The Cancer Institute is a leader in cutting-edge treatments. Using a truly multidisciplinary approach, patients have access to advanced diagnostics, minimally invasive surgical interventions, and personalized genomic and immune-oncologic treatment options. Our team of cancer specialists – many of whom completed fellowships and specialty training at prestigious academic centers – offers comprehensive services for individuals with a cancer diagnosis.

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Submissions from 2020

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Pemigatinib for previously treated, locally advanced or metastatic cholangiocarcinoma: a multicentre, open-label, phase 2 study., Ghassan K Abou-Alfa, Vaibhav Sahai, Antoine Hollebecque, Gina Vaccaro, Davide Melisi, Raed Al-Rajabi, Andrew S Paulson, Mitesh J Borad, David Gallinson, Adrian G Murphy, Do-Youn Oh, Efrat Dotan, Daniel V Catenacci, Eric Van Cutsem, Tao Ji, Christine F Lihou, Huiling Zhen, Luis Féliz, and Arndt Vogel

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Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer., Joanna Achinger-Kawecka, Fatima Valdes-Mora, Phuc-Loi Luu, Katherine A Giles, C Elizabeth Caldon, Wenjia Qu, Shalima Nair, Sebastian Soto, Warwick J Locke, Nicole S Yeo-Teh, Cathryn M Gould, Qian Du, Grady C Smith, Irene R Ramos, Kristine F Fernandez, Dave S B Hoon, Julia M W Gee, Clare Stirzaker, and Susan J Clark

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Cytotoxic T cell depletion with increasing epithelial abnormality in women with benign breast disease., Sabina Adhikary, Tanya L Hoskin, Melody L Stallings-Mann, Muhammad Arshad, Marlene H Frost, Stacey J Winham, Alvaro Peña, Delphine J Lee, Linda M Murphy, Michele Rakoff, Lori A Denison, Keith L Knutson, Derek C Radisky, Daniel W Visscher, and Amy C Degnim

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Preoperative imaging characteristics predict poor survival and inadequate resection for left-sided pancreatic adenocarcinoma: a multi-institutional analysis., Farzad Alemi, Zeljka Jutric, George R Marshall, Elliot J Scott, Jan Grendar, Alexandra M Roch, Lucio L Pereira, An-Lin Cheng, Paul D Hansen, Eugene P Ceppa, Horacio J Asbun, Susanne Warner, and Adnan A Alseidi

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Intratumoral delivery of tavokinogene telseplasmid yields systemic immune responses in metastatic melanoma patients., A Algazi, S Bhatia, S Agarwala, M Molina, K Lewis, M Faries, L Fong, L P Levine, M Franco, A Oglesby, C Ballesteros-Merino, C B Bifulco, B A Fox, D Bannavong, R Talia, E Browning, M H Le, R H Pierce, S Gargosky, K K Tsai, C Twitty, and A I Daud

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Estrogen and Progesterone Receptor Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Guideline Update., Kimberly H Allison, M Elizabeth H Hammond, Mitchell Dowsett, Shannon E McKernin, Lisa A Carey, Patrick L Fitzgibbons, Daniel F Hayes, Sunil R Lakhani, Mariana Chavez-MacGregor, Jane Perlmutter, Charles M Perou, Meredith M Regan, David L Rimm, W Fraser Symmans, Emina E Torlakovic, Leticia Varella, Giuseppe Viale, Tracey F Weisberg, Lisa M McShane, and Antonio C Wolff

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Estrogen and Progesterone Receptor Testing in Breast Cancer: ASCO/CAP Guideline Update., Kimberly H Allison, M Elizabeth H Hammond, Mitchell Dowsett, Shannon E McKernin, Lisa A Carey, Patrick L Fitzgibbons, Daniel F Hayes, Sunil R Lakhani, Mariana Chavez-MacGregor, Jane Perlmutter, Charles M Perou, Meredith M Regan, David L Rimm, W Fraser Symmans, Emina E Torlakovic, Leticia Varella, Giuseppe Viale, Tracey F Weisberg, Lisa M McShane, and Antonio C Wolff

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Physiological and Pathological Roles of Cdk5: Potential Directions for Therapeutic Targeting in Neurodegenerative Disease., Annamarie B Allnutt, Ariana K Waters, Santosh Kesari, and Venkata Mahidhar Yenugonda

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Sgnlva-005: Open-label, phase II study of ladiratuzumab vedotin (LV) for advanced aerodigestive tract malignancies, Ian Churchill Anderson, Yinghui Wang, Zejing Wang, and Rachel E Sanborn

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Updates on the Management of Thyroid Cancer., Katherine A Araque, Sriram Gubbi, and Joanna Klubo-Gwiezdzinska

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The Society for Immunotherapy of Cancer perspective on regulation of interleukin-6 signaling in COVID-19-related systemic inflammatory response, Fernanda I. Arnaldez, Steven J. O'Day, Charles G. Drake, Bernard A Fox, Bingqing Fu, Walter Urba, Vincenzo Montesarchio, Jeffrey S. Weber, Haiming Wei, Jon M. Wigginton, and Paolo Antonio Ascierto

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Phase II Trial of Carfilzomib Plus Irinotecan in Patients with Small Cell Lung Cancer Who Have Progressed on Prior Platinum-Based Chemotherapy., Susanne M. Arnold, Kari Chansky, Maria Q. Baggstrom, Michael A. Thompson, Rachel E Sanborn, John L. Villano, Saiama N. Wagar, John Hamm, Markos Leggas, Maurice Willis, Joseph Rosales, and John J. Crowley

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Phase II Trial of Carfilzomib Plus Irinotecan in Patients With Small-cell Lung Cancer Who Have Progressed on Prior Platinum-based Chemotherapy., Susanne M Arnold, Kari Chansky, Maria Q Baggstrom, Michael A Thompson, Rachel E Sanborn, John L Villano, Saiama N Waqar, John Hamm, Markos Leggas, Maurice Willis, Joseph Rosales, and John J Crowley

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Insights from immuno-oncology: The Society for Immunotherapy of Cancer statement on access to IL-6-targeting therapies for COVID-19, Paolo A. Ascierto; Bernard A Fox; Walter Urba; Ana Carrizosa Anderson; Michael Atkins; Ernest C. Borden; Julie R. Brahmer; Lisa H. Butterfield; Alessandra Cesano; Daniel S. Chen; Tanja D. De Gruijl; Robert O. Dillman; Charles G. Drake; Leisha A. Emens; Thomas F. Gajewski; James L. Gulley; F Stephen Hodi, Jr.; Patrick Hwu; David Kaufman; Howard L. Kaufman; Michael T. Lotze; Francesco M. Marincola; Kim A. Margolin; Michael J. Mastrangelo; Marcela V. Maus; Douglas G. McNeel; David R. Parkinson; Pedro J. Romero; Paul M. Sondel; Stefani Spranger; Mario Sznol; George J. Weiner; Jon M. Wigginton; and Jeffrey S. Weber

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Insights from immuno-oncology: the Society for Immunotherapy of Cancer Statement on access to IL-6-targeting therapies for COVID-19., Paolo Antonio Ascierto, Bernard A Fox, Walter Urba, Ana Carrizosa Anderson, Michael B Atkins, Ernest C Borden, Julie Brahmer, Lisa H Butterfield, Alessandra Cesano, Daniel Chen, Tanja de Gruijl, Robert O Dillman, Charles G Drake, Leisha A Emens, Thomas F Gajewski, James L Gulley, F Stephen Hodi, Patrick Hwu, David Kaufman, Howard Kaufman, Michael Lotze, Douglas G McNeel, Kim Margolin, Francesco Marincola, Michael J Mastrangelo, Marcela V Maus, David R Parkinson, Pedro J Romero, Paul M Sondel, Stefani Spranger, Mario Sznol, George J Weiner, Jon M Wiggington, and Jeffrey S Weber

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Disparities in Risk Reduction Therapy Recommendations for Young Women With Lobular Carcinoma In-Situ., Bradley Bandera, Amy Voci, Daniel Nelson, Stacey L Stern, Dany Barrak, Trevan D Fischer, Maggie L DiNome, and Melanie Goldfarb

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A Mother in Jeopardy: The Ethics of Pregnancy and Chemotherapy., Steven J Baumrucker, Wendy H Vogel, Robert M Stolick, Russell W Adkins, Heather Holland, Gregg VandeKieft, and Angela Eastridge

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Peptidomimetic Polo-Box-Targeted Inhibitors that Engage PLK1 in Tumor Cells and Are Selective against the PLK3 Tumor Suppressor., Merissa Baxter, Danda Chapagai, Sandra Craig, Cecilia Hurtado, Jessy Varghese, Elmar Nurmemmedov, Michael D Wyatt, and Campbell McInnes

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Cohort Expansion Study of Neoadjvuant Immunoradiotherapy in Locoregionally Advanced HPV+ and HPV- Head and Neck Squamous Cell Carcinoma, Richard Bryan Bell, Rom Leidner, Kristina H Young, Brendan Curti, Marcus Couey, A Patel, Amber L Watters, Hong D Xiao, G Morris, L Rushforth, Michael J. Gough, and Marka R Crittenden

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Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-γ, CXCL9 and CXCL10., Cristina Bergamaschi, Hrishikesh Pandit, Bethany A Nagy, Dimitris Stellas, Shawn M. Jensen, Jenifer Bear, Maggie Cam, Antonio Valentin, Bernard A Fox, Barbara K Felber, and George N Pavlakis

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Dendritic Cell Maturation Defines Immunological Responsiveness of Tumors and Radiation, Tiffany Blair, S Bambina, Alejandro F Alice, Gwen Kramer, Jason R Baird, Terry R Medler, V Troesch, Marka R Crittenden, and Michael J. Gough

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Dendritic Cell Maturation Defines Immunological Responsiveness of Tumors to Radiation Therapy., Tiffany C Blair, Shelly Bambina, Alejandro F Alice, Gwen Kramer, Terry R Medler, Jason R Baird, Miranda L Broz, Garth W Tormoen, Victoria Troesch, Marka R Crittenden, and Michael J. Gough

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Surgery as a Component of Multimodality Care for Known Stage IIIA-N2 Non-small Cell Lung Cancer., Adam J Bograd and Eric Vallières

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Part Two: 8. Immunology, Christine Boley Ed.

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Transcriptome-wide association study reveals candidate causal genes for lung cancer., Yohan Bossé, Zhonglin Li, Jun Xia, Venkata Manem, Robert Carreras-Torres, Aurélie Gabriel, Nathalie Gaudreault, Demetrius Albanes, Melinda C Aldrich, Angeline Andrew, Susanne Arnold, Heike Bickeböller, Stig E Bojesen, Paul Brennan, Hans Brunnstrom, Neil Caporaso, Chu Chen, David C Christiani, John K Field, Gary E Goodman, Kjell Grankvist, Richard Houlston, Mattias Johansson, Mikael Johansson, Lambertus A Kiemeney, Stephen Lam, Maria T Landi, Philip Lazarus, Loic Le Marchand, Geoffrey Liu, Olle Melander, Gadi Rennert, Angela Risch, Susan M Rosenberg, Matthew B Schabath, Sanjay Shete, Zhuoyi Song, Victoria L Stevens, Adonina Tardon, H-Erich Wichmann, Penella Woll, Shan Zienolddiny, Ma'en Obeidat, Wim Timens, Rayjean J Hung, Philippe Joubert, Christopher I Amos, and James D McKay

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Robotic Partial Nephrectomy versus Minimally Invasive Radical Nephrectomy for Clinical T2a Renal Mass: A Propensity Score Matched Comparison from the ROSULA (Robotic Surgery for Large Renal Mass) Collaborative Group., Aaron W Bradshaw, Riccardo Autorino, Giuseppe Simone, Bo Yang, Robert G Uzzo, Francesco Porpiglia, Umberto Capitanio, James R Porter, Riccardo Bertolo, Andrea Minervini, Clayton Lau, Kenneth Jacobsohn, Akbar Ashrafi, Daniel Eun, Alexander Mottrie, Wesley M White, Luigi Schips, Benjamin J Challacombe, Ottavio De Cobelli, Carmen M Mir, Alessandro Veccia, Alessandro Larcher, Alexander Kutikov, Monish Aron, Prokar Dasgupta, Francesco Montorsi, Inderbir S Gill, Chandru P Sundaram, Jihad Kaouk, and Ithaar H Derweesh

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Core Curriculum for Oncology Nursing 6th ed. St. Louis, MO: Elsevier., Jeannine M. Brant, Diane G. Cope, and Marlon G Saria

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Minimally Invasive Esophagectomy: A Consensus Statement., Robert J Cerfolio, Anne-Sophie Laliberte, Shanda Blackmon, Jelle P Ruurda, Richard van Hillegersberg, Inderpal Sarkaria, and Brian Louie

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Patient-reported outcomes at discontinuation of anti-angiogenesis therapy in the randomized trial of chemotherapy with bevacizumab for advanced cervical cancer: an NRG Oncology Group study., Dana Chase, Helen Q Huang, Bradley J Monk, Lois Michelle Ramondetta, Richard T Penson, Karen Gil, Lisa M Landrum, Mario Leitao, Ana Oaknin, Warner K Huh, Heather L Pulaski, Katina Robison, Saketh R Guntupalli, Debra Richardson, Ritu Salani, Michael W Sill, Lari B Wenzel, and Krishnansu S Tewari

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Allosteric inhibitor of β-catenin selectively targets oncogenic Wnt signaling in colon cancer., Anton Cheltsov, Natsuko Nomura, Venkata Mahidhar Yenugonda, Jatin Roper, Rajesh Mukthavaram, Pengfei Jiang, Nam-Gu Her, Ivan Babic, Santosh Kesari, and Elmar Nurmemmedov

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Enhanced B7-H4 expression in gliomas with low PD-L1 expression identifies super-cold tumors., Di Chen, Gaopeng Li, Chunxia Ji, Qiqi Lu, Ying Qi, Chao Tang, Ji Xiong, Jian Hu, Fatma Betul Aksoy Yasar, Yan Zhang, Dave S B Hoon, Yu Yao, and Liangfu Zhou

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Multimodality screening and prevention of cervical cancer in sub-Saharan Africa: a collaborative model., Justine Chinn and Krishnansu S Tewari

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A phase II trial evaluating the efficacy of high-dose Radioiodinated Tositumomab (Anti-CD20) antibody, etoposide and cyclophosphamide followed by autologous transplantation, for high-risk relapsed or refractory non-hodgkin lymphoma., Victor A Chow, Joseph G Rajendran, Darrell R Fisher, Frederick R Appelbaum, Ryan D Cassaday, Paul S Martin, Leona A Holmberg, Theodore A Gooley, Philip A Stevenson, John M Pagel, Damian J Green, Oliver W Press, and Ajay K Gopal

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Oncology Care Delivery in the COVID-19 Pandemic: An Opportunity to Study Innovations and Outcomes., Pelin Cinar, John Cox, Arif Kamal, Kathleen Bickel, Monika Krzyzanowska, James Armitage, Apar Kishor Ganti, Jeffery C Ward, Sandra Wong, Sagar Lonial, and Linda Bosserman

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Results of a randomized phase IIb trial of nelipepimut-S + trastuzumab vs trastuzumab to prevent recurrences in high-risk HER2 low-expressing breast cancer patients., G Travis Travis Clifton, Diane Hale, Timothy J Vreeland, Annelies T Hickerson, Jennifer K Litton, Gheath Alatrash, Rashmi K Murthy, Na Qiao, Anne V Philips, Jason J Lukas, Jarrod P Holmes, George E Peoples, and Elizabeth A Mittendorf

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Patient-reported outcomes from KATHERINE: A phase 3 study of adjuvant trastuzumab emtansine versus trastuzumab in patients with residual invasive disease after neoadjuvant therapy for human epidermal growth factor receptor 2-positive breast cancer., PierFranco Conte, Andreas Schneeweiss, Sibylle Loibl, Eleftherios P Mamounas, Gunter von Minckwitz, Max S Mano, Michael Untch, Chiun-Sheng Huang, Norman Wolmark, Priya Rastogi, Veronique D'Hondt, Andrés Redondo, Ljiljana Stamatovic, Hervé Bonnefoi, Hugo Castro-Salguero, Hans H Fischer, Tanya Wahl, Chunyan Song, Thomas Boulet, Peter Trask, and Charles E Geyer

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The Impact of Late Luteinizing Hormone-Releasing Hormone Agonist Dosing on Testosterone Suppression in Patients with Prostate Cancer: An Analysis of United States Clinical Data., E David Crawford, Przemyslaw Twardowski, Raoul S Concepcion, Jason M Hafron, Richard G Harris, Judd W Moul, Lucio N Gordan, Daniel P Petrylak, Stuart N Atkinson, Deborah M Boldt-Houle, Thomas E Keane, Celestia S Higano, R Jonathan Henderson, A Karim Kader, Maha H Hussain, and Neal D Shore

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Randomized phase II study of stereotactic body radiotherapy and interleukin-2 versus interleukin-2 in patients with metastatic melanoma., Brendan Curti, Marka R Crittenden, Steven K Seung, Christopher B Fountain, Roxanne Payne, ShuChing Chang, Jessica Fleser, Kimberly Phillips, Ian Malkasian, Lyn B Dobrunick, and Walter Urba

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Olaparib for Metastatic Castration-Resistant Prostate Cancer., Johann de Bono, Joaquin Mateo, Karim Fizazi, Fred Saad, Neal Shore, Shahneen Sandhu, Kim N Chi, Oliver Sartor, Neeraj Agarwal, David Olmos, Antoine Thiery-Vuillemin, Przemyslaw Twardowski, Niven Mehra, Carsten Goessl, Jinyu Kang, Joseph Burgents, Wenting Wu, Alexander Kohlmann, Carrie A Adelman, and Maha Hussain

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Bempegaldesleukin (NKTR-214) plus Nivolumab in Patients with Advanced Solid Tumors: Phase I Dose-Escalation Study of Safety, Efficacy, and Immune Activation (PIVOT-02)., Adi Diab, Nizar M Tannir, Salah-Eddine Bentebibel, Patrick Hwu, Vassiliki Papadimitrakopoulou, Cara Haymaker, Harriet M Kluger, Scott N Gettinger, Mario Sznol, Scott S Tykodi, Brendan Curti, Mary A Tagliaferri, Jonathan Zalevsky, Alison L Hannah, Ute Hoch, Sandra Aung, Christie Fanton, Ahsan Rizwan, Ernesto Iacucci, Yijie Liao, Chantale Bernatchez, Michael E Hurwitz, and Daniel C Cho

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Glioblastoma Multiforme Stem Cell Cycle Arrest by Alkylaminophenol Through the Modulation of EGFR and CSC Signaling Pathways., Phuong Doan, Aliyu Musa, Akshaya Murugesan, Vili Sipilä, Nuno R Candeias, Frank Emmert-Streib, Pekka Ruusuvuori, Kirsi Granberg, Olli Yli-Harja, and Meenakshisundaram Kandhavelu

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Scrotal and Penile Erythrodysesthesia Associated with Neoadjuvant Capecitabine Chemoradiation., Julie Dricken, Erica Pettke, John A Griffin, Henry Y Li, and Vivek Mehta

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Real-world burden of myelosuppression in patients with small cell lung cancer (SCLC): Retrospective, longitudinal data analysis., Robert S. Epstein, JoAnn Krenitsky, Roshanthi Weerasinghe, Amy S. Parrish, Rachel E Sanborn, and Tehseen Salimi

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Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase., Justin T Ernst, Peggy A Thompson, Christian Nilewski, Paul A Sprengeler, Samuel Sperry, Garrick Packard, Theodore Michels, Alan Xiang, Chinh Tran, Christopher J Wegerski, Boreth Eam, Nathan P Young, Sarah Fish, Joan Chen, Haleigh Howard, Jocelyn Staunton, Jolene Molter, Jeff Clarine, Andres Nevarez, Gary G Chiang, Jim R Appleman, Kevin R Webster, and Siegfried H Reich

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A profile on the FoundationFocus CDxBRCA tests., Lindsey Ford, Juliet E Wolford, Sandra Brown, and Leslie M Randall

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The combination of ibrutinib and rituximab demonstrates activity in first-line follicular lymphoma., Nathan H Fowler, Loretta Nastoupil, Sven De Vos, Mark Knapp, Ian W Flinn, Robert Chen, Ranjana H Advani, Sumeet Bhatia, Peter Martin, Raul Mena, Richard Eric Davis, Sattva S Neelapu, Karl Eckert, Jerry Ping, Melannie Co, Darrin M Beaupre, Jutta K Neuenburg, and M Lia Palomba

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Life Is Really Simple, but We Insist on Making It Complicated-Lessons From Confucius on Ultrasound Use in the ICU., Christopher R Gilbert, Fabien Maldonado, Lonny B Yarmus, Jason A Akulian, Candice L Wilshire, and Jed A Gorden

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Poor Monitor Screen Height Positioning by Pulmonologists During Flexible Bronchoscopy: A Nested, Prospective Observational Trial., Christopher R Gilbert, Jeffrey Thiboutot, Alexander Chen, A Christine Argento, Nicholas J Pastis, Hans J Lee, Andrew D Lerner, and Lonny B Yarmus

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Part One: 2. Screening and Early Detection, Jaya M. Gill Ed.

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Blood test shows high accuracy in detecting stage I non-small cell lung cancer., Cherylle Goebel, Christopher L Louden, Robert McKenna, Osita Onugha, Andrew Wachtel, and Thomas Long

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Recent advances in the understanding and management of primary hyperparathyroidism., Melanie Goldfarb and Frederick R Singer

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Utilization of Claims Data in Research: Are We Missing the Forest and the Trees?, Jed A Gorden, Candice Wilshire, and Christopher R Gilbert

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Pembrolizumab immunotherapy for relapsed CNS Lymphoma., Jerome J Graber, Benjamin Plato, Raya Mawad, and Daniel J Moore

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TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking., Andrew J Gunderson, Tomoko Yamazaki, Kayla McCarty, Nathaniel E Fox, Michaela Phillips, Alejandro F Alice, Tiffany Blair, Mark Whiteford, David O'Brien, Rehan Ahmad, Maria X Kiely, Amanda Hayman, Todd Crocenzi, Michael J. Gough, Marka R. Crittenden, and Kristina H Young

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Surveillance for second breast cancer events in women with a personal history of breast cancer using breast MRI: a systematic review and meta-analysis., Cameron B Haas, Larissa Nekhlyudov, Janie M Lee, Sara H Javid, Mary Bush, Dianne Johnson, Timothy Gleason, Cary Kaufman, Jennifer Specht, Sean Stitham, and Karen J Wernli

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Laparoscopic Transhiatal Esophagectomy for Invasive Esophageal Adenocarcinoma., Kelly R Haisley, Walaa F Abdelmoaty, and Christy M Dunst

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Use of Convalescent Plasma in Hospitalized Patients with Covid-19 - Case Series., Livia Hegerova, Ted Gooley, Kelly A Sweerus, Cynthia L Maree, Neil Bailey, Megumi Bailey, Vanessa Dunleavy, Krish Patel, Kirsten Alcorn, N Rebecca Haley, Jill M Johnsen, Barbara A Konkle, Annamarie C Lahti, Morgan L Alexander, Jason D Goldman, Anne B Lipke, Sun-Jung Lim, Mark David Sullivan, John S Pauk, and John M Pagel

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Cellular thermal shift analysis for interrogation of CRISPR-assisted proteomic changes., Nam-Gu Her, Ivan Babic, Venkata Yenugonda, Santosh Kesari, and Elmar Nurmemmedov

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Thrombospondin-1 counteracts the p97 inhibitor CB-5083 in colon carcinoma cells., Nam-Gu Her, Santosh Kesari, and Elmar Nurmemmedov

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Stapled Diaphragmatic Plication: Is It Better Than Suture Plication?, Terra M Hill and Osita Onugha

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Breast cancer care during a pandemic: an opportune time for cryoablation?, Dennis R Holmes

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Determinant factors on differences in survival for gastric cancer between the US and Japan using nationwide databases., Yuri Ito, Isao Miyashiro, Takashi Ishikawa, Kohei Akazawa, Keisuke Fukui, Hitoshi Katai, Souya Nunobe, Ichiro Oda, Yoh Isobe, Shunichi Tsujitani, Hiroyuki Ono, Satoshi Tanabe, Takeo Fukagawa, Satoshi Suzuki, Yoshihiro Kakeji, Mitsuru Sasako, Anton J Bilchik, and Manabu Fujita

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Staging System for Neuroendocrine Tumors of the Lung Needs to Incorporate Histologic Grade., Anee Sophia Jackson, Adam Rosenthal, Maria Cattoni, Adam J Bograd, Alexander S Farivar, Ralph W Aye, Eric Vallières, and Brian Louie

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Comparative lipidomics of 5-Fluorouracil-sensitive and -resistant colorectal cancer cells reveals altered sphingomyelin and ceramide controlled by acid sphingomyelinase (SMPD1)., Jae Hun Jung, Kohei Taniguchi, Hyeong Min Lee, Min Young Lee, Raju Bandu, Kazumasa Komura, Kil Yeon Lee, Yukihiro Akao, and Kwang Pyo Kim

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Maximizing Breast Cancer Therapy with Awareness of Potential Treatment-Related Blood Disorders., Henry G Kaplan, Gregory S Calip, and Judith A Malmgren

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Tumor slice culture as a biologic surrogate of human cancer., Heidi L Kenerson, Kevin M Sullivan, Yongwoo D Seo, Kathryn M Stadeli, Cigdem Ussakli, Xiaowei Yan, Christopher G Lausted, Venu G Pillarisetty, James O Park, Kimberly J Riehle, Matthew Yeh, Qiang Tian, and Raymond S Yeung

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BRAINSTORM: A Multi-Institutional Phase 1/2 Study of RRx-001 in Combination With Whole Brain Radiation Therapy for Patients With Brain Metastases., Michelle M Kim, Hemant A Parmar, Matthew Schipper, Theresa Devasia, Madhava P Aryal, Santosh Kesari, Steven J O'Day, Aki Morikawa, Daniel E Spratt, Larry Junck, Aaron Mammoser, James A Hayman, Theodore S Lawrence, Christina I Tsien, Robert Aiken, Sharad Goyal, Nacer Abrouk, Malcolm Trimble, Yue Cao, and Christopher D Lao

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Management of CLL Patients Early in the COVID-19 Pandemic: An International Survey of CLL Experts, Brian Koffman, Anthony Mato, John C. Byrd, Alexey Danilov, Brad Hedrick, Chaitra Ujjani, Lindsey Roeker, Deborah M. Stephens, Matthew S. Davids, John M Pagel, and Mazyar Shadman

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ANG1005, a brain penetrating peptide-drug conjugate, shows activity in patients with breast cancer with leptomeningeal carcinomatosis and recurrent brain metastases., Priya Kumthekar, Shou-Ching Tang, Andrew J Brenner, Santosh Kesari, David E Piccioni, Carey K Anders, Jose A Carrillo, Pavani Chalasani, Peter Kabos, Shannon L Puhalla, Katherine H R Tkaczuk, Agustin Garcia, Manmeet S Ahluwalia, Jeffrey S Wefel, Nehal Lakhani, and Nuhad K Ibrahim

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Intracranial Efficacy and Survival With Tucatinib Plus Trastuzumab and Capecitabine for Previously Treated HER2-Positive Breast Cancer With Brain Metastases in the HER2CLIMB Trial., Nancy U Lin, Virginia Borges, Carey Anders, Rashmi K Murthy, Elisavet Paplomata, Erika Hamilton, Sara Hurvitz, Sherene Loi, Alicia Okines, Vandana Abramson, Philippe L Bedard, Mafalda Oliveira, Volkmar Mueller, Amelia Zelnak, Michael P DiGiovanna, Thomas Bachelot, A Jo Chien, Ruth O'Regan, Andrew Wardley, Alison Conlin, David Cameron, Lisa Carey, Giuseppe Curigliano, Karen Gelmon, Sibylle Loibl, JoAl Mayor, Suzanne McGoldrick, Xuebei An, and Eric P Winer

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Pregnancy associated breast cancer., Heather MacDonald

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Superior Extended Nasal Myocutaneous Island Flap: An Alternative to Forehead Flap Reconstruction of the Nose., Simon Madorsky, Anthony Do, and Orr Meltzer

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Myomucosal Lip Island Flap for Reconstruction of Small to Medium Lower Lip Defects., Simon Madorsky and Orr Meltzer

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Biokinetics of Radiolabeled Monoclonal Antibody BC8: Differences in Biodistribution and Dosimetry among Hematologic Malignancies., Manuela Cristina Matesan, Darrell R Fisher, Roger Wong, Ajay K Gopal, Damian J Green, William Bensinger, Brenda Sandmaier, John Pagel, Johnnie Orozco, Oliver W Press, Ryan Cassaday, Michele Wanner, Eric Hutchinson, Sujit Pal, Carolyn Thostenton, and Joseph Rajendran

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Prognostic Testing and Treatment Patterns in Chronic Lymphocytic Leukemia in the Era of Novel Targeted Therapies: Results From the informCLL Registry., Anthony R Mato, Jacqueline C Barrientos, Nilanjan Ghosh, John M Pagel, Danielle M Brander, Meghan Gutierrez, Karen Kadish, Brian Tomlinson, Reethi Iyengar, David Ipe, Sandhya Upasani, Carlos I Amaya-Chanaga, Murali Sundaram, Jennifer Han, Nick Giafis, and Jeff P Sharman

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Assessment of the Efficacy of Therapies Following Venetoclax Discontinuation in CLL Reveals BTK inhibition as an Effective Strategy., Anthony R Mato, Lindsey E Roeker, Ryan Jacobs, Brian T Hill, Nicole Lamanna, Danielle Brander, Mazyar Shadman, Chaitra S Ujjani, Maryam Sarraf Yazdy, Guilherme Fleury Perini, Javier A Pinilla-Ibarz, Jacqueline Barrientos, Alan P Skarbnik, Pallawi Torka, Jeffrey J Pu, John M Pagel, Satyen Gohil, Bita Fakhri, Michael Choi, Catherine C Coombs, Joanna Rhodes, Paul M Barr, Craig A Portell, Helen Parry, Christine A Garcia, Kate J Whitaker, Allison M Winter, Andrea Sitlinger, Sirin Khajavian, Ariel F Grajales-Cruz, Krista M Isaac, Pratik Shah, Othman S Akhtar, Rachael Pocock, Kentson Lam, Timothy J Voorhees, Stephen J Schuster, Thomas D Rodgers, Christopher P Fox, Nicolas Martinez-Calle, Talha Munir, Erica B Bhavsar, Neil Bailey, Jason C Lee, Hanna B Weissbrot, Chadi Nabhan, Julie M Goodfriend, Amber C King, Andrew D Zelenetz, Colleen Dorsey, Kayla Bigelow, Bruce D Cheson, John N Allan, and Toby A Eyre

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"I am a Genetic Counselor": A qualitative exploration of field leaders' perceptions of the title "genetic counselor"., Chandler Means, Allison Cirino, Kathleen B Swenson, and Jehannine Austin

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Robot-assisted laparoscopic retroperitoneal lymph node dissection: a minimally invasive surgical approach for testicular cancer., Harsha R Mittakanti and James R Porter

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Comment on: "Active Surveillance Versus Immediate Surgery in Clinically Complete Responders After Neoadjuvant Chemoradiotherapy for Esophageal Cancer"., Daniela Molena, Brian Louie, and Steven R Demeester

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Phenobarbital for Acute Alcohol Withdrawal Management in Surgical Trauma Patients-A Retrospective Comparison Study., Shamim H Nejad, Mladen Nisavic, Andreas Larentzakis, Suzan Dijkink, Yuchiao Chang, Alexander R Levine, Marc de Moya, and George Velmahos

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Primary CNS lymphoma commonly expresses immune response biomarkers., Alexander Ou, Ashley Sumrall, Surasak Phuphanich, David Spetzler, Zoran Gatalica, Joanne Xiu, Sharon Michelhaugh, Andrew Brenner, Manjari Pandey, Santosh Kesari, W Michael Korn, Sandeep Mittal, Jason Westin, and Amy B Heimberger

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Rapid Donor Identification Improves Survival in High-Risk First-Remission Patients With Acute Myeloid Leukemia., John M Pagel, Megan Othus, Guillermo Garcia-Manero, Min Fang, Jerald P Radich, David A Rizzieri, Guido Marcucci, Stephen A Strickland, Mark R Litzow, M Lynn Savoie, Stephen R Spellman, Dennis L Confer, Jeffrey W Chell, Maria Brown, Bruno C Medeiros, Mikkael A Sekeres, Tara L Lin, Geoffrey L Uy, Bayard L Powell, Ruthee-Lu Bayer, Richard A Larson, Richard M Stone, David Claxton, James Essell, Selina M Luger, Sanjay R Mohan, Anna Moseley, Harry P Erba, and Frederick R Appelbaum

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Antiproliferative and apoptotic effects of indole derivative, N-(2-hydroxy-5-nitrophenyl (4'-methylphenyl) methyl) indoline in breast cancer cells., Suresh Palanivel, Akshaya Murugesan, Kumar Subramanian, Olli Yli-Harja, and Meenakshisundaram Kandhavelu

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Anticancer activity of THMPP: Downregulation of PI3K/ S6K1 in breast cancer cell line., Suresh Palanivel, Akshaya Murugesan, Olli Yli-Harja, and Meenakshisundaram Kandhavelu

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Pixantrone plus rituximab versus gemcitabine plus rituximab in patients with relapsed aggressive B-cell non-Hodgkin lymphoma not eligible for stem cell transplantation: a phase 3, randomized, multicentre trial (PIX306)., Ruth Pettengell, Monika Długosz-Danecka, David Andorsky, David Belada, Pencho Georgiev, Donald Quick, Jack W Singer, Simran B Singh, Athanasios Pallis, Anton Egorov, and Gilles Salles

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Ageotypes: Distinct Biomolecular Trajectories in Human Aging., Brian D. Piening, Jennifer Lovejoy, and John C Earls

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Comprehensive Immune Profiling of Medullary Thyroid Cancer., Nikita Pozdeyev, Timothy A Erickson, Lian Zhang, Kim Ellison, Christopher J Rivard, Sharon Sams, Fred R Hirsch, Bryan R Haugen, and Jena D French

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Upregulation of Cell Surface GD3 Ganglioside Phenotype is Associated with Human Melanoma Brain Metastasis., Romela Irene Ramos, Matias Bustos, Jinfeng Wu, Peter Jones, Shu Ching Chang, Eiji Kiyohara, Kevin Tran, Xiaoqing Zhang, Stacey L Stern, Sivan Izraely, Orit Sagi-Assif, Isaac P Witz, Michael A Davies, Gordon B Mills, Daniel F Kelly, Reiko F Irie, and Dave S B Hoon

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Response to Grannis FW. Current Controversies in Cardiothoracic Imaging: Overdiagnosis at Lung Cancer Screening-No So Bad After All-Counterpoint., Jerome M Reich and Jong S Kim

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A Multi-Institutional Analysis of the Effect of Positive Surgical Margins Following Robot-Assisted Partial Nephrectomy on Oncologic Outcomes., Michael Rothberg, David J Paulucci, Kennedy E Okhawere, Christopher Reynolds, Ketan K Badani, Ronney Abaza, Daniel Eun, Akshay Bhandari, James R Porter, and Ashok Hemal

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Part Two: 24. Skin Cancer, Krista M. Rubin Ed. and Christine Boley Ed.

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Parathyroidectomy and Hypertension-Reply., Meena Said

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Part One: 11. Clinical Trials and Research Protocols, Marlon G Saria Ed. and Santosh Kesari Ed.

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Part Two: 9. Precision Medicine, Marlon G Saria Ed. and Santosh Kesari Ed.

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Acalabrutinib with or without obinutuzumab versus chlorambucil and obinutuzmab for treatment-naive chronic lymphocytic leukaemia (ELEVATE TN): a randomised, controlled, phase 3 trial., Jeff P Sharman, Miklos Egyed, Wojciech Jurczak, Alan Skarbnik, John M Pagel, Ian W Flinn, Manali Kamdar, Talha Munir, Renata Walewska, Gillian Corbett, Laura Maria Fogliatto, Yair Herishanu, Versha Banerji, Steven Coutre, George Follows, Patricia Walker, Karin Karlsson, Paolo Ghia, Ann Janssens, Florence Cymbalista, Jennifer A Woyach, Gilles Salles, William G Wierda, Raquel Izumi, Veerendra Munugalavadla, Priti Patel, Min Hui Wang, Sofia Wong, and John C Byrd

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Review of Procedures and Outcomes of Video-Assisted Thoracic Surgery for the Treatment of Non-Small Cell Lung Cancer in 45 Patients Undergoing Segmentectomy., Rachel Sier and Osita Onugha

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Elevating your breast program to the next level., Melvin J Silverstein

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A phase 1/2 study of the oral FLT3 inhibitor pexidartinib in relapsed/refractory FLT3-ITD-mutant acute myeloid leukemia., Catherine C Smith, Mark J Levis, Olga Frankfurt, John M Pagel, Gail J Roboz, Richard M Stone, Eunice S Wang, Paul L Severson, Brian L West, Mai H Le, Sabine Kayser, Bao Lam, Henry H Hsu, Chao Zhang, Gideon Bollag, and Alexander E Perl

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An exercise oncology clinical pathway: Screening and referral for personalized interventions., Nicole L Stout, Justin C Brown, Anna L Schwartz, Timothy F Marshall, Anna M Campbell, Larissa Nekhlyudov, David S Zucker, Karen M Basen-Engquist, Grace Campbell, Jeffrey Meyerhardt, Andrea L Cheville, Kelley R Covington, Jennifer A Ligibel, Jonas M Sokolof, Kathryn H Schmitz, and Catherine M Alfano

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Phase IB/II Trial of Lenvatinib Plus Pembrolizumab in Patients With Advanced Renal Cell Carcinoma, Endometrial Cancer, and Other Selected Advanced Solid Tumors., Matthew H Taylor, Chung-Han Lee, Vicky Makker, Drew Rasco, Corina E Dutcus, Jane Wu, Daniel E Stepan, Robert C Shumaker, and Robert J Motzer