The Cancer Institute is a leader in cutting-edge treatments. Using a truly multidisciplinary approach, patients have access to advanced diagnostics, minimally invasive surgical interventions, and personalized genomic and immune-oncologic treatment options. Our team of cancer specialists – many of whom completed fellowships and specialty training at prestigious academic centers – offers comprehensive services for individuals with a cancer diagnosis.

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Submissions from 2019

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False-positive screening events and worry influence decisions about surgery among high-risk women., M Robyn Andersen, Beth Y Karlan, Charles W Drescher, Pamela Paley, Sarah Hawley, Melanie Palomares, Mary B Daly, and Nicole Urban

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Hypothalamic Vasopressin-Producing Tumors: Often Inappropriate Diuresis But Occasionally Cushing Disease., Sylvia L Asa, Shereen Ezzat, Daniel F Kelly, Pejman Cohan, Yuki Takasumi, Garni Barkhoudarian, Anthony P Heaney, Rowena Ridout, Constance L Chik, Lester D R Thompson, Fred Gentili, and Ozgur Mete

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Addressing current challenges and future directions in immuno-oncology: expert perspectives from the 2017 NIBIT Foundation Think Tank, Siena, Italy., Michele Maio, George Coukos, Soldano Ferrone, Bernard A Fox, Wolf H Fridman, Patrick L Garcia, Michael Lahn, Olivier Provendier, Vincenzo Russo, Dominik Rüttinger, Aiman Shalabi, Zlatko Trajanoski, Jean Viallet, Jedd D Wolchok, and Ramy Ibrahim

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Immunotherapy for Head and Neck Cancer., Felix Sim, Rom Leidner, and Richard Bryan Bell

Submissions from 2018

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Clear cell carcinoma of the pelvic side wall arising from endometriosis., Lisa N Abaid, John S Cupp, Miles Chang, Steven R Beanes, and Bram H Goldstein

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A phase II study of frontline paclitaxel/carboplatin/bevacizumab, paclitaxel/carboplatin/temsirolimus, or ixabepilone/carboplatin/bevacizumab in advanced/recurrent endometrial cancer., Carol Aghajanian, Virginia Filiaci, Don S Dizon, Jay W Carlson, Matthew A Powell, Angeles Alvarez Secord, Krishnansu S Tewari, David P Bender, David M O'Malley, Ashley Stuckey, JianJiong Gao, Fanny Dao, Robert A Soslow, Heather A Lankes, Kathleen Moore, and Douglas A Levine

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Unintended consequences of decreased PSA-based prostate cancer screening., Thomas Ahlering, Linda My Huynh, Kamaljot S Kaler, Stephen Williams, Kathryn Osann, Jean Joseph, David Lee, John W Davis, Ronney Abaza, Jihad Kaouk, Vipul Patel, Isaac Yi Kim, James Porter, and Jim C Hu

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Clinical Development of Novel Drug-Radiotherapy Combinations., Saif S Ahmad, Marka R Crittenden, Phuoc T Tran, Paul G Kluetz, Gideon M Blumenthal, Helen Bulbeck, Richard D Baird, Kaye J Williams, Tim Illidge, Stephen M Hahn, Theodore S Lawrence, Patricia A Spears, Amanda J Walker, and Ricky A Sharma

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Amplifying IFN-γ Signaling in Dendritic Cells by CD11c-Specific Loss of SOCS1 Increases Innate Immunity to Infection while Decreasing Adaptive Immunity., Alejandro F Alice, Gwen Kramer, Shelly Bambina, Jason R Baird, Keith S Bahjat, Michael J Gough, and Marka R Crittenden

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Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsy., Mariet Allen, Xue Wang, Daniel J Serie, Samantha L Strickland, Jeremy D Burgess, Shunsuke Koga, Curtis S Younkin, Thuy T Nguyen, Kimberly G Malphrus, Sarah J Lincoln, Melissa Alamprese, Kuixi Zhu, Rui Chang, Minerva M Carrasquillo, Naomi Kouri, Melissa E Murray, Joseph S Reddy, Cory Funk, Nathan D Price, Todd E Golde, Steven G Younkin, Yan W Asmann, Julia E Crook, Dennis W Dickson, and Nilüfer Ertekin-Taner

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Perspectives in immunotherapy: meeting report from the Immunotherapy Bridge (29-30 November, 2017, Naples, Italy)., Paolo A Ascierto, James Brugarolas, Luigi Buonaguro, Lisa H Butterfield, David Carbone, Bruno Daniele, Robert Ferris, Bernard A Fox, Jérôme Galon, Cesare Gridelli, Howard L Kaufman, Christopher A Klebanoff, Ignacio Melero, Paul Nathan, Chrystal M Paulos, Marco Ruella, Ryan Sullivan, Hassane Zarour, and Igor Puzanov

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Perspectives in melanoma: Meeting report from the Melanoma Bridge (30 November-2 December, 2017, Naples, Italy)., Paolo A Ascierto, Igor Puzanov, Sanjiv S Agarwala, Carlo Bifulco, Gerardo Botti, Corrado Caracò, Gennaro Ciliberto, Michael A Davies, Reinhard Dummer, Soldano Ferrone, Thomas F Gajewski, Claus Garbe, Jason J Luke, Francesco M Marincola, Giuseppe Masucci, Janice M Mehnert, Nicola Mozzillo, Giuseppe Palmieri, Michael A Postow, Stephen P Schoenberger, Ena Wang, and Magdalena Thurin

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Evaluating the effectiveness and implementation of evidence-based treatment: A multisite hybrid design., Jamile A Ashmore, Kirk W Ditterich, Claire C Conley, Melissa R Wright, Peggy S Howland, Kelly L Huggins, Jena Cooreman, Priscilla S Andrews, Donald R Nicholas, Lind Roberts, Larissa Hewitt, Joan N Scales, Jenny K Delap, Christine A Gray, Lynelle A Tyler, Charlotte Collins, Catherine M Whiting, Brittany M Brothers, Marlena M Ryba, and Barbara L Andersen

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Discussion of "Sarcopenia is not associated with morbidity, mortality, or recurrence after esophagectomy for cancer"., Ralph W. Aye MD

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Cellular target engagement: a new paradigm in drug discovery., Ivan Babic, Santosh Kesari, and Elmar Nurmemmedov

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Pritumumab, the first therapeutic antibody for glioma patients., Ivan Babic, Elmar Nurmemmedov, Venkata Yenugonda, Tiffany Juarez, Natsuko Nomura, Sandeep C Pingle, Mark C Glassy, and Santosh Kesari

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Wnt pathway: a hallmark of drug discovery challenge., Ivan Babic, Venkata M Yenugonda, Santosh Kesari, and Elmar Nurmemmedov

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MV-626, a potent and selective inhibitor of ENPP1 enhances STING activation and augments T-cell mediated anti-tumor activity in vivo, Jason Baird, Gregory Dietsch, Vincent Florio, Michael Gallatin, Clayton Knox, Joshua Odingo, Marka Crittenden, and Michael J. Gough

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Evaluation of explant responses to STING ligands: personalized immunosurgical therapy for head and neck squamous cell carcinoma., Jason R Baird, R Bryan Bell, Victoria Troesch, David J Friedman, Shelly Bambina, Gwen Kramer, Tiffany Blair, Terry R Medler, Yaping Wu, Zhaoyu Sun, Tanja D de Gruijl, Rieneke van de Ven, Rom Leidner, Marka R Crittenden, and Michael J. Gough

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Targeted Intraoperative Radiation Therapy-A Promising Option for Accelerated Partial Breast Irradiation., Amishi Bajaj, Dennis R Holmes, and William Small

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Integrative spatially-resolved, high-plex digital profiling enables characterization of complex immune biology in the tumor microenvironment of mesothelioma, Carmen Ballesteros-Merino, Moritz Widmaier, Sarah Church, Thomas Herz, Alexei Budco, Das Medrikova, Ivan Kanchev, Andrew White, Douglas Hinerfeld, Shawn Jensen, John Handy, Rachel Sanborn, Carlo Bifulco, Sarah Warren, Joseph Beechem, and Bernard .. Fox

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In Reply: Microsurgical Endoscope-Assisted Gravity-Aided Transfalcine Approach for Contralateral Metastatic Deep Medial Cortical Tumors., Garni Barkhoudarian and Daniel F Kelly

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Discussion of "Effects of radiation and surgery on function and quality of life in rectal cancer patients"., Amir Bastawrous

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The Immune Landscape of Non-Small-Cell Lung Cancer. Utility of Cytologic and Histologic Samples Obtained through Minimally Invasive Pulmonary Procedures., Jason Beattie, Lonny Yarmus, Momen Wahidi, M Patricia Rivera, Christopher Gilbert, Fabien Maldonado, Kasia Czarnecka, Angela Argento, Alexander Chen, Felix Herth, and Daniel H Sterman

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Discussion of "Patient navigation reduces time to care for patients with breast symptoms and abnormal screening mammograms"., J David Beatty

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Underdiagnosis of Hereditary Breast Cancer: Are Genetic Testing Guidelines a Tool or an Obstacle?, Peter D Beitsch, Pat W Whitworth, Kevin Hughes, Rakesh Patel, Barry Rosen, Gia Compagnoni, Paul Baron, Rache Simmons, Linda Ann Smith, Ian Grady, Michael Kinney, Cynara Coomer, Karen Barbosa, Dennis R Holmes, Eric Brown, Linsey Gold, Patricia Clark, Lee Riley, Samuel Lyons, Antonio Ruiz, Sadia Kahn, Heather MacDonald, Lisa Curcio, Mary Kay Hardwick, Shan Yang, Ed D Esplin, and Robert L Nussbaum

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A History of Orthognathic Surgery in North America., Richard Bryan Bell

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Phase 2 study of gandotinib (LY2784544) in patients with myeloproliferative neoplasms., J Berdeja, F Palandri, M R Baer, Donald Quick, J J Kiladjian, G Martinelli, A Verma, O Hamid, R Walgren, C Pitou, P L Li, and A T Gerds

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Outcomes of Robot-assisted Partial Nephrectomy for Clinical T2 Renal Tumors: A Multicenter Analysis (ROSULA Collaborative Group)., Riccardo Bertolo, Riccardo Autorino, Giuseppe Simone, Ithaar Derweesh, Juan D Garisto, Andrea Minervini, Daniel Eun, Sisto Perdona, James Porter, Koon Ho Rha, Alexander Mottrie, Wesley M White, Luigi Schips, Bo Yang, Kenneth Jacobsohn, Robert G Uzzo, Ben Challacombe, Matteo Ferro, Jay Sulek, Umberto Capitanio, Uzoma A Anele, Gabriele Tuderti, Manuela Costantini, Stephen Ryan, Ahmet Bindayi, Andrea Mari, Marco Carini, Aryeh Keehn, Giuseppe Quarto, Michael Liao, Kidon Chang, Alessandro Larcher, Geert De Naeyer, Ottavio De Cobelli, Francesco Berardinelli, Chao Zhang, Peter Langenstroer, Alexander Kutikov, David Chen, Nicolo De Luyk, Chandru P Sundaram, Francesco Montorsi, Robert J Stein, Georges Pascal Haber, Lance J Hampton, Prokar Dasgupta, Michele Gallucci, Jihad Kaouk, and Francesco Porpiglia

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Outcomes of Robot-assisted Partial Nephrectomy for Clinical T2 Renal Tumors: A Multicenter Analysis (ROSULA Collaborative Group)., Riccardo Bertolo, Riccardo Autorino, Giuseppe Simone, Ithaar Derweesh, Juan D Garisto, Andrea Minervini, Daniel Eun, Sisto Perdona, James Porter, Koon Ho Rha, Alexander Mottrie, Wesley M White, Luigi Schips, Bo Yang, Kenneth Jacobsohn, Robert G Uzzo, Ben Challacombe, Matteo Ferro, Jay Sulek, Umberto Capitanio, Uzoma A Anele, Gabriele Tuderti, Manuela Costantini, Stephen Ryan, Ahmet Bindayi, Andrea Mari, Marco Carini, Aryeh Keehn, Giuseppe Quarto, Michael Liao, Kidon Chang, Alessandro Larcher, Geert De Naeyer, Ottavio De Cobelli, Francesco Berardinelli, Chao Zhang, Peter Langenstroer, Alexander Kutikov, David Chen, Nicolo De Luyk, Chandru P Sundaram, Francesco Montorsi, Robert J Stein, Georges Pascal Haber, Lance J Hampton, Prokar Dasgupta, Michele Gallucci, Jihad Kaouk, and Francesco Porpiglia

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Tumor Mutational Burden Guides Therapy in a Treatment Refractory, Munveer S Bhangoo, Peter Boasberg, Pareen Mehta, Julia A Elvin, Siraj M Ali, Winnie Wu, and Samuel J Klempner

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Minimally Invasive Lung Cancer Surgery Performed by Thoracic Surgeons as Effective as Thoracotomy., Daniel J Boffa, Andrzej S Kosinski, Anthony P Furnary, Sunghee Kim, Mark W Onaitis, Betty C Tong, Patricia A Cowper, Jessica R Hoag, Jeffrey P Jacobs, Cameron D Wright, Joe B Putnam, and Felix G Fernandez

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Tucatinib Combined With Ado-Trastuzumab Emtansine in Advanced ERBB2/HER2-Positive Metastatic Breast Cancer: A Phase 1b Clinical Trial., Virginia F Borges, Cristiano Ferrario, Nathalie Aucoin, Carla Falkson, Qamar Khan, Ian Krop, Stephen Welch, Alison Conlin, Jorge Chaves, Philippe L Bedard, Marc Chamberlain, Todd Gray, Alex Vo, and Erika Hamilton

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Socioeconomic disparities affect survival in malignant ovarian germ cell tumors in AYA population., Laura V Bownes, Laura L Stafman, Ilan I Maizlin, Matthew Dellinger, Kenneth W Gow, Adam B Goldin, Melanie Goldfarb, Monica Langer, Mehul V Raval, John J Doski, Jed G Nuchtern, Sanjeev A Vasudevan, and Elizabeth A Beierle

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Extended follow-up and impact of high-risk prognostic factors from the phase 3 RESONATE study in patients with previously treated CLL/SLL., J R Brown, P Hillmen, S O'Brien, J C Barrientos, N M Reddy, S E Coutre, C S Tam, S P Mulligan, U Jaeger, P M Barr, R R Furman, T J Kipps, F Cymbalista, P Thornton, F Caligaris-Cappio, J Delgado, M Montillo, S DeVos, C Moreno, J M Pagel, T Munir, J A Burger, D Chung, J Lin, L Gau, B Chang, G Cole, E Hsu, D F James, and J C Byrd

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SITC 2018 workshop report: Immuno-Oncology Biomarkers: State of the Art., Lisa H Butterfield, Mary L Disis, Bernard A Fox, David R Kaufman, Samir N Khleif, and Ena Wang

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Lenalidomide consolidation benefits patients with CLL receiving chemoimmunotherapy: results for CALGB 10404 (Alliance)., John C Byrd, Amy S Ruppert, Nyla A Heerema, Alese E Halvorson, Eva Hoke, Mitchell R Smith, John E Godwin, Stephen Couban, Todd A Fehniger, Michael J Thirman, Martin S Tallman, Frederick R Appelbaum, Richard M Stone, Sue Robinson, Julie E Chang, Sumithra J Mandrekar, and Richard A Larson

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Antithrombotic Therapy: Evaluation of the Safety of Performing Core Needle Biopsy of the Breast Without Suspending Medication
., Patrice Cameron, Jana Lesko, and Marla R London

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Exploratory Analysis of Brigatinib Activity in Patients With Anaplastic Lymphoma Kinase-Positive Non-Small-Cell Lung Cancer and Brain Metastases in Two Clinical Trials., D Ross Camidge, Dong-Wan Kim, Marcello Tiseo, Corey J Langer, Myung-Ju Ahn, Alice T Shaw, Rudolf M Huber, Maximilian J Hochmair, Dae Ho Lee, Lyudmila A Bazhenova, Kathryn A Gold, Sai-Hong Ignatius Ou, Howard L West, William Reichmann, Jeff Haney, Tim Clackson, David Kerstein, and Scott N Gettinger

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Improvement in TNM staging of pulmonary neuroendocrine tumors requires histology and regrouping of tumor size., Maria Cattoni, Eric Vallières, Lisa M Brown, Amir A Sarkeshik, Stefano Margaritora, Alessandra Siciliani, Pier Luigi Filosso, Francesco Guerrera, Andrea Imperatori, Nicola Rotolo, Farhood Farjah, Grace Wandell, Kimberly Costas, Catherine Mann, Michal Hubka, Stephen Kaplan, Alexander S Farivar, Ralph W Aye, and Brian E Louie

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Chemotherapy-generated cell debris stimulates colon carcinoma tumor growth via osteopontin., Jaimie Chang, Swati S Bhasin, Diane R Bielenberg, Vikas P Sukhatme, Manoj Bhasin, Sui Huang, Mark W Kieran, and Dipak Panigrahy

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Evaluating the potential benefit of reduced planning target volume margins for low and intermediate risk patients with prostate cancer using real-time electromagnetic tracking., Avinash R Chaurasia, Kelly J Sun, Christopher Premo, Timothy Brand, Brent Tinnel, Stacie Barczak, John Halligan, Michael Brown, and Dusten Macdonald

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A Phase II Study of Celecoxib With Irinotecan, 5-Fluorouracil, and Leucovorin in Patients With Previously Untreated Advanced or Metastatic Colorectal Cancer., Emerson Y Chen, Charles D Blanke, Daniel G Haller, Al B Benson, Tomislav Dragovich, Heinz-Josef Lenz, Carlos Robles, Hong Li, Motomi Mori, Nora Mattek, Rachel E Sanborn, and Charles D Lopez

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Targeting Mcl-1 enhances DNA replication stress sensitivity to cancer therapy., Guo Chen, Andrew T Magis, Ke Xu, Dongkyoo Park, David S Yu, Taofeek K Owonikoko, Gabriel L Sica, Sarah W Satola, Suresh S Ramalingam, Walter J Curran, Paul W Doetsch, and Xingming Deng

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Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity., Hui-Ming Chen, William van der Touw, Yuan Shuo Wang, Kyeongah Kang, Sunny Mai, Jilu Zhang, Dayanira Alsina-Beauchamp, James A Duty, Sathish Kumar Mungamuri, Bin Zhang, Thomas Moran, Richard Flavell, Stuart Aaronson, Hong-Ming Hu, Hisashi Arase, Suresh Ramanathan, Raja Flores, Ping-Ying Pan, and Shu-Hsia Chen

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Histopathology of locally advanced colorectal carcinoma, with emphasis on tumor invasion of adherent peritoneal membranes., Jey-Hsin Chen

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Relapse pathway of glioblastoma revealed by single-cell molecular analysis., Xuelian Chen, Qin Wen, Andres Stucky, Yunjing Zeng, Shengjia Gao, William G Loudon, Hector W Ho, Mustafa H Kabeer, Shengwen Calvin Li, Xi Zhang, and Jiang F Zhong

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Phase IIIb safety results from an expanded-access protocol of talimogene laherparepvec for patients with unresected, stage IIIB-IVM1c melanoma., Jason Chesney, Sanjay Awasthi, Brendan Curti, Laura Hutchins, Gerald Linette, Pierre Triozzi, Marcus C B Tan, Russell E Brown, John Nemunaitis, Eric Whitman, Christopher Windham, Jose Lutzky, Gerald F Downey, Nicolas Batty, and Thomas Amatruda

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Reply to S. Nakamura et al and S. Narod et al., Christopher P Childers, Kimberly K Childers, Melinda Maggard-Gibbons, and James Macinko

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National Distribution of Cancer Genetic Testing in the United States: Evidence for a Gender Disparity in Hereditary Breast and Ovarian Cancer., Kimberly K Childers, Melinda Maggard-Gibbons, James Macinko, and Christopher P Childers

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Surgical Interventions for Advanced Parameningeal Rhabdomyosarcoma of Children and Adolescents., Paul J Choi, Joe Iwanaga, R Shane Tubbs, and Emre Yilmaz

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Emerging Cellular Therapies for Glioblastoma Multiforme., Paul J Choi, R Shane Tubbs, and Rod J Oskouian

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Rates of Prevalent Colorectal Cancer Occurrence in Persons 75 Years of Age and Older: A Population-Based National Study., Vijit Chouhan, Emad Mansoor, Sravanthi Parasa, and Gregory S Cooper

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Implementation of an integrated computerized prescriber order-entry system for chemotherapy in a multisite safety-net health system., Clement Chung, Shital Patel, Rosetta Lee, Lily Fu, Sean Reilly, Tuyet Ho, Jason Lionetti, Michael D George, and Pam Taylor

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A multi-center phase II study of high dose interleukin-2 sequenced with vemurafenib in patients with BRAF-V600 mutation positive metastatic melanoma., Joseph I Clark, Jatinder Singh, Marc S Ernstoff, Christopher D Lao, Lawrence E Flaherty, Theodore F Logan, Brendan Curti, Sanjiv S Agarwala, Bret Taback, Lee Cranmer, Jose Lutzky, Theresa L Luna, Sandra Aung, and David H Lawson

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Balancing the benefits and harms of thyroid cancer surveillance in survivors of Childhood, adolescent and young adult cancer: Recommendations from the international Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCareSurFup Consortium., S C Clement, L C M Kremer, F A Verburg, J H Simmons, M Goldfarb, R P Peeters, E K Alexander, E Bardi, E Brignardello, L S Constine, C A Dinauer, V M Drozd, F Felicetti, E Frey, A Heinzel, M M van den Heuvel-Eibrink, S A Huang, T P Links, K Lorenz, R L Mulder, S J Neggers, E J M Nieveen van Dijkum, K C Oeffinger, R R van Rijn, S A Rivkees, C M Ronckers, A B Schneider, R Skinner, J D Wasserman, T Wynn, M M Hudson, P C Nathan, and H M van Santen

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An early feasibility study of the Nativis Voyager, Charles Cobbs, Edward McClay, J Paul Duic, L Burt Nabors, Donna Morgan Murray, and Santosh Kesari

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Safety and efficacy of pomalidomide, dexamethasone and pegylated liposomal doxorubicin for patients with relapsed or refractory multiple myeloma., Alexa Cohen, Tanya M Spektor, Laura Stampleman, Alberto Bessudo, Peter J Rosen, Leonard M Klein, Thomas Woliver, Marshall Flam, Shahrooz Eshaghian, Youram Nassir, Tina Maluso, Regina A Swift, Robert Vescio, and James R Berenson

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Evolution of the graded repair of CSF leaks and skull base defects in endonasal endoscopic tumor surgery: trends in repair failure and meningitis rates in 509 patients., Andrew Conger, Fan Zhao, Xiaowen Wang, Amy Eisenberg, Chester Griffiths, Felice Esposito, Ricardo L Carrau, Garni Barkhoudarian, and Daniel F Kelly

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Implementation and Validation of an Automated Flow Cytometry Analysis Pipeline for Human Immune Profiling., Valerie Conrad, Christopher Dubay, Mehrnoush Malek, Ryan R Brinkman, Yoshinobu Koguchi, and William L. Redmond

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Prediagnostic circulating markers of inflammation and risk of oesophageal adenocarcinoma: a study within the National Cancer Institute Cohort Consortium., Michael B Cook, Matthew J Barnett, Cathryn H Bock, Amanda J Cross, Phyllis J Goodman, Gary E Goodman, Christopher A Haiman, Kay-Tee Khaw, Marjorie L McCullough, Christine C Newton, Marie-Christine Boutron-Ruault, Eiliv Lund, Martin Rutegård, Mark D Thornquist, Michael Spriggs, Carol Giffen, Neal D Freedman, Troy Kemp, Candyce H Kroenke, Loïc Le Marchand, Jin Young Park, Michael Simon, Lynne R Wilkens, Ligia Pinto, Allan Hildesheim, and Peter T Campbell

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Delayed immune-related events after discontinuation of immunotherapy – DIRE syndrome?, Marcus Couey, R. Bryan Bell, Ashish Patel, Marka R Crittenden, Brendan Curti, and Rom Leidner

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Tumor cure by radiation therapy and checkpoint inhibitors depends on pre-existing immunity., Marka R Crittenden, Lauren Zebertavage, Gwen Kramer, Shelly Bambina, David Friedman, Victoria Troesch, Tiffany Blair, Jason R Baird, Alejandro F Alice, and Michael J Gough

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Immunotherapy in Advanced Renal Cancer - Is Cure Possible?, Brendan D Curti

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Correlation Between Clinical and Pathologic Staging in Colon Cancer: Implications for Neoadjuvant Treatment., Ahmed N Dehal, Amanda N Graff-Baker, Brooke Vuong, Daniel Nelson, Shu-Ching Chang, David Y Lee, Melanie Goldfarb, and Anton J Bilchik

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Robot-assisted partial nephrectomy for large renal masses: a multi-institutional series., Joan C Delto, David Paulucci, Michael W Helbig, Ketan K Badani, Daniel Eun, James Porter, Ronney Abaza, Ashok K Hemal, and Akshay Bhandari

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Modified carbazoles destabilize microtubules and kill glioblastoma multiform cells., Philippe Diaz, Eric Horne, Cong Xu, Ernest Hamel, Michael Wagenbach, Ravil R Petrov, Benjamin Uhlenbruck, Brian Haas, Parvinder Hothi, Linda Wordeman, Rick Gussio, and Nephi Stella

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Randomized phase II trial of autologous dendritic cell vaccines versus autologous tumor cell vaccines in metastatic melanoma: 5-year follow up and additional analyses., Robert O. Dillman, Andrew N Cornforth, Gabriel I Nistor, Edward F McClay, Thomas T Amatruda, and Carol Depriest

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Digitizing omics profiles by divergence from a baseline., Wikum Dinalankara, Qian Ke, Yiran Xu, Lanlan Ji, Nicole Pagane, Anching Lien, Tejasvi Matam, Elana J Fertig, Nathan D Price, Laurent Younes, Luigi Marchionni, and Donald Geman

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Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics., Li Ding, Matthew H Bailey, Eduard Porta-Pardo, Vesteinn Thorsson, Antonio Colaprico, Denis Bertrand, David L Gibbs, Amila Weerasinghe, Kuan-Lin Huang, Collin Tokheim, Isidro Cortés-Ciriano, Reyka Jayasinghe, Feng Chen, Lihua Yu, Sam Sun, Catharina Olsen, Jaegil Kim, Alison M Taylor, Andrew D Cherniack, Rehan Akbani, Chayaporn Suphavilai, Niranjan Nagarajan, Joshua M Stuart, Gordon B Mills, Matthew A Wyczalkowski, Benjamin G Vincent, Carolyn M Hutter, Jean Claude Zenklusen, Katherine A Hoadley, Michael C Wendl, Llya Shmulevich, Alexander J Lazar, David A Wheeler, and Gad Getz

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Recent Approvals in Immunotherapy Options for Patients with Lung Cancer, Lavinia Dobrea and Timothy E. Byun

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Navigating the Complex Terrain of Clinical Trials, Lavinia Dobrea and Lucy Gansauer

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The Navigator's Role in Supporting Clinical Trials, Lavinia Dobrea and Lucy J. Gansauer

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Polyethyleneimine modification of aluminum hydroxide nanoparticle enhances antigen transportation and cross-presentation of dendritic cells., Heng Dong, Zhi-Fa Wen, Lin Chen, Na Zhou, Hui Liu, Shiling Dong, Hong-Ming Hu, and Yongbin Mou

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Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors., Thomas Duhen, Rebekka Duhen, Ryan Montler, Jake Moses, Tarsem Moudgil, Noel F de Miranda, Cheri P Goodall, Tiffany C Blair, Bernard A Fox, Jason E McDermott, Shu-Ching Chang, Gary Grunkemeier, Rom Leidner, Richard Bryan Bell, and Andrew D Weinberg

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Earle A. Chiles Research Institute 2017 Year In Review, Earle A. Chiles Research Institute

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Overcoming Tumor-Induced Immune Suppression: From Relieving Inhibition to Providing Costimulation with T Cell Agonists., Dana A Emerson and William L Redmond

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Correlation between Surgeon's assessment and radiographic evaluation of residual disease in women with advanced stage ovarian cancer reported to have undergone optimal surgical cytoreduction: An NRG Oncology/Gynecologic Oncology Group study., Ramez N Eskander, James Kauderer, Krishnansu S Tewari, Robert S Mannel, Robert E Bristow, David M O'Malley, Stephen C Rubin, Gretchen E Glaser, Chad A Hamilton, Keiichi Fujiwara, Warner K Huh, Frederick Ueland, Jean-Marie Stephan, and Robert A Burger

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Multiplatform profiling of meningioma provides molecular insight and prioritization of drug targets for rational clinical trial design., Richard G Everson, Yuuri Hashimoto, Jacob L Freeman, Tiffany R Hodges, Jason Huse, Shouhao Zhou, Joanne Xiu, David Spetzler, Nader Sanai, Lyndon Kim, Santosh Kesari, Andrew Brenner, Franco De Monte, Amy Heimberger, and Shaan M Raza

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The role of Galectin-3 in modulating tumor growth and immunosuppression within the tumor microenvironment., Mohammad Farhad, Annah S Rolig, and William L Redmond

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Endoscopic Resection in the Esophagus., Andrew F Feczko and Brian E Louie

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Profiles of Brain Metastases: Prioritization of Therapeutic Targets., Sherise D Ferguson, Siyuan Zheng, Joanne Xiu, Shouhao Zhou, Mustafa Khasraw, Priscilla K Brastianos, Santosh Kesari, Jethro Hu, Jeremy Rudnick, Michael E Salacz, David Piccioni, Suyun Huang, Michael A Davies, Isabella C Glitza, John V Heymach, Jianjun Zhang, Nuhad K Ibrahim, John F DeGroot, Joseph McCarty, Barbara J O'Brien, Raymond Sawaya, Roeland G W Verhaak, Sandeep K Reddy, Waldemar Priebe, Zoran Gatalica, David Spetzler, and Amy B Heimberger

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Ependymomas overexpress chemoresistance and DNA repair-related proteins., Sherise D Ferguson, Shouhao Zhou, Joanne Xiu, Yuuri Hashimoto, Nader Sanai, Lyndon Kim, Santosh Kesari, John de Groot, David Spetzler, and Amy B Heimberger

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Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity., Aida Ferreiro-Iglesias, Corina Lesseur, James McKay, Rayjean J Hung, Younghun Han, Xuchen Zong, David Christiani, Mattias Johansson, Xiangjun Xiao, Yafang Li, David C Qian, Xuemei Ji, Geoffrey Liu, Neil Caporaso, Ghislaine Scelo, David Zaridze, Anush Mukeriya, Milica Kontic, Simona Ognjanovic, Jolanta Lissowska, Małgorzata Szołkowska, Beata Swiatkowska, Vladimir Janout, Ivana Holcatova, Ciprian Bolca, Milan Savic, Miodrag Ognjanovic, Stig Egil Bojesen, Xifeng Wu, Demetrios Albanes, Melinda C Aldrich, Adonina Tardon, Ana Fernandez-Somoano, Guillermo Fernandez-Tardon, Loic Le Marchand, Gadi Rennert, Chu Chen, Jennifer Doherty, Gary Goodman, Heike Bickeböller, H-Erich Wichmann, Angela Risch, Albert Rosenberger, Hongbing Shen, Juncheng Dai, John K Field, Michael Davies, Penella Woll, M Dawn Teare, Lambertus A Kiemeney, Erik H F M van der Heijden, Jian-Min Yuan, Yun-Chul Hong, Aage Haugen, Shanbeh Zienolddiny, Stephen Lam, Ming-Sound Tsao, Mikael Johansson, Kjell Grankvist, Matthew B Schabath, Angeline Andrew, Eric Duell, Olle Melander, Hans Brunnström, Philip Lazarus, Susanne Arnold, Stacey Slone, Jinyoung Byun, Ahsan Kamal, Dakai Zhu, Maria Teresa Landi, Christopher I Amos, and Paul Brennan

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Pediatric-protocol of multimodal therapy is associated with improved survival in AYAs and adults with rhabdomyosarcoma., Trevan D Fischer, Shrawan G Gaitonde, Bradley C Bandera, Mehul V Raval, Sanjeev A Vasudevan, Kenneth W Gow, Elizabeth A Beierle, John J Doski, Adam B Goldin, Monica Langer, Jed G Nuchtern, Stacey Stern, Leland J Foshag, and Melanie Goldfarb

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The Negative Impact of Body Mass Index on the Tumor Microenvironment in Colon Cancer: Results of a Prospective Trial., Devin C Flaherty, John R Jalas, Myung S Sim, Alexander Stojadinovic, Mladjan Protic, Delphine J Lee, and Anton J Bilchik

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Driver Fusions and Their Implications in the Development and Treatment of Human Cancers., Qingsong Gao, Wen-Wei Liang, Steven M Foltz, Gnanavel Mutharasu, Reyka G Jayasinghe, Song Cao, Wen-Wei Liao, Sheila M Reynolds, Matthew A Wyczalkowski, Lijun Yao, Lihua Yu, Sam Q Sun, Ken Chen, Alexander J Lazar, Ryan C Fields, Michael C Wendl, Brian A Van Tine, Ravi Vij, Feng Chen, Matti Nykter, Ilya Shmulevich, and Li Ding

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Tumor cell-released autophagosomes (TRAP) enhance apoptosis and immunosuppressive functions of neutrophils., Rong Gao, Jie Ma, Zhifa Wen, Peiying Yang, Jinjin Zhao, Meng Xue, Yongqiang Chen, Mohanad Aldarouish, Hong-Ming Hu, Xue-Jun Zhu, Ning Pan, and Li-Xin Wang

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Randomized phase II study of fulvestrant and erlotinib compared with erlotinib alone in patients with advanced or metastatic non-small cell lung cancer., Edward B Garon, Jill M Siegfried, Laura P Stabile, Patricia A Young, Diana C Marquez-Garban, David J Park, Ravi Patel, Eddie H Hu, Saeed Sadeghi, Rupesh J Parikh, Karen L Reckamp, Brad Adams, Robert M Elashoff, David Elashoff, Tristan Grogan, He-Jing Wang, Sanja Dacic, Meghan Brennan, Yacgley Valdes, Simon Davenport, Steven M Dubinett, Michael F Press, Dennis J Slamon, and Richard J Pietras

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Pathologists' Use of Second Opinions in Interpretation of Melanocytic Cutaneous Lesions: Policies, Practices, and Perceptions., Berta M Geller, Paul D Frederick, Stevan R Knezevich, Jason P Lott, Heidi D Nelson, Linda J Titus, Patricia A Carney, Anna N A Tosteson, Tracy L Onega, Raymond L Barnhill, Martin A Weinstock, David E Elder, Michael W Piepkorn, and Joann G Elmore

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Voxel-Wise Analysis of Fluoroethyltyrosine PET and MRI in the Assessment of Recurrent Glioblastoma During Antiangiogenic Therapy., Elizabeth George, Marie F Kijewski, Shipra Dubey, Anthony P Belanger, David A Reardon, Patrick Y Wen, Santosh Kesari, Laura Horky, Mi-Ae Park, and Raymond Y Huang

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Randomized phase III study of docetaxel plus bavituximab in previously treated advanced non-squamous non-small-cell lung cancer., D E Gerber, L Horn, M Boyer, Rachel E Sanborn, R Natale, R Palmero, P Bidoli, I Bondarenko, P Germonpre, D Ghizdavescu, A Kotsakis, H Lena, G Losonczy, K Park, W-C Su, M Tang, J Lai, N L Kallinteris, J S Shan, M Reck, and D R Spigel

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A Placebo-Controlled Phase II Study of Ruxolitinib in Combination With Pemetrexed and Cisplatin for First-Line Treatment of Patients With Advanced Nonsquamous Non-Small-Cell Lung Cancer and Systemic Inflammation., Giuseppe Giaccone, Rachel E Sanborn, Saiama N Waqar, Alex Martinez-Marti, Santiago Ponce, Huiling Zhen, Gerard Kennealey, Susan Erickson-Viitanen, and Eric Schaefer

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The Impact of the ASAP Trial: Maybe We Shouldn't Act So Quickly., Christopher R Gilbert, Jason A Akulian, and Jed A Gorden

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The decision to biopsy in a lung cancer screening program: Potential impact of risk calculators., Christopher R Gilbert, Alexander S Carlson, Candice L Wilshire, Ralph W Aye, Alexander S Farivar, Adam J Bograd, and Jed A Gorden

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The economic impact of a nurse practitioner-directed lung cancer screening, incidental pulmonary nodule, and tobacco-cessation clinic., Christopher R Gilbert, Rob Ely, Joelle T Fathi, Brian E Louie, Candice L Wilshire, Hannah Modin, Ralph W Aye, Alexander S Farivar, Eric Vallières, and Jed A Gorden

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TP73 DNA methylation and upregulation of ΔNp73 are associated with an adverse prognosis in breast cancer, Laura C Gomez, Mayra L Sottile, Martin E Guerrero-Gimenez, Felipe C M Zoppino, Analia L Redondo, Francisco E Gago, Javier I Orozco, Olga M Tello, Maria Roqué, Silvina B Nadin, Diego M Marzese, and Laura M Vargas-Roig

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Oncofertility in the setting of advanced cervical cancer - A case report., Catherine Gordon, Joseph C Carmichael, and Krishnansu S Tewari

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Inducible T cell Co-stimulator (ICOS) is upregulated on lymphocytes following radiation of tumors and ICOS agonism in combination with radiation results in enhanced tumor control, Michael J. Gough, Shelly Bambina, Monica Gostissa, Christopher Harvey, David Friedman, and Marka R Crittenden

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Leptomeningeal Metastases., Jerome J Graber and Santosh Kesari