo Bordoni, Manuel Cobo, Pascale Dubray Longeras, Jerome Goldschmidt, Silvia Novello, Francisco Orlandi, Rachel E Sanborn, Zsuzsanna Szalai, Grigoriy Ursol, Diana Mendus, Lijia Wang, Xiaohui Wen, Mark McCleland, Tien Hoang, See Phan, and Mark A Socinski

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Safety and efficacy of durvalumab with R-CHOP or R, Grzegorz S Nowakowski, Wolfgang Willenbacher, Richard Greil, Thomas S Larsen, Krish Patel, Ulrich Jäger, Robert F Manges, Lorenz Trümper, Hele Everaus, Nagesh Kalakonda, Peter Brown, Judit Meszaros Jørgensen, David Cunningham, Justine Dell'Aringa, Brian Fox, Neus Domper Rubio, Nurgul Kilavuz, Marie-Laure Casadebaig, Oliver Manzke, and Javier Munoz

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Allogeneic Transplantation in Fit Older Adults Is Feasible and Encouragingly Efficacious. Post Remission Data from the Prospective ECOG-ACRIN (E2906) Clinical Study, Yishai Ofran, John E Godwin, and See full list of authors in comments

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PRoBE the cloud toolkit: finding the best biomarkers of drug response within a breast cancer clinical trial., Nicholas O'Grady, David L Gibbs, Kawther Abdilleh, Adam Asare, Smita Asare, Sara Venters, Lamorna Brown-Swigart, Gillian L Hirst, Denise Wolf, Christina Yau, Laura J van 't Veer, Laura Esserman, and Amrita Basu

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The TIME Trial® Network facilitates rapid clinical trial activation, patient screening, and enrollment in molecularly targeted trials, Stephanie O'Leary, Megan Shulman, Kevin Ritt, Meghan Degele, Ewelina Protomastro, Jennifer Clauson, Amy Franzen, Ian Churchill Anderson, Minal A. Barve, David N. Oubre, Victor Priego, Angela Saverimuthu, Francis Mark Senecal, Raju Kumar Vaddepally, Kimberly L. Blackwell, and Matthew M. Cooney

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RaPiDS (GOG-3028): randomized Phase II study of balstilimab alone or in combination with zalifrelimab in cervical cancer., David M O'Malley, Leslie M Randall, Camille Gunderson Jackson, Robert L Coleman, John L Hays, Kathleen N Moore, R Wendel Naumann, Rodney P Rocconi, Brian M Slomovitz, Krishnansu S Tewari, Marek Ancukiewicz, Waldo Ortuzar Feliu, and Bradley J Monk

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Breast MRI during Neoadjuvant Chemotherapy: Lack of Background Parenchymal Enhancement Suppression and Inferior Treatment Response., Natsuko Onishi, Wen Li, David C Newitt, Roy J Harnish, Fredrik Strand, Alex Anh-Tu Nguyen, Vignesh Amal Arasu, Jessica Gibbs, Ella F Jones, Lisa J Wilmes, John Kornak, Bonnie N Joe, Elissa R Price, Haydee Ojeda-Fournier, Mohammad Eghtedari, Kathryn W Zamora, Stefanie Woodard, Heidi R Umphrey, Michael T Nelson, An L Church, Patrick J Bolan, Theresa Kuritza, Kathleen Ward, Kevin Morley, Dulcy Wolverton, Kelly Fountain, Dan Lopez Paniagua, Lara Hardesty, Kathleen R Brandt, Elizabeth S McDonald, Mark Rosen, Despina Kontos, Hiroyuki Abe, Deepa Sheth, Erin Crane, Charlotte Dillis, Pulin Sheth, Linda Hovanessian-Larsen, Dae Hee Bang, Bruce Porter, Karen Y Oh, Neda Jafarian, Luminita A Tudorica, Bethany Niell, Jennifer Drukteinis, Mary S Newell, Marina E Giurescu, Elise Berman, Constance D Lehman, Savannah C Partridge, Kimberly A Fitzpatrick, Marisa H Borders, Wei Tse Yang, Basak Dogan, Sally Hayward Goudreau, Thomas Chenevert, Christina Yau, Angela DeMichele, Donald A Berry, Laura J Esserman, and Nola M Hylton

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Radiotherapy Versus Inguinofemoral Lymphadenectomy as Treatment for Vulvar Cancer Patients With Micrometastases in the Sentinel Node: Results of GROINSS-V II., Maaike H M Oonk, Brian Slomovitz, Peter J W Baldwin, Helena C van Doorn, Jacobus van der Velden, Joanne A de Hullu, Katja N Gaarenstroom, Brigitte F M Slangen, Ignace Vergote, Mats Brännström, Eleonora B L van Dorst, Willemien J van Driel, Ralph H Hermans, David Nunns, Martin Widschwendter, David Nugent, Cathrine M Holland, Aarti Sharma, Paul A DiSilvestro, Robert Mannel, Dorry Boll, David Cibula, Al Covens, Diane Provencher, Ingo B Runnebaum, David Luesley, Patricia Ellis, Timothy J Duncan, Ming Y Tjiong, Derek J Cruickshank, Preben Kjølhede, Charles F Levenback, Jiri Bouda, Katharina E Kieser, Connie Palle, Nicola M Spirtos, David M O'Malley, Mario M Leitao, Melissa A Geller, Kalyan Dhar, Viren Asher, Karl Tamussino, Daniel H Tobias, Christer Borgfeldt, Jayanthi S Lea, Jo Bailey, Margareta Lood, Brynhildur Eyjolfsdottir, Stephen Attard-Montalto, Krishnansu S Tewari, Ranjit Manchanda, Pernille T Jensen, Par Persson, Linda Van Le, Hein Putter, Geertruida H de Bock, Bradley J Monk, Carien L Creutzberg, and Ate G J van der Zee

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ASO Author Reflections: Molecular Testing in Breast Cancer: Is Core Biopsy Equivalent to Surgical Specimen?, Javier I Orozco and Janie Grumley

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Is the 21-Gene Recurrence Score on Core Needle Biopsy Equivalent to Surgical Specimen in Early-Stage Breast Cancer? A Comparison of Gene Expression Between Paired Core Needle Biopsy and Surgical Specimens., Javier I J Orozco, Shu-Ching Chang, Chikako Matsuba, Miquel Ensenyat-Mendez, Gary L Grunkemeier, Diego M Marzese, and Janie G Grumley

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ASO Visual Abstract: Is the 21-Gene Recurrence Score on Core Needle Biopsy Equivalent to Surgical Specimen in Early-Stage Breast Cancer? : A Comparison of Gene Expression Between Paired Core Needle Biopsy and Surgical Specimens., Javier I J Orozco, Shu-Ching Chang, Chikako Matsuba, Miquel Ensenyat-Mendez, Gary L Grunkemeier, Diego M Marzese, and Janie G Grumley

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Associations between complete remission and 2- to 3-year survival following 7 + 3 induction for acute myeloid leukemia., Megan Othus, Guillermo Garcia-Manero, John E Godwin, James Weick, Derek Stirewalt, Frederick Appelbaum, Harry Erba, and Elihu Estey

Advances in Immunotherapy, David B Page

Teaming up to Finish Triple-Negative Breast Cancer, David B Page

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399 A phase II study of nivolumab, ipilimumab, plus androgen receptor blockade with bicalutamide to enhance thymic T-cell production and immunotherapy response in metastatic breast cancer, David B Page, Krystle Collins, Brie Chun, Zhaoyu Sun, Yoshinobu Koguchi, William L. Redmond, Maritza Martel, Yaping Wu, Nikki Moxon, Staci Mellinger, Walter Urba, Ayca Gucalp, and Tiffany Traina

A phase II study of nivolumab, ipilimumab, plus androgen receptor blockade with bicalutamide to enhance thymic T-cell production and immunotherapy response in metastatic breast cancer, David B Page, Krystle Collins, Brie Chun, Zhaoyu Sun, Yoshinobu Koguchi, William D Ryan, Maritza Martel, Yaping Wu, Nikki Moxon, Staci Mellinger, Walter Urba, Ayca Gucalp, and Tiffany A. Traina

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OT1-18-04. A phase II study of dual immune checkpoint blockade (ICB) plus bicalutamide to enhance thymic T-cell production and immunotherapy response in metastatic breast cancer (MBC), David B Page, Krystle L. Collins, Brie Chun, Zhaoyu Sun, William L. Redmond, Maritza Martel, Yaping Wu, Nikki Moxon, Staci Mellinger, Walter Urba, Tiffany Traina, and Ayca Gucalp

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Molecular interaction study of novel indoline derivatives with EGFR-kinase domain using multiple computational analysis., Suresh Palanivel, Olli Yli-Harja, and Meenakshisundaram Kandhavelu

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A Randomized Phase II Study of Androgen Deprivation Therapy with or without Palbociclib in RB-positive Metastatic Hormone Sensitive Prostate Cancer (mHSPC)., Phillip L Palmbos, Stephanie Daignault-Newton, Scott A Tomlins, Neeraj Agarwal, Przemyslaw Twardowski, Alicia K Morgans, William K Kelly, Vivek K Arora, Emmanuel S Antonarakis, Javed Siddiqui, Jon Jacobson, Mathew S Davenport, Dan R Robinson, Arul M Chinnaiyan, Karen E Knudsen, and Maha Hussain

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Postinfusion monitoring costs by site of care for patients with relapsed/refractory large B-cell lymphoma receiving third- or later-line treatment with lisocabtagene maraleucel in the TRANSCEND NHL 001 and OUTREACH trials., M Lia Palomba, Monika Parisi Jun, James Lymp, Andy Nguyen, November McGarvey, Matthew Gitlin, Corey Pelletier, Scott J Keating, and John Godwin

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Discovery of Small Molecule Bak Activator for Lung Cancer Therapy., Dongkyoo Park, Abu Syed Md Anisuzzaman, Andrew T Magis, Guo Chen, Maohua Xie, Guojing Zhang, Madhusmita Behera, Gabriel L Sica, Suresh S Ramalingam, Taofeek K Owonikoko, and Xingming Deng

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Translating 2019 ACSM Cancer Exercise Recommendations for a Physiatric Practice - Derived recommendations from an international expert panel., Sara C Parke, Amy Ng, Patrick Martone, Lynn H Gerber, David S Zucker, Jessica Engle, Ekta Gupta, Katherine Power, Jonas Sokolof, Sam Shapar, Leslie Bagay, Bruce E Becker, and David Michael Langelier

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A Systems Approach to Brain Tumor Treatment., James H Park, Adrian Lopez Garcia de Lomana, Diego M Marzese, Tiffany Juarez, Abdullah Feroze, Parvinder Hothi, Charles Cobbs, Anoop P Patel, Santosh Kesari, Sui Huang, and Nitin S Baliga

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Amivantamab in EGFR Exon 20 Insertion-Mutated Non-Small-Cell Lung Cancer Progressing on Platinum Chemotherapy: Initial Results From the CHRYSALIS Phase I Study., Keunchil Park, Eric B Haura, Natasha B Leighl, Paul Mitchell, Catherine A Shu, Nicolas Girard, Santiago Viteri, Ji-Youn Han, Sang-We Kim, Chee Khoon Lee, Joshua K Sabari, Alexander I Spira, Tsung-Ying Yang, Dong-Wan Kim, Ki Hyeong Lee, Rachel E Sanborn, José Trigo, Koichi Goto, Jong-Seok Lee, James Chih-Hsin Yang, Ramaswamy Govindan, Joshua M Bauml, Pilar Garrido, Matthew G Krebs, Karen L Reckamp, John Xie, Joshua C Curtin, Nahor Haddish-Berhane, Amy Roshak, Dawn Millington, Patricia Lorenzini, Meena Thayu, Roland E Knoblauch, and Byoung Chul Cho

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1247P - Management of infusion-related reactions (IRRs) in patients receiving amivantamab, K Park, JK Sabari, EB Haura, CA Shu, A Spira, R Salgia, KL Reckamp, Rachel E Sanborn, R Govindan, JM Bauml, JC Curtin, J Xie, A Roshak, P Lorenzini, D Millington, M Thayu, RE Knoblauch, and BC Cho

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Immune checkpoint inhibitor therapy in HIV-associated Merkel cell carcinoma: A case series of 3 patients., Song Y Park, Candice Church, Nora A Alexander, Michi M Shinohara, Kelly G Paulson, Karl D Lewis, Nancy S Lee, and Paul Nghiem

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TBX2 Drives Neuroendocrine Prostate Cancer through Exosome-Mediated Repression of miR-200c-3p., Girijesh Kumar Patel, Sayanika Dutta, Mosharaf Mahmud Syed, Sabarish Ramachandran, Monica Sharma, Venkatesh Rajamanickam, Vadivel Ganapathy, David J DeGraff, Kevin Pruitt, Manisha Tripathi, and Srinivas Nandana

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Current and future treatment strategies in chronic lymphocytic leukemia., Krish Patel and John M Pagel

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A phase 1 study of SGN-B6A, an antibody-drug conjugate targeting integrin beta-6, in patients with advanced solid tumors (SGNB6A-001, Trial in Progress)., Amita Patnaik, Emiliano Calvo, Rachel E Sanborn, and See list of authors in comments

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Double the Battle: Two Cases of Irreversible Endocrinopathies in Patients Already Fighting Metastatic Cancer., Olesya Petrenko and Nicholas L Stucky

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Mobile Smartphone Thermal Imaging Characterization and Identification of Microvascular Flow Insufficiencies in Deep Inferior Epigastric Artery Perforator Free Flaps., Cody J Phillips, Morgan R Barron, John Kuckelman, Michael Derickson, Vance Y Sohn, Keith T Paige, and Kevin Beshlian

Integrated Personal Omics Profiling for Obesity, Brian D. Piening

Multi-Omics at Providence, Brian D. Piening

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Palbociclib (P) in patients (pts) with head and neck cancer (HNC) with CDKN2A loss or mutation: Results from the Targeted Agent and Profiling Utilization Registry (TAPUR) study., Evan P. Pisick, Matthew Rothe, Rom Leidner, and See list of authors in comments

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961MO - Safety, efficacy, immunogenicity of arenavirus-based vectors HB-201 and HB-202 in patients with HPV16+ cancers, MR Posner, AL Ho, J Niu, L Nabell, Rom Leidner, J Nieva, DL Richardson, AT Pearson, D Wang, K Chung, DR Adkins, A Pimentel, S Wong, C Iacobucci, X Qing, K Katchar, K Schlienger, I Matushansky, S Fu, and DG Pfister

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Targeted genomic analysis of 364 adrenocortical carcinomas., Nikita Pozdeyev, Lauren Fishbein, Laurie M Gay, Ethan S Sokol, Ryan Hartmaier, Jeffrey S Ross, Sourat Darabi, Michael J Demeure, Adwitiya Kar, Lindsey J Foust, Katrina Koc, Daniel W Bowles, Stephen Leong, Margaret E Wierman, and Katja Kiseljak-Vassiliades

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Intralesional TTI-621, a novel biologic targeting the innate immune checkpoint CD47, in patients with relapsed or refractory mycosis fungoides or Sézary syndrome: a multicentre, phase 1 study., Christiane Querfeld, John A Thompson, Matthew H Taylor, Jennifer A DeSimone, Jasmine M Zain, Andrei R Shustov, Carolyn Johns, Sue McCann, Gloria H Y Lin, Penka S Petrova, Robert A Uger, Naomi Molloy, Yaping Shou, and Oleg E Akilov

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Phase II study of the histone deacetylase inhibitor vorinostat (Suberoylanilide Hydroxamic Acid; SAHA) in recurrent or metastatic transitional cell carcinoma of the urothelium - an NCI-CTEP sponsored: California Cancer Consortium trial, NCI 6879., David I Quinn, Denice D Tsao-Wei, Przemyslaw Twardowski, Ana M Aparicio, Paul Frankel, Gurkamal Chatta, John J Wright, Susan G Groshen, Stella Khoo, Heinz-Josef Lenz, Primo N Lara, David R Gandara, and Edward Newman

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Pooled Safety Results Through One Year of Two Phase-3 Trials of Guselkumab in Patients with Psoriatic Arthritis., Proton Rahman, Christopher T Ritchlin, Philip S Helliwell, Wolf-Henning Boehncke, Philip J Mease, Alice B Gottlieb, Shelly Kafka, Alexa P Kollmeier, Elizabeth C Hsia, Xie L Xu, May Shawi, Shihong Sheng, Prasheen Agarwal, Bei Zhou, Paraneedharan Ramachandran, Yanli Zhuang, and Iain B McInnes

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Robust Antitumor Immunity in a Patient with Metastatic Colorectal Cancer Treated with Cytotoxic Regimens., Venkatesh Rajamanickam, Carmen Ballesteros-Merino, Kimberly Samson, David Ross, Brady Bernard, Bernard A Fox, Pippa Newell, Thomas Duhen, and Eric Tran

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1360TiP First-line (1L) maintenance therapy with niraparib (nira) + pembrolizumab (pembro) vs placebo + pembro in advanced/metastatic non-small cell lung cancer (NSCLC): Phase III ZEAL-1L study, SS Ramalingam, G de Castro Jr, MCC Garassino, J Mazieres, Rachel E Sanborn, EFF Smit, DR Spigel, M Thomas, V Velcheti, E Zhi, M Whipple Neibauer, A Stojadinovic, and S Peters

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Eosinophilic fasciitis as a paraneoplastic syndrome in melanoma., Andrea Rea, Alexis Anderson, Ata Moshiri, Kelly G Paulson, John A Thompson, and Andrea Kalus

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Progression to pseudomyxoma peritonei in patients with low grade appendiceal mucinous neoplasms discovered at time of appendectomy., Shelby Reiter, Colin J Rog, Mohamed Alassas, and Evan Ong

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Efficient antigen cross-presentation through coating conventional aluminum adjuvant particles with PEI., Hongyan Ren, Yongbin Mou, Lin Lin, Lixin Wang, and Hongming Hu

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558TiP - Phase I study of effector-function enhanced monoclonal antibody (mAb), SEA-TGT, in advanced malignancies, V Ribrag, D Davar, E Garralda, G Curigliano, J Zain, A Mehta, A Minchom, Rachel E Sanborn, F Foss, HK Oberoi, A Forero-Torres, and S Ansell

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Predictive biomarkers with isatuximab plus pomalidomide and dexamethasone in relapsed/refractory multiple myeloma., Paul G Richardson, Thierry Facon, William I Bensinger, Xavier Leleu, Frank Campana, Sandrine Macé, Marielle Chiron, Helgi van de Velde, and Joseph Mikhael

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Integrative modeling identifies genetic ancestry-associated molecular correlates in human cancer., A Gordon Robertson, Christina Yau, Jian Carrot-Zhang, Jeffrey S Damrauer, Theo A Knijnenburg, Nyasha Chambwe, Katherine A Hoadley, Anab Kemal, Jean C Zenklusen, Andrew D Cherniack, Rameen Beroukhim, and Wanding Zhou

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Evaluation of Indocyanine Green Fluorescence Imaging for Intraoperative Identification of Liver Malignancy., Jorge G Zarate Rodriguez, Jan Grendar, Zeljka Jutric, Maria A Cassera, Ronald F Wolf, Paul D Hansen, and Chet W Hammill

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COVID-19 in patients with CLL: improved survival outcomes and update on management strategies., Lindsey Elizabeth Roeker, Toby Andrew Eyre, Meghan C Thompson, Nicole Lamanna, Alexander Coltoff, Matthew S Davids, Peter Baker, Lori A Leslie, Kerry A Rogers, John N Allan, Raul Cordoba, Alberto Lopez-Garcia, Darko Antic, John M Pagel, Nicolás Martinez-Calle, Jose Antonio Garcia-Marco, José-Ángel Hernández-Rivas, Fatima Miras, Catherine C Coombs, Anders Österborg, Amanda N Seddon, Javier López-Jiménez, Matthew R Wilson, Dima El-Sharkawi, Daniel Wojenski, Shuo Ma, Talha Munir, Susana Valenciano, Erlene Seymour, Paul M Barr, Jeffrey J Pu, Piers Em Patten, Guilherme Fleury Perini, Scott F Huntington, Helen Parry, Suchitra Sundaram, Alan P Skarbnik, Manali Kamdar, Ryan W Jacobs, Harriet Sarah Walter, Renata Walewska, Angus Broom, Sonia Lebowitz, Krista Isaac, Craig A Portell, Inhye E Ahn, Chaitra Ujjani, Mazyar Shadman, Sigrid S Skånland, Elise A Chong, and Anthony R Mato

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Optimal oncologic and perioperative outcomes of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy are attainable at a community center., Colin J Rog, Gary Lucas, Shelby Reiter, Susan Vetto, Mohamed Alassas, and Evan Ong

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596 Combining Bempegaldesleukin (CD122-preferential IL-2 pathway agonist) and NKTR-262 (TLR7/8 agonist) pairs local innate activation with systemic CD8+ T cell expansion to enhance anti-tumor immunity, Annah S Rolig, Daniel Rose, Grace Helen McGee, Saul Kivimae, Werner Rubas, and William L. Redmond

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GM-CSF drives myelopoiesis, recruitment and polarisation of tumour-associated macrophages in cholangiocarcinoma and systemic blockade facilitates antitumour immunity., Luis I Ruffolo, Katherine M Jackson, Peyton C Kuhlers, Benjamin S Dale, Nathania M Figueroa Guilliani, Nicholas A Ullman, Paul R Burchard, Shuyang S Qin, Peter G Juviler, Jessica Millian Keilson, Ashley B Morrison, Mary Georger, Rachel Jewell, Laura M Calvi, Timothy M Nywening, Michael R O'Dell, Aram F Hezel, Luis De Las Casas, Gregory B Lesinski, Jen Jen Yeh, Roberto Hernandez-Alejandro, Brian A Belt, and David C Linehan

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Amivantamab in Post-platinum EGFR Exon 20 Insertion Mutant Non-small Cell Lung Cancer, JK Sabari, CA Shu, K Park, N Leighl, P Mitchell, S Kim, J Lee, D Kim, S Viteri, A Spira, J Han, J Trigo, CK Lee, KH Lee, N Girard, T Yang, K Goto, Rachel E Sanborn, JC Yang, J Xie, A Roshak, M Thayu, RE Knoblauch, and BC Cho

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601 Sequencing immunotherapy before lymphatic ablation unleashes cDC1-dependent antitumor immunity in HNSCC, Robert Saddami-Konefka, Shawn M. Jensen, Bernard A Fox, and See all authors in comments

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Physical Activity Patterns and Relationships With Cognitive Function in Patients With Breast Cancer Before, During, and After Chemotherapy in a Prospective, Nationwide Study., Elizabeth A Salerno, Eva Culakova, Amber S Kleckner, Charles E Heckler, Po-Ju Lin, Charles E Matthews, Alison Conlin, Lora Weiselberg, Jerry Mitchell, Karen M Mustian, and Michelle C Janelsins

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RAMOSE: An Open-Label Randomized Phase II Study of Osimertinib with or without Ramucirumab in TKI-Naïve EGFR-Mutant Metastatic NSCLC, A Saltos, C Baik, Rachel E Sanborn, E Shum, C Kim, R Hall, MJ Fidler, CA Shu, G Otterson, J Patel, K Wong, N Hanna, J Gray, J Heymach, and X Le