The Cancer Institute is a leader in cutting-edge treatments. Using a truly multidisciplinary approach, patients have access to advanced diagnostics, minimally invasive surgical interventions, and personalized genomic and immune-oncologic treatment options. Our team of cancer specialists – many of whom completed fellowships and specialty training at prestigious academic centers – offers comprehensive services for individuals with a cancer diagnosis.

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Submissions from 2022

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Orteronel for Metastatic Hormone-Sensitive Prostate Cancer: A Multicenter, Randomized, Open-Label Phase III Trial (SWOG-1216)., Neeraj Agarwal, Catherine M Tangen, Maha H A Hussain, Shilpa Gupta, Melissa Plets, Primo N Lara, Andrea L Harzstark, Przemyslaw W Twardowski, Channing J Paller, Dylan Zylla, Matthew R Zibelman, Ellis Levine, Bruce J Roth, Amir Goldkorn, Daniel A Vaena, Manish Kohli, Tony Crispino, Nicholas J Vogelzang, Ian M Thompson, and David I Quinn

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Impact of veliparib, paclitaxel dosing regimen, and germline BRCA status on the primary treatment of serous ovarian cancer - an ancillary data analysis of the VELIA trial., Carol Aghajanian, Elizabeth M Swisher, Aikou Okamoto, Karina Dahl Steffensen, Michael A Bookman, Gini F Fleming, Michael Friedlander, Kathleen N Moore, Krishnansu S Tewari, David M O'Malley, John K Chan, Christine Ratajczak, Hideyuki Hashiba, Meijing Wu, Minh H Dinh, and Robert L Coleman

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Impact of veliparib, paclitaxel dosing regimen, and germline BRCA status on the primary treatment of serous ovarian cancer - an ancillary data analysis of the VELIA trial., Carol Aghajanian, Elizabeth M Swisher, Aikou Okamoto, Karina Dahl Steffensen, Michael A Bookman, Gini F Fleming, Michael Friedlander, Kathleen N Moore, Krishnansu S Tewari, David M O'Malley, John K Chan, Christine Ratajczak, Hideyuki Hashiba, Meijing Wu, Minh H Dinh, and Robert L Coleman

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Development and Validation of Dynamic Multivariate Prediction Models of Sexual Function Recovery in Patients with Prostate Cancer Undergoing Radical Prostatectomy: Results from the MUSIC Statewide Collaborative., Nnenaya Agochukwu-Mmonu, Adharsh Murali, Daniela Wittmann, Brian Denton, Rodney L Dunn, James Montie, James Peabody, David Miller, Karandeep Singh, and Michigan Urological Surgery Improvement Collaborative

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A phase 1 multiple-ascending dose study to evaluate the safety and tolerability of XmAb23104 (PD-1 x ICOS) in subjects with selected advanced solid tumors (DUET-3)., Mehmet Akce, Rom Leidner, and See full list of authors in comments

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Resection of persistent stage IIIA-N2 NSCLC following induction therapy., Weston Garrett Andrews, Brian Louie, and Adam J Bograd

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Perspectives in Immunotherapy: meeting report from the Immunotherapy Bridge, December 1st-2nd, 2021., Paolo A Ascierto, Antonio Avallone, Nina Bhardwaj, Carlo Bifulco, Sergio Bracarda, Joshua D Brody, Luigi Buonaguro, Sandra Demaria, Leisha A Emens, Robert L Ferris, Jérôme Galon, Samir N Khleif, Christopher A Klebanoff, Tamara Laskowski, Ignacio Melero, Chrystal M Paulos, Sandro Pignata, Marco Ruella, Inge Marie Svane, Janis M Taube, Bernard A Fox, Patrick Hwu, and Igor Puzanov

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The "Great Debate" at Immunotherapy Bridge 2021, December 1st-2nd, 2021., Paolo A Ascierto, Lisa H Butterfield, Olivera J Finn, Andrew Futreal, Omid Hamid, Theresa LaVallee, Michael A Postow, Igor Puzanov, Jeffrey Sosman, Bernard A Fox, and Patrick Hwu

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Pomalidomide, dexamethasone, and daratumumab immediately after lenalidomide-based treatment in patients with multiple myeloma: updated efficacy, safety, and health-related quality of life results from the phase 2 MM-014 trial., Nizar J Bahlis, David S Siegel, Gary J Schiller, Christy Samaras, Michael Sebag, Jesus Berdeja, Siddhartha Ganguly, Jeffrey Matous, Kevin Song, Christopher S Seet, Mirelis Acosta-Rivera, Michael Bar, Donald Quick, Bertrand Anz, Gustavo Fonseca, Weiyuan Chung, Kim Lee, Jorge Mouro, Amit Agarwal, and Donna Reece

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The Impact of Ineffective Esophageal Motility On Patients Undergoing Magnetic Sphincter Augmentation., George N Baison, Anee Sophia Jackson, Candice Wilshire, Reginald C W Bell, Veronica Lazzari, Luigi Bonavina, Shahin Ayazi, Blair A Jobe, Sebastian F Schoppmann, Colin P Dunn, John C Lipham, Christy M Dunst, Alexander S Farivar, Adam J Bograd, and Brian Louie

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Blocking UBE2N abrogates oncogenic immune signaling in acute myeloid leukemia., Laura Barreyro, Avery M Sampson, Chiharu Ishikawa, Kathleen M Hueneman, Kwangmin Choi, Mario A Pujato, Somchai Chutipongtanate, Michael Wyder, Wendy D Haffey, Eric O'Brien, Mark Wunderlich, Vighnesh Ramesh, Ellen M Kolb, Cem Meydan, Yaseswini Neelamraju, Lyndsey C Bolanos, Susanne Christie, Molly A Smith, Madeline Niederkorn, Tomoya Muto, Santosh Kesari, Francine E Garrett-Bakelman, Boris Bartholdy, Britta Will, Matthew T Weirauch, James C Mulloy, Zartash Gul, Stephen Medlin, Rhett A Kovall, Ari M Melnick, John P Perentesis, Kenneth D Greis, Elmar Nurmemmedov, William L Seibel, and Daniel T Starczynowski

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Single-Port Retzius-Sparing Robot-Assisted Radical Prostatectomy: Feasibility and Early Outcomes., Jeffrey C Bassett, Salpi Salibian, and Simone Crivellaro

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Autoimmune Hemolytic Anemia in Children: Laboratory Investigation, Disease Associations, and Treatment Strategies., Douglas Blackall and Lily Dolatshahi

Fluorescence tagging to monitor CD8 T cell recirculation from the tumor to the tumor-draining lymph node: the impact of focal radiation therapy on recirculation, TC Blair, Brian D. Piening, Marka R Crittenden, Michael J. Gough, and See full list of authors in comments

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Praluzatamab ravtansine, a CD166-targeting antibody-drug conjugate, in patients with advanced solid tumors: an open-label phase 1/2 trial., Valentina Boni, Mary J Fidler, Hendrik-Tobias Arkenau, Alexander Spira, Funda Meric-Bernstam, Nataliya Uboha, Rachel E Sanborn, Randy F Sweis, Patricia LoRusso, Misako Nagasaka, Javier Garcia-Corbacho, Shadia Jalal, James J Harding, Stella K Kim, Iris H C Miedema, Danielle J Vugts, Marc C Huisman, Gerben J C Zwezerijnen, Guus A M S van Dongen, Catharina W Menke-van der Houven van Oordt, Song Wang, Tam Dang, Ivan A Zein, Olga Vasiljeva, Susan K Lyman, Virginia Paton, Alison Hannah, and Joyce F Liu

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Automatic Analysis of Asymmetry in Facial Paralysis Patients Using Landmark-Based Measures., Digbalay Bose, Krishna Somandepalli, Tymon Tai, Courtney Voelker, Shrikanth Narayanan, and Amit Kochhar

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Implementation of High-Dose-Rate, CT-Based Prostate Brachytherapy in an Academic Teaching Hospital and Residency Training Program., Daniel Brunnhoelzl, Alexander Hanania, Sam Sun, Sergio Jaramillo, Linfeng Lu, and Pavan Jhaveri

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Prognostic Utility of CpG Island Hypermethylated Phenotype in Early-Stage Invasive Primary Melanomas., Matias A Bustos and Dave Hoon

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Cell-free plasma microRNAs that identify patients with glioblastoma., Matias A Bustos, Negin Rahimzadeh, Suyeon Ryu, Rebecca Gross, Linh T Tran, Victor M Renteria-Lopez, Romela Irene Ramos, Amy Eisenberg, Parvinder Hothi, Santosh Kesari, Garni Barkhoudarian, Yuki Takasumi, Charles Cobbs, Daniel F Kelly, and Dave Hoon

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Editorial: Cancer Immunotherapies: From Efficacy to Resistance Mechanisms., Janin Chandra, Morten Hansen, Nathalie Labarriere, Ilaria Marigo, Fernando Souza-Fonseca-Guimaraes, Lazar Vujanovic, Yoshinobu Koguchi, and Nicolas Jacquelot

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Topical therapy for regression and melanoma prevention of congenital giant nevi., Yeon Sook Choi, Tal H Erlich, Max von Franque, Inbal Rachmin, Jessica L Flesher, Erik B Schiferle, Yi Zhang, Marcello Pereira da Silva, Alva Jiang, Allison S Dobry, Mack Su, Sharon Germana, Sebastian Lacher, Orly Freund, Ezra Feder, Jose L Cortez, Suyeon Ryu, Tamar Babila Propp, Yedidyah Leo Samuels, Labib R Zakka, Marjan Azin, Christin E Burd, Norman E Sharpless, X Shirley Liu, Clifford Meyer, William Gerald Austen, Branko Bojovic, Curtis L Cetrulo, Martin C Mihm, Dave S Hoon, Shadmehr Demehri, Elena B Hawryluk, and David E Fisher

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Changes in T-cell subsets and clonal repertoire during chemoimmunotherapy with pembrolizumab and paclitaxel or capecitabine for metastatic triple-negative breast cancer., Brie Chun, Joanna Pucilowska, Shu-Ching Chang, Isaac Kim, Benjamin Nikitin, Yoshinobu Koguchi, William L. Redmond, Brady Bernard, Venkatesh Rajamanickam, Nathan Polaske, Paul A Fields, Valerie Conrad, Mark Schmidt, Walter Urba, Alison Conlin, Heather L McArthur, and David B Page

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Sentinel lymph node melanoma metastases: Assessment of tumor burden for clinical prediction of outcome in the first Multicenter Selective Lymphadenectomy Trial (MSLT-I)., Alistair J Cochran, Duan-Ren Wen, Rong-Rong Huang, Payam Abrishami, Chandra Smart, Scott Binder, Richard A Scolyer, John F Thompson, Stacey Stern, Lisa Van Kreuningen, David E Elashoff, Myung-Shin Sim, He-Jing Wang, Mark Faries, and MSLT-I Study Group

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CT243 / 4 - Phase 1 study of TAK-676 + pembrolizumab following radiation therapy in patients with advanced non-small-cell lung cancer (NSCLC), triple-negative breast cancer (TNBC), or squamous-cell carcinoma of the head and neck (SCCHN), Benjamin Cooper, David B Page, and See full list of authors in comments

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TAK-676 in combination with pembrolizumab after radiation therapy in patients (pts) with advanced non–small cell lung cancer (NSCLC), triple-negative breast cancer (TNBC), or squamous-cell carcinoma of the head and neck (SCCHN): Phase 1 study design., Benjamin T. Cooper and David B Page

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Phase III Randomized Trial of Maintenance Taxanes Versus Surveillance in Women With Advanced Ovarian/Tubal/Peritoneal Cancer: A Gynecologic Oncology Group 0212:NRG Oncology Study., Larry J Copeland, Mark F Brady, Robert A Burger, William H Rodgers, Helen Q Huang, David Cella, David M O'Malley, Daron G Street, Krishnansu S Tewari, David P Bender, Robert T Morris, William J Lowery, David S Miller, Summer B Dewdney, Nick M Spirtos, Shashikant B Lele, Saketh Guntupalli, Frederick R Ueland, Gretchen E Glaser, Robert S Mannel, and Philip J DiSaia

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Genomic Correlates of Outcome in Tumor-Infiltrating Lymphocyte Therapy for Metastatic Melanoma., Caitlin A Creasy, Yuzhong Jeff Meng, Marie-Andrée Forget, Tatiana Karpinets, Katarzyna Tomczak, Chip Stewart, Carlos A Torres-Cabala, Shari Pilon-Thomas, Amod A Sarnaik, James J Mule, Levi Garraway, Matias A Bustos, Jianhua Zhang, Sapna P Patel, Adi Diab, Isabella C Glitza, Cassian Yee, Hussein Tawbi, Michael K Wong, Jennifer McQuade, Dave S B Hoon, Michael A Davies, Patrick Hwu, Rodabe N Amaria, Cara Haymaker, Rameen Beroukhim, and Chantale Bernatchez

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Easing the Journey-an Updated Review of Palliative Care for the Patient with High-Grade Glioma., Rita C Crooms, Margaret O Johnson, Heather Leeper, Ambereen Mehta, Michelle McWhirter, and Akanksha Sharma

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ASO Author Reflections: Reinforcing the Safety Net: Supporting Safety-Net Hospitals in Mitigating Breast Cancer Disparities., Angelena Crown and Kathie-Ann Joseph

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Fertility Preservation in Young Women with Breast Cancer: Impact on Treatment and Outcomes., Angelena Crown, Shirin Muhsen, Varadan Sevilimedu, Joanne Kelvin, Shari B Goldfarb, and Mary L Gemignani

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ASO Visual Abstract: The Role of Safety Net Hospitals in Reducing Disparities in Breast Cancer Care., Angelena Crown, Kalpana Ramiah, Bruce Siegel, and Kathie-Ann Joseph

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The Role of Safety-Net Hospitals in Reducing Disparities in Breast Cancer Care., Angelena Crown, Kalpana Ramiah, Bruce Siegel, and Kathie-Ann Joseph

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Dose escalation of davoceticept, a conditional CD28 costimulator and dual checkpoint inhibitor, in advanced malignancies (NEON-1), Diwakar Davar, Rachel E Sanborn, and See full list of authors in comments

Phase 1 study of SEA-TGT, a human, nonfucosylated monoclonal antibody directed to TIGIT with enhanced immune effector function, in patients with advanced malignancies (SGNTGT-001, trial in progress), D Davar, Rachel E Sanborn, and See full list of authors in comments

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The TP53 Database: transition from the International Agency for Research on Cancer to the US National Cancer Institute., Kelvin César de Andrade, Elaine E Lee, Elise M Tookmanian, Chimene A Kesserwan, James J Manfredi, Jessica N Hatton, Jennifer K Loukissas, Jiri Zavadil, Lei Zhou, Magali Olivier, Megan N Frone, Owais Shahzada, William J R Longabaugh, Christian P Kratz, David Malkin, Pierre Hainaut, and Sharon A Savage

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Comparison of health-care utilization and expenditures for minimally invasive vs. open colectomy for benign disease., Sarah E Diaz, Yongjin F Lee, Amir Bastawrous, I-Fan Shih, Shih-Hao Lee, Yanli Li, and Robert K Cleary

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PD-1 and ICOS co-expression identifies tumor-reactive CD4 T cells in human solid tumors., Rebekka Duhen, Olivier Fesneau, Kimberly Samson, Alexandra K Frye, Michael Beymer, Venkatesh Rajamanickam, David Ross, Eric Tran, Brady Bernard, Andrew D Weinberg, and Thomas Duhen

PD-1 and ICOS co-expression identifies tumor-reactive CD4 T cells in human solid tumors, Thomas Duhen

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Prognostic significance of ethnicity and age in advanced stage epithelial ovarian cancer: An NRG oncology/gynecologic oncology group study., Nefertiti C duPont, Danielle Enserro, Mark F Brady, Katherine Moxley, Joan L Walker, Casey Cosgrove, Kristin Bixel, Krishnansu S Tewari, Premal Thaker, Andrea E Wahner Hendrickson, Stephen Rubin, Keiichi Fujiwara, A Catherine Casey, John Soper, Robert A Burger, and Bradley J Monk

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Prognostic significance of ethnicity and age in advanced stage epithelial ovarian cancer: An NRG oncology/gynecologic oncology group study., Nefertiti C duPont, Danielle Enserro, Mark F Brady, Katherine Moxley, Joan L Walker, Casey Cosgrove, Kristin Bixel, Krishnansu S Tewari, Premal Thaker, Andrea E Wahner Hendrickson, Stephen Rubin, Keiichi Fujiwara, A Catherine Casey, John Soper, Robert A Burger, and Bradley J Monk

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The Emergence of Virtual Tumor Boards in Neuro-Oncology: Opportunities and Challenges., Chukwuyem Ekhator, Santosh Kesari, Ramya Tadipatri, Ekokobe Fonkem, and Jai Grewal

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Epigenetic Signatures Predict Pathologic Nodal Stage in Breast Cancer Patients with Estrogen Receptor-Positive, Clinically Node-Positive Disease., Miquel Ensenyat-Mendez, Dennis Rünger, Javier I Orozco, Julie Le, Jennifer L Baker, Joanne Weidhaas, Diego M Marzese, and Maggie L DiNome

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Real-world burden of chemotherapy-induced myelosuppression in patients with small cell lung cancer: a retrospective analysis of electronic medical data from community cancer care providers., Robert S. Epstein, Roshanthi Weerasinghe, Amy S. Parrish, JoAnn Krenitsky, Rachel E Sanborn, and Tehseen Salimi

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Dental management in head and neck cancers: from intensity-modulated radiotherapy with photons to proton therapy., Sabah Falek, Rajesh Regmi, Joel Herault, Melanie Dore, Anthony Vela, Pauline Dutheil, Cyril Moignier, Pierre-Yves Marcy, Julien Drouet, Arnaud Beddok, Noah E Letwin, Joel Epstein, Upendra Parvathaneni, and Juliette Thariat

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A Phase II, Single-arm Trial of Sunitinib and Erlotinib in Advanced Renal Cell Carcinoma., Zizhen Feng, Brendan Curti, David I Quinn, John M Strother, Zunqiu Chen, Rebecca Agnor, Tomasz M Beer, and Christopher W Ryan

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Phase II Randomized Trial of Transoral Surgery and Low-Dose Intensity Modulated Radiation Therapy in Resectable p16+ Locally Advanced Oropharynx Cancer: An ECOG-ACRIN Cancer Research Group Trial (E3311)., Robert L Ferris, Yael Flamand, Gregory S Weinstein, Shuli Li, Harry Quon, Ranee Mehra, Joaquin J Garcia, Christine H Chung, Maura L Gillison, Umamaheswar Duvvuri, Bert W O'Malley, Enver Ozer, Giovana R Thomas, Wayne M Koch, Neil D Gross, Richard Bryan Bell, Nabil F Saba, Miriam Lango, Eduardo Méndez, and Barbara Burtness

Identification of a subset of tumor-reactive CD8 TILs expressing NKG2A in HNSCC and CRC., O Fesneau, Thomas Duhen, and See full list of authors in comments

Identification of a subset of tumor-reactive CD8 TIL expressing NKG2A in HNSCC and CRC, O Fesneau, K Samson, V Rajamanickam, D Ross, and Thomas Duhen

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Roadmap on plasticity and epigenetics in cancer., Jasmine Foo, David Basanta, Russell C Rockne, Carly Strelez, Curran Shah, Kimya Ghaffarian, Shannon M Mumenthaler, Kelly Mitchell, Justin D Lathia, David Frankhouser, Sergio Branciamore, Ya-Huei Kuo, Guido Marcucci, Robert Vander Velde, Andriy Marusyk, Sui Huang, Kishore Hari, Mohit Kumar Jolly, Haralampos Hatzikirou, Kamrine Poels, Mary Spilker, Blerta Shtylla, Mark Robertson-Tessi, and Alexander R A Anderson

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Correction: Interplay between soluble CD74 and macrophage-migration inhibitory factor drives tumor growth and influences patient survival in melanoma., Yasunari Fukuda, Matias A Bustos, Sung-Nam Cho, Jason Roszik, Suyeon Ryu, Victor M Lopez, Jared K Burks, Jeffrey E Lee, Elizabeth A Grimm, Dave S B Hoon, and Suhendan Ekmekcioglu

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Interplay between soluble CD74 and macrophage-migration inhibitory factor drives tumor growth and influences patient survival in melanoma., Yasunari Fukuda, Matias A Bustos, Sung-Nam Cho, Jason Roszik, Suyeon Ryu, Victor M Renteria-Lopez, Jared K Burks, Jeffrey E Lee, Elizabeth A Grimm, Dave Hoon, and Suhendan Ekmekcioglu

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Recommended phase 2 dose (RP2D) of HB-200 arenavirus-based cancer immunotherapies in patients with HPV16+ cancers., Siqing Fu, Rom Leidner, and Matthew H Taylor

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Organ Preservation in Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant Therapy., Julio Garcia-Aguilar, Sujata Patil, Marc J Gollub, Jin K Kim, Jonathan B Yuval, Hannah M Thompson, Floris S Verheij, Dana M Omer, Meghan Lee, Richard F Dunne, Jorge Marcet, Peter Cataldo, Blase Polite, Daniel O Herzig, David Liska, Samuel Oommen, Charles M Friel, Charles Ternent, Andrew L Coveler, Steven Hunt, Anita Gregory, Madhulika G Varma, Brian L Bello, Joseph C Carmichael, John Krauss, Ana Gleisner, Philip B Paty, Martin R Weiser, Garrett M Nash, Emmanouil Pappou, José G Guillem, Larissa Temple, Iris H Wei, Maria Widmar, Sabrina Lin, Neil H Segal, Andrea Cercek, Rona Yaeger, J Joshua Smith, Karyn A Goodman, Abraham J Wu, and Leonard B Saltz

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Management of the undescended testis in children: An American pediatric surgical association outcomes and evidence based practice committee systematic review., Robert L Gates, Julia Shelton, Karen A Diefenbach, Meghan Arnold, Shawn D St Peter, Elizabeth J Renaud, Mark B Slidell, Stig Sømme, Patricia Valusek, Gustavo A Villalona, Jarod P McAteer, Alana L Beres, Joanne Baerg, Rebecca M Rentea, Lorraine Kelley-Quon, Akemi L Kawaguchi, Yue-Yung Hu, Doug Miniati, Robert Ricca, and Robert Baird

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Label-free plasma proteomics for the identification of the putative biomarkers of oral squamous cell carcinoma., Shashyendra Singh Gautam, Raghwendra Pratap Singh, Kajal Karsauliya, Ashish Kumar Sonker, Panga Jaipal Reddy, Divya Mehrotra, Sameer Gupta, Sudhir Singh, Rashmi Kumar, and Sheelendra Pratap Singh

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A phase 2 study of an off-the-shelf, multi-neoantigen vector (ADXS-503) in patients with metastatic non–small cell lung cancer either progressing on prior pembrolizumab or in the first-line setting., Gregory James Gerstner, Rachel E Sanborn, and See full list of authors in comments

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Management of recurrent transudative pleural effusions: can we REDUCE unnecessary interventions?, Christopher R Gilbert and José M Porcel

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A phase 1b, multicenter, dose-escalation study of subasumstat (TAK-981) in combination with pembrolizumab in patients (pts) with advanced solid tumors., Sanjay Goel, Rachel E Sanborn, and See full list of authors in comments

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COVID-19 and Cancer: Special Considerations for Patients Receiving Immunotherapy and Immunosuppressive Cancer Therapies., Jason D Goldman, Michael A Gonzalez, Maria Madeleine Rüthrich, Elad Sharon, and Marie von Lilienfeld-Toal

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Safety and tolerability of MEDI0562, an OX40 agonist monoclonal antibody, in combination with durvalumab or tremelimumab in adult patients with advanced solid tumors., Jonathan W Goldman, Sarina A Piha-Paul, Brendan Curti, Katrina S Pedersen, Todd M Bauer, Stefanie L Groenland, Richard D Carvajal, Vaishali Chhaya, Gray Kirby, Kelly McGlinchey, Scott A Hammond, Katie L Streicher, Danielle Townsley, Young Kwang Chae, Jens Voortman, Aurelien Marabelle, and John Powderly

Fluorescence tagging to monitor CD8 T cell recirculation from the tumor to the tumor-draining lymph node: the impact of focal radiation therapy on recirculation, Michael J. Gough

Tumor resident memory CD8 T cell formation and concomitant tumor immunity is CD40L dependent and CD4 independent, Michael J. Gough

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The paradox of radiation and T cells in tumors., Michael J. Gough and Marka R Crittenden

Tumor resident memory CD8 T cell formation and concomitant tumor immunity is CD40L dependent and CD4 independent., Michael J. Gough, Thomas Duhen, Marka R Crittenden, and See all authors in comments

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Pembrolizumab plus dinaciclib in patients with hematologic malignancies: the phase 1b KEYNOTE-155 study., Gareth P Gregory, Shaji Kumar, Ding Wang, Daruka Mahadevan, Patricia Walker, Nina Wagner-Johnston, Carolina Escobar, Rajat Bannerji, Divaya Bhutani, Julie Chang, Francisco J Hernandez-Ilizaliturri, Andreas Klein, John M Pagel, Witold Rybka, Andrew J Yee, Anne Mohrbacher, Mo Huang, Mohammed Farooqui, Patricia Marinello, and Hang Quach

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Impact of neurofibromatosis type 1 in an adult community population., Timothy A Gregory, Peter Simon B Molina, Gregory D Phillips, and John W Henson

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Prospective biomarker study in newly diagnosed glioblastoma: Cyto-C clinical trial., Corinne E Griguer, Claudia R Oliva, Christopher S Coffey, Merit E Cudkowicz, Robin A Conwit, Anna L Gudjonsdottir, Dixie J Ecklund, Janel K Fedler, Tina M Neill-Hudson, Louis B Nabors, Melanie Benge, James R Hackney, Marianne Chase, Timothy P Leonard, Toral Patel, Howard Colman, Macarena de la Fuente, Rekha Chaudhary, Karen Marder, Teri Kreisl, Nimish Mohile, Milan G Chheda, Katharine McNeill, Priya Kumthekar, Aclan Dogan, Jan Drappatz, Vinay Puduvalli, Agnes Kowalska, Jerome J Graber, Elizabeth Gerstner, Stephen Clark, Michael Salacz, and James Markert

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Outcomes of Lymph Node Dissection in Nephroureterectomy in the Treatment of Upper Tract Urothelial Carcinoma: Analysis of the ROBUUST Registry., Kevin Hakimi, Umberto Carbonara, Hooman Djaladat, Reza Mehrazin, Daniel Eun, Adam Reese, Mark L Gonzalgo, Vitaly Margulis, Robert G Uzzo, James R Porter, Chandru P Sundaram, Firas Abdollah, Alexandre Mottrie, Riccardo Tellini, Matteo Ferro, Arman Walia, Ava Saidian, Shady Soliman, Julia Yuan, Alessandro Veccia, Alireza Ghoreifi, Giovanni Cacciamani, Amit S Bhattu, Xiaosong Meng, Jason M Farrow, Marcus Jamil, Andrea Minervini, Koon H Rha, Zhenjie Wu, Giuseppe Simone, Riccardo Autorino, and Ithaar H Derweesh

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Intratumoral Electroporation of Plasmid Encoded IL12 and Membrane-Anchored Anti-CD3 Increases Systemic Tumor Immunity., Mia Han, Bianca Nguyen, Jack Y Lee, Erica Browning, Jun Zhang, Anandaroop Mukhopadhyay, Ravindra Gujar, Jon Salazar, Reneta Hermiz, Lauren Svenson, Annah S Rolig, William L. Redmond, Alain P Algazi, Adil I Daud, David A Canton, and Christopher G Twitty

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Risk factors for cervical cancer among distinct populations in low-resource countries: feasibility of cervical cancer screen-and-treat program on ukerewe island of lake victoria, Tanzania., Anjali Y Hari, Megan Bernstein, Jamie Temko, Danielle E Brabender, Aricia Shen, and Krishnansu S Tewari

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Assessment of Regional Variability in COVID-19 Outcomes Among Patients With Cancer in the United States., Jessica E Hawley, Tianyi Sun, David D Chism, Narjust Duma, Julie C Fu, Na Tosha N Gatson, Sanjay Mishra, Ryan H Nguyen, Sonya A Reid, Oscar K Serrano, Sunny R K Singh, Neeta K Venepalli, Ziad Bakouny, Babar Bashir, Mehmet A Bilen, Paolo F Caimi, Toni K Choueiri, Scott J Dawsey, Leslie A Fecher, Daniel B Flora, Christopher R Friese, Michael J Glover, Cyndi J Gonzalez, Sharad Goyal, Thorvardur R Halfdanarson, Dawn L Hershman, Hina Khan, Chris Labaki, Mark A Lewis, Rana R McKay, Ian Messing, Nathan A Pennell, Matthew Puc, Deepak Ravindranathan, Terence D Rhodes, Andrea V Rivera, John Roller, Gary K Schwartz, Sumit A Shah, Justin A Shaya, Mitrianna Streckfuss, Michael A Thompson, Elizabeth M Wulff-Burchfield, Zhuoer Xie, Peter Paul Yu, Jeremy L Warner, Dimpy P Shah, Benjamin French, Clara Hwang, COVID-19 and Cancer Consortium (CCC19), and Hagen F Kennecke (COVID-19 and Cancer Consortium (CCC19))

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Radiofrequency ablation in the management of primary hepatic and biliary tumors., Richard Hendriquez, Tara Keihanian, Jatinder Goyal, Rtika R Abraham, Rajnish Mishra, and Mohit Girotra

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Meta-analysis of randomized controlled trials on primary ambulatory thromboprophylaxis in patients with nonpancreatic gastrointestinal cancers receiving chemotherapy., Thura Win Htut, Kyaw Zin Thein, Donald Paul Quick, and Thein Hlaing Oo

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Real-world evidence of a successful biosimilar adoption program., Sophia Z Humphreys

Proteogenomic Characterization of Head and Neck Squamous Cell Cancer Immunopeptidomes to Detect Non Canonical Protein Targets for Cancer Immunotherapy., N Iwamoto, Richard Bryan Bell, Carlo Bifulco, Walter Urba, Rom Leidner, Brian D. Piening, Bernard A Fox, and See full author list in comments

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RECOVERY AND SURVIVAL IN COVID-19 RESPIRATORY FAILURE‚ WHEN TREATED WITH AVIPTADIL, Dushyantha Jayaweera, David J Park, and See full list of authors in comments

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Agent-based computational modeling of glioblastoma predicts that stromal density is central to oncolytic virus efficacy., Adrianne L Jenner, Munisha Smalley, David Goldman, William F Goins, Charles Cobbs, Ralph B Puchalski, E Antonio Chiocca, Sean Lawler, Paul Macklin, Aaron Goldman, and Morgan Craig

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Interim results of an ongoing phase 1/2a study of HPN328, a tri-specific, half-life extended, DLL3-targeting, T-cell engager, in patients with small cell lung cancer and other neuroendocrine cancers., Melissa Lynne Johnson, Rachel E Sanborn, and See full list of authors in comments

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PCM1-JAK2 Fusion Tyrosine Kinase Gene-Related Neoplasia: A Systematic Review of the Clinical Literature., Henry G Kaplan, Ruyun Jin, Carlo Bifulco, James M Scanlan, and David R Corwin

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The SAGES MASTERS program presents: the 10 seminal articles for the Laparoscopic Right Colectomy Pathway., Deborah S Keller, Giovanni Dapri, Alexis L Grucela, George Melich, Ian M Paquette, Virginia O Shaffer, Konstantin Umanskiy, Angela H Kuhnen, Jeremy Lipman, Elisabeth C Mclemore, Mark Whiteford, and Patricia Sylla

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A preliminary safety assessment of vertebral augmentation with 32 P brachytherapy bone cement, Joyce H Keyak, Mando L Eijansantos, Katherine G Rosecrance, Daniel Wong, Sayeh Feizi, Aleen L Meldosian, Pranav Peddinti, Clifford M Les, Harry B Skinner, and Varun Sehgal

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Early Local Therapy for the Primary Site in De Novo Stage IV Breast Cancer: Results of a Randomized Clinical Trial (EA2108)., Seema A Khan, Fengmin Zhao, Lori J Goldstein, David Cella, Mark Basik, Mehra Golshan, Thomas B Julian, Barbara A Pockaj, Christine A Lee, Wajeeha Razaq, Joseph A Sparano, Gildy V Babiera, Irene A Dy, Sarika Jain, Paula Silverman, Carla S Fisher, Amye J Tevaarwerk, Lynne I Wagner, and George W Sledge

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Urine Cell-Free MicroRNAs in Localized Prostate Cancer Patients., Yoko Koh, Matias A Bustos, Jamie Moon, Rebecca Gross, Romela Irene Ramos, Suyeon Ryu, Jane Choe, Selena Y Lin, Warren M Allen, David L Krasne, Timothy G Wilson, and Dave Hoon

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Everolimus with or without bevacizumab in advanced pNET: CALGB 80701 (Alliance)., Matthew H Kulke, Fang-Shu Ou, Donna Niedzwiecki, Lucas Huebner, Pamela Kunz, Hagen F Kennecke, Edward M Wolin, Jennifer A Chan, Eileen M O'Reilly, Jeffrey A Meyerhardt, and Alan Venook

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Sustained postoperative plasma elevations of plasminogen activator inhibitor-1 following minimally invasive colorectal cancer resection., H M C Shantha Kumara, Poppy Addison, Dasuni N Gamage, Erica Pettke, Abhinit Shah, Xiaohong Yan, Vesna Cekic, and Richard L Whelan

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Real-World Treatment Patterns and Clinical Effectiveness of Palbociclib Plus an Aromatase Inhibitor as First-Line Therapy in Advanced/Metastatic Breast Cancer: Analysis from the US Syapse Learning Health Network., Jeanna Wallenta Law, Debanjali Mitra, Henry G Kaplan, Tamuno Alfred, Adam M Brufsky, Birol Emir, Haley McCracken, Xianchen Liu, Ronda G Broome, Chenan Zhang, Caroline DiCristo, and Connie Chen

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More autopsy studies are needed to understand the pathogenesis of severe COVID-19., Scott P Layne, Kathie-Anne Walters, John C Kash, and Jeffery K Taubenberger

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P2Y1 agonist HIC in combination with androgen receptor inhibitor abiraterone acetate impairs cell growth of prostate cancer., Hien Thi Thu Le, Akshaya Murugesan, Nuno R Candeias, Thiyagarajan Ramesh, Olli Yli-Harja, and Meenakshisundaram Kandhavelu

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Neoantigen T-Cell Receptor Gene Therapy in Pancreatic Cancer., Rom Leidner, Nelson Sanjuan Silva, Huayu Huang, David Sprott, Chunhong Zheng, Yi-Ping Shih, Amy Leung, Roxanne Payne, Kim Sutcliffe, Julie Cramer, Steven A Rosenberg, Bernard A Fox, Walter Urba, and Eric Tran

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CT502 - Preliminary immunological monitoring of first-in-human immunotherapy-trio for advanced head and neck squamous cell carcinoma, Rom Leidner, Matthew H Taylor, William L. Redmond, Brady Bernard, Richard Bryan Bell, Walter Urba, Carlo Bifulco, Brian D. Piening, Bernard A Fox, and See full authors list in comments

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Successful endovascular treatment of abdominal aortic rupture secondary to bacillus Calmette-Guérin vaccine., Andrew E Liechty, Albert Pacifico, and Peter Brant-Zawadzki

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Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk., Yafang Li, Xiangjun Xiao, Jianrong Li, Jinyoung Byun, Chao Cheng, Yohan Bossé, James McKay, Demetrios Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Stig E Bojesen, Maria T Landi, Mattias Johansson, Angela Risch, Heike Bickeböller, H-Erich Wichmann, David C Christiani, Gad Rennert, Susanne Arnold, Gary E Goodman, John K Field, Michael P A Davies, Sanjay S Shete, Loic Le Marchand, Olle Melander, Hans Brunnström, Geoffrey Liu, Rayjean J Hung, Angeline S Andrew, Lambertus A Kiemeney, Hongbing Shen, Ryan Sun, Shan Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Dawn M Teare, Yun-Chul Hong, Philip Lazarus, Matthew B Schabath, Melinda C Aldrich, Ann G Schwartz, Ivan Gorlov, Kristen Purrington, Ping Yang, Yanhong Liu, Younghun Han, Joan E Bailey-Wilson, Susan M Pinney, Diptasri Mandal, James C Willey, Colette Gaba, Paul Brennan, Christopher I Amos, and INTEGRAL-ILCCO lung cancer consortium

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Commentary: The forgotten nodal station in esophageal cancer., Brian Louie

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Drug-Eluting Bead, Irinotecan Therapy of Unresectable Intrahepatic Cholangiocarcinoma (DELTIC) with Concomitant Systemic Gemcitabine and Cisplatin., Robert C G Martin, Kerri A Simo, Paul D Hansen, Flavio Rocha, Prejesh Philips, Kelly M McMasters, Clifton M Tatum, Lawrence R Kelly, Michael Driscoll, Vivek R Sharma, Todd S Crocenzi, and Charles R Scoggins

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ASO Visual Abstract: Timing of Presentation and Outcomes of Women with Stage IV Pregnancy-Associated Breast Cancer (PABC)., Regina Matar, Angelena Crown, Varadan Sevilimedu, Shari B Goldfarb, and Mary L Gemignani

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Reply by Authors., Surena F Matin, Phillip M Pierorazio, Nir Kleinmann, John L Gore, Ahmad Shabsigh, Brian Hu, Karim Chamie, Guilherme Godoy, Scott G Hubosky, Marcelino Rivera, Michael O'Donnell, Marcus Quek, Jay D Raman, John J Knoedler, Douglas Scherr, Christopher Weight, Alon Weizer, Michael Woods, Hristos Kaimakliotis, Angela B Smith, Jennifer M Linehan, Jonathan Coleman, Mitchell R Humphreys, Raymond Pak, David Lifshitz, Michael Verni, Ifat Klein, Marina Konorty, Dalit Strauss-Ayali, Gil Hakim, Elyse Seltzer, Mark Schoenberg, and Seth P Lerner

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A single-arm, phase 2 study of perioperative ipilimumab, nivolumab, and cryoablation in women with hormone receptor-negative, HER2-negative, early-stage/resectable breast cancer., Heather L. McArthur, David B Page, and See full list of authors in comments

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Neoadjuvant HER2-targeted therapy +/- immunotherapy with pembrolizumab (neoHIP): An open-label randomized phase II trial., Heather L. McArthur, David B Page, and See full list of authors in comments

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Recurrence and Mortality Risk of Merkel Cell Carcinoma by Cancer Stage and Time From Diagnosis., Aubriana M McEvoy, Kristina Lachance, Daniel S Hippe, Kelsey Cahill, Yasman Moshiri, Christopher W Lewis, Neha Singh, Song Y Park, Zoe Thuesmunn, Maclean M Cook, Nora A Alexander, Lauren Zawacki, Hannah Thomas, Kelly G Paulson, and Paul Nghiem

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Outcomes by tobacco history in E3311, a phase II trial of transoral surgery (TOS) followed by pathology-based adjuvant treatment in HPV-associated (HPV+) oropharynx cancer (OPC): A trial of the ECOG-ACRIN Cancer Research Group., Ranee Mehra, Richard Bryan Bell, and See full list of authors in comments