The Cancer Institute is a leader in cutting-edge treatments. Using a truly multidisciplinary approach, patients have access to advanced diagnostics, minimally invasive surgical interventions, and personalized genomic and immune-oncologic treatment options. Our team of cancer specialists – many of whom completed fellowships and specialty training at prestigious academic centers – offers comprehensive services for individuals with a cancer diagnosis.

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Submissions from 2021

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Small molecules inhibitors of the heterogeneous ribonuclear protein A18 (hnRNP A18): a regulator of protein translation and an immune checkpoint., Eduardo Solano-Gonzalez, Katherine M Coburn, Wenbo Yu, Gerald M Wilson, Elmar Nurmemmedov, Santosh Kesari, Elizabeth T Chang, Alexander D MacKerell, David J Weber, and France Carrier

Submissions from 2020

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Pemigatinib for previously treated, locally advanced or metastatic cholangiocarcinoma: a multicentre, open-label, phase 2 study., Ghassan K Abou-Alfa, Vaibhav Sahai, Antoine Hollebecque, Gina Vaccaro, Davide Melisi, Raed Al-Rajabi, Andrew S Paulson, Mitesh J Borad, David Gallinson, Adrian G Murphy, Do-Youn Oh, Efrat Dotan, Daniel V Catenacci, Eric Van Cutsem, Tao Ji, Christine F Lihou, Huiling Zhen, Luis Féliz, and Arndt Vogel

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Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer., Joanna Achinger-Kawecka, Fatima Valdes-Mora, Phuc-Loi Luu, Katherine A Giles, C Elizabeth Caldon, Wenjia Qu, Shalima Nair, Sebastian Soto, Warwick J Locke, Nicole S Yeo-Teh, Cathryn M Gould, Qian Du, Grady C Smith, Irene R Ramos, Kristine F Fernandez, Dave S B Hoon, Julia M W Gee, Clare Stirzaker, and Susan J Clark

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Cytotoxic T cell depletion with increasing epithelial abnormality in women with benign breast disease., Sabina Adhikary, Tanya L Hoskin, Melody L Stallings-Mann, Muhammad Arshad, Marlene H Frost, Stacey J Winham, Alvaro Peña, Delphine J Lee, Linda M Murphy, Michele Rakoff, Lori A Denison, Keith L Knutson, Derek C Radisky, Daniel W Visscher, and Amy C Degnim

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A generalizable data-driven multicellular model of pancreatic ductal adenocarcinoma., Boris Aguilar, David L Gibbs, David J Reiss, Mark McConnell, Samuel A Danziger, Andrew Dervan, Matthew Trotter, Douglas Bassett, Robert Hershberg, Alexander V Ratushny, and Ilya Shmulevich

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Preoperative imaging characteristics predict poor survival and inadequate resection for left-sided pancreatic adenocarcinoma: a multi-institutional analysis., Farzad Alemi, Zeljka Jutric, George R Marshall, Elliot J Scott, Jan Grendar, Alexandra M Roch, Lucio L Pereira, An-Lin Cheng, Paul D Hansen, Eugene P Ceppa, Horacio J Asbun, Susanne Warner, and Adnan A Alseidi

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Intratumoral delivery of tavokinogene telseplasmid yields systemic immune responses in metastatic melanoma patients., A Algazi, S Bhatia, S Agarwala, M Molina, K Lewis, M Faries, L Fong, L P Levine, M Franco, A Oglesby, C Ballesteros-Merino, C B Bifulco, B A Fox, D Bannavong, R Talia, E Browning, M H Le, R H Pierce, S Gargosky, K K Tsai, C Twitty, and A I Daud

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Phase II Trial of IL-12 Plasmid Transfection and PD-1 Blockade in Immunologically Quiescent Melanoma., Alain P Algazi, Christopher G Twitty, Katy K Tsai, Mai Le, Robert Pierce, Erica Browning, Reneta Hermiz, David A Canton, Donna Bannavong, Arielle Oglesby, Murray Francisco, Lawrence Fong, Mikael J Pittet, Sean P Arlauckas, Christopher Garris, Lauren P Levine, Carlo Bifulco, Carmen Ballesteros-Merino, Shailender Bhatia, Sharron Gargosky, Robert H I Andtbacka, Bernard A Fox, Michael D Rosenblum, and Adil I Daud

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Estrogen and Progesterone Receptor Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Guideline Update., Kimberly H Allison, M Elizabeth H Hammond, Mitchell Dowsett, Shannon E McKernin, Lisa A Carey, Patrick L Fitzgibbons, Daniel F Hayes, Sunil R Lakhani, Mariana Chavez-MacGregor, Jane Perlmutter, Charles M Perou, Meredith M Regan, David L Rimm, W Fraser Symmans, Emina E Torlakovic, Leticia Varella, Giuseppe Viale, Tracey F Weisberg, Lisa M McShane, and Antonio C Wolff

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Estrogen and Progesterone Receptor Testing in Breast Cancer: ASCO/CAP Guideline Update., Kimberly H Allison, M Elizabeth H Hammond, Mitchell Dowsett, Shannon E McKernin, Lisa A Carey, Patrick L Fitzgibbons, Daniel F Hayes, Sunil R Lakhani, Mariana Chavez-MacGregor, Jane Perlmutter, Charles M Perou, Meredith M Regan, David L Rimm, W Fraser Symmans, Emina E Torlakovic, Leticia Varella, Giuseppe Viale, Tracey F Weisberg, Lisa M McShane, and Antonio C Wolff

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Physiological and Pathological Roles of Cdk5: Potential Directions for Therapeutic Targeting in Neurodegenerative Disease., Annamarie B Allnutt, Ariana K Waters, Santosh Kesari, and Venkata Mahidhar Yenugonda

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A phase 1b study of once-weekly carfilzomib combined with lenalidomide and dexamethasone in patients with newly diagnosed multiple myeloma., Melissa Alsina, Ola Landgren, Noopur Raje, Ruben Niesvizky, William Bensinger, Jesus G Berdeja, Tibor Kovacsovics, David H Vesole, Belle Fang, Amy S Kimball, and David S Siegel

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Intracellular Galectin-3 Is Essential for OX40-Mediated Memory CD8, Mohammad Farhad Amani, Annah S Rolig, and William L. Redmond

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Correction: Incorporating Breast Cancer Recurrence Events Into Population-Based Cancer Registries Using Medical Claims: Cohort Study., Teresa A'mar, J David Beatty, Catherine Fedorenko, Daniel Markowitz, Thomas Corey, Jane Lange, Stephen M Schwartz, Bin Huang, Jessica Chubak, and Ruth Etzioni

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Incorporating Breast Cancer Recurrence Events Into Population-Based Cancer Registries Using Medical Claims: Cohort Study., Teresa A'mar, J David Beatty, Catherine Fedorenko, Daniel Markowitz, Thomas Corey, Jane Lange, Stephen M Schwartz, Bin Huang, Jessica Chubak, and Ruth Etzioni

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Sgnlva-005: Open-label, phase II study of ladiratuzumab vedotin (LV) for advanced aerodigestive tract malignancies, Ian Churchill Anderson, Yinghui Wang, Zejing Wang, and Rachel E Sanborn

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Sgnlva-005: Open-label, phase II study of ladiratuzumab vedotin (LV) for advanced aerodigestive tract malignancies., Ian Churchill Anderson, Yinghui Wang, Zejing Wang, and Rachel E Sanborn

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The Supraorbital Eyebrow Craniotomy for Intra- and Extra-Axial Brain Tumors: A Single-Center Series and Technique Modification., Shaheryar F Ansari, Amy Eisenberg, Amanda Rodriguez, Garni Barkhoudarian, and Daniel F Kelly

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Safety and activity of varlilumab, a novel and first-in-class agonist anti-CD27 antibody, for hematologic malignancies., Stephen M Ansell, Ian Flinn, Matthew H Taylor, Branimir I Sikic, Joshua Brody, John Nemunaitis, Andrew Feldman, Thomas R Hawthorne, Tracey Rawls, Tibor Keler, and Michael J Yellin

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Updates on the Management of Thyroid Cancer., Katherine A Araque, Sriram Gubbi, and Joanna Klubo-Gwiezdzinska

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Pembrolizumab in relapsed or refractory Richter syndrome., Philippe Armand, Niels Murawski, Daniel Molin, Jasmine Zain, Barbara Eichhorst, Zafer Gulbas, Eliza A Hawkes, John M Pagel, Tycel Phillips, Vincent Ribrag, Jakub Svoboda, Anastasios Stathis, Arkendu Chatterjee, Robert Orlowski, Patricia Marinello, and Beth Christian

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The Society for Immunotherapy of Cancer perspective on regulation of interleukin-6 signaling in COVID-19-related systemic inflammatory response, Fernanda I. Arnaldez, Steven J. O'Day, Charles G. Drake, Bernard A Fox, Bingqing Fu, Walter Urba, Vincenzo Montesarchio, Jeffrey S. Weber, Haiming Wei, Jon M. Wigginton, and Paolo Antonio Ascierto

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Phase II Trial of Carfilzomib Plus Irinotecan in Patients with Small Cell Lung Cancer Who Have Progressed on Prior Platinum-Based Chemotherapy., Susanne M. Arnold, Kari Chansky, Maria Q. Baggstrom, Michael A. Thompson, Rachel E Sanborn, John L. Villano, Saiama N. Wagar, John Hamm, Markos Leggas, Maurice Willis, Joseph Rosales, and John J. Crowley

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Phase II Trial of Carfilzomib Plus Irinotecan in Patients With Small-cell Lung Cancer Who Have Progressed on Prior Platinum-based Chemotherapy., Susanne M Arnold, Kari Chansky, Maria Q Baggstrom, Michael A Thompson, Rachel E Sanborn, John L Villano, Saiama N Waqar, John Hamm, Markos Leggas, Maurice Willis, Joseph Rosales, and John J Crowley

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The Great Debate at 'Immunotherapy Bridge', Naples, December 5, 2019., Paolo A Ascierto, Carlo Bifulco, Jerome Galon, Claus Garbe, Samir N Khleif, Jennifer McQuade, Kunle Odunsi, Hideho Okada, Chrystal M Paulos, Sergio A Quezada, Hussein A Tawbi, John Timmerman, Giorgio Trinchieri, Lisa H Butterfield, and Igor Puzanov

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Insights from immuno-oncology: The Society for Immunotherapy of Cancer statement on access to IL-6-targeting therapies for COVID-19, Paolo A. Ascierto; Bernard A Fox; Walter Urba; Ana Carrizosa Anderson; Michael Atkins; Ernest C. Borden; Julie R. Brahmer; Lisa H. Butterfield; Alessandra Cesano; Daniel S. Chen; Tanja D. De Gruijl; Robert O. Dillman; Charles G. Drake; Leisha A. Emens; Thomas F. Gajewski; James L. Gulley; F Stephen Hodi, Jr.; Patrick Hwu; David Kaufman; Howard L. Kaufman; Michael T. Lotze; Francesco M. Marincola; Kim A. Margolin; Michael J. Mastrangelo; Marcela V. Maus; Douglas G. McNeel; David R. Parkinson; Pedro J. Romero; Paul M. Sondel; Stefani Spranger; Mario Sznol; George J. Weiner; Jon M. Wigginton; and Jeffrey S. Weber

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No time to die: the consensus immunoscore for predicting survival and response to chemotherapy of locally advanced colon cancer patients in a multicenter international study., Paolo A Ascierto, Francesco M Marincola, Bernard A Fox, and Jérôme Galon

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Insights from immuno-oncology: the Society for Immunotherapy of Cancer Statement on access to IL-6-targeting therapies for COVID-19., Paolo Antonio Ascierto, Bernard A Fox, Walter Urba, Ana Carrizosa Anderson, Michael B Atkins, Ernest C Borden, Julie Brahmer, Lisa H Butterfield, Alessandra Cesano, Daniel Chen, Tanja de Gruijl, Robert O Dillman, Charles G Drake, Leisha A Emens, Thomas F Gajewski, James L Gulley, F Stephen Hodi, Patrick Hwu, David Kaufman, Howard Kaufman, Michael Lotze, Douglas G McNeel, Kim Margolin, Francesco Marincola, Michael J Mastrangelo, Marcela V Maus, David R Parkinson, Pedro J Romero, Paul M Sondel, Stefani Spranger, Mario Sznol, George J Weiner, Jon M Wiggington, and Jeffrey S Weber

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Perspectives in melanoma: meeting report from the "Melanoma Bridge" (December 5th-7th, 2019, Naples, Italy)., Paolo A Ascierto, Igor Puzanov, Sanjiv S Agarwala, Christian Blank, Richard D Carvajal, Sandra Demaria, Reinhard Dummer, Marc Ernstoff, Soldano Ferrone, Bernard A Fox, Thomas F Gajewski, Claus Garbe, Patrick Hwu, Roger S Lo, Georgina V Long, Jason J Luke, Iman Osman, Michael A Postow, Ryan J Sullivan, Janis M Taube, Giorgio Trinchieri, Hassane M Zarour, Corrado Caracò, and Magdalena Thurin

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Contemporary Techniques in Orbital Reconstruction: A Review of the Literature and Report of a Case Combining Surgical Navigation, Computer-Aided Surgical Simulation, and a Patient-Specific Implant., Iman Azarmehr, Kasper Stokbro, R Bryan Bell, and Torben Thygesen

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Outpatient treatment with lisocabtagene maraleucel (liso-cel) across a variety of clinical sites from three ongoing clinical studies in relapsed/refractory (R/R) large B-cell lymphoma (LBCL)., Carlos R. Bachier, John E Godwin, Charalambos Andreadis, Maria Lia Palomba, Jeremy S. Abramson, Alison R. Sehgal, Gerhard Hildebrandt, Don A. Stevens, Daanish Hoda, Edward J. Licitra, Tanya Siddiqi, Thalia Andrea Farazi, Ana Kostic, Nikolaus S. Trede, Lei Wang, James Lymp, and David G. Mahoney

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Outpatient Treatment with Lisocabtagene Maraleucel (liso-cel) in 3 Ongoing Clinical Studies in Relapsed/Refractory (R/R) Large B Cell Non-Hodgkin Lymphoma (NHL), Including Second-Line Transplant Noneligible (TNE) Patients: Transcend NHL 001, Outreach, and PILOT, Carlos R. Bachier, M Lia Palomba, Jeremy S. Abramson, Charalambos Andreadis, Alison Sehgal, John E Godwin, Gerhard C. Hildebrandt, Tanya Siddiqi, Don Stevens, Thalia Farazi, Ana Kostic, Nikolaus S. Trede, Lei Wang, James Lymp, Tennille Thelen, Ken Ogasawara, and David G. Maloney

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Disparities in Risk Reduction Therapy Recommendations for Young Women With Lobular Carcinoma In-Situ., Bradley Bandera, Amy Voci, Daniel Nelson, Stacey L Stern, Dany Barrak, Trevan D Fischer, Maggie L DiNome, and Melanie Goldfarb

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Improved tolerability of neratinib in patients with HER2-positive early-stage breast cancer: the CONTROL trial., C H Barcenas, S A Hurvitz, J A Di Palma, R Bose, A J Chien, N Iannotti, G Marx, A Brufsky, A Litvak, E Ibrahim, R H Alvarez, M Ruiz-Borrego, N Chan, Y Manalo, A Kellum, M Trudeau, M Thirlwell, J Garcia Saenz, D Hunt, R Bryce, L McCulloch, H S Rugo, D Tripathy, A Chan, CONTROL Study Investigators, and Alison Conlin

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A Mother in Jeopardy: The Ethics of Pregnancy and Chemotherapy., Steven J Baumrucker, Wendy H Vogel, Robert M Stolick, Russell W Adkins, Heather Holland, Gregg VandeKieft, and Angela Eastridge

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Peptidomimetic Polo-Box-Targeted Inhibitors that Engage PLK1 in Tumor Cells and Are Selective against the PLK3 Tumor Suppressor., Merissa Baxter, Danda Chapagai, Sandra Craig, Cecilia Hurtado, Jessy Varghese, Elmar Nurmemmedov, Michael D Wyatt, and Campbell McInnes

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Abstract B01: Surgical outcomes following neoadjuvant hypofractionated radiation in combination with nivolumab: High rate of pathologic complete response in patients with p16+ head and neck squamous cell carcinoma, Richard Bryan Bell, Rom Leidner, Marcus Couey, Ashish Patel, Amber L Watters, Hong Ziao, Carlo Bifulco, Brian D. Piening, George Morris, Lessli Rushforth, Dawn Brucker, Shorin Nemeth, Kristina H Young, Michael J. Gough, and Marka R Crittenden

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Abstract B01: Surgical outcomes following neoadjuvant hypofractionated radiation in combination with nivolumab: High rate of pathologic complete response in patients with p16+ head and neck squamous cell carcinoma, Richard Bryan Bell, Rom Leidner, Marcus Couey, Ashish Patel, Amber L Watters, Hong Ziao, Carlo Bifulco, Brian D. Piening, George Morris, Lessli Rushforth, Dawn Brucker, Shorin Nemeth, Kristina H Young, Michael J. Gough, and Marka R Crittenden

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Cohort Expansion Study of Neoadjvuant Immunoradiotherapy in Locoregionally Advanced HPV+ and HPV- Head and Neck Squamous Cell Carcinoma, Richard Bryan Bell, Rom Leidner, Kristina H Young, Brendan Curti, Marcus Couey, Ashish Patel, Amber L Watters, Hong D Xiao, George Morris, Lessli Rushforth, Michael J. Gough, and Marka R Crittenden

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Cohort Expansion Study of Neoadjvuant Immunoradiotherapy in Locoregionally Advanced HPV+ and HPV- Head and Neck Squamous Cell Carcinoma, Richard Bryan Bell, Rom Leidner, Kristina H Young, Brendan Curti, Marcus Couey, A Patel, Amber L Watters, Hong D Xiao, G Morris, L Rushforth, Michael J. Gough, and Marka R Crittenden

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Medial Femoral Condyle Vascularized Bone Graft for Treatment of Midshaft Clavicle Recalcitrant Nonunion With Use of the Transverse Cervical Artery as an Anastomosis., Christopher M Belyea, Jefferson L Lansford, Joseph B Golden, Emily H Shin, and Rey D L Gumboc

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Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-γ, CXCL9 and CXCL10., Cristina Bergamaschi, Hrishikesh Pandit, Bethany A Nagy, Dimitris Stellas, Shawn M. Jensen, Jenifer Bear, Maggie Cam, Antonio Valentin, Bernard A Fox, Barbara K Felber, and George N Pavlakis

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Transcriptional and immunohistological assessment of immune infiltration in pancreatic cancer., Brady Bernard, Venkatesh Rajamanickam, Christopher Dubay, Brian D. Piening, Emilio Alonso, Zeljka Jutric, Ephraim Tang, Pippa Newell, Paul D Hansen, Terry R Medler, Andrew J Gunderson, Kristina H Young, Carlo Bifulco, Joanna Pucilowska, Marka R Crittenden, and Michael J. Gough

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Baseline Demographics and Clinical Characteristics Among 3471 US Patients Hospitalized with COVID-19 and Pulmonary Involvement: A Retrospective Study., Jennie H Best, Shalini V Mohan, Amanda M Kong, Krish Patel, John M Pagel, Boris Ivanov, Otis W Brawley, Krutika Jariwala-Parikh, James L Zazzali, and John S Pauk

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Flt3 ligand augments immune responses to anti-DEC-205-NY-ESO-1 vaccine through expansion of dendritic cell subsets, Nina Bhardwaj, Philip A. Friedlander, Anna C. Pavlick, Marc S. Ernstoff, Brian R. Gastman, Brent A. Hanks, Brendan Curti, Mark R. Albertini, Jason J. Luke, Ana B. Blazquez, Sreekumar Balan, Davide Bedognetti, Joseph M. Beechem, Andrea S. Crocker, Leonard D'Amico, Patrick Danaher, Thomas A. Davis, Thomas Hawthorne, Bruce W. Hess, Tibor Keler, Lisa Lundgren, Chihiro Morishima, Nirasha Ramchurren, Darawan Rinchai, Andres M. Salazar, Bob A. Salim, Elad Sharon, Laura A. Vitale, Ena Wang, Sarah Warren, Michael J. Yellin, Mary L. Disis, Martin A. Cheever, and Steven P. Fling

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72 Routine use of comprehensive genomic profiling to assess tumor mutational burden across a community health system, Carlo Bifulco, Roshanthi Weerasinghe, Bela Bapat, Alexa K Dowdell, Shwetha Pindikuri, Sheila Reynolds, Nancy Biery, David Ball, Mary Campbell, Thomas R. Ward, Alisha Stein, Brock Schroeder, David Eberhard, and Brian D. Piening

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72 Routine use of comprehensive genomic profiling to assess tumor mutational burden across a community health system, Carlo Bifulco, Roshanthi Weerasinghe, Bela Bepat, Alexa K Dowdell, Shwetha Pindikuri, Sheila Reynolds, Nancy Biery, David Ball, Mary Campbell, Thomas R. Ward, Alisha Stein, Brock Schroeder, David Eberhard, and Brian D. Piening

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Dendritic Cell Maturation Defines Immunological Responsiveness of Tumors and Radiation, Tiffany Blair, S Bambina, Alejandro F Alice, Gwen Kramer, Jason R Baird, Terry R Medler, V Troesch, Marka R Crittenden, and Michael J. Gough

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Dendritic Cell Maturation Defines Immunological Responsiveness of Tumors and Radiation, Tiffany C. Blair, Shelly Bambina, Alejandro F Alice, Gwen Kramer, Terry R Medler, Jason R Baird, Miranda L. Broz, Garth Tormoen, Victoria Troesch, Marka R Crittenden, and Michael J. Gough

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Dendritic Cell Maturation Defines Immunological Responsiveness of Tumors to Radiation Therapy., Tiffany C Blair, Shelly Bambina, Alejandro F Alice, Gwen Kramer, Terry R Medler, Jason R Baird, Miranda L Broz, Garth W Tormoen, Victoria Troesch, Marka R Crittenden, and Michael J. Gough

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Salvage Lung Resections After Definitive Chemoradiotherapy: A Safe and Effective Oncologic Option., Adam J Bograd, Catherine Mann, Jed A Gorden, Christopher R Gilbert, Alexander S Farivar, Ralph W Aye, Brian Louie, and Eric Vallières

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Surgery as a Component of Multimodality Care for Known Stage IIIA-N2 Non-small Cell Lung Cancer., Adam J Bograd and Eric Vallières

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Part Two: 8. Immunology, Christine Boley Ed.

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CX-2009, a CD166-directed probody drug conjugate (PDC): Results from the first-in-human study in patients (Pts) with advanced cancer including breast cancer (BC)., Valentina Boni, Howard A. Burris III, Joyce F. Liu, Alexandra I. Spira, Hendrik-Tobias Arkenau, Mary J. Fidler, Lee S. Rosen, Randy F. Sweis, Nataliya Volodymyrivna Uboha, Rachel E Sanborn, Bert O'Neil, James J. Harding, Patricia LoRusso, Amy M. Weise, Javier Garcia-Corbacho, Ivan Victoria, John W. Frye, Rachel Li, Mark Stroh, and Funda Meric-Bernstam

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The Landscape of Glycogen synthase kinase-3 beta (GSK-3b) Genomic Alterations in Cancer., Brittany A Borden, Yasmine Baca, Joanne Xiu, Fabio Tavora, Ira Winer, Benjamin A Weinberg, Ari M VanderWalde, Sourat Darabi, W Michael Korn, Andrew P Mazar, Francis J Giles, Lorin Crawford, Howard Safran, Wafik S El-Deiry, and Benedito A Carneiro

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Transcriptome-wide association study reveals candidate causal genes for lung cancer., Yohan Bossé, Zhonglin Li, Jun Xia, Venkata Manem, Robert Carreras-Torres, Aurélie Gabriel, Nathalie Gaudreault, Demetrius Albanes, Melinda C Aldrich, Angeline Andrew, Susanne Arnold, Heike Bickeböller, Stig E Bojesen, Paul Brennan, Hans Brunnstrom, Neil Caporaso, Chu Chen, David C Christiani, John K Field, Gary E Goodman, Kjell Grankvist, Richard Houlston, Mattias Johansson, Mikael Johansson, Lambertus A Kiemeney, Stephen Lam, Maria T Landi, Philip Lazarus, Loic Le Marchand, Geoffrey Liu, Olle Melander, Gadi Rennert, Angela Risch, Susan M Rosenberg, Matthew B Schabath, Sanjay Shete, Zhuoyi Song, Victoria L Stevens, Adonina Tardon, H-Erich Wichmann, Penella Woll, Shan Zienolddiny, Ma'en Obeidat, Wim Timens, Rayjean J Hung, Philippe Joubert, Christopher I Amos, and James D McKay

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PANEL DISCUSSION: Future Directions for Adoptive Cell Therapy, Adrian Bot, Andreas Bader, Christina Coughlin, and Andrew D Weinberg

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The Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of acute leukemia., Michael M Boyiadzis, Ivan Aksentijevich, Daniel A Arber, John Barrett, Renier J Brentjens, Jill Brufsky, Jorge Cortes, Marcos De Lima, Stephen J Forman, Ephraim J Fuchs, Linda J Fukas, Steven D Gore, Mark R Litzow, Jeffrey S Miller, John M Pagel, Edmund K Waller, and Martin S Tallman

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Robotic Partial Nephrectomy versus Minimally Invasive Radical Nephrectomy for Clinical T2a Renal Mass: A Propensity Score Matched Comparison from the ROSULA (Robotic Surgery for Large Renal Mass) Collaborative Group., Aaron W Bradshaw, Riccardo Autorino, Giuseppe Simone, Bo Yang, Robert G Uzzo, Francesco Porpiglia, Umberto Capitanio, James R Porter, Riccardo Bertolo, Andrea Minervini, Clayton Lau, Kenneth Jacobsohn, Akbar Ashrafi, Daniel Eun, Alexander Mottrie, Wesley M White, Luigi Schips, Benjamin J Challacombe, Ottavio De Cobelli, Carmen M Mir, Alessandro Veccia, Alessandro Larcher, Alexander Kutikov, Monish Aron, Prokar Dasgupta, Francesco Montorsi, Inderbir S Gill, Chandru P Sundaram, Jihad Kaouk, and Ithaar H Derweesh

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Core Curriculum for Oncology Nursing 6th ed. St. Louis, MO: Elsevier., Jeannine M. Brant, Diane G. Cope, and Marlon G Saria

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A phase I/II study of HB-201, an arenavirus-based cancer immunotherapy, alone, or in combination with anti-PD-1 in patients with HPV16+ cancers., Bharat Burman, Jiaxin Niu, Rom Leidner, Ding Wang, Debra L. Richardson, Corinne Iacobucci, Andy Hwang, Xiaoping Qing, Igor Matushansky, Dmitriy Zamarin, Alan Loh Ho, David G. Pfister, and Marshall R. Posner

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A Pilot Study Comparing the Efficacy of Lactate Dehydrogenase Levels Versus Circulating Cell-Free microRNAs in Monitoring Responses to Checkpoint Inhibitor Immunotherapy in Metastatic Melanoma Patients., Matias A Bustos, Rebecca Gross, Negin Rahimzadeh, Hunter Cole, Linh T Tran, Kevin Tran, Ling Takeshima, Stacey L Stern, Steven O'Day, and Dave Hoon

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Integrated Assessment of Circulating Cell-Free MicroRNA Signatures in Plasma of Patients with Melanoma Brain Metastasis., Matias Bustos, Kevin Tran, Negin Rahimzadeh, Rebecca Gross, Selena Y Lin, Yoshiaki Shoji, Tomohiro Murakami, Christine L Boley, Linh T Tran, Hunter Cole, Daniel F Kelly, Steven J O'Day, and Dave Hoon

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Acalabrutinib monotherapy in patients with relapsed/refractory chronic lymphocytic leukemia: updated phase 2 results., John C Byrd, William G Wierda, Anna Schuh, Stephen Devereux, Jorge M Chaves, Jennifer R Brown, Peter Hillmen, Peter Martin, Farrukh T Awan, Deborah M Stephens, Paolo Ghia, Jacqueline Barrientos, John M Pagel, Jennifer A Woyach, Kathleen Burke, Todd Covey, Michael Gulrajani, Ahmed Hamdy, Raquel Izumi, Melanie M Frigault, Priti Patel, Wayne Rothbaum, Min Hui Wang, Susan O'Brien, and Richard R Furman

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Discovery of driver non-coding splice-site-creating mutations in cancer., Song Cao, Daniel Cui Zhou, Clara Oh, Reyka G Jayasinghe, Yanyan Zhao, Christopher J Yoon, Matthew A Wyczalkowski, Matthew H Bailey, Terrence Tsou, Qingsong Gao, Andrew Malone, Sheila Reynolds, Ilya Shmulevich, Michael C Wendl, Feng Chen, and Li Ding

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PD-1 Blockade in Anaplastic Thyroid Carcinoma., Jaume Capdevila, Lori J Wirth, Thomas Ernst, Santiago Ponce Aix, Chia-Chi Lin, Rodryg Ramlau, Marcus O Butler, Jean-Pierre Delord, Hans Gelderblom, Paolo A Ascierto, Angelica Fasolo, Dagmar Führer, Marie Luise Hütter-Krönke, Patrick M Forde, Anna Wrona, Armando Santoro, Peter M Sadow, Sebastian Szpakowski, Hongqian Wu, Geraldine Bostel, Jason Faris, Scott Cameron, Andreea Varga, and Matthew H Taylor

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Comprehensive Analysis of Genetic Ancestry and Its Molecular Correlates in Cancer., Jian Carrot-Zhang, Nyasha Chambwe, Jeffrey S Damrauer, Theo A Knijnenburg, A Gordon Robertson, Christina Yau, Wanding Zhou, Ashton C Berger, Kuan-Lin Huang, Justin Y Newberg, R Jay Mashl, Alessandro Romanel, Rosalyn W Sayaman, Francesca Demichelis, Ina Felau, Garrett M Frampton, Seunghun Han, Katherine A Hoadley, Anab Kemal, Peter W Laird, Alexander J Lazar, Xiuning Le, Ninad Oak, Hui Shen, Christopher K Wong, Jean C Zenklusen, Elad Ziv, Cancer Genome Atlas Analysis Network, Andrew D Cherniack, and Rameen Beroukhim

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Margetuximab plus pembrolizumab in patients with previously treated, HER2-positive gastro-oesophageal adenocarcinoma (CP-MGAH22-05): a single-arm, phase 1b-2 trial., Daniel V T Catenacci, Yoon-Koo Kang, Haeseong Park, Hope E Uronis, Keun-Wook Lee, Matthew C H Ng, Peter C Enzinger, Se Hoon Park, Philip J Gold, Jill Lacy, Howard S Hochster, Sang Cheul Oh, Yeul Hong Kim, Kristen A Marrone, Ronan J Kelly, Rosalyn A Juergens, Jong Gwang Kim, Johanna C Bendell, Thierry Alcindor, Sun Jin Sym, Eun-Kee Song, Cheng Ean Chee, Yee Chao, Sunnie Kim, A Craig Lockhart, Keith L Knutson, Jennifer Yen, Aleksandra Franovic, Jeffrey L Nordstrom, Daner Li, Jon Wigginton, Jan K Davidson-Moncada, Minori Koshiji Rosales, Yung-Jue Bang, and CP-MGAH22-5 Study Group

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Minimally Invasive Esophagectomy: A Consensus Statement., Robert J Cerfolio, Anne-Sophie Laliberte, Shanda Blackmon, Jelle P Ruurda, Richard van Hillegersberg, Inderpal Sarkaria, and Brian Louie

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Society for Immunotherapy of Cancer clinical and biomarkers data sharing resource document: Volume II-practical challenges., Alessandra Cesano, Michael A Cannarile, Sacha Gnjatic, Bruno Gomes, Justin Guinney, Vaios Karanikas, Mohan Karkada, John M Kirkwood, Beatrix Kotlan, Giuseppe V Masucci, Els Meeusen, Anne Monette, Aung Naing, Vésteinn Thorsson, Nicholas Tschernia, Ena Wang, Daniel K Wells, Timothy L Wyant, and Sergio Rutella

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Hysterectomy Versus Hysteropexy at the Time of Native Tissue Pelvic Organ Prolapse Repair: A Cost-Effectiveness Analysis., Olivia H Chang, Jonathan P Shepherd, Beri M Ridgeway, and Lauren A Cadish

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Patient-reported outcomes at discontinuation of anti-angiogenesis therapy in the randomized trial of chemotherapy with bevacizumab for advanced cervical cancer: an NRG Oncology Group study., Dana Chase, Helen Q Huang, Bradley J Monk, Lois Michelle Ramondetta, Richard T Penson, Karen Gil, Lisa M Landrum, Mario Leitao, Ana Oaknin, Warner K Huh, Heather L Pulaski, Katina Robison, Saketh R Guntupalli, Debra Richardson, Ritu Salani, Michael W Sill, Lari B Wenzel, and Krishnansu S Tewari

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Allosteric inhibitor of β-catenin selectively targets oncogenic Wnt signaling in colon cancer., Anton Cheltsov, Natsuko Nomura, Venkata Mahidhar Yenugonda, Jatin Roper, Rajesh Mukthavaram, Pengfei Jiang, Nam-Gu Her, Ivan Babic, Santosh Kesari, and Elmar Nurmemmedov

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Enhanced B7-H4 expression in gliomas with low PD-L1 expression identifies super-cold tumors., Di Chen, Gaopeng Li, Chunxia Ji, Qiqi Lu, Ying Qi, Chao Tang, Ji Xiong, Jian Hu, Fatma Betul Aksoy Yasar, Yan Zhang, Dave S B Hoon, Yu Yao, and Liangfu Zhou

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Cancer Systems Biology in the Era of Single-Cell Multi-Omics., Hanjun Cheng, Rong Fan, and Wei Wei

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Multimodality screening and prevention of cervical cancer in sub-Saharan Africa: a collaborative model., Justine Chinn and Krishnansu S Tewari

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1258O Amivantamab (JNJ-61186372), an EGFR-MET bispecific antibody, in combination with lazertinib, a 3rd-generation tyrosine kinase inhibitor (TKI), in advanced EGFR NSCLC, BC Cho, KH Lee, EK Cho, D-W Kim, J-S Lee, J-Y Han, S-W Kim, A Spira, EB Haura, EK Sabari, Rachel E Sanborn, JM Bauml, JE Gomez, P Lorenzini, JR Infante, J Xie, N Haddish-Berhane, M Thayu, RE Knoblauch, and K Park

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A phase II trial evaluating the efficacy of high-dose Radioiodinated Tositumomab (Anti-CD20) antibody, etoposide and cyclophosphamide followed by autologous transplantation, for high-risk relapsed or refractory non-hodgkin lymphoma., Victor A Chow, Joseph G Rajendran, Darrell R Fisher, Frederick R Appelbaum, Ryan D Cassaday, Paul S Martin, Leona A Holmberg, Theodore A Gooley, Philip A Stevenson, John M Pagel, Damian J Green, Oliver W Press, and Ajay K Gopal

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Oncology Care Delivery in the COVID-19 Pandemic: An Opportunity to Study Innovations and Outcomes., Pelin Cinar, John Cox, Arif Kamal, Kathleen Bickel, Monika Krzyzanowska, James Armitage, Apar Kishor Ganti, Jeffery C Ward, Sandra Wong, Sagar Lonial, and Linda Bosserman

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Robotic surgery for gynecologic cancers: indications, techniques and controversies., Kiran H Clair and Krishnansu S Tewari

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Results of a randomized phase IIb trial of nelipepimut-S + trastuzumab vs trastuzumab to prevent recurrences in high-risk HER2 low-expressing breast cancer patients., G Travis Travis Clifton, Diane Hale, Timothy J Vreeland, Annelies T Hickerson, Jennifer K Litton, Gheath Alatrash, Rashmi K Murthy, Na Qiao, Anne V Philips, Jason J Lukas, Jarrod P Holmes, George E Peoples, and Elizabeth A Mittendorf

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976TiP SPEARHEAD-2 trial design: A phase II pilot trial of ADP-A2M4 in combination with pembrolizumab in patients with recurrent or metastatic head and neck cancer, EE Cohen, L Dunn, P Neupane, M Gibson, Rom Leidner, P Savvides, N Hyland, T Trivedi, M Dudley, S Biswas, D Williams, and E Norry

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Patient-reported outcomes from KATHERINE: A phase 3 study of adjuvant trastuzumab emtansine versus trastuzumab in patients with residual invasive disease after neoadjuvant therapy for human epidermal growth factor receptor 2-positive breast cancer., PierFranco Conte, Andreas Schneeweiss, Sibylle Loibl, Eleftherios P Mamounas, Gunter von Minckwitz, Max S Mano, Michael Untch, Chiun-Sheng Huang, Norman Wolmark, Priya Rastogi, Veronique D'Hondt, Andrés Redondo, Ljiljana Stamatovic, Hervé Bonnefoi, Hugo Castro-Salguero, Hans H Fischer, Tanya Wahl, Chunyan Song, Thomas Boulet, Peter Trask, and Charles E Geyer

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Implementation of human papillomavirus video education for women participating in mass cervical cancer screening in Tanzania., Emma C Cooper, Justine A Maher, Ariana Naaseh, Elizabeth W Crawford, Justine O Chinn, Ava S Runge, Alexa N Lucas, Danielle C Zezoff, Kevin R Bera, Andreea I Dinicu, Kayla M White, Sujata E Tewari, Anjali Hari, Megan Bernstein, Jenny Chang, Argyrios Ziogas, Diana C Pearre, and Krishnansu S Tewari

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Impact of Late Dosing on Testosterone Suppression with Two Different Leuprolide Acetate Formulations: In Situ Gel and Microsphere - An Analysis of US Clinical Data., E David Crawford, Jason M Hafron, Scott T Tagawa, Przemyslaw Twardowski, Richard G Harris, Judd W Moul, Thomas E Keane, Raoul S Concepcion, Celestia S Higano, Lucio N Gordan, Daniel P Petrylak, Chaundre K Cross, A Karim Kader, and Neal D Shore

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The Impact of Late Luteinizing Hormone-Releasing Hormone Agonist Dosing on Testosterone Suppression in Patients with Prostate Cancer: An Analysis of United States Clinical Data., E David Crawford, Przemyslaw Twardowski, Raoul S Concepcion, Jason M Hafron, Richard G Harris, Judd W Moul, Lucio N Gordan, Daniel P Petrylak, Stuart N Atkinson, Deborah M Boldt-Houle, Thomas E Keane, Celestia S Higano, R Jonathan Henderson, A Karim Kader, Maha H Hussain, and Neal D Shore

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Feasibility of Treating High Grade Gliomas in Children with Tumor-Treating Fields: A Case Series., John Crawford, Marlon G Saria, Girish Dhall, Ashley Margol, and Santosh Kesari

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Oncoplastic breast-conserving therapy and intraoperative radiotherapy for management of carcinoma in situ of the breast: A single-center experience., Angelena Crown, Elizabeth Carlson, Flavio G Rocha, and Janie Grumley

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Oncoplastic Breast-Conserving Surgery: Can We Reduce Rates of Mastectomy and Chemotherapy Use in Patients with Traditional Indications for Mastectomy?, Angelena Crown, Nicketti Handy, Christina Weed, Ruby Laskin, Flavio G Rocha, and Janie Grumley

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Efficacy of bendamustine and rituximab in unfit patients with previously untreated chronic lymphocytic leukemia. Indirect comparison with ibrutinib in a real-world setting. A GIMEMA-ERIC and US study., Antonio Cuneo; Anthony R Mato; Gian Matteo Rigolin; Alfonso Piciocchi; Massimo Gentile; Luca Laurenti; John N Allan; John M Pagel; Danielle M Brander; Brian T Hill; Allison Winter; Nicole Lamanna; Constantine S Tam; Ryan Jacobs; Frederick Lansigan; Paul M Barr; Mazyar Shadman; Alan P Skarbnik; Jeffrey J Pu; Alison R Sehgal; Stephen J Schuster; Nirav N Shah; Chaitra S Ujjani; Lindsey Roeker; Ester Maria Orlandi; Atto Billio; Livio Trentin; Martin Spacek; Monia Marchetti; Alessandra Tedeschi; Fiorella Ilariucci; Gianluca Gaidano; Michael Doubek; Lucia Farina; Stefano Molica; Francesco Di Raimondo; Marta Coscia; Francesca Romana Mauro; Javier de la Serna; Angeles Medina Perez; Isacco Ferrarini; Giuseppe Cimino; Maurizio Cavallari; Rosalba Cucci; Marco Vignetti; Robin Foà; Paolo Ghia; and GIMEMA, European Research Initiative (ERIC) on CLL, US study group

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Randomized phase II study of stereotactic body radiotherapy and interleukin-2 versus interleukin-2 in patients with metastatic melanoma., Brendan Curti, Marka R Crittenden, Steven K Seung, Christopher B Fountain, Roxanne Payne, ShuChing Chang, Jessica Fleser, Kimberly Phillips, Ian Malkasian, Lyn B Dobrunick, and Walter Urba

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Multi-Center Analysis of Liver Transplantation for Combined Hepatocellular Carcinoma-Cholangiocarcinoma Liver Tumors., Leigh Anne Dageforde, Neeta Vachharajani, Parissa Tabrizian, Vatche Agopian, Karim Halazun, Erin Maynard, Kristopher Croome, David Nagorney, Johnny C Hong, David Lee, Cristina Ferrone, Erin Baker, William Jarnagin, Alan Hemming, Gabriel Schnickel, Shoko Kimura, Ronald Busuttil, Jessica Lindemann, Sander Florman, Matthew L Holzner, Rami Srouji, Marc Najjar, Lavanya Yohanathan, Jane Cheng, Hiral Amin, Charles A Rickert, Ju Dong Yang, Joohyun Kim, Jennifer Pasko, William C Chapman, and Maria B Majella Doyle

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Genome-wide association study of INDELs identified four novel susceptibility loci associated with lung cancer risk., Juncheng Dai, Mingtao Huang, Christopher I Amos, Rayjean J Hung, Adonina Tardon, Angeline Andrew, Chu Chen, David C Christiani, Demetrius Albanes, Gadi Rennert, Jingyi Fan, Gary E Goodman, Geoffrey Liu, John K Field, Kjell Grankvist, Lambertus A Kiemeney, Loic Le Marchand, Matthew B Schabath, Mattias Johansson, Melinda C Aldrich, Mikael Johansson, Neil Caporaso, Philip Lazarus, Stephan Lam, Stig E Bojesen, Susanne Arnold, Maria Teresa Landi, Angela Risch, H-Erich Wichmann, Heike Bickeboller, Paul Brennan, Sanjay Shete, Olle Melander, Hans Brunnstrom, Shan Zienolddiny, Penella Woll, Victoria Stevens, Zhibin Hu, and Hongbing Shen

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Review of Radium-223 and Metastatic Castration-Sensitive Prostate Cancer., Savita V Dandapani, Jeffrey Wong, and Przemyslaw Twardowski

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Molecular genomic profiling of adrenocortical cancers in clinical practice., Sourat Darabi, David R Braxton, Burton L Eisenberg, and Michael J Demeure

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Predictive Biomarkers for Immunotherapy Response Beyond PD-1/PD-L1., Sourat Darabi, David R Braxton, Burton L Eisenberg, and Michael J Demeure

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Impact of geography and travel distance on outcomes in epithelial ovarian cancer: a national cancer database analysis., Ava Daruvala, F Lee Lucas, Jesse Sammon, Christopher Darus, and Leslie Bradford

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368 REVEAL: Phase 1 dose-escalation study of NKTR-262, a novel TLR7/8 agonist, plus bempegaldesleukin: local innate immune activation and systemic adaptive immune expansion for treating solid tumors, Adi Daub, Brendan Curti, Mehmet Bilen, Andrew Brohl, Evidio Domingo-Musibay, Erkut Borazanci, Christine Fanton, Cat Haglund, Mona Vimal, Mann Muhsin, Mario Marcondes, Anh Nguyen, Mary Tagliaferri, Wei Lin, Jonathan Zalevsky, and Sandra D'Angelo

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420 Progression-free survival and biomarker correlates of response with BEMPEG plus NIVO in previously untreated patients with metastatic melanoma: results from the PIVOT-02 study, Adi Daub, Scott Tykodi, Gregory Daniels, Michele Maio, Brendan Curti, Karl Lewis, Sekwon Jang, Ewa Kalinka, Igor Puzanov, Alexander Spira, Daneil Cho, Shanhong Guan, Erika Puente, Ute Hoch, Sue Currie, Tuan Nguyen, Wei Lin, Mary Tagliaferri, Jonathan Zalevsky, Mario Sznol, and Michael Hurwitz

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Olaparib for Metastatic Castration-Resistant Prostate Cancer., Johann de Bono, Joaquin Mateo, Karim Fizazi, Fred Saad, Neal Shore, Shahneen Sandhu, Kim N Chi, Oliver Sartor, Neeraj Agarwal, David Olmos, Antoine Thiery-Vuillemin, Przemyslaw Twardowski, Niven Mehra, Carsten Goessl, Jinyu Kang, Joseph Burgents, Wenting Wu, Alexander Kohlmann, Carrie A Adelman, and Maha Hussain