The Cancer Institute is a leader in cutting-edge treatments. Using a truly multidisciplinary approach, patients have access to advanced diagnostics, minimally invasive surgical interventions, and personalized genomic and immune-oncologic treatment options. Our team of cancer specialists – many of whom completed fellowships and specialty training at prestigious academic centers – offers comprehensive services for individuals with a cancer diagnosis.

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Submissions from 2020

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Pemigatinib for previously treated, locally advanced or metastatic cholangiocarcinoma: a multicentre, open-label, phase 2 study., Ghassan K Abou-Alfa, Vaibhav Sahai, Antoine Hollebecque, Gina Vaccaro, Davide Melisi, Raed Al-Rajabi, Andrew S Paulson, Mitesh J Borad, David Gallinson, Adrian G Murphy, Do-Youn Oh, Efrat Dotan, Daniel V Catenacci, Eric Van Cutsem, Tao Ji, Christine F Lihou, Huiling Zhen, Luis Féliz, and Arndt Vogel

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Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer., Joanna Achinger-Kawecka, Fatima Valdes-Mora, Phuc-Loi Luu, Katherine A Giles, C Elizabeth Caldon, Wenjia Qu, Shalima Nair, Sebastian Soto, Warwick J Locke, Nicole S Yeo-Teh, Cathryn M Gould, Qian Du, Grady C Smith, Irene R Ramos, Kristine F Fernandez, Dave S B Hoon, Julia M W Gee, Clare Stirzaker, and Susan J Clark

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Cytotoxic T cell depletion with increasing epithelial abnormality in women with benign breast disease., Sabina Adhikary, Tanya L Hoskin, Melody L Stallings-Mann, Muhammad Arshad, Marlene H Frost, Stacey J Winham, Alvaro Peña, Delphine J Lee, Linda M Murphy, Michele Rakoff, Lori A Denison, Keith L Knutson, Derek C Radisky, Daniel W Visscher, and Amy C Degnim

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A generalizable data-driven multicellular model of pancreatic ductal adenocarcinoma., Boris Aguilar, David L Gibbs, David J Reiss, Mark McConnell, Samuel A Danziger, Andrew Dervan, Matthew Trotter, Douglas Bassett, Robert Hershberg, Alexander V Ratushny, and Ilya Shmulevich

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Preoperative imaging characteristics predict poor survival and inadequate resection for left-sided pancreatic adenocarcinoma: a multi-institutional analysis., Farzad Alemi, Zeljka Jutric, George R Marshall, Elliot J Scott, Jan Grendar, Alexandra M Roch, Lucio L Pereira, An-Lin Cheng, Paul D Hansen, Eugene P Ceppa, Horacio J Asbun, Susanne Warner, and Adnan A Alseidi

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Intratumoral delivery of tavokinogene telseplasmid yields systemic immune responses in metastatic melanoma patients., A Algazi, S Bhatia, S Agarwala, M Molina, K Lewis, M Faries, L Fong, L P Levine, M Franco, A Oglesby, C Ballesteros-Merino, C B Bifulco, B A Fox, D Bannavong, R Talia, E Browning, M H Le, R H Pierce, S Gargosky, K K Tsai, C Twitty, and A I Daud

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Phase II Trial of IL-12 Plasmid Transfection and PD-1 Blockade in Immunologically Quiescent Melanoma., Alain P Algazi, Christopher G Twitty, Katy K Tsai, Mai Le, Robert Pierce, Erica Browning, Reneta Hermiz, David A Canton, Donna Bannavong, Arielle Oglesby, Murray Francisco, Lawrence Fong, Mikael J Pittet, Sean P Arlauckas, Christopher Garris, Lauren P Levine, Carlo Bifulco, Carmen Ballesteros-Merino, Shailender Bhatia, Sharron Gargosky, Robert H I Andtbacka, Bernard A Fox, Michael D Rosenblum, and Adil I Daud

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Estrogen and Progesterone Receptor Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Guideline Update., Kimberly H Allison, M Elizabeth H Hammond, Mitchell Dowsett, Shannon E McKernin, Lisa A Carey, Patrick L Fitzgibbons, Daniel F Hayes, Sunil R Lakhani, Mariana Chavez-MacGregor, Jane Perlmutter, Charles M Perou, Meredith M Regan, David L Rimm, W Fraser Symmans, Emina E Torlakovic, Leticia Varella, Giuseppe Viale, Tracey F Weisberg, Lisa M McShane, and Antonio C Wolff

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Estrogen and Progesterone Receptor Testing in Breast Cancer: ASCO/CAP Guideline Update., Kimberly H Allison, M Elizabeth H Hammond, Mitchell Dowsett, Shannon E McKernin, Lisa A Carey, Patrick L Fitzgibbons, Daniel F Hayes, Sunil R Lakhani, Mariana Chavez-MacGregor, Jane Perlmutter, Charles M Perou, Meredith M Regan, David L Rimm, W Fraser Symmans, Emina E Torlakovic, Leticia Varella, Giuseppe Viale, Tracey F Weisberg, Lisa M McShane, and Antonio C Wolff

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Physiological and Pathological Roles of Cdk5: Potential Directions for Therapeutic Targeting in Neurodegenerative Disease., Annamarie B Allnutt, Ariana K Waters, Santosh Kesari, and Venkata Mahidhar Yenugonda

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Intracellular Galectin-3 Is Essential for OX40-Mediated Memory CD8, Mohammad Farhad Amani, Annah S Rolig, and William L. Redmond

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Incorporating Breast Cancer Recurrence Events Into Population-Based Cancer Registries Using Medical Claims: Cohort Study., Teresa A'mar, J David Beatty, Catherine Fedorenko, Daniel Markowitz, Thomas Corey, Jane Lange, Stephen M Schwartz, Bin Huang, Jessica Chubak, and Ruth Etzioni

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Sgnlva-005: Open-label, phase II study of ladiratuzumab vedotin (LV) for advanced aerodigestive tract malignancies, Ian Churchill Anderson, Yinghui Wang, Zejing Wang, and Rachel E Sanborn

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Safety and activity of varlilumab, a novel and first-in-class agonist anti-CD27 antibody, for hematologic malignancies., Stephen M Ansell, Ian Flinn, Matthew H Taylor, Branimir I Sikic, Joshua Brody, John Nemunaitis, Andrew Feldman, Thomas R Hawthorne, Tracey Rawls, Tibor Keler, and Michael J Yellin

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Updates on the Management of Thyroid Cancer., Katherine A Araque, Sriram Gubbi, and Joanna Klubo-Gwiezdzinska

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Pembrolizumab in relapsed or refractory Richter syndrome., Philippe Armand, Niels Murawski, Daniel Molin, Jasmine Zain, Barbara Eichhorst, Zafer Gulbas, Eliza A Hawkes, John M Pagel, Tycel Phillips, Vincent Ribrag, Jakub Svoboda, Anastasios Stathis, Arkendu Chatterjee, Robert Orlowski, Patricia Marinello, and Beth Christian

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The Society for Immunotherapy of Cancer perspective on regulation of interleukin-6 signaling in COVID-19-related systemic inflammatory response, Fernanda I. Arnaldez, Steven J. O'Day, Charles G. Drake, Bernard A Fox, Bingqing Fu, Walter Urba, Vincenzo Montesarchio, Jeffrey S. Weber, Haiming Wei, Jon M. Wigginton, and Paolo Antonio Ascierto

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Phase II Trial of Carfilzomib Plus Irinotecan in Patients with Small Cell Lung Cancer Who Have Progressed on Prior Platinum-Based Chemotherapy., Susanne M. Arnold, Kari Chansky, Maria Q. Baggstrom, Michael A. Thompson, Rachel E Sanborn, John L. Villano, Saiama N. Wagar, John Hamm, Markos Leggas, Maurice Willis, Joseph Rosales, and John J. Crowley

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Phase II Trial of Carfilzomib Plus Irinotecan in Patients With Small-cell Lung Cancer Who Have Progressed on Prior Platinum-based Chemotherapy., Susanne M Arnold, Kari Chansky, Maria Q Baggstrom, Michael A Thompson, Rachel E Sanborn, John L Villano, Saiama N Waqar, John Hamm, Markos Leggas, Maurice Willis, Joseph Rosales, and John J Crowley

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Insights from immuno-oncology: The Society for Immunotherapy of Cancer statement on access to IL-6-targeting therapies for COVID-19, Paolo A. Ascierto; Bernard A Fox; Walter Urba; Ana Carrizosa Anderson; Michael Atkins; Ernest C. Borden; Julie R. Brahmer; Lisa H. Butterfield; Alessandra Cesano; Daniel S. Chen; Tanja D. De Gruijl; Robert O. Dillman; Charles G. Drake; Leisha A. Emens; Thomas F. Gajewski; James L. Gulley; F Stephen Hodi, Jr.; Patrick Hwu; David Kaufman; Howard L. Kaufman; Michael T. Lotze; Francesco M. Marincola; Kim A. Margolin; Michael J. Mastrangelo; Marcela V. Maus; Douglas G. McNeel; David R. Parkinson; Pedro J. Romero; Paul M. Sondel; Stefani Spranger; Mario Sznol; George J. Weiner; Jon M. Wigginton; and Jeffrey S. Weber

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Insights from immuno-oncology: the Society for Immunotherapy of Cancer Statement on access to IL-6-targeting therapies for COVID-19., Paolo Antonio Ascierto, Bernard A Fox, Walter Urba, Ana Carrizosa Anderson, Michael B Atkins, Ernest C Borden, Julie Brahmer, Lisa H Butterfield, Alessandra Cesano, Daniel Chen, Tanja de Gruijl, Robert O Dillman, Charles G Drake, Leisha A Emens, Thomas F Gajewski, James L Gulley, F Stephen Hodi, Patrick Hwu, David Kaufman, Howard Kaufman, Michael Lotze, Douglas G McNeel, Kim Margolin, Francesco Marincola, Michael J Mastrangelo, Marcela V Maus, David R Parkinson, Pedro J Romero, Paul M Sondel, Stefani Spranger, Mario Sznol, George J Weiner, Jon M Wiggington, and Jeffrey S Weber

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Disparities in Risk Reduction Therapy Recommendations for Young Women With Lobular Carcinoma In-Situ., Bradley Bandera, Amy Voci, Daniel Nelson, Stacey L Stern, Dany Barrak, Trevan D Fischer, Maggie L DiNome, and Melanie Goldfarb

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A Mother in Jeopardy: The Ethics of Pregnancy and Chemotherapy., Steven J Baumrucker, Wendy H Vogel, Robert M Stolick, Russell W Adkins, Heather Holland, Gregg VandeKieft, and Angela Eastridge

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Peptidomimetic Polo-Box-Targeted Inhibitors that Engage PLK1 in Tumor Cells and Are Selective against the PLK3 Tumor Suppressor., Merissa Baxter, Danda Chapagai, Sandra Craig, Cecilia Hurtado, Jessy Varghese, Elmar Nurmemmedov, Michael D Wyatt, and Campbell McInnes

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Cohort Expansion Study of Neoadjvuant Immunoradiotherapy in Locoregionally Advanced HPV+ and HPV- Head and Neck Squamous Cell Carcinoma, Richard Bryan Bell, Rom Leidner, Kristina H Young, Brendan Curti, Marcus Couey, A Patel, Amber L Watters, Hong D Xiao, G Morris, L Rushforth, Michael J. Gough, and Marka R Crittenden

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Medial Femoral Condyle Vascularized Bone Graft for Treatment of Midshaft Clavicle Recalcitrant Nonunion With Use of the Transverse Cervical Artery as an Anastomosis., Christopher M Belyea, Jefferson L Lansford, Joseph B Golden, Emily H Shin, and Rey D L Gumboc

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Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-γ, CXCL9 and CXCL10., Cristina Bergamaschi, Hrishikesh Pandit, Bethany A Nagy, Dimitris Stellas, Shawn M. Jensen, Jenifer Bear, Maggie Cam, Antonio Valentin, Bernard A Fox, Barbara K Felber, and George N Pavlakis

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Dendritic Cell Maturation Defines Immunological Responsiveness of Tumors and Radiation, Tiffany Blair, S Bambina, Alejandro F Alice, Gwen Kramer, Jason R Baird, Terry R Medler, V Troesch, Marka R Crittenden, and Michael J. Gough

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Dendritic Cell Maturation Defines Immunological Responsiveness of Tumors to Radiation Therapy., Tiffany C Blair, Shelly Bambina, Alejandro F Alice, Gwen Kramer, Terry R Medler, Jason R Baird, Miranda L Broz, Garth W Tormoen, Victoria Troesch, Marka R Crittenden, and Michael J. Gough

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Salvage Lung Resections After Definitive Chemoradiotherapy: A Safe and Effective Oncologic Option., Adam J Bograd, Catherine Mann, Jed A Gorden, Christopher R Gilbert, Alexander S Farivar, Ralph W Aye, Brian Louie, and Eric Vallières

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Surgery as a Component of Multimodality Care for Known Stage IIIA-N2 Non-small Cell Lung Cancer., Adam J Bograd and Eric Vallières

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Part Two: 8. Immunology, Christine Boley Ed.

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Transcriptome-wide association study reveals candidate causal genes for lung cancer., Yohan Bossé, Zhonglin Li, Jun Xia, Venkata Manem, Robert Carreras-Torres, Aurélie Gabriel, Nathalie Gaudreault, Demetrius Albanes, Melinda C Aldrich, Angeline Andrew, Susanne Arnold, Heike Bickeböller, Stig E Bojesen, Paul Brennan, Hans Brunnstrom, Neil Caporaso, Chu Chen, David C Christiani, John K Field, Gary E Goodman, Kjell Grankvist, Richard Houlston, Mattias Johansson, Mikael Johansson, Lambertus A Kiemeney, Stephen Lam, Maria T Landi, Philip Lazarus, Loic Le Marchand, Geoffrey Liu, Olle Melander, Gadi Rennert, Angela Risch, Susan M Rosenberg, Matthew B Schabath, Sanjay Shete, Zhuoyi Song, Victoria L Stevens, Adonina Tardon, H-Erich Wichmann, Penella Woll, Shan Zienolddiny, Ma'en Obeidat, Wim Timens, Rayjean J Hung, Philippe Joubert, Christopher I Amos, and James D McKay

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Robotic Partial Nephrectomy versus Minimally Invasive Radical Nephrectomy for Clinical T2a Renal Mass: A Propensity Score Matched Comparison from the ROSULA (Robotic Surgery for Large Renal Mass) Collaborative Group., Aaron W Bradshaw, Riccardo Autorino, Giuseppe Simone, Bo Yang, Robert G Uzzo, Francesco Porpiglia, Umberto Capitanio, James R Porter, Riccardo Bertolo, Andrea Minervini, Clayton Lau, Kenneth Jacobsohn, Akbar Ashrafi, Daniel Eun, Alexander Mottrie, Wesley M White, Luigi Schips, Benjamin J Challacombe, Ottavio De Cobelli, Carmen M Mir, Alessandro Veccia, Alessandro Larcher, Alexander Kutikov, Monish Aron, Prokar Dasgupta, Francesco Montorsi, Inderbir S Gill, Chandru P Sundaram, Jihad Kaouk, and Ithaar H Derweesh

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Core Curriculum for Oncology Nursing 6th ed. St. Louis, MO: Elsevier., Jeannine M. Brant, Diane G. Cope, and Marlon G Saria

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Integrated Assessment of Circulating Cell-Free MicroRNA Signatures in Plasma of Patients with Melanoma Brain Metastasis., Matias Bustos, Kevin Tran, Negin Rahimzadeh, Rebecca Gross, Selena Y Lin, Yoshiaki Shoji, Tomohiro Murakami, Christine L Boley, Linh T Tran, Hunter Cole, Daniel F Kelly, Steven J O'Day, and Dave Hoon

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Margetuximab plus pembrolizumab in patients with previously treated, HER2-positive gastro-oesophageal adenocarcinoma (CP-MGAH22-05): a single-arm, phase 1b-2 trial., Daniel V T Catenacci, Yoon-Koo Kang, Haeseong Park, Hope E Uronis, Keun-Wook Lee, Matthew C H Ng, Peter C Enzinger, Se Hoon Park, Philip J Gold, Jill Lacy, Howard S Hochster, Sang Cheul Oh, Yeul Hong Kim, Kristen A Marrone, Ronan J Kelly, Rosalyn A Juergens, Jong Gwang Kim, Johanna C Bendell, Thierry Alcindor, Sun Jin Sym, Eun-Kee Song, Cheng Ean Chee, Yee Chao, Sunnie Kim, A Craig Lockhart, Keith L Knutson, Jennifer Yen, Aleksandra Franovic, Jeffrey L Nordstrom, Daner Li, Jon Wigginton, Jan K Davidson-Moncada, Minori Koshiji Rosales, Yung-Jue Bang, and CP-MGAH22-5 Study Group

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Minimally Invasive Esophagectomy: A Consensus Statement., Robert J Cerfolio, Anne-Sophie Laliberte, Shanda Blackmon, Jelle P Ruurda, Richard van Hillegersberg, Inderpal Sarkaria, and Brian Louie

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Hysterectomy Versus Hysteropexy at the Time of Native Tissue Pelvic Organ Prolapse Repair: A Cost-Effectiveness Analysis., Olivia H Chang, Jonathan P Shepherd, Beri M Ridgeway, and Lauren A Cadish

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Patient-reported outcomes at discontinuation of anti-angiogenesis therapy in the randomized trial of chemotherapy with bevacizumab for advanced cervical cancer: an NRG Oncology Group study., Dana Chase, Helen Q Huang, Bradley J Monk, Lois Michelle Ramondetta, Richard T Penson, Karen Gil, Lisa M Landrum, Mario Leitao, Ana Oaknin, Warner K Huh, Heather L Pulaski, Katina Robison, Saketh R Guntupalli, Debra Richardson, Ritu Salani, Michael W Sill, Lari B Wenzel, and Krishnansu S Tewari

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Allosteric inhibitor of β-catenin selectively targets oncogenic Wnt signaling in colon cancer., Anton Cheltsov, Natsuko Nomura, Venkata Mahidhar Yenugonda, Jatin Roper, Rajesh Mukthavaram, Pengfei Jiang, Nam-Gu Her, Ivan Babic, Santosh Kesari, and Elmar Nurmemmedov

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Enhanced B7-H4 expression in gliomas with low PD-L1 expression identifies super-cold tumors., Di Chen, Gaopeng Li, Chunxia Ji, Qiqi Lu, Ying Qi, Chao Tang, Ji Xiong, Jian Hu, Fatma Betul Aksoy Yasar, Yan Zhang, Dave S B Hoon, Yu Yao, and Liangfu Zhou

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Multimodality screening and prevention of cervical cancer in sub-Saharan Africa: a collaborative model., Justine Chinn and Krishnansu S Tewari

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A phase II trial evaluating the efficacy of high-dose Radioiodinated Tositumomab (Anti-CD20) antibody, etoposide and cyclophosphamide followed by autologous transplantation, for high-risk relapsed or refractory non-hodgkin lymphoma., Victor A Chow, Joseph G Rajendran, Darrell R Fisher, Frederick R Appelbaum, Ryan D Cassaday, Paul S Martin, Leona A Holmberg, Theodore A Gooley, Philip A Stevenson, John M Pagel, Damian J Green, Oliver W Press, and Ajay K Gopal

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Oncology Care Delivery in the COVID-19 Pandemic: An Opportunity to Study Innovations and Outcomes., Pelin Cinar, John Cox, Arif Kamal, Kathleen Bickel, Monika Krzyzanowska, James Armitage, Apar Kishor Ganti, Jeffery C Ward, Sandra Wong, Sagar Lonial, and Linda Bosserman

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Results of a randomized phase IIb trial of nelipepimut-S + trastuzumab vs trastuzumab to prevent recurrences in high-risk HER2 low-expressing breast cancer patients., G Travis Travis Clifton, Diane Hale, Timothy J Vreeland, Annelies T Hickerson, Jennifer K Litton, Gheath Alatrash, Rashmi K Murthy, Na Qiao, Anne V Philips, Jason J Lukas, Jarrod P Holmes, George E Peoples, and Elizabeth A Mittendorf

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Patient-reported outcomes from KATHERINE: A phase 3 study of adjuvant trastuzumab emtansine versus trastuzumab in patients with residual invasive disease after neoadjuvant therapy for human epidermal growth factor receptor 2-positive breast cancer., PierFranco Conte, Andreas Schneeweiss, Sibylle Loibl, Eleftherios P Mamounas, Gunter von Minckwitz, Max S Mano, Michael Untch, Chiun-Sheng Huang, Norman Wolmark, Priya Rastogi, Veronique D'Hondt, Andrés Redondo, Ljiljana Stamatovic, Hervé Bonnefoi, Hugo Castro-Salguero, Hans H Fischer, Tanya Wahl, Chunyan Song, Thomas Boulet, Peter Trask, and Charles E Geyer

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The Impact of Late Luteinizing Hormone-Releasing Hormone Agonist Dosing on Testosterone Suppression in Patients with Prostate Cancer: An Analysis of United States Clinical Data., E David Crawford, Przemyslaw Twardowski, Raoul S Concepcion, Jason M Hafron, Richard G Harris, Judd W Moul, Lucio N Gordan, Daniel P Petrylak, Stuart N Atkinson, Deborah M Boldt-Houle, Thomas E Keane, Celestia S Higano, R Jonathan Henderson, A Karim Kader, Maha H Hussain, and Neal D Shore

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Randomized phase II study of stereotactic body radiotherapy and interleukin-2 versus interleukin-2 in patients with metastatic melanoma., Brendan Curti, Marka R Crittenden, Steven K Seung, Christopher B Fountain, Roxanne Payne, ShuChing Chang, Jessica Fleser, Kimberly Phillips, Ian Malkasian, Lyn B Dobrunick, and Walter Urba

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Predictive Biomarkers for Immunotherapy Response Beyond PD-1/PD-L1., Sourat Darabi, David R Braxton, Burton L Eisenberg, and Michael J Demeure

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Olaparib for Metastatic Castration-Resistant Prostate Cancer., Johann de Bono, Joaquin Mateo, Karim Fizazi, Fred Saad, Neal Shore, Shahneen Sandhu, Kim N Chi, Oliver Sartor, Neeraj Agarwal, David Olmos, Antoine Thiery-Vuillemin, Przemyslaw Twardowski, Niven Mehra, Carsten Goessl, Jinyu Kang, Joseph Burgents, Wenting Wu, Alexander Kohlmann, Carrie A Adelman, and Maha Hussain

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Bempegaldesleukin (NKTR-214) plus Nivolumab in Patients with Advanced Solid Tumors: Phase I Dose-Escalation Study of Safety, Efficacy, and Immune Activation (PIVOT-02)., Adi Diab, Nizar M Tannir, Salah-Eddine Bentebibel, Patrick Hwu, Vassiliki Papadimitrakopoulou, Cara Haymaker, Harriet M Kluger, Scott N Gettinger, Mario Sznol, Scott S Tykodi, Brendan Curti, Mary A Tagliaferri, Jonathan Zalevsky, Alison L Hannah, Ute Hoch, Sandra Aung, Christie Fanton, Ahsan Rizwan, Ernesto Iacucci, Yijie Liao, Chantale Bernatchez, Michael E Hurwitz, and Daniel C Cho

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Autologous mastectomy reconstruction: Communication among the breast surgery team to maximize aesthetic and oncologic outcome., Brian P Dickinson, Dennis Holmes, Nikkie Vu-Huynh, Monica B Vu, Lincoln Snyder, Heather MacDonald, Lisa Guerra, Colleen Coleman, Crystal Fancher, Nahid Hamoui, Sadia Khan, Sadie Kim, January Lopez, Jennifer Overstreet, and Peter H Ashjian

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Disparities in Amputation Rates for Non-metastatic Extremity Soft Tissue Sarcomas and the Impact on Survival., Joshua C Dilday, Daniel W Nelson, Trevan D Fischer, and Melanie Goldfarb

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Glioblastoma Multiforme Stem Cell Cycle Arrest by Alkylaminophenol Through the Modulation of EGFR and CSC Signaling Pathways., Phuong Doan, Aliyu Musa, Akshaya Murugesan, Vili Sipilä, Nuno R Candeias, Frank Emmert-Streib, Pekka Ruusuvuori, Kirsi Granberg, Olli Yli-Harja, and Meenakshisundaram Kandhavelu

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Evolution of a 4-Benzyloxy-benzylamino Chemotype to Provide Efficacious, Potent, and Isoform Selective PPARα Agonists as Leads for Retinal Disorders., Xiaozheng Dou, Dinesh Nath, Henry Shin, Elmar Nurmemmedov, Philip C Bourne, Jian-Xing Ma, and Adam S Duerfeldt

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Scrotal and Penile Erythrodysesthesia Associated with Neoadjuvant Capecitabine Chemoradiation., Julie Dricken, Erica Pettke, John A Griffin, Henry Y Li, and Vivek Mehta

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Real-world burden of myelosuppression in patients with small cell lung cancer (SCLC): Retrospective, longitudinal data analysis., Robert S. Epstein, JoAnn Krenitsky, Roshanthi Weerasinghe, Amy S. Parrish, Rachel E Sanborn, and Tehseen Salimi

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Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase., Justin T Ernst, Peggy A Thompson, Christian Nilewski, Paul A Sprengeler, Samuel Sperry, Garrick Packard, Theodore Michels, Alan Xiang, Chinh Tran, Christopher J Wegerski, Boreth Eam, Nathan P Young, Sarah Fish, Joan Chen, Haleigh Howard, Jocelyn Staunton, Jolene Molter, Jeff Clarine, Andres Nevarez, Gary G Chiang, Jim R Appleman, Kevin R Webster, and Siegfried H Reich

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Resolution of eicosanoid/cytokine storm prevents carcinogen and inflammation-initiated hepatocellular cancer progression., Anna Fishbein, Weicang Wang, Haixia Yang, Jun Yang, Victoria M Hallisey, Jianjun Deng, Sanne M L Verheul, Sung Hee Hwang, Allison Gartung, Yuxin Wang, Diane R Bielenberg, Sui Huang, Mark W Kieran, Bruce D Hammock, and Dipak Panigrahy

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A profile on the FoundationFocus CDxBRCA tests., Lindsey Ford, Juliet E Wolford, Sandra Brown, and Leslie M Randall

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The combination of ibrutinib and rituximab demonstrates activity in first-line follicular lymphoma., Nathan H Fowler, Loretta Nastoupil, Sven De Vos, Mark Knapp, Ian W Flinn, Robert Chen, Ranjana H Advani, Sumeet Bhatia, Peter Martin, Raul Mena, Richard Eric Davis, Sattva S Neelapu, Karl Eckert, Jerry Ping, Melannie Co, Darrin M Beaupre, Jutta K Neuenburg, and M Lia Palomba

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Prior tonsillectomy is associated with an increased risk of esophageal adenocarcinoma., Katherine S Garman, Teminioluwa A Ajayi, Harold J Boutte, Shih-Ting Chiu, Richard J von Furstenberg, Benjamin R Lloyd, Cecelia Zhang, Mark W Onaitis, Shein-Chung Chow, and Shannon J McCall

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Life Is Really Simple, but We Insist on Making It Complicated-Lessons From Confucius on Ultrasound Use in the ICU., Christopher R Gilbert, Fabien Maldonado, Lonny B Yarmus, Jason A Akulian, Candice Wilshire, and Jed A Gorden

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Life Is Really Simple, but We Insist on Making It Complicated-Lessons From Confucius on Ultrasound Use in the ICU., Christopher R Gilbert, Fabien Maldonado, Lonny B Yarmus, Jason A Akulian, Candice L Wilshire, and Jed A Gorden

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Poor Monitor Screen Height Positioning by Pulmonologists During Flexible Bronchoscopy: A Nested, Prospective Observational Trial., Christopher R Gilbert, Jeffrey Thiboutot, Alexander Chen, A Christine Argento, Nicholas J Pastis, Hans J Lee, Andrew D Lerner, and Lonny B Yarmus

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Assessment of Ergonomic Strain and Positioning During Bronchoscopic Procedures: A Feasibility Study., Christopher R Gilbert, Jeffrey Thiboutot, Christopher Mallow, Alexander Chen, Nicholas J Pastis, A Christine Argento, Jennifer Millar, Robert A Lavin, Andrew D Lerner, Diana H Yu, Ben Salwen, Daniel Lunz, Hans J Lee, and Lonny B Yarmus

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Management of Indwelling Tunneled Pleural Catheters: A Modified Delphi Consensus Statement., Christopher R Gilbert, Momen M Wahidi, Richard W Light, M Patricia Rivera, Daniel H Sterman, Rajesh Thomas, Samira Shojaee, Shmuel Shoham, Ionnis Psallidas, David E Ost, Daniela Molena, Nick Maskell, Fabien Maldonado, Moishe Liberman, Y C Gary Lee, Hans Lee, Felix J F Herth, Horiana Grosu, Jed A Gorden, Edward T H Fysh, John P Corcoran, A Christine Argento, Jason A Akulian, Najib M Rahman, and Lonny B Yarmus

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Part One: 2. Screening and Early Detection, Jaya M. Gill Ed.

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Safety and Clinical Activity of MEDI0562, a Humanized OX40 Agonist Monoclonal Antibody, in Adult Patients with Advanced Solid Tumors., Bonnie S Glisson, Rom Leidner, Robert L Ferris, John Powderly, Naiyer A Rizvi, Bhumsuk Keam, Reva Schneider, Sanjay Goel, James P Ohr, Jennifer Burton, Yanan Zheng, Steven Eck, Matthew Gribbin, Katie Streicher, Danielle M Townsley, and Sandip Pravin Patel

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Blood test shows high accuracy in detecting stage I non-small cell lung cancer., Cherylle Goebel, Christopher L Louden, Robert McKenna, Osita Onugha, Andrew Wachtel, and Thomas Long

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Recent advances in the understanding and management of primary hyperparathyroidism., Melanie Goldfarb and Frederick R Singer

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Utilization of Claims Data in Research: Are We Missing the Forest and the Trees?, Jed A Gorden, Candice Wilshire, and Christopher R Gilbert

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Using Preclinical Data to Design Combination Clinical Trials of Radiation Therapy and Immunotherapy., Michael J. Gough, Shay Sharon, Marka R Crittenden, and Kristina H Young

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Pembrolizumab immunotherapy for relapsed CNS Lymphoma., Jerome J Graber, Benjamin Plato, Raya Mawad, and Daniel J Moore

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A phase II single-arm study of pembrolizumab with enzalutamide in men with metastatic castration-resistant prostate cancer progressing on enzalutamide alone., Julie N Graff, Tomasz M Beer, Joshi J Alumkal, Rachel E Slottke, William L. Redmond, George V Thomas, Reid F Thompson, Mary A Wood, Yoshinobu Koguchi, Yiyi Chen, Emile Latour, Raymond C Bergan, Charles G Drake, and Amy E Moran

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TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking., Andrew J Gunderson, Tomoko Yamazaki, Kayla McCarty, Nathaniel E Fox, Michaela Phillips, Alejandro F Alice, Tiffany Blair, Mark Whiteford, David O'Brien, Rehan Ahmad, Maria X Kiely, Amanda Hayman, Todd Crocenzi, Michael J. Gough, Marka R. Crittenden, and Kristina H Young

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Novel application of vinylpolysiloxane hearing aid impression mold as patient-specific bolus for head and neck cancer radiotherapy., Anne Elizabeth Gunter, John Burgoyne, Min Park, Namou Kim, Daliang Cao, and Vivek Mehta

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Surveillance for second breast cancer events in women with a personal history of breast cancer using breast MRI: a systematic review and meta-analysis., Cameron B Haas, Larissa Nekhlyudov, Janie M Lee, Sara H Javid, Mary Bush, Dianne Johnson, Timothy Gleason, Cary Kaufman, Jennifer Specht, Sean Stitham, and Karen J Wernli

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Perianal basal cell carcinoma: a common cancer in an uncommon location., Ed Hagen, Nathan Hite, John A Griffin, and Rodney Kratz

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Laparoscopic Transhiatal Esophagectomy for Invasive Esophageal Adenocarcinoma., Kelly R Haisley, Walaa F Abdelmoaty, and Christy M Dunst

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Results of Lung Cancer Screening in the Community., John R Handy, Michael Skokan, Erika Rauch, Steven Zinck, Rachel E Sanborn, Svetlana Kotova, and Mansen Wang

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How we treat left-sided vs right-sided colon cancer., Diana L Hanna and Heinz-Josef Lenz

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The Effects of Music Medicine on Reducing Distress, Anxiety, and Pain During Bone Marrow Biopsy Procedures, Betsy Hartman, Sharon Mast, and Judy Delismon

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Use of Convalescent Plasma in Hospitalized Patients with Covid-19 - Case Series., Livia Hegerova, Ted Gooley, Kelly A Sweerus, Cynthia L Maree, Neil Bailey, Megumi Bailey, Vanessa Dunleavy, Krish Patel, Kirsten Alcorn, N Rebecca Haley, Jill M Johnsen, Barbara A Konkle, Annamarie C Lahti, Morgan L Alexander, Jason D Goldman, Anne B Lipke, Sun-Jung Lim, Mark David Sullivan, John S Pauk, and John M Pagel

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Cellular thermal shift analysis for interrogation of CRISPR-assisted proteomic changes., Nam-Gu Her, Ivan Babic, Venkata Yenugonda, Santosh Kesari, and Elmar Nurmemmedov

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Thrombospondin-1 counteracts the p97 inhibitor CB-5083 in colon carcinoma cells., Nam-Gu Her, Santosh Kesari, and Elmar Nurmemmedov

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Stapled Diaphragmatic Plication: Is It Better Than Suture Plication?, Terra M Hill and Osita Onugha

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Breast cancer care during a pandemic: an opportune time for cryoablation?, Dennis R Holmes

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Complete response with talimogene laherparepvec in recurrent melanoma of the ear: A case report., Ashley C Hsu, Niels C Kokot, Burton L Eisenberg, and Jacob S Thomas

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Association of Event-Free and Distant Recurrence-Free Survival With Individual-Level Pathologic Complete Response in Neoadjuvant Treatment of Stages 2 and 3 Breast Cancer: Three-Year Follow-up Analysis for the I-SPY2 Adaptively Randomized Clinical Trial., I-SPY2 Trial Consortium, Douglas Yee, Angela M DeMichele, Christina Yau, Claudine Isaacs, W Fraser Symmans, Kathy S Albain, Yunn-Yi Chen, Gregor Krings, Shi Wei, Shuko Harada, Brian Datnow, Oluwole Fadare, Molly Klein, Stefan Pambuccian, Beiyun Chen, Kathi Adamson, Sharon Sams, Paulette Mhawech-Fauceglia, Anthony Magliocco, Mike Feldman, Mara Rendi, Husain Sattar, Jay Zeck, Idris T Ocal, Ossama Tawfik, Lauren Grasso LeBeau, Sunati Sahoo, Tuyethoa Vinh, A Jo Chien, Andres Forero-Torres, Erica Stringer-Reasor, Anne M Wallace, Lajos Pusztai, Judy C Boughey, Erin D Ellis, Anthony D Elias, Janice Lu, Julie E Lang, Hyo S Han, Amy S Clark, Rita Nanda, Donald W Northfelt, Qamar J Khan, Rebecca K Viscusi, David M Euhus, Kirsten K Edmiston, Stephen Y Chui, Kathleen Kemmer, John W Park, Minetta C Liu, Olufunmilayo Olopade, Brian Leyland-Jones, Debasish Tripathy, Stacy L Moulder, Hope S Rugo, Richard Schwab, Shelly Lo, Teresa Helsten, Heather Beckwith, Patricia Haugen, Nola M Hylton, Laura J Van't Veer, Jane Perlmutter, Michelle E Melisko, Amy Wilson, Garry Peterson, Adam L Asare, Meredith B Buxton, Melissa Paoloni, Julia L Clennell, Gillian L Hirst, Ruby Singhrao, Katherine Steeg, Jeffrey B Matthews, Smita M Asare, Ashish Sanil, Scott M Berry, Laura J Esserman, and Donald A Berry

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Determinant factors on differences in survival for gastric cancer between the US and Japan using nationwide databases., Yuri Ito, Isao Miyashiro, Takashi Ishikawa, Kohei Akazawa, Keisuke Fukui, Hitoshi Katai, Souya Nunobe, Ichiro Oda, Yoh Isobe, Shunichi Tsujitani, Hiroyuki Ono, Satoshi Tanabe, Takeo Fukagawa, Satoshi Suzuki, Yoshihiro Kakeji, Mitsuru Sasako, Anton J Bilchik, and Manabu Fujita

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Staging System for Neuroendocrine Tumors of the Lung Needs to Incorporate Histologic Grade., Anee Sophia Jackson, Adam Rosenthal, Maria Cattoni, Adam J Bograd, Alexander S Farivar, Ralph W Aye, Eric Vallières, and Brian Louie

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Comparative lipidomics of 5-Fluorouracil-sensitive and -resistant colorectal cancer cells reveals altered sphingomyelin and ceramide controlled by acid sphingomyelinase (SMPD1)., Jae Hun Jung, Kohei Taniguchi, Hyeong Min Lee, Min Young Lee, Raju Bandu, Kazumasa Komura, Kil Yeon Lee, Yukihiro Akao, and Kwang Pyo Kim

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Maximizing Breast Cancer Therapy with Awareness of Potential Treatment-Related Blood Disorders., Henry G Kaplan, Gregory S Calip, and Judith A Malmgren

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Tumor slice culture as a biologic surrogate of human cancer., Heidi L Kenerson, Kevin M Sullivan, Yongwoo D Seo, Kathryn M Stadeli, Cigdem Ussakli, Xiaowei Yan, Christopher G Lausted, Venu G Pillarisetty, James O Park, Kimberly J Riehle, Matthew Yeh, Qiang Tian, and Raymond S Yeung

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BRAINSTORM: A Multi-Institutional Phase 1/2 Study of RRx-001 in Combination With Whole Brain Radiation Therapy for Patients With Brain Metastases., Michelle M Kim, Hemant A Parmar, Matthew Schipper, Theresa Devasia, Madhava P Aryal, Santosh Kesari, Steven J O'Day, Aki Morikawa, Daniel E Spratt, Larry Junck, Aaron Mammoser, James A Hayman, Theodore S Lawrence, Christina I Tsien, Robert Aiken, Sharad Goyal, Nacer Abrouk, Malcolm Trimble, Yue Cao, and Christopher D Lao

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Primary chemoablation of low-grade upper tract urothelial carcinoma using UGN-101, a mitomycin-containing reverse thermal gel (OLYMPUS): an open-label, single-arm, phase 3 trial., Nir Kleinmann, Surena F Matin, Phillip M Pierorazio, John L Gore, Ahmad Shabsigh, Brian Hu, Karim Chamie, Guilherme Godoy, Scott Hubosky, Marcelino Rivera, Michael O'Donnell, Marcus Quek, Jay D Raman, John J Knoedler, Douglas Scherr, Joshua Stern, Christopher Weight, Alon Weizer, Michael Woods, Hristos Kaimakliotis, Angela B Smith, Jennifer M Linehan, Jonathan Coleman, Mitchell R Humphreys, Raymond Pak, David Lifshitz, Michael Verni, Mehrad Adibi, Mahul B Amin, Elyse Seltzer, Ifat Klein, Marina Konorty, Dalit Strauss-Ayali, Gil Hakim, Mark Schoenberg, and Seth P Lerner

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Management of CLL Patients Early in the COVID-19 Pandemic: An International Survey of CLL Experts, Brian Koffman, Anthony Mato, John C. Byrd, Alexey Danilov, Brad Hedrick, Chaitra Ujjani, Lindsey Roeker, Deborah M. Stephens, Matthew S. Davids, John M Pagel, and Mazyar Shadman

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ANG1005, a brain penetrating peptide-drug conjugate, shows activity in patients with breast cancer with leptomeningeal carcinomatosis and recurrent brain metastases., Priya Kumthekar, Shou-Ching Tang, Andrew J Brenner, Santosh Kesari, David E Piccioni, Carey K Anders, Jose A Carrillo, Pavani Chalasani, Peter Kabos, Shannon L Puhalla, Katherine H R Tkaczuk, Agustin Garcia, Manmeet S Ahluwalia, Jeffrey S Wefel, Nehal Lakhani, and Nuhad K Ibrahim